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Laboratory for Transplantation Immunology (LIT)

The current organ shortage in transplantation medicine stimulates the exploration of new strategies to expand the donor pool including the utilization of living donors, ABO-incompatible grafts and possibly xenotransplantation. Our research focuses on:

1. Preformed natural antibodies, such as anti-A/B histo-blood group antibodies, mediate hyper-acute graft rejection in solid organ transplantation but do not seem to affect the outcome of hematopoietic stem cell transplantation (HSCT). Thus, ABO-incompatible HSCT may serve as an in vivo model to study the immunological mechanisms leading to successful carbohydrate-antigen mismatched transplantation. Our goal is to analyze the mechanisms such as deletion or anergy of B cells and understand the mechanisms of B cell tolerance induction in recipients of solid organ transplantation.

2. Cellular immune responses represent a major obstacle to successful transplantation. A major challenge in organ transplantation is to impair recipients'potential to reject the transplanted organ while preserving its function and limit the adverse effect of immunosuppression on patients' overall survival. The immunosuppressive regimens are mostly assessed on T and B lymphocytes but remain poorly explored with regard to post-transplant function and reconstitution of other immune effector cells, such as natural killer (NK) cells.

3. Porcine and human endothelial cells (EC) share the expression of receptors involved in the adhesion and transmigration of leukocytes into the graft. The interactions between human leukocytes and porcine EC depend on the existence of intact cross-species receptor-ligand interactions. Blocking of the crucial receptors for adhesion and transmigration, in combination with prevention of hyperacute rejection, may lead to the clinical feasibility of pig-to-human xenotransplantation. The goal of this project is to define the mechanisms of interactions between human leukocyte subsets and porcine EC in chemotaxis, adhesion, and transendothelial migration.

4. The induction of antigen-specific immunological tolerance, leaving the immune system intact, to prevent the cellular immune responses in transplantation is an attractive alternative for xenotranplantation. Naturally occurring CD4+CD25+Foxp3+ regulatory T (Treg) cells, contribute to immune regulation and tolerance induction in vivo. Treg cells showed suppressive function of self- and allo-reactive T effectors (Teff) cells in vitro and in vivo. However, the capacity of Treg to suppress the proliferation and Teff cells in response to xenogeneic cells is unknown. The aim of the present study is to investigate these mechanisms of tolerance in this xenogeneic islets transplantation model and to search the potential of ex vivo xenogeneic antigen specific Tregs in the induction of tolerance.

5. Infections represent a major cause of morbidity and mortality post-transplant. Human cytomegalovirus (CMV) establishes life-long latent infection and frequently reactivates in immuno-suppressed transplant recipients which potentially triggers graft rejection. The goal of these reserach is :

1) to elucidate the molecular effects of human CMV infection in porcine and human endothelial cells
2) the resulting influence on human leukocyte chemotaxis, adhesion and transmigration
3) the analyze of effector functions, in particular NK cell responses.

Group's publications

Changes of circulating antibody levels induced by ABO antibody adsorption for ABO-incompatible kidney transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
2009 vol. ;9(5) pp. 1072-1080
VALLI PV. AND AL.

Immune responses to alpha1,3 galactosyltransferase knockout pigs.
CURRENT OPINION IN ORGAN TRANSPLANTATION
2009 vol. 14(2) pp. 154-160
PUGA YUNG G, SCHNEIDER MKJ, SEEBACH JD

Prevention of pure red cell aplasia after major or bidirectional ABO blood group incompatible hematopoietic stem cell transplantation by pretransplant reduction of host anti-donor isoagglutinins.
HAEMATOLOGICA
2009 vol. 94(2) pp. 239-248
STUSSI G, HALTER J, BUCHELI E, VALLI PV, SEEBACH L, GMÜR J, GRATWOHL A, SCHANZ U, PASSWEG J, SEEBACH JD

Spontaneous Splenic Rupture as Manifestation of the Immune Reconstitution Inflammatory Syndrome in an HIV Type 1 Infected Patient with Tuberculosis
INFECTION
2009 vol. 37(2) pp. 163-165
WEBER E, GÜNTHARD HF, SCHERTLER T, SEEBACH JD

HLA-E/human beta2-microglobulin transgenic pigs: protection against xenogeneic human anti-pig natural killer cell cytotoxicity.
TRANSPLANTATION
2009 vol. 87(1) pp. 35-43
WEISS EH. AND AL.

Human CMV infection of porcine endothelial cells increases adhesion receptor expression and human leukocyte recruitment.
TRANSPLANTATION
2009 vol. 87(12) pp. 1792-1800
GHIELMETTI M, MILLARD AL, HÄBERLI L, BOSSART W, SEEBACH JD, SCHNEIDER MKJ, MUELLER NJ

Human leukocyte transmigration across Galalpha(1,3)Gal-negative porcine endothelium is regulated by human CD18 and CD99.
TRANSPLANTATION
2009 vol. 87(4) pp. 491-499
SCHNEIDER MKJ, GHIELMETTI M, RHYNER DM, ANTSIFEROVA MA, SEEBACH JD

Current status of xenotransplantation and prospects for clinical application.
XENOTRANSPLANTATION
2009 vol. 16(5) pp. 263-280
PIERSON RN 3RD, DORLING A, AYARES D, REES MA, SEEBACH JD, FISHMAN JA, HERING BJ, COOPER DK

HLA-Cw4 expression on porcine endothelial cells reduces cytotoxicity and adhesion mediated by CD158a+ human NK cells.
XENOTRANSPLANTATION
2009 vol. 16(1) pp. 19-26
FORTE P, BAUMANN BC, SCHNEIDER MKJ, SEEBACH JD

T regulatory cells in xenotransplantation.
XENOTRANSPLANTATION
2009 vol. 16(3) pp. 121-128
MULLER Y, GOLSHAYAN D, EHIRCHIOU D, WEKERLE T, SEEBACH JD, BUHLER LH

Xenotransplantation literature update March-April, 2009.
XENOTRANSPLANTATION
2009 vol. 16(3) pp. 187-191
SCHNEIDER MKJ, SEEBACH JD

Xenotransplantation literature update: May-October, 2009.
XENOTRANSPLANTATION
2009 vol. 16(6) pp. 555-562
SCHNEIDER MK, SEEBACH JD

Xenotransplantation literature update: November-December, 2008.
XENOTRANSPLANTATION
2009 vol. 16(1) pp. 50-53
SCHNEIDER MKJ, SEEBACH JD

Retinal microangiopathy and rapidly fatal cerebral edema in a patient with adult-onset Still's disease and concurrent macrophage activation syndrome.
AMERICAN JOURNAL OF HEMATOLOGY
2008 vol. 83(5) pp. 424-427
GIANELLA S, SCHAER DJ, SCHWARZ U, KURRER M, HEPPNER FL, FEHR J, SEEBACH JD

Natural killer cell receptor repertoire and their ligands, and the risk of CMV infection after kidney transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
2008 vol. 8(12) pp. 2674-2683
HADAYA K, DE RHAM C, BANDELIER C, BANDELIER CH, FERRARI-LACRAZ SYLVIE, JENDLY S, BERNEY T, BUHLER L, KAISER L, SEEBACH J, TIERCY JM, MARTIN PY, VILLARD J

Current cellular innate immune hurdles in pig-to-primate xenotransplantation.
CURRENT OPINION IN ORGAN TRANSPLANTATION
2008 vol. 13(2) pp. 171-177
SCHNEIDER M, SEEBACH JD

Cytokine secretion depends on Galalpha(1,3)Gal expression in a pig-to-human whole blood model.
JOURNAL OF IMMUNOLOGY
2008 vol. 180(9) pp. 6346-6353
SAETHRE M, SCHNEIDER M, LAMBRIS JD, MAGOTTI P, HARALDSEN G, SEEBACH JD, MOLLNES TE

Cytomegalovirus-associated chorioretinitis after liver transplantation: case report and review of the literature.
TRANSPLANT INFECTIOUS DISEASE : AN OFFICIAL JOURNAL OF THE TRANSPLANTATION SOCIETY
2008 vol. 10(1) pp. 27-43
EGLI A, BERGAMIN O, MULLHAUPT B, SEEBACH JD, MUELLER NJ, HIRSCH HH

Characterization of porcine UL16-binding protein 1 endothelial cell surface expression.
XENOTRANSPLANTATION
2008 vol. 15(2) pp. 136-144
LILIENFELD BG, SCHILDKNECHT A, IMBACH LL, MUELLER NJ, SCHNEIDER M, SEEBACH JD

Porcine cells express more than one functional ligand for the human lymphocyte activating receptor NKG2D.
XENOTRANSPLANTATION
2008 vol. 15(5) pp. 321-332
TRAN P, CHRISTIANSEN D, WINTERHALTER A, BROOKS A, GORRELL M, LILIENFELD B, SEEBACH JD, SANDRIN M, SHARLAND A

Xenotransplantation literature update May-August, 2008.
XENOTRANSPLANTATION
2008 vol. 15(5) pp. 344-351
SCHNEIDER MK, SEEBACH JD

Xenotransplantation literature update: September-October 2008.
XENOTRANSPLANTATION
2008 vol. 15(6) pp. 417-421
SCHNEIDER MK, SEEBACH JD

ABO blood group incompatible haematopoietic stem cell transplantation and xenograft rejection
SWISS MEDICAL WEEKLY
2007 vol. 137 pp. 13-20
STUSSI G, MUELLER RJ, PASSWEG JAKOB, SCHANZ U, RIEBEN R, SEEBACH JD

Alpha1,3-galactosyltransferase gene-knockout pigs for xenotransplantation: where do we go from here?
TRANSPLANTATION
2007 vol. 84(1) pp. 1-7
COOPER DK, DORLING A, PIERSON RN 3RD, REES M, SEEBACH J, YAZER M, OHDAN H, AWWAD M, AYARES D

Characterization of natural human anti-non-gal antibodies and their effect on activation of porcine gal-deficient endothelial cells
TRANSPLANTATION
2007 vol. 84(2) pp. 244-250
SAETHRE M, BAUMANN BC, FUNG M, SEEBACH JD, MOLLNES TE

Flow cytometric measurement of ABO antibodies in ABO-incompatible living donor kidney transplantation
TRANSPLANTATION
2007 vol. 84 pp. 20-23
YUNG GP, VALLI PV, STARKE A, MUELLER RJ, FEHR T, CESAR-OZPAMIR M, SCHANZ U, WEBER M, WÜTHRICH RP, SEEBACH JD, STUSSI G

Reactivity of human natural antibodies to endothelial cells from Galalpha(1,3)Gal-deficient pigs
TRANSPLANTATION
2007 vol. 83(2) pp. 193-201
BAUMANN BC, STUSSI G, HUGGEL K, RIEBEN R, SEEBACH JD

Transgenic expression of HLA-E single chain trimer protects porcine endothelial cells against human natural killer cell-mediated cytotoxicity
XENOTRANSPLANTATION
2007 vol. 4(2) pp. 126-134
LILIENFELD BG, CREW MD, FORTE P, BAUMANN BC, SEEBACH JD

Porcine UL16-binding protein 1 expressed on the surface of endothelial cells triggers human NK cytotoxicity through NKG2D
JOURNAL OF IMMUNOLOGY
2006 vol. 177(4) pp. 2146-2152
LILIENFELD BENJAMIN G., GARCIA-BORGES CARMEN, CREW MARK D., SEEBACH JÖRG D.

ABO-histo blood group incompatibility in hematopoietic stem cell and solid organ transplantation
TRANSFUSION AND APHERESIS SCIENCE
2006 vol. 35(1) pp. 59-69
STUSSI GEORG ET AL.

Activation of human microvascular endothelial cells with TNF-alpha and hypoxia/reoxygenation enhances NK-cell adhesion, but not NK-Cytotoxicity
TRANSPLANTATION
2006 vol. 81(8) pp. 1204-12011
MAURUS CF, SCHNEIDER MKJ, SCHMIDT D, ZÜND G, SEEBACH JD

ABO-incompatible allotransplantation as a basis for clinical xenotransplantation
XENOTRANSPLANTATION
2006 vol. 13(5) pp. 390-399
STUSSI G, WEST L, COOPER DKC, SEEBACH JD

Major ABO-incompatible hematopoietic stem cell transplantation: study of post-transplant pure red cell aplasia and endothelial cell chimerism
XENOTRANSPLANTATION
2006 vol. 13(2) pp. 126-132
MUELLER RJ, STUSSI G, ODERMATT B, HALTER J, SCHANZ U, SEEBACH JD

HLA-E expression on porcine cells: protection from human NK cytotoxicity depends on peptide loading
AMERICAN JOURNAL OF TRANSPLANTATION
2005 vol. 5(9) pp. 2085-2093
FORTE P, BAUMANN BC, WEISS EH, GERAGHTY DE, SEEBACH JD

ABO blood group barrier in allogeneic bone marrow transplantation revisited
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
2005 vol. 11(12) pp. 1006-1013
SEEBACH JD ET AL.

Isotype-specific detection of ABO blood group antibodies using a novel flow cytometric method
BRITISH JOURNAL OF HAEMATOLOGY
2005 vol. 130(6) pp. 954-963
STÜSSI G, HUGGEL K, LUTZ HU, SCHANZ U, RIEBEN R, SEEBACH JD

Deadly carousel or difficult interpretation of new diagnostic tools for Whipple's disease: case report and review of the literature
INFECTION
2005 vol. 33(1) pp. 39-42
MÜLLER SA, VOGT P, ALTWEGG M, SEEBACH JD

Human NK cytotoxicity against porcine cells is triggered by NKp44 and NKG2Dl
JOURNAL OF IMMUNOLOGY
2005 vol. 175(8) pp. 5463-5470
FORTE P, LILIENFELD BG, BAUMANN BC, SEEBACH JD

Sudden leg paralysis in a 26-year-old nurse
SWISS MEDICAL WEEKLY
2005 vol. 135(13-14) pp. 206-207
ULRICH S, MÜLLER V, KEEL M, SEEBACH JD

Endothelial cells derived from pigs lacking Gal alpha(1,3)Gal: no reduction of human leukocyte adhesion and natural killer cell cytotoxicity
TRANSPLANTATION
2005 vol. 79(9) pp. 1067-1072
BAUMANN BC, LILIENFELD BG, ANTSIFEROVA MA, RYNER DM, HAWLEY RJ, SCHNEIDER MKJ, SEEBACH JD

Human polymorphonuclear neutrophils are recruited by porcine chemokines acting on CXC chemokine receptor 2, and platelet-activating factor
TRANSPLANTATION
2005 vol. 79(10) pp. 1324-1331
GILLI UO, SCHNEIDER MKJ, LOETSCHER P, SEEBACH JD

Levels of anti-A/B antibodies after ABO-incompatible hematopoietic stem cell transplantation
TRANSPLANTATION PROCEEDINGS
2005 vol. 37(2) pp. 1385-1387
STUSSI G, HUGGEL K, SCHANZ U, PASSWEG JR, SEEBACH JD

Xenograft rejection: IgG1, complement and NK cells team up to activate and destroy the endothelium
TRENDS IN IMMUNOLOGY
2005 vol. 26(1) pp. 2-5
RIEBEN R, SEEBACH JD

Transvenous biopsy of cavo-atrial tumors with the Quick-Core needle
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
2004 vol. 27(3) pp. 251-253
HECHELHAMMER L, SCHERTLER T, SEEBACH JD, KURRER MO, MARINCEK B, PFAMMATTER T

Lack of galactose-alpha-1,3-galactose expression on porcine endothelial cells prevents complement-induced lysis but not direct xenogeneic NK cytotoxicity
JOURNAL OF IMMUNOLOGY
2004 vol. 172(10) pp. 6460-6467
BAUMANN BC, FOTE P, HAWLEY R, RIEBEN R, SCHNEIDER MKJ, SEEBACH JD

An unusual cause of transient small bowel thickening
SWISS MEDICAL WEEKLY
2004 vol. 34(15-16) pp. 223-224
NOVAK U, WEISHAUPT D, SEEBACH JD

Everolimus-induced drug fever after heart transplantation
TRANSPLANTATION
2004 vol. 78(2) pp. 303-304
DORSCHNER L, SPEICH R, RUSCHITZKA F, GALLINO A, SEEBACH JD

Human Fas-ligand expression on porcine endothelial cells does not protect against xenogeneic natural killer cytotoxicity
XENOTRANSPLANTATION
2004 vol. 11(1) pp. 43-52
MATTER-REISSMANN UB, SONNTAG KC, GILLI UO, LEGUERN C, SCHNEIDER MKJ, SEEBACH JD

Hypoxia and reoxygenation do not upregulate adhesion molecules and natural killer cell adhesion on human endothelial cells in vitro
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY : OFFICIAL JOURNAL OF THE EUROPEAN ASSOCIATION FOR CARDIO-THORACIC SURGERY
2003 vol. 23(6) pp. 976-983
MAURUS CF, SCHMIDT D, SCHNEIDER MKJ, TURINA MI, ZÜND G, SEEBACH JD

Ultra-sensitive and specific detection of porcine endogenous retrovirus (PERV) using a sequence-capture real-time PCR approach
JOURNAL OF VIROLOGICAL METHODS
2003 vol. 109(2) pp. 209-216
SHAH CA, BÖNI J, BISSER LR, SEEBACH JD, KRONENBERG A

Dextran sulfate acts as an endothelial cell protectant and inhibits human complement and natural killer cell-mediated cytotoxicity against porcine cells
TRANSPLANTATION
2003 vol. 76(5) pp. 838-843
LAUMONIER T ET AL.

Acral necrosis of the fingers as initial manifestation of cutaneous polyarteritis nodosa--a case report
ANGIOLOGY : THE JOURNAL OF VASCULAR DISEASES
2001 vol. 52(1) pp. 63-67
STÜSSI G, SCHNEIDER E, TRÜEB RM, SEEBACH JD

Inhibition of human NK cell-mediated cytotoxicity by exposure to ammonium chloride
JOURNAL OF IMMUNOLOGICAL METHODS
2001 vol. 252(1-2) pp. 1-14
BRANDER C, MATTER-REISSMANN UB, JONES NG, WALKER BD, SACHS DH, SEEBACH JD

Human NK cells lyse porcine endothelial cells via the perforin/granzyme B pathway
TRANSPLANTATION PROCEEDINGS
2001 vol. 33(1-2) pp. 439-440
MATTER-REISSMANN UB, FORTE P, SEEBACH JD

Immortalized bone-marrow derived pig endothelial cells
XENOTRANSPLANTATION
2001 vol. 8(1) pp. 48-61
SEEBACH JD ET AL.

Adenoid cystic carcinoma of the breast : utility of immunocytochemical study with collagen IV on fine-needle aspiration
DIAGNOSTIC CYTOPATHOLOGY
1996 vol. 16 pp. 0-
SZALAY QUINODO I, DIEBOLD BERGER S, SCHAFER P, REMADI S

Research's domains




DATABASE-RESEARCH	GROUP OF CLINICAL BIOLOGY RESEARCH

Jorg Seebach	Head of group CV	Research subject	Members of the group


	Links about the group Prof. J. SEEBACH HUG/Spécialités de Médecine Serv Immunologie Allergologie Rue Gabrielle-Perret-Gentil 4 1211 Genève 14 Suisse Joerg.Seebach@hcuge.ch Tel.: 022 372 93 98 Fax: 022 372 33 84 Comments Pages updated the 17.11.2015		Reseach's subject \| Group's publications \| Research's domains Laboratory for Transplantation Immunology (LIT) The current organ shortage in transplantation medicine stimulates the exploration of new strategies to expand the donor pool including the utilization of living donors, ABO-incompatible grafts and possibly xenotransplantation. Our research focuses on: 1. Preformed natural antibodies, such as anti-A/B histo-blood group antibodies, mediate hyper-acute graft rejection in solid organ transplantation but do not seem to affect the outcome of hematopoietic stem cell transplantation (HSCT). Thus, ABO-incompatible HSCT may serve as an in vivo model to study the immunological mechanisms leading to successful carbohydrate-antigen mismatched transplantation. Our goal is to analyze the mechanisms such as deletion or anergy of B cells and understand the mechanisms of B cell tolerance induction in recipients of solid organ transplantation. 2. Cellular immune responses represent a major obstacle to successful transplantation. A major challenge in organ transplantation is to impair recipients'potential to reject the transplanted organ while preserving its function and limit the adverse effect of immunosuppression on patients' overall survival. The immunosuppressive regimens are mostly assessed on T and B lymphocytes but remain poorly explored with regard to post-transplant function and reconstitution of other immune effector cells, such as natural killer (NK) cells. 3. Porcine and human endothelial cells (EC) share the expression of receptors involved in the adhesion and transmigration of leukocytes into the graft. The interactions between human leukocytes and porcine EC depend on the existence of intact cross-species receptor-ligand interactions. Blocking of the crucial receptors for adhesion and transmigration, in combination with prevention of hyperacute rejection, may lead to the clinical feasibility of pig-to-human xenotransplantation. The goal of this project is to define the mechanisms of interactions between human leukocyte subsets and porcine EC in chemotaxis, adhesion, and transendothelial migration. 4. The induction of antigen-specific immunological tolerance, leaving the immune system intact, to prevent the cellular immune responses in transplantation is an attractive alternative for xenotranplantation. Naturally occurring CD4+CD25+Foxp3+ regulatory T (Treg) cells, contribute to immune regulation and tolerance induction in vivo. Treg cells showed suppressive function of self- and allo-reactive T effectors (Teff) cells in vitro and in vivo. However, the capacity of Treg to suppress the proliferation and Teff cells in response to xenogeneic cells is unknown. The aim of the present study is to investigate these mechanisms of tolerance in this xenogeneic islets transplantation model and to search the potential of ex vivo xenogeneic antigen specific Tregs in the induction of tolerance. 5. Infections represent a major cause of morbidity and mortality post-transplant. Human cytomegalovirus (CMV) establishes life-long latent infection and frequently reactivates in immuno-suppressed transplant recipients which potentially triggers graft rejection. The goal of these reserach is : 1) to elucidate the molecular effects of human CMV infection in porcine and human endothelial cells 2) the resulting influence on human leukocyte chemotaxis, adhesion and transmigration 3) the analyze of effector functions, in particular NK cell responses. Group's publications Changes of circulating antibody levels induced by ABO antibody adsorption for ABO-incompatible kidney transplantation. AMERICAN JOURNAL OF TRANSPLANTATION 2009 vol. ;9(5) pp. 1072-1080 VALLI PV. AND AL. Immune responses to alpha1,3 galactosyltransferase knockout pigs. CURRENT OPINION IN ORGAN TRANSPLANTATION 2009 vol. 14(2) pp. 154-160 PUGA YUNG G, SCHNEIDER MKJ, SEEBACH JD Prevention of pure red cell aplasia after major or bidirectional ABO blood group incompatible hematopoietic stem cell transplantation by pretransplant reduction of host anti-donor isoagglutinins. HAEMATOLOGICA 2009 vol. 94(2) pp. 239-248 STUSSI G, HALTER J, BUCHELI E, VALLI PV, SEEBACH L, GMÜR J, GRATWOHL A, SCHANZ U, PASSWEG J, SEEBACH JD Spontaneous Splenic Rupture as Manifestation of the Immune Reconstitution Inflammatory Syndrome in an HIV Type 1 Infected Patient with Tuberculosis INFECTION 2009 vol. 37(2) pp. 163-165 WEBER E, GÜNTHARD HF, SCHERTLER T, SEEBACH JD HLA-E/human beta2-microglobulin transgenic pigs: protection against xenogeneic human anti-pig natural killer cell cytotoxicity. TRANSPLANTATION 2009 vol. 87(1) pp. 35-43 WEISS EH. AND AL. Human CMV infection of porcine endothelial cells increases adhesion receptor expression and human leukocyte recruitment. TRANSPLANTATION 2009 vol. 87(12) pp. 1792-1800 GHIELMETTI M, MILLARD AL, HÄBERLI L, BOSSART W, SEEBACH JD, SCHNEIDER MKJ, MUELLER NJ Human leukocyte transmigration across Galalpha(1,3)Gal-negative porcine endothelium is regulated by human CD18 and CD99. TRANSPLANTATION 2009 vol. 87(4) pp. 491-499 SCHNEIDER MKJ, GHIELMETTI M, RHYNER DM, ANTSIFEROVA MA, SEEBACH JD Current status of xenotransplantation and prospects for clinical application. XENOTRANSPLANTATION 2009 vol. 16(5) pp. 263-280 PIERSON RN 3RD, DORLING A, AYARES D, REES MA, SEEBACH JD, FISHMAN JA, HERING BJ, COOPER DK HLA-Cw4 expression on porcine endothelial cells reduces cytotoxicity and adhesion mediated by CD158a+ human NK cells. XENOTRANSPLANTATION 2009 vol. 16(1) pp. 19-26 FORTE P, BAUMANN BC, SCHNEIDER MKJ, SEEBACH JD T regulatory cells in xenotransplantation. XENOTRANSPLANTATION 2009 vol. 16(3) pp. 121-128 MULLER Y, GOLSHAYAN D, EHIRCHIOU D, WEKERLE T, SEEBACH JD, BUHLER LH Xenotransplantation literature update March-April, 2009. XENOTRANSPLANTATION 2009 vol. 16(3) pp. 187-191 SCHNEIDER MKJ, SEEBACH JD Xenotransplantation literature update: May-October, 2009. XENOTRANSPLANTATION 2009 vol. 16(6) pp. 555-562 SCHNEIDER MK, SEEBACH JD Xenotransplantation literature update: November-December, 2008. XENOTRANSPLANTATION 2009 vol. 16(1) pp. 50-53 SCHNEIDER MKJ, SEEBACH JD Retinal microangiopathy and rapidly fatal cerebral edema in a patient with adult-onset Still's disease and concurrent macrophage activation syndrome. AMERICAN JOURNAL OF HEMATOLOGY 2008 vol. 83(5) pp. 424-427 GIANELLA S, SCHAER DJ, SCHWARZ U, KURRER M, HEPPNER FL, FEHR J, SEEBACH JD Natural killer cell receptor repertoire and their ligands, and the risk of CMV infection after kidney transplantation. AMERICAN JOURNAL OF TRANSPLANTATION 2008 vol. 8(12) pp. 2674-2683 HADAYA K, DE RHAM C, BANDELIER C, BANDELIER CH, FERRARI-LACRAZ SYLVIE, JENDLY S, BERNEY T, BUHLER L, KAISER L, SEEBACH J, TIERCY JM, MARTIN PY, VILLARD J Current cellular innate immune hurdles in pig-to-primate xenotransplantation. CURRENT OPINION IN ORGAN TRANSPLANTATION 2008 vol. 13(2) pp. 171-177 SCHNEIDER M, SEEBACH JD Cytokine secretion depends on Galalpha(1,3)Gal expression in a pig-to-human whole blood model. JOURNAL OF IMMUNOLOGY 2008 vol. 180(9) pp. 6346-6353 SAETHRE M, SCHNEIDER M, LAMBRIS JD, MAGOTTI P, HARALDSEN G, SEEBACH JD, MOLLNES TE Cytomegalovirus-associated chorioretinitis after liver transplantation: case report and review of the literature. TRANSPLANT INFECTIOUS DISEASE : AN OFFICIAL JOURNAL OF THE TRANSPLANTATION SOCIETY 2008 vol. 10(1) pp. 27-43 EGLI A, BERGAMIN O, MULLHAUPT B, SEEBACH JD, MUELLER NJ, HIRSCH HH Characterization of porcine UL16-binding protein 1 endothelial cell surface expression. XENOTRANSPLANTATION 2008 vol. 15(2) pp. 136-144 LILIENFELD BG, SCHILDKNECHT A, IMBACH LL, MUELLER NJ, SCHNEIDER M, SEEBACH JD Porcine cells express more than one functional ligand for the human lymphocyte activating receptor NKG2D. XENOTRANSPLANTATION 2008 vol. 15(5) pp. 321-332 TRAN P, CHRISTIANSEN D, WINTERHALTER A, BROOKS A, GORRELL M, LILIENFELD B, SEEBACH JD, SANDRIN M, SHARLAND A Xenotransplantation literature update May-August, 2008. XENOTRANSPLANTATION 2008 vol. 15(5) pp. 344-351 SCHNEIDER MK, SEEBACH JD Xenotransplantation literature update: September-October 2008. XENOTRANSPLANTATION 2008 vol. 15(6) pp. 417-421 SCHNEIDER MK, SEEBACH JD ABO blood group incompatible haematopoietic stem cell transplantation and xenograft rejection SWISS MEDICAL WEEKLY 2007 vol. 137 pp. 13-20 STUSSI G, MUELLER RJ, PASSWEG JAKOB, SCHANZ U, RIEBEN R, SEEBACH JD Alpha1,3-galactosyltransferase gene-knockout pigs for xenotransplantation: where do we go from here? TRANSPLANTATION 2007 vol. 84(1) pp. 1-7 COOPER DK, DORLING A, PIERSON RN 3RD, REES M, SEEBACH J, YAZER M, OHDAN H, AWWAD M, AYARES D Characterization of natural human anti-non-gal antibodies and their effect on activation of porcine gal-deficient endothelial cells TRANSPLANTATION 2007 vol. 84(2) pp. 244-250 SAETHRE M, BAUMANN BC, FUNG M, SEEBACH JD, MOLLNES TE Flow cytometric measurement of ABO antibodies in ABO-incompatible living donor kidney transplantation TRANSPLANTATION 2007 vol. 84 pp. 20-23 YUNG GP, VALLI PV, STARKE A, MUELLER RJ, FEHR T, CESAR-OZPAMIR M, SCHANZ U, WEBER M, WÜTHRICH RP, SEEBACH JD, STUSSI G Reactivity of human natural antibodies to endothelial cells from Galalpha(1,3)Gal-deficient pigs TRANSPLANTATION 2007 vol. 83(2) pp. 193-201 BAUMANN BC, STUSSI G, HUGGEL K, RIEBEN R, SEEBACH JD Transgenic expression of HLA-E single chain trimer protects porcine endothelial cells against human natural killer cell-mediated cytotoxicity XENOTRANSPLANTATION 2007 vol. 4(2) pp. 126-134 LILIENFELD BG, CREW MD, FORTE P, BAUMANN BC, SEEBACH JD Porcine UL16-binding protein 1 expressed on the surface of endothelial cells triggers human NK cytotoxicity through NKG2D JOURNAL OF IMMUNOLOGY 2006 vol. 177(4) pp. 2146-2152 LILIENFELD BENJAMIN G., GARCIA-BORGES CARMEN, CREW MARK D., SEEBACH JÖRG D. ABO-histo blood group incompatibility in hematopoietic stem cell and solid organ transplantation TRANSFUSION AND APHERESIS SCIENCE 2006 vol. 35(1) pp. 59-69 STUSSI GEORG ET AL. Activation of human microvascular endothelial cells with TNF-alpha and hypoxia/reoxygenation enhances NK-cell adhesion, but not NK-Cytotoxicity TRANSPLANTATION 2006 vol. 81(8) pp. 1204-12011 MAURUS CF, SCHNEIDER MKJ, SCHMIDT D, ZÜND G, SEEBACH JD ABO-incompatible allotransplantation as a basis for clinical xenotransplantation XENOTRANSPLANTATION 2006 vol. 13(5) pp. 390-399 STUSSI G, WEST L, COOPER DKC, SEEBACH JD Major ABO-incompatible hematopoietic stem cell transplantation: study of post-transplant pure red cell aplasia and endothelial cell chimerism XENOTRANSPLANTATION 2006 vol. 13(2) pp. 126-132 MUELLER RJ, STUSSI G, ODERMATT B, HALTER J, SCHANZ U, SEEBACH JD HLA-E expression on porcine cells: protection from human NK cytotoxicity depends on peptide loading AMERICAN JOURNAL OF TRANSPLANTATION 2005 vol. 5(9) pp. 2085-2093 FORTE P, BAUMANN BC, WEISS EH, GERAGHTY DE, SEEBACH JD ABO blood group barrier in allogeneic bone marrow transplantation revisited BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 2005 vol. 11(12) pp. 1006-1013 SEEBACH JD ET AL. Isotype-specific detection of ABO blood group antibodies using a novel flow cytometric method BRITISH JOURNAL OF HAEMATOLOGY 2005 vol. 130(6) pp. 954-963 STÜSSI G, HUGGEL K, LUTZ HU, SCHANZ U, RIEBEN R, SEEBACH JD Deadly carousel or difficult interpretation of new diagnostic tools for Whipple's disease: case report and review of the literature INFECTION 2005 vol. 33(1) pp. 39-42 MÜLLER SA, VOGT P, ALTWEGG M, SEEBACH JD Human NK cytotoxicity against porcine cells is triggered by NKp44 and NKG2Dl JOURNAL OF IMMUNOLOGY 2005 vol. 175(8) pp. 5463-5470 FORTE P, LILIENFELD BG, BAUMANN BC, SEEBACH JD Sudden leg paralysis in a 26-year-old nurse SWISS MEDICAL WEEKLY 2005 vol. 135(13-14) pp. 206-207 ULRICH S, MÜLLER V, KEEL M, SEEBACH JD Endothelial cells derived from pigs lacking Gal alpha(1,3)Gal: no reduction of human leukocyte adhesion and natural killer cell cytotoxicity TRANSPLANTATION 2005 vol. 79(9) pp. 1067-1072 BAUMANN BC, LILIENFELD BG, ANTSIFEROVA MA, RYNER DM, HAWLEY RJ, SCHNEIDER MKJ, SEEBACH JD Human polymorphonuclear neutrophils are recruited by porcine chemokines acting on CXC chemokine receptor 2, and platelet-activating factor TRANSPLANTATION 2005 vol. 79(10) pp. 1324-1331 GILLI UO, SCHNEIDER MKJ, LOETSCHER P, SEEBACH JD Levels of anti-A/B antibodies after ABO-incompatible hematopoietic stem cell transplantation TRANSPLANTATION PROCEEDINGS 2005 vol. 37(2) pp. 1385-1387 STUSSI G, HUGGEL K, SCHANZ U, PASSWEG JR, SEEBACH JD Xenograft rejection: IgG1, complement and NK cells team up to activate and destroy the endothelium TRENDS IN IMMUNOLOGY 2005 vol. 26(1) pp. 2-5 RIEBEN R, SEEBACH JD Transvenous biopsy of cavo-atrial tumors with the Quick-Core needle CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY 2004 vol. 27(3) pp. 251-253 HECHELHAMMER L, SCHERTLER T, SEEBACH JD, KURRER MO, MARINCEK B, PFAMMATTER T Lack of galactose-alpha-1,3-galactose expression on porcine endothelial cells prevents complement-induced lysis but not direct xenogeneic NK cytotoxicity JOURNAL OF IMMUNOLOGY 2004 vol. 172(10) pp. 6460-6467 BAUMANN BC, FOTE P, HAWLEY R, RIEBEN R, SCHNEIDER MKJ, SEEBACH JD An unusual cause of transient small bowel thickening SWISS MEDICAL WEEKLY 2004 vol. 34(15-16) pp. 223-224 NOVAK U, WEISHAUPT D, SEEBACH JD Everolimus-induced drug fever after heart transplantation TRANSPLANTATION 2004 vol. 78(2) pp. 303-304 DORSCHNER L, SPEICH R, RUSCHITZKA F, GALLINO A, SEEBACH JD Human Fas-ligand expression on porcine endothelial cells does not protect against xenogeneic natural killer cytotoxicity XENOTRANSPLANTATION 2004 vol. 11(1) pp. 43-52 MATTER-REISSMANN UB, SONNTAG KC, GILLI UO, LEGUERN C, SCHNEIDER MKJ, SEEBACH JD Hypoxia and reoxygenation do not upregulate adhesion molecules and natural killer cell adhesion on human endothelial cells in vitro EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY : OFFICIAL JOURNAL OF THE EUROPEAN ASSOCIATION FOR CARDIO-THORACIC SURGERY 2003 vol. 23(6) pp. 976-983 MAURUS CF, SCHMIDT D, SCHNEIDER MKJ, TURINA MI, ZÜND G, SEEBACH JD Ultra-sensitive and specific detection of porcine endogenous retrovirus (PERV) using a sequence-capture real-time PCR approach JOURNAL OF VIROLOGICAL METHODS 2003 vol. 109(2) pp. 209-216 SHAH CA, BÖNI J, BISSER LR, SEEBACH JD, KRONENBERG A Dextran sulfate acts as an endothelial cell protectant and inhibits human complement and natural killer cell-mediated cytotoxicity against porcine cells TRANSPLANTATION 2003 vol. 76(5) pp. 838-843 LAUMONIER T ET AL. Acral necrosis of the fingers as initial manifestation of cutaneous polyarteritis nodosa--a case report ANGIOLOGY : THE JOURNAL OF VASCULAR DISEASES 2001 vol. 52(1) pp. 63-67 STÜSSI G, SCHNEIDER E, TRÜEB RM, SEEBACH JD Inhibition of human NK cell-mediated cytotoxicity by exposure to ammonium chloride JOURNAL OF IMMUNOLOGICAL METHODS 2001 vol. 252(1-2) pp. 1-14 BRANDER C, MATTER-REISSMANN UB, JONES NG, WALKER BD, SACHS DH, SEEBACH JD Human NK cells lyse porcine endothelial cells via the perforin/granzyme B pathway TRANSPLANTATION PROCEEDINGS 2001 vol. 33(1-2) pp. 439-440 MATTER-REISSMANN UB, FORTE P, SEEBACH JD Immortalized bone-marrow derived pig endothelial cells XENOTRANSPLANTATION 2001 vol. 8(1) pp. 48-61 SEEBACH JD ET AL. Adenoid cystic carcinoma of the breast : utility of immunocytochemical study with collagen IV on fine-needle aspiration DIAGNOSTIC CYTOPATHOLOGY 1996 vol. 16 pp. 0- SZALAY QUINODO I, DIEBOLD BERGER S, SCHAFER P, REMADI S Research's domains