Faculté de Médecine

BASIC MEDICAL SCIENCE: PATHOLOGY AND IMMUNOLOGY

he Pathology Department conducts research into anatomical and clinical correlations in human pathology, and in the fields of cell biology, general immunology and immunopathology.  
Concerning cell biology, several teams study:

• growth factors and the oncogenes involved in the differentiation and functioning of the lymphohematopoietic system;
• the functional role of certain parts of the cytoskeletal apparatus, in particular actin and intermediary filaments, and how they change in the course of the arterial pathology of scar-tissue formation and the development of epithelial tumours and conjunctive tissue;
• the structure and function of the cell membrane.

Work on general immunology comprises:

• the functional specificities in vivo of the T-lymphocyte subpopulations in a variety of experimental diseases;
• the conditions of synthesis and the role of the interleukins secreted by lymphoid system cells in different experimental and pathological conditions.

Work in the field of immunopathology focuses on:

• the cell interactions leading to the development of spontaneous or provoked auto-immune diseases;
• the role of specific interactions between immunoglobulin molecules in provoking vascular lesions caused by immune complexes;
• the role of the immune response in the pathological symptoms of infectious diseases.

 

RESEARCH GROUPS
Chief of the department: Prof. Walter Reith
Pathology and immunology D. Belin   The orphan genes of bacteriophage T4, a biological dark matter J. Bertrand   Hemato-vascular development in vertebrates M.-L. Bochaton-Piallat   Smooth muscle cells (SMCs) I.Garcia-Gabay   Role of cytokines of the TNF family in mycobacterial infections O. Hartley   VIH S. Hugues   Stéphanie Hugues's Group B. Imhof   Adhésion molecules and the process of cell migration  M. Jaconi   Stem cells and cardiac differentiation K.-H. Krause   Reactive oxygen species (ROS) B. Kwak   Atherosclerosis D. Merkler   Multiple Sclerosis W.Reith   Major Histocompatibility Complex class II  M-L. Santiago-Raber   Marie-Laure Santiago-Raber's Group Affiliated clinical groups C. Barazzone   Oxidatif stress W-H. Boehncke   Mechanisms of the pathologies of the cutaneous inflammation C.Chizzolini   The extracellular matrix (ECM) C. Gabay   Arthritis M. Ghannage   Monique Ghannage's Group C. Pot-Kreis   C. Pot-kreis's Group C.-A. Siegrist   Vaccinology and immunology center P. Lalive d'Epinay   Neuroimmunology and multiple sclerosis B.Wildhaber   Barbara Wildhaber's Group	Service of clinical pathology T. Mc Kee   Mckee Thomas S. Moll   Nephro-pathology F. Negro   Hépatites B et C  J.C Pache   Jean-Claude Pache's Group L. Rubbia-Brandt   Liver metastases (HCRM)