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Activation of monocytes/ macrophages and neutrophils

The project we are conducting is tightly linked with that carried out by Dr. D. Burger and Prof. JM Dayer. It deals with the activation of monocytes/ macrophages and neutrophils by direct contact with molecules expressed at the surface of activated T cells and with the inhibition of this activation by high-density lipoproteins, especially their main protein component apolipoprotein A1 (Apo A1). Our group is involved in clinical investigations in immuno-inflammatory diseases and their possible association with atherosclerosis. It is particularly implicated in transferring research findings and technologies to clinical applications.More precisely, we are committed to
· studying the capacity of T cell surface molecules to stimulate phagocyte (monocyte/macrophage and neutrophil) oxidative metabolism and its regulation by HDL.
· determining positive (CRP, SAA) and negative (Apo-A1) acute phase proteins in the serum of patients with acute (septic shock) and chronic (rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis) inflammatory diseases in order to establish their kinetics and their potential prognostic value.
· setting up an assay for detecting auto-antibodies to Apo-A1 and to studying their prevalence in auto-immune and cardio-vascular diseasesassessing the levels of cytokines and their inhibitors in biological fluids in various immmuno-inflammatory conditions

Group's publications

Tuberculosis screening in patients with psoriasis before antitumour necrosis factor therapy: comparison of an interferon-gamma release assay vs. tuberculin skin test.
BRITISH JOURNAL OF DERMATOLOGY
2009 vol. 161(4) pp. 797-800
LAFFITTE E, JANSSENS JP, ROUX-LOMBARD P, THIELEN AM, BARDE C, MARAZZA G, PANIZZON RG, SAURAT JH

Serum levels of tissue inhibitor of metalloproteinase-1 and periarticular bone loss in early rheumatoid arthritis.
CLINICAL RHEUMATOLOGY
2009 vol. 28(3) pp. 285-291
MURPHY E, ROUX-LOMBARD P, ROONEY T, FITZGERALD O, DAYER JM, BRESNIHAN B

Interferon-gamma release assays versus tuberculin skin testing for detection of latent tuberculosis in chronic haemodialysis patients.
NEPHROLOGY, DIALYSIS, TRANSPLANTATION : OFFICIAL PUBLICATION OF THE EUROPEAN DIALYSIS AND TRANSPLANT ASSOCIATION - EUROPEAN RENAL ASSOCIATION
2009 vol. 24(6) pp. 1952-1956
TRIVERIO PA, BRIDEVAUX PO, ROUX-LOMBARD P, NIKSIC L, ROCHAT T, MARTIN PY, SAUDAN P, JANSSENS JP

Endothelial dysfunction and specific inflammation in obesity hypoventilation syndrome.
PLOS ONE
2009 vol. 4(8) pp. 6733-6733
BOREL JC, ROUX-LOMBARD P, TAMISIER R, MONNERET D, ARMOL N, BAGUET JP, LEVY P, PEPIN JL

Do results of the T-SPOT.TB interferon-gamma release assay change after treatment of tuberculosis?
RESPIRATORY MEDICINE
2009 vol. 103(1) pp. 30-34
BOSSHARD V, ROUX-LOMBARD P, PERNEGER T, ROCHAT T, METZGER M, VIVIEN R, JANSSENS JP

Prostaglandin E2 synergistically with interleukin-23 favors human Th17 expansion.
BLOOD
2008 vol. 112(9) pp. 3696-3703
CHIZZOLINI C, CHICHEPORTICHE R, ALVAREZ M, DE RHAM C, ROUX-LOMBARD P, FERRARI-LACRAZ SYLVIE, DAYER JM

Anti-apolipoprotein A-1 IgG are associated with high oxidized low-density lipoprotein levels of in acute coronary syndrome
CLINICAL SCIENCE
2008 vol. 115(1) pp. 25-33
VUILLEUMIER NICOLAS ET AL.

Gender-based dimorphic pattern for interleukin-1 receptor antagonist in type 2 diabetes mellitus.
DIABETES & METABOLISM
2008 vol. 34(1) pp. 75-81
YBARRA J, LEHMANN TN, GOLAY A, JUGE-AUBRY CRISTIANA, ROUX LOMBARD P, DAYER JM, MEIER C

Contribution of a IFN-gamma assay in contact tracing for tuberculosis in a low-incidence, high immigration area.
SWISS MEDICAL WEEKLY
2008 vol. 138(39-40) pp. 585-593
JANSSENS JP, ROUX-LOMBARD P, PERNEGER T, METZGER M, VIVIEN R, ROCHAT T

Autoantibodies against protective molecules--C1q, C-reactive protein, serum amyloid P, mannose-binding lectin, and apolipoprotein A1: prevalence in systemic lupus erythematosus
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
2007 vol. 1108 pp. 227-239
SHOENFELD Y, SZYPER-KRAVITZ M, WITTE T, DORIA A, TSUTSUMI A, TATSUYA A, DAYER JM, ROUX-LOMBARD P, FONTAO L, KALLENBERG CG, BIJL M, MATTHIAS T, FRASER A, ZANDMAN-GODDARD G, BLANK M, GILBURD B, MERONI PL.

Quantitative scoring of an interferon-gamma assay for differentiating active from latent tuberculosis
EUROPEAN JOURNAL OF RESPIRATORY DISEASES.
2007 vol. 30(4) pp. 722-728
JANSSENS JP, ROUX-LOMBARD P, PERNEGER T, METZGER M, VIVIEN R, ROCHAT T

Cerebrospinal fluid anti-SSA autoantibodies in primary Sjogren's syndrome with central nervous system involvement
EUROPEAN NEUROLOGY
2007 vol. 57 pp. 166-171
MEGEVAND P, CHIZZOLINI C, CHOFFLON M, ROUX-LOMBARD P, LALIVE PH, PICARD F

Primer: the practical use of biological markers of rheumatic and systemic inflammatory diseases.
NATURE CLINICAL PRACTICE RHEUMATOLOGY
2007 vol. 3(9) pp. 512-520
DAYER E, DAYER JM, ROUX LOMBARD P

Serum interleukin-18 and interleukin-18 binding protein levels in rheumatoid arthritis
ANNALS OF THE RHEUMATIC DISEASES
2002 vol. 61 pp. 726-729
BRESNIHAN B, ROUX-LOMBARD P, MURPHY E, KANE D, FITZGERALD O, DAYER JM

Diagnostic tests for rheumatoid arthritis: comparison of anti-cyclic citrullinated peptide antibodies, anti-keratin antibodies and IgM rheumatoid factors
RHEUMATOLOGY : OFFICIAL JOURNAL OF THE BRITISH SOCIETY FOR RHEUMATOLOGY
2002 vol. 41 pp. 809-814
BAS S, PERNEGER TV, SEITZ M, TIERCY JM, ROUX-LOMBARD P, GUERNE PA

Cytokines, metalloproteinases, their inhibitors and cartilage oligomeric matrix protein: relationship to radiological progression and inflammation in early rheumatoid arthritis. A prospective 5-year s tudy.
RHEUMATOLOGY : OFFICIAL JOURNAL OF THE BRITISH SOCIETY FOR RHEUMATOLOGY
2001 vol. 40 pp. 544-551
ROUX LOMBARD P, EBERHARDT K, SAXNE T, DAYER JM, WOLLHEIM FA

Research's domains




DATABASE-RESEARCH	GROUP OF CLINICAL BIOLOGY RESEARCH

Pascale ROUX-LOMBARD	Head of group CV	Research subject	Members of the group


	Links about the group Prof. P. ROUX-LOMBARD HUG/Spécialités de Médecine Serv Immunologie Allergologie Rue Gabrielle-Perret-Gentil 4 1211 Genève 14 Pascale.Roux-Lombard@hcuge.ch Tel.: 022.372.39.42 Fax: 022.372.72.88 Comments Pages updated the 17.11.2015		Reseach's subject \| Group's publications \| Research's domains Activation of monocytes/ macrophages and neutrophils The project we are conducting is tightly linked with that carried out by Dr. D. Burger and Prof. JM Dayer. It deals with the activation of monocytes/ macrophages and neutrophils by direct contact with molecules expressed at the surface of activated T cells and with the inhibition of this activation by high-density lipoproteins, especially their main protein component apolipoprotein A1 (Apo A1). Our group is involved in clinical investigations in immuno-inflammatory diseases and their possible association with atherosclerosis. It is particularly implicated in transferring research findings and technologies to clinical applications.More precisely, we are committed to · studying the capacity of T cell surface molecules to stimulate phagocyte (monocyte/macrophage and neutrophil) oxidative metabolism and its regulation by HDL. · determining positive (CRP, SAA) and negative (Apo-A1) acute phase proteins in the serum of patients with acute (septic shock) and chronic (rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis) inflammatory diseases in order to establish their kinetics and their potential prognostic value. · setting up an assay for detecting auto-antibodies to Apo-A1 and to studying their prevalence in auto-immune and cardio-vascular diseasesassessing the levels of cytokines and their inhibitors in biological fluids in various immmuno-inflammatory conditions Group's publications Tuberculosis screening in patients with psoriasis before antitumour necrosis factor therapy: comparison of an interferon-gamma release assay vs. tuberculin skin test. BRITISH JOURNAL OF DERMATOLOGY 2009 vol. 161(4) pp. 797-800 LAFFITTE E, JANSSENS JP, ROUX-LOMBARD P, THIELEN AM, BARDE C, MARAZZA G, PANIZZON RG, SAURAT JH Serum levels of tissue inhibitor of metalloproteinase-1 and periarticular bone loss in early rheumatoid arthritis. CLINICAL RHEUMATOLOGY 2009 vol. 28(3) pp. 285-291 MURPHY E, ROUX-LOMBARD P, ROONEY T, FITZGERALD O, DAYER JM, BRESNIHAN B Interferon-gamma release assays versus tuberculin skin testing for detection of latent tuberculosis in chronic haemodialysis patients. NEPHROLOGY, DIALYSIS, TRANSPLANTATION : OFFICIAL PUBLICATION OF THE EUROPEAN DIALYSIS AND TRANSPLANT ASSOCIATION - EUROPEAN RENAL ASSOCIATION 2009 vol. 24(6) pp. 1952-1956 TRIVERIO PA, BRIDEVAUX PO, ROUX-LOMBARD P, NIKSIC L, ROCHAT T, MARTIN PY, SAUDAN P, JANSSENS JP Endothelial dysfunction and specific inflammation in obesity hypoventilation syndrome. PLOS ONE 2009 vol. 4(8) pp. 6733-6733 BOREL JC, ROUX-LOMBARD P, TAMISIER R, MONNERET D, ARMOL N, BAGUET JP, LEVY P, PEPIN JL Do results of the T-SPOT.TB interferon-gamma release assay change after treatment of tuberculosis? RESPIRATORY MEDICINE 2009 vol. 103(1) pp. 30-34 BOSSHARD V, ROUX-LOMBARD P, PERNEGER T, ROCHAT T, METZGER M, VIVIEN R, JANSSENS JP Prostaglandin E2 synergistically with interleukin-23 favors human Th17 expansion. BLOOD 2008 vol. 112(9) pp. 3696-3703 CHIZZOLINI C, CHICHEPORTICHE R, ALVAREZ M, DE RHAM C, ROUX-LOMBARD P, FERRARI-LACRAZ SYLVIE, DAYER JM Anti-apolipoprotein A-1 IgG are associated with high oxidized low-density lipoprotein levels of in acute coronary syndrome CLINICAL SCIENCE 2008 vol. 115(1) pp. 25-33 VUILLEUMIER NICOLAS ET AL. Gender-based dimorphic pattern for interleukin-1 receptor antagonist in type 2 diabetes mellitus. DIABETES & METABOLISM 2008 vol. 34(1) pp. 75-81 YBARRA J, LEHMANN TN, GOLAY A, JUGE-AUBRY CRISTIANA, ROUX LOMBARD P, DAYER JM, MEIER C Contribution of a IFN-gamma assay in contact tracing for tuberculosis in a low-incidence, high immigration area. SWISS MEDICAL WEEKLY 2008 vol. 138(39-40) pp. 585-593 JANSSENS JP, ROUX-LOMBARD P, PERNEGER T, METZGER M, VIVIEN R, ROCHAT T Autoantibodies against protective molecules--C1q, C-reactive protein, serum amyloid P, mannose-binding lectin, and apolipoprotein A1: prevalence in systemic lupus erythematosus ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 2007 vol. 1108 pp. 227-239 SHOENFELD Y, SZYPER-KRAVITZ M, WITTE T, DORIA A, TSUTSUMI A, TATSUYA A, DAYER JM, ROUX-LOMBARD P, FONTAO L, KALLENBERG CG, BIJL M, MATTHIAS T, FRASER A, ZANDMAN-GODDARD G, BLANK M, GILBURD B, MERONI PL. Quantitative scoring of an interferon-gamma assay for differentiating active from latent tuberculosis EUROPEAN JOURNAL OF RESPIRATORY DISEASES. 2007 vol. 30(4) pp. 722-728 JANSSENS JP, ROUX-LOMBARD P, PERNEGER T, METZGER M, VIVIEN R, ROCHAT T Cerebrospinal fluid anti-SSA autoantibodies in primary Sjogren's syndrome with central nervous system involvement EUROPEAN NEUROLOGY 2007 vol. 57 pp. 166-171 MEGEVAND P, CHIZZOLINI C, CHOFFLON M, ROUX-LOMBARD P, LALIVE PH, PICARD F Primer: the practical use of biological markers of rheumatic and systemic inflammatory diseases. NATURE CLINICAL PRACTICE RHEUMATOLOGY 2007 vol. 3(9) pp. 512-520 DAYER E, DAYER JM, ROUX LOMBARD P Serum interleukin-18 and interleukin-18 binding protein levels in rheumatoid arthritis ANNALS OF THE RHEUMATIC DISEASES 2002 vol. 61 pp. 726-729 BRESNIHAN B, ROUX-LOMBARD P, MURPHY E, KANE D, FITZGERALD O, DAYER JM Diagnostic tests for rheumatoid arthritis: comparison of anti-cyclic citrullinated peptide antibodies, anti-keratin antibodies and IgM rheumatoid factors RHEUMATOLOGY : OFFICIAL JOURNAL OF THE BRITISH SOCIETY FOR RHEUMATOLOGY 2002 vol. 41 pp. 809-814 BAS S, PERNEGER TV, SEITZ M, TIERCY JM, ROUX-LOMBARD P, GUERNE PA Cytokines, metalloproteinases, their inhibitors and cartilage oligomeric matrix protein: relationship to radiological progression and inflammation in early rheumatoid arthritis. A prospective 5-year s tudy. RHEUMATOLOGY : OFFICIAL JOURNAL OF THE BRITISH SOCIETY FOR RHEUMATOLOGY 2001 vol. 40 pp. 544-551 ROUX LOMBARD P, EBERHARDT K, SAXNE T, DAYER JM, WOLLHEIM FA Research's domains