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Régulation de l'expression génique par le complexe Ccr4-Not dans la levure S.cerevisiae

Les projets du laboratoire Collart sont centrés sur l'étude d'un complexe, le complexe Ccr4-Not, conservé à travers le royaume eucaryote, et un régulateur central de l'expression des gènes.

Le laboratoire Collart étudie ce régulateur conservé et central dans la levure S.cerevisiae, un organisme eucaryote modèle pour lequel il y a des outils génétiques très puissants qui peuvent être combinés à des approches biochimiques.

Dans la levure, ce complexe consiste en 9 sous-unités : Not1-5, Caf1, Caf40, Caf130 et Ccr4. Des homologues de ces sous-unités existent dans la plupart des cas chez les autres eucaryotes, et chez tous les eucaryotes il y a 2 activités enzymatiques associées au complexe, une déadenylase et une ubiquitine ligase.

De nombreuses fonctions cellulaires ont été attribuées au complexe Ccr4-Not chez la levure ou les autres eucaryotes. Le rôle majeur confirmé à ce jour est sa contribution au métabolisme des ARNs messagers, puisque le complexe porte la déadénylase eucaroyte majeure qui catalyse l'étape initiale et limitante pour la dégradation des ARNs messagers. Le groupe Collart a connecté le complexe à la transcription par l'ARN polymérase II, et plus récemment leur travail a étendu le rôle du complexe Ccr4-Not à la surveillance nucléaire et l'export des mRNAs.

Cette dernière année, des études du laboratoire Collart ont révélé l'importance du complexe Ccr4-Not pour le métabolisme des protéines. Les substrats de Not4, la ligase E3 à motif RING, sont connectés au ribosome, en particulier la protéine ribosomale Rps7A, et une chaperone associée au ribosome, NAC. De plus, le complexe Ccr4-Not est associé aux polysomes en phase de traduction. Plusieurs sous-unités du complexe Ccr4-Not sont nécessaires pour éviter l'agrégation des protéines et pour l'assemblage de la machinerie de dégradation majeure des protéines cellulaires, le protéasome.

Le modèle de travail du laboratoire Collart pour le complexe Ccr4-Not, est que le complexe fonctionne comme une Ť plateforme chaperone ť, qui régule les interactions fonctionnelles et dynamiques entre partenaires cellulaires participant à diverses fonctions cellulaires. En interagissant avec les ribosomes en phase de traduction et les chaperones, le complexe a la possibilité d'interagir avec les protéines nouvellement synthétisées et les délivrer à leurs partenaires cellulaires de façon fonctionnelle. Les projects actuels du laboratoire Collart sont dirigés pour adresser ce modèle.

Publications du groupe

Ribosome Association and Stability of the Nascent Polypeptide-Associated Complex Is Dependent Upon Its Own Ubiquitination
GENETICS
2009 vol. 181 pp. 447-460
PANASENKO O, DAVID FP, COLLART M

The CCR4-NOT complex physically and functionally interacts with TRAMP and the nuclear exosome
PLOS ONE
2009 vol. 4(8) pp. 6760-6760
AZZOUZ N, PANASENKO O, COLAU G, COLLART M

Specific roles for the Ccr4-Not complex subunits in expression of the genome.
RNA (NEW YORK, N.Y.)
2009 vol. 15(3) pp. 377-383
AZZOUZ N, PANASENKO O, DELUEN C, HSIEH J, THEILER G, COLLART M

The dual control of TFIIB recruitment by NC2 is gene specific
NUCLEIC ACIDS RESEARCH
2008 vol. 36(2) pp. 539-549
MASSON PATRICK, LEIMGRUBER ELISA, CRETON SANDRINE, COLLART MARTINE A.

The dual control of TFIIB recruitment by NC2 is gene specific.
NUCLEIC ACIDS RESEARCH
2008 vol. 36(2) pp. 539-549
MASSON P, LEIMGRUBER E, CRETON S, COLLART MARTINE

The Ccr4-not complex regulates Skn7 through Srb10 kinase
EUKARYOTIC CELL
2007 vol. 6(12) pp. 2251-2259
LENSSEN EVE, AZZOUZ NOWEL, MICHEL AGNES, LANDRIEUX EMILIE, COLLART MARTINE A.

A SAGA-Independent function of SPT3 mediates transcriptional deregulation in a mutant of the Ccr4-Not complex in Saccharomyces cerevisiae
GENETICS
2007 vol. 177 pp. 123-135
JAMES, N, LANDRIEUX, E, COLLART, MA

Modulation of Ubc4p/Ubc5p-mediated stress responses by the RING-finger-dependent ubiquitin-protein ligase Not4p in Saccharomyces cerevisiae
GENETICS
2007 vol. 176(1) pp. 181-192
MULDER KLAAS W., INAGAKI AKIKO, CAMERONI ELISABETTA, MASSON FLORENCE, WINKLER G. SEBASTIAN, DE VIRGILIO CLAUDIO, COLLART MARTINE A., TIMMERS H. TH. MARC

Crystal structure, biochemical and genetic characterization of yeast and E-cuniculi TAF(II)5 N-terminal domain: Implications for TRID assembly
JOURNAL OF MOLECULAR BIOLOGY
2007 vol. 368 pp. 1292-1306
ROMIER, C, JAMES, N, BIRCK, C, CAVARELLI, J, VIVARES, C, COLLART, MA, MORAS, D

The yeast Ccr4-Not complex controls ubiquitination of the nascent-associated polypeptide (NAC-EGD) complex
JOURNAL OF BIOLOGICAL CHEMISTRY
2006 vol. 281(42) pp. 31389-31398
PANASENKO OLESYA, LANDRIEUX EMILIE, FEUERMANN MARC, FINKA ANDRIJA, PAQUET NICOLE, COLLART MARTINE A.

LKB1 interacts with and phosphorylates PTEN : a functional link between two proteins involved in cancer predisposing syndromes
HUMAN MOLECULAR GENETICS
2005 vol. 14 pp. 2209-2219
MEHENNI HAMID, MARQ-LIN NATHALIE, BUCHET-POYAU K, REYMOND ALEXANDRE, COLLART MARTINE, PICARD DIDIER, ANTONARAKIS STYLIANOS

The Ccr4-not complex independently controls both Msn2-dependent transcriptional activation-via a newly identified Glc7/Bud14 type 1 protein phosphatase module-and TFIID promoter distribution
MOLECULAR AND CELLULAR BIOLOGY : MCB
2005 vol. 25 pp. 488-498
LENSSEN EVE, JAMES FARESSE NICOLE, PEDRUZZI IVO, DUBOULOZ FREDERIQUE, CAMERONI ELISABETTA, BISIG RUTH, MAILLET LAURENT, MICHEL WERNER, JOHNNY ROOSEN, KATARINA PETROVIC, JORIS WINDERICKX, COLLART MARTINE, DE VIRGILIO CLAUDIO

The eukaryotic Ccr4-not complex: a regulatory platform integrating mRNA metabolism with cellular signaling pathways?
PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY
2004 vol. 77 pp. 289-322
COLLART BURKHARD MARTINE, TIMMERS H. TH. MARC

Global control of gene expression in yeast by the Ccr4-Not complex
GENE
2003 vol. 313 pp. 1-16
COLLART MA

The critical cis-acting element required for IMD2 feedback regulation by GDP is a TATA box located 202 nucleotides upstream of the transcription start site
MOLECULAR AND CELLULAR BIOLOGY : MCB
2003 vol. 23 pp. 6267-6278
MAFALDA ESCOBAR-HENRIQUES, BERTRAND DAIGNAN-FORNIER, COLLART MA

Transcription initiation of the yeast IMD2 gene is abolished in response to nutrient limitation through a sequence in its coding region
MOLECULAR AND CELLULAR BIOLOGY : MCB
2003 vol. 23 pp. 6279-6290
MAFALDA ESCOBAR-HENRIQUES, COLLART MA, BERTRAND DAIGNAN-FORNIER

Identification of a ubiquitin-protein ligase subunit within the CCR4-NOT transcription repressor complex
EMBO JOURNAL
2002 vol. 21 pp. 355-364
ALBERT THOMAS K, HANZAWA HIROYUKI, LEGTENBERG YVONNE I.A, DE RUWE MARJOLEIN J, VAN DEN HEUVEL FIONA AJ, COLLART MA, BOELENS ROLF, TIMMERS H.TH.MARC

The NC2 alpha and beta subunits play different roles in vivo
GENES AND DEVELOPMENT
2002 vol. 16 pp. 3265-3276
CRETON S, SVEJSTRUP JESPER Q, COLLART MA

Interaction between Not1p, a component of the Ccr4-not complex, a global regulator of transcription, and Dhh1p, a putative RNA helicase
JOURNAL OF BIOLOGICAL CHEMISTRY
2002 vol. 277 pp. 2835-2842
MAILLET L, COLLART MA

The Ccr4-not complex and yTAF1 (yTaf(II)130p/yTaf(II)145p) show physical and functional interactions
MOLECULAR AND CELLULAR BIOLOGY : MCB
2002 vol. 22 pp. 6735-6749
DELUEN C, JAMES N, MAILLET LAURENT, MOLINETE M, THEILER G, LEMAIRE MARC, PAQUET N, COLLART MA

Saccharomyces cerevisiae Ccr4-not complex contributes to the control of Msn2p-dependent transcription by the Ras/cAMP pathway
MOLECULAR MICROBIOLOGY
2002 vol. 43 pp. 1023-1037
LENSSEN E, OBERHOLZER U, LABARRE J, DE VIRGILIO C, COLLART MA

A single point mutation in TFIIA suppresses NC2 requirement in vivo.
EMBO JOURNAL
2000 vol. 19(4) pp. 672-682
XIE J, COLLART MARTINE, LEMAIRE M, STELZER G, MEISTERERNST M

The TATA-binding protein-associated factor yTafII19p functionally interacts with components of the global transcriptional regulator Ccr4-Not complex and physically interacts with the Not5 subunit.
JOURNAL OF BIOLOGICAL CHEMISTRY
2000 vol. 275(35) pp. 26925-26934
LEMAIRE M, COLLART M

The essential function of Not1 lies within the Ccr4-Not complex.
JOURNAL OF MOLECULAR BIOLOGY
2000 vol. 303(2) pp. 131-143
MAILLET L, TU C, HONG YK, SHUSTER EO, COLLART MARTINE

The NC2 repressor is dispensable in yeast mutated for the Sin4p component of the holoenzyme and plays roles similar to Mot1p in vivo.
MOLECULAR MICROBIOLOGY
2000 vol. 36(1) pp. 163-173
LEMAIRE M, XIE J, MEISTERERNST M, COLLART MARTINE

Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits.
NUCLEIC ACIDS RESEARCH
2000 vol. 28(3) pp. 809-817
ALBERT TK, LEMAIRE M, VAN BERKUM NL, GENTZ R, COLLART MARTINE, TIMMERS HT

In vitro transcription of a yeast TATA-less promoter> negative regulation by the Not1 protein
BIOLOGICAL CHEMISTRY
1999 vol. 380 pp. 1365-1370
OBERHOLZER U., COLLART MARTINE

The CCR4 and CAF1 proteins of the CCR4-NOT complex are physically and functionally separated from NOT2, NOT4, and NOT5.
MOLECULAR AND CELLULAR BIOLOGY : MCB
1999 vol. 19 pp. 6642-6651
BAI Y, SALVADORE C., CHIANG Y.-C., COLLART MARTINE, LIU H.-Y., DENIS C.L.

Characterization of NOT5 that encodes a new component of the Not protein complex
GENE
1998 vol. 207 pp. 61-69
OBERHOLZER U, COLLART MARTINE

TOM1p, a yeast hect-domain protein which mediates transcriptional regulation through the ADA/SAGA coactivator complexes
JOURNAL OF MOLECULAR BIOLOGY
1998 vol. 282 pp. 933-946
SALEH A, COLLART M, MARTENS JA, GENEREAUX J, COTE J, BRANDL CJ

MHP1, an essential gene in CS required for microtubule function
JOURNAL OF CELL BIOLOGY
1996 vol. 135 pp. 0-
IRMINGER-FINGER I, HURT E, ROEBUCK A, COLLART MA, EDELSTEIN SJ

MHP1, an essential gene in Saccharomyces cerevisiae required for microtubule function.
JOURNAL OF CELL BIOLOGY
1996 vol. 135(5) pp. 1323-1339
IRMINGER-FINGER I, HURT E, ROEBUCK A, COLLART MARTINE, EDELSTEIN SJ

The NOT, SPT3, and MOT1 genes functionally interact to regulate transcription at core promoters.
MOLECULAR AND CELLULAR BIOLOGY : MCB
1996 vol. 16(12) pp. 6668-6676
COLLART MARTINE

NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization.
GENES AND DEVELOPMENT
1994 vol. 8(5) pp. 525-537
COLLART MARTINE, STRUHL K

NOT1(CDC39), NOT2(CDC36), NOT3 and NOT4 encode a global-negative regulator of transcription that differentially affects TAT-element utilization
GENES AND DEVELOPMENT
1994 vol. 8 pp. 0-
COLLART MA, STRUHL K

CDC39, an essential nuclear protein that negatively regulates transcription and differentially affects the constitutive and inducible HIS3 promoters.
EMBO JOURNAL
1993 vol. 12(1) pp. 177-186
COLLART MARTINE, STRUHL K

c-fos gene transcription in murine macrophages is modulated by a calcium-dependent block to elongation in intron 1.
MOLECULAR AND CELLULAR BIOLOGY : MCB
1991 vol. 11(5) pp. 2826-2831
COLLART MARTINE, TOURKINE N, BELIN D, VASSALLI P, JEANTEUR PH, BLANCHARD JM

Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages.
JOURNAL OF EXPERIMENTAL MEDICINE
1990 vol. 171(1) pp. 35-47
SHAKOV AN, COLLART MARTINE, VASSALLI P, NEDOSPASOV SA, JONGENEEL CV

Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis.
JOURNAL OF EXPERIMENTAL MEDICINE
1990 vol. 170(3) pp. 655-663
PIGUET PF, COLLART MARTINE, GRAU GE, SAPPINO AP, VASSALLI P

Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B.
MOLECULAR AND CELLULAR BIOLOGY : MCB
1990 vol. 10(4) pp. 1498-1506
COLLART MARTINE, BAEUERLE P, VASSALLI P

Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis.
JOURNAL OF EXPERIMENTAL MEDICINE
1989 vol. 170(3) pp. 655-663
PIGUET PF, COLLART MARTINE, GRAU GE, KAPANCI Y, VASSALLI P

Pneumopathies of the graft-versus-host reaction. Alveolitis associated with an increased level of tumor necrosis factor mRNA and chronic interstitial pneumonitis.
LABORATORY INVESTIGATION
1989 vol. 61(1) pp. 37-45
PIGUET PF, GRAU GE, COLLART MARTINE, VASSALLI P, KAPANCI Y

Receptor-mediated phagocytosis by macrophages induces a calcium-dependent transient increase in c-fos transcription.
ONCOGENE : AN INTERNATIONAL JOURNAL
1989 vol. 4(2) pp. 237-241
COLLART MARTINE, BELIN D, BRIOTTET C, THORENS B, VASSALLI JD, VASSALLI P

Antagonist effect of RU 486 on transcription of glucocorticoid-regulated genes.
EXPERIMENTAL CELL RESEARCH
1987 vol. 173(2) pp. 425-430
BUSSO N, COLLART MARTINE, VASSALLI JD, VASSALLI P

Modulations of functional activity in differentiated macrophages are accompanied by early and transient increase or decrease in c-fos gene transcription.
JOURNAL OF IMMUNOLOGY
1987 vol. 139(3) pp. 949-955
COLLART M, BELIN D, VASSALLI JD, VASSALLI P

Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors.
JOURNAL OF EXPERIMENTAL MEDICINE
1986 vol. 164(6) pp. 2113-2118
COLLART M, BELIN D, VASSALLI JD, KOSSODO S, VASSALLI P

Domaines de recherche




BASE DE DONNÉES-RECHERCHE	GROUPE DE RECHERCHE FONDAMENTALE

Martine COLLART BURKHARD	CV du Chef de Groupe	Sujet de Recherche	Composition du Groupe


	Coordonnées du groupe Pr. M. COLLART CMU/ Dpt MIMOL Rue Michel-Servet 1 1211 Genève 4 Suisse Martine.Collart@unige.ch Tél.: 022 379 55 16 / 022 379 54 76 Fax: 022 379 57 02 Commentaires Pages générées le 16.05.2012		Sujet de recherche \| Publications du groupe \| Domaines de recherche Régulation de l'expression génique par le complexe Ccr4-Not dans la levure S.cerevisiae Régulation de l'expression génique par le complexe Ccr4-Not dans la levure S.cerevisiae Les projets du laboratoire Collart sont centrés sur l'étude d'un complexe, le complexe Ccr4-Not, conservé à travers le royaume eucaryote, et un régulateur central de l'expression des gènes. Le laboratoire Collart étudie ce régulateur conservé et central dans la levure S.cerevisiae, un organisme eucaryote modèle pour lequel il y a des outils génétiques très puissants qui peuvent être combinés à des approches biochimiques. Dans la levure, ce complexe consiste en 9 sous-unités : Not1-5, Caf1, Caf40, Caf130 et Ccr4. Des homologues de ces sous-unités existent dans la plupart des cas chez les autres eucaryotes, et chez tous les eucaryotes il y a 2 activités enzymatiques associées au complexe, une déadenylase et une ubiquitine ligase. De nombreuses fonctions cellulaires ont été attribuées au complexe Ccr4-Not chez la levure ou les autres eucaryotes. Le rôle majeur confirmé à ce jour est sa contribution au métabolisme des ARNs messagers, puisque le complexe porte la déadénylase eucaroyte majeure qui catalyse l'étape initiale et limitante pour la dégradation des ARNs messagers. Le groupe Collart a connecté le complexe à la transcription par l'ARN polymérase II, et plus récemment leur travail a étendu le rôle du complexe Ccr4-Not à la surveillance nucléaire et l'export des mRNAs. Cette dernière année, des études du laboratoire Collart ont révélé l'importance du complexe Ccr4-Not pour le métabolisme des protéines. Les substrats de Not4, la ligase E3 à motif RING, sont connectés au ribosome, en particulier la protéine ribosomale Rps7A, et une chaperone associée au ribosome, NAC. De plus, le complexe Ccr4-Not est associé aux polysomes en phase de traduction. Plusieurs sous-unités du complexe Ccr4-Not sont nécessaires pour éviter l'agrégation des protéines et pour l'assemblage de la machinerie de dégradation majeure des protéines cellulaires, le protéasome. Le modèle de travail du laboratoire Collart pour le complexe Ccr4-Not, est que le complexe fonctionne comme une Ť plateforme chaperone ť, qui régule les interactions fonctionnelles et dynamiques entre partenaires cellulaires participant à diverses fonctions cellulaires. En interagissant avec les ribosomes en phase de traduction et les chaperones, le complexe a la possibilité d'interagir avec les protéines nouvellement synthétisées et les délivrer à leurs partenaires cellulaires de façon fonctionnelle. Les projects actuels du laboratoire Collart sont dirigés pour adresser ce modèle. Publications du groupe Ribosome Association and Stability of the Nascent Polypeptide-Associated Complex Is Dependent Upon Its Own Ubiquitination GENETICS 2009 vol. 181 pp. 447-460 PANASENKO O, DAVID FP, COLLART M The CCR4-NOT complex physically and functionally interacts with TRAMP and the nuclear exosome PLOS ONE 2009 vol. 4(8) pp. 6760-6760 AZZOUZ N, PANASENKO O, COLAU G, COLLART M Specific roles for the Ccr4-Not complex subunits in expression of the genome. RNA (NEW YORK, N.Y.) 2009 vol. 15(3) pp. 377-383 AZZOUZ N, PANASENKO O, DELUEN C, HSIEH J, THEILER G, COLLART M The dual control of TFIIB recruitment by NC2 is gene specific NUCLEIC ACIDS RESEARCH 2008 vol. 36(2) pp. 539-549 MASSON PATRICK, LEIMGRUBER ELISA, CRETON SANDRINE, COLLART MARTINE A. The dual control of TFIIB recruitment by NC2 is gene specific. NUCLEIC ACIDS RESEARCH 2008 vol. 36(2) pp. 539-549 MASSON P, LEIMGRUBER E, CRETON S, COLLART MARTINE The Ccr4-not complex regulates Skn7 through Srb10 kinase EUKARYOTIC CELL 2007 vol. 6(12) pp. 2251-2259 LENSSEN EVE, AZZOUZ NOWEL, MICHEL AGNES, LANDRIEUX EMILIE, COLLART MARTINE A. A SAGA-Independent function of SPT3 mediates transcriptional deregulation in a mutant of the Ccr4-Not complex in Saccharomyces cerevisiae GENETICS 2007 vol. 177 pp. 123-135 JAMES, N, LANDRIEUX, E, COLLART, MA Modulation of Ubc4p/Ubc5p-mediated stress responses by the RING-finger-dependent ubiquitin-protein ligase Not4p in Saccharomyces cerevisiae GENETICS 2007 vol. 176(1) pp. 181-192 MULDER KLAAS W., INAGAKI AKIKO, CAMERONI ELISABETTA, MASSON FLORENCE, WINKLER G. SEBASTIAN, DE VIRGILIO CLAUDIO, COLLART MARTINE A., TIMMERS H. TH. MARC Crystal structure, biochemical and genetic characterization of yeast and E-cuniculi TAF(II)5 N-terminal domain: Implications for TRID assembly JOURNAL OF MOLECULAR BIOLOGY 2007 vol. 368 pp. 1292-1306 ROMIER, C, JAMES, N, BIRCK, C, CAVARELLI, J, VIVARES, C, COLLART, MA, MORAS, D The yeast Ccr4-Not complex controls ubiquitination of the nascent-associated polypeptide (NAC-EGD) complex JOURNAL OF BIOLOGICAL CHEMISTRY 2006 vol. 281(42) pp. 31389-31398 PANASENKO OLESYA, LANDRIEUX EMILIE, FEUERMANN MARC, FINKA ANDRIJA, PAQUET NICOLE, COLLART MARTINE A. LKB1 interacts with and phosphorylates PTEN : a functional link between two proteins involved in cancer predisposing syndromes HUMAN MOLECULAR GENETICS 2005 vol. 14 pp. 2209-2219 MEHENNI HAMID, MARQ-LIN NATHALIE, BUCHET-POYAU K, REYMOND ALEXANDRE, COLLART MARTINE, PICARD DIDIER, ANTONARAKIS STYLIANOS The Ccr4-not complex independently controls both Msn2-dependent transcriptional activation-via a newly identified Glc7/Bud14 type 1 protein phosphatase module-and TFIID promoter distribution MOLECULAR AND CELLULAR BIOLOGY : MCB 2005 vol. 25 pp. 488-498 LENSSEN EVE, JAMES FARESSE NICOLE, PEDRUZZI IVO, DUBOULOZ FREDERIQUE, CAMERONI ELISABETTA, BISIG RUTH, MAILLET LAURENT, MICHEL WERNER, JOHNNY ROOSEN, KATARINA PETROVIC, JORIS WINDERICKX, COLLART MARTINE, DE VIRGILIO CLAUDIO The eukaryotic Ccr4-not complex: a regulatory platform integrating mRNA metabolism with cellular signaling pathways? PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY 2004 vol. 77 pp. 289-322 COLLART BURKHARD MARTINE, TIMMERS H. TH. MARC Global control of gene expression in yeast by the Ccr4-Not complex GENE 2003 vol. 313 pp. 1-16 COLLART MA The critical cis-acting element required for IMD2 feedback regulation by GDP is a TATA box located 202 nucleotides upstream of the transcription start site MOLECULAR AND CELLULAR BIOLOGY : MCB 2003 vol. 23 pp. 6267-6278 MAFALDA ESCOBAR-HENRIQUES, BERTRAND DAIGNAN-FORNIER, COLLART MA Transcription initiation of the yeast IMD2 gene is abolished in response to nutrient limitation through a sequence in its coding region MOLECULAR AND CELLULAR BIOLOGY : MCB 2003 vol. 23 pp. 6279-6290 MAFALDA ESCOBAR-HENRIQUES, COLLART MA, BERTRAND DAIGNAN-FORNIER Identification of a ubiquitin-protein ligase subunit within the CCR4-NOT transcription repressor complex EMBO JOURNAL 2002 vol. 21 pp. 355-364 ALBERT THOMAS K, HANZAWA HIROYUKI, LEGTENBERG YVONNE I.A, DE RUWE MARJOLEIN J, VAN DEN HEUVEL FIONA AJ, COLLART MA, BOELENS ROLF, TIMMERS H.TH.MARC The NC2 alpha and beta subunits play different roles in vivo GENES AND DEVELOPMENT 2002 vol. 16 pp. 3265-3276 CRETON S, SVEJSTRUP JESPER Q, COLLART MA Interaction between Not1p, a component of the Ccr4-not complex, a global regulator of transcription, and Dhh1p, a putative RNA helicase JOURNAL OF BIOLOGICAL CHEMISTRY 2002 vol. 277 pp. 2835-2842 MAILLET L, COLLART MA The Ccr4-not complex and yTAF1 (yTaf(II)130p/yTaf(II)145p) show physical and functional interactions MOLECULAR AND CELLULAR BIOLOGY : MCB 2002 vol. 22 pp. 6735-6749 DELUEN C, JAMES N, MAILLET LAURENT, MOLINETE M, THEILER G, LEMAIRE MARC, PAQUET N, COLLART MA Saccharomyces cerevisiae Ccr4-not complex contributes to the control of Msn2p-dependent transcription by the Ras/cAMP pathway MOLECULAR MICROBIOLOGY 2002 vol. 43 pp. 1023-1037 LENSSEN E, OBERHOLZER U, LABARRE J, DE VIRGILIO C, COLLART MA A single point mutation in TFIIA suppresses NC2 requirement in vivo. EMBO JOURNAL 2000 vol. 19(4) pp. 672-682 XIE J, COLLART MARTINE, LEMAIRE M, STELZER G, MEISTERERNST M The TATA-binding protein-associated factor yTafII19p functionally interacts with components of the global transcriptional regulator Ccr4-Not complex and physically interacts with the Not5 subunit. JOURNAL OF BIOLOGICAL CHEMISTRY 2000 vol. 275(35) pp. 26925-26934 LEMAIRE M, COLLART M The essential function of Not1 lies within the Ccr4-Not complex. JOURNAL OF MOLECULAR BIOLOGY 2000 vol. 303(2) pp. 131-143 MAILLET L, TU C, HONG YK, SHUSTER EO, COLLART MARTINE The NC2 repressor is dispensable in yeast mutated for the Sin4p component of the holoenzyme and plays roles similar to Mot1p in vivo. MOLECULAR MICROBIOLOGY 2000 vol. 36(1) pp. 163-173 LEMAIRE M, XIE J, MEISTERERNST M, COLLART MARTINE Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. NUCLEIC ACIDS RESEARCH 2000 vol. 28(3) pp. 809-817 ALBERT TK, LEMAIRE M, VAN BERKUM NL, GENTZ R, COLLART MARTINE, TIMMERS HT In vitro transcription of a yeast TATA-less promoter> negative regulation by the Not1 protein BIOLOGICAL CHEMISTRY 1999 vol. 380 pp. 1365-1370 OBERHOLZER U., COLLART MARTINE The CCR4 and CAF1 proteins of the CCR4-NOT complex are physically and functionally separated from NOT2, NOT4, and NOT5. MOLECULAR AND CELLULAR BIOLOGY : MCB 1999 vol. 19 pp. 6642-6651 BAI Y, SALVADORE C., CHIANG Y.-C., COLLART MARTINE, LIU H.-Y., DENIS C.L. Characterization of NOT5 that encodes a new component of the Not protein complex GENE 1998 vol. 207 pp. 61-69 OBERHOLZER U, COLLART MARTINE TOM1p, a yeast hect-domain protein which mediates transcriptional regulation through the ADA/SAGA coactivator complexes JOURNAL OF MOLECULAR BIOLOGY 1998 vol. 282 pp. 933-946 SALEH A, COLLART M, MARTENS JA, GENEREAUX J, COTE J, BRANDL CJ MHP1, an essential gene in CS required for microtubule function JOURNAL OF CELL BIOLOGY 1996 vol. 135 pp. 0- IRMINGER-FINGER I, HURT E, ROEBUCK A, COLLART MA, EDELSTEIN SJ MHP1, an essential gene in Saccharomyces cerevisiae required for microtubule function. JOURNAL OF CELL BIOLOGY 1996 vol. 135(5) pp. 1323-1339 IRMINGER-FINGER I, HURT E, ROEBUCK A, COLLART MARTINE, EDELSTEIN SJ The NOT, SPT3, and MOT1 genes functionally interact to regulate transcription at core promoters. MOLECULAR AND CELLULAR BIOLOGY : MCB 1996 vol. 16(12) pp. 6668-6676 COLLART MARTINE NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization. GENES AND DEVELOPMENT 1994 vol. 8(5) pp. 525-537 COLLART MARTINE, STRUHL K NOT1(CDC39), NOT2(CDC36), NOT3 and NOT4 encode a global-negative regulator of transcription that differentially affects TAT-element utilization GENES AND DEVELOPMENT 1994 vol. 8 pp. 0- COLLART MA, STRUHL K CDC39, an essential nuclear protein that negatively regulates transcription and differentially affects the constitutive and inducible HIS3 promoters. EMBO JOURNAL 1993 vol. 12(1) pp. 177-186 COLLART MARTINE, STRUHL K c-fos gene transcription in murine macrophages is modulated by a calcium-dependent block to elongation in intron 1. MOLECULAR AND CELLULAR BIOLOGY : MCB 1991 vol. 11(5) pp. 2826-2831 COLLART MARTINE, TOURKINE N, BELIN D, VASSALLI P, JEANTEUR PH, BLANCHARD JM Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages. JOURNAL OF EXPERIMENTAL MEDICINE 1990 vol. 171(1) pp. 35-47 SHAKOV AN, COLLART MARTINE, VASSALLI P, NEDOSPASOV SA, JONGENEEL CV Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis. JOURNAL OF EXPERIMENTAL MEDICINE 1990 vol. 170(3) pp. 655-663 PIGUET PF, COLLART MARTINE, GRAU GE, SAPPINO AP, VASSALLI P Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B. MOLECULAR AND CELLULAR BIOLOGY : MCB 1990 vol. 10(4) pp. 1498-1506 COLLART MARTINE, BAEUERLE P, VASSALLI P Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis. JOURNAL OF EXPERIMENTAL MEDICINE 1989 vol. 170(3) pp. 655-663 PIGUET PF, COLLART MARTINE, GRAU GE, KAPANCI Y, VASSALLI P Pneumopathies of the graft-versus-host reaction. Alveolitis associated with an increased level of tumor necrosis factor mRNA and chronic interstitial pneumonitis. LABORATORY INVESTIGATION 1989 vol. 61(1) pp. 37-45 PIGUET PF, GRAU GE, COLLART MARTINE, VASSALLI P, KAPANCI Y Receptor-mediated phagocytosis by macrophages induces a calcium-dependent transient increase in c-fos transcription. ONCOGENE : AN INTERNATIONAL JOURNAL 1989 vol. 4(2) pp. 237-241 COLLART MARTINE, BELIN D, BRIOTTET C, THORENS B, VASSALLI JD, VASSALLI P Antagonist effect of RU 486 on transcription of glucocorticoid-regulated genes. EXPERIMENTAL CELL RESEARCH 1987 vol. 173(2) pp. 425-430 BUSSO N, COLLART MARTINE, VASSALLI JD, VASSALLI P Modulations of functional activity in differentiated macrophages are accompanied by early and transient increase or decrease in c-fos gene transcription. JOURNAL OF IMMUNOLOGY 1987 vol. 139(3) pp. 949-955 COLLART M, BELIN D, VASSALLI JD, VASSALLI P Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors. JOURNAL OF EXPERIMENTAL MEDICINE 1986 vol. 164(6) pp. 2113-2118 COLLART M, BELIN D, VASSALLI JD, KOSSODO S, VASSALLI P Domaines de recherche