Faculté de Médecine

BASIC MEDICAL SCIENCE: PHATHOLOGY AND IMMUNOLOGY

he Pathology Department conducts research into anatomical and clinical correlations in human pathology, and in the fields of cell biology, general immunology and immunopathology.  
Concerning cell biology, several teams study:

• growth factors and the oncogenes involved in the differentiation and functioning of the lymphohematopoietic system;
• the functional role of certain parts of the cytoskeletal apparatus, in particular actin and intermediary filaments, and how they change in the course of the arterial pathology of scar-tissue formation and the development of epithelial tumours and conjunctive tissue;
• the structure and function of the cell membrane.

Work on general immunology comprises:

• the functional specificities in vivo of the T-lymphocyte subpopulations in a variety of experimental diseases;
• the conditions of synthesis and the role of the interleukins secreted by lymphoid system cells in different experimental and pathological conditions.

Work in the field of immunopathology focuses on:

• the cell interactions leading to the development of spontaneous or provoked auto-immune diseases;
• the role of specific interactions between immunoglobulin molecules in provoking vascular lesions caused by immune complexes;
• the role of the immune response in the pathological symptoms of infectious diseases.

 

RESEARCH GROUPS
Chief of the department: Prof. Walter Reith
Pathology and immunology D. Belin   Protein secretion across membranes M.-L. Bochaton-Piallat   Smooth muscle cells (SMCs) Ch. Chaponnier   Actin isoform fuction I.Garcia-Gabay   Role of cytokines of the TNF family in mycobacterial infections B. Imhof   Adhésion molecules and the process of cell migration  M. Jaconi   Stem cells and cardiac differentiation K.-H. Krause   Reactive oxygen species (ROS) D. Pinschewer   Under construction W.Reith   Major Histocompatibility Complex class II  M.-L Santiago-Raber   Under construction Affiliated clinical groups C. Barazzone   oxidatif stress C. Gabay   Arthritis J.-H. Saurat - O. Gaide   Dermatology C.-A. Siegrist   Vaccinology and immunology center P. Lalive d'Epinay   Neuroimmunology and multiple sclerosis	Service of clinical pathology T. Mc Kee   Mckee Thomas D. Merkler   Multiple Sclerosis S. Moll   Nephro-pathology  J.C Pache   Pache Jean-Claude M. Bongiovanni   Bongiovanni M L. Rubbia-Brandt   Liver metastases (HCRM)