SOLDATI-FAVRE D  CV du Chef de Groupe  Composition du Groupe

  Coordonnées du groupe

Prof. D. SOLDATI-FAVRE
CMU/ Dpt MIMOL
Rue Michel-Servet
1211 Genève 4
Suisse

Dominique.Soldati-Favre@unige.ch

Tél.: 022 379 56 72 / 022 379 57 71
Fax: 022 379 57 02




Commentaires



Pages générées le 25.04.2014
Sujet de recherche | Publications du groupe | Domaines de recherche

La biologie d'un parasite intracellulaire obligatoire

Parasitologie Moléculaire: La biologie d'un parasite intracellulaire obligatoire

Une des questions fondamentales de parasitologie consiste à comprendre comment une cellule eucaryote peut pénétrer, survivre et se multiplier dans une autre cellule eucaryote. La maîtrise de cette connaissance apparaît comme un pré requis à la mise en place de stratégies préventives et thérapeutiques des maladies infectieuse.
Les membres de la famille des Apicomplexa ont une importance médicale et vétérinaire considérable, étant responsables d'une large gamme de maladies humaines et animales incluant la malaria, la toxoplasmose, les sporidioses et coccidoses. Parasites intracellulaires obligatoires, les Apicomplexa franchissent de façon active les barrières biologiques, pénètrent dans les cellules hôtes et en ressortent en utilisant un mode unique et conservé de motilité "glissée".
Pour aborder l'étude de cette question complexe, nous avons choisi Toxopalsma gondii qui infecte presque tous les mammifères de même que les oiseaux, et qui colonisent quasiment toutes les cellules nucléées. C'est l'agent causal de la toxoplasmose, qui, habituellement, ne provoque pas de symptômes mais qui peut conduire à des complications sérieuses en cas d'infections congénitales et à une toxoplasmose cérébrale mortelle chez des individus immuno-compromis.

Nous avons tout d'abord concentré nos efforts sur le développement de méthodologies qui permettent de manipuler génétiquement cet organisme. Plus récemment, nous avons établi un système inductible permettant l'étude de la fonction de gènes essentiels. impliqués dans la motilité, l'attachement à la cellule hôte, l'invasion et la survie intracellulaire.




Publications du groupe

Role of the parasite and host cytoskeleton in apicomplexa parasitism.
CELL HOST & MICROBE
2009 vol. 5(6) pp. 602-611
FRENAL K, SOLDATI-FAVRE D

Mechanisms controlling glideosome function in apicomplexans
CURRENT OPINION IN MICROBIOLOGY
2009 vol. 12(4) pp. 408-414
DAHER W, SOLDATI-FAVRE D

Apicomplexan cytoskeleton and motors: key regulators in morphogenesis, cell division, transport and motility.
INTERNATIONAL JOURNAL FOR PARASITOLOGY
2009 vol. 39(2) pp. 153-162
SANTOS JM, LEBRUN M, DAHER W, SOLDATI-FAVRE D, DUBREMETZ JF

A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3
JOURNAL OF EXPERIMENTAL MEDICINE
2009 vol. 206(12) pp. 2747-2760
YAMAMOTO M AND AL.

Host-derived glucose and its transporter in the obligate intracellular pathogen Toxoplasma gondii are dispensable by glutaminolysis
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2009 vol. 106(31) pp. 12998-13003
BLUME M, RODRIGUEZ-CONTRERAS D, LANDFEAR S, FLEIGE T, SOLDATI-FAVRE D, LUCIUS R, GUPTA N

Detailed insights from microarray and crystallographic studies into carbohydrate recognition by microneme protein 1 (MIC1) of Toxoplasma gondii.
PROTEIN SCIENCE : A PUBLICATION OF THE PROTEIN SOCIETY
2009 vol. 18(9) pp. 1935-1947
GARNETT JA, LIU Y, LEON E, ALLMAN SA, FRIEDRICH N, SAOUROS S, CURRY S, SOLDATI-FAVRE D, DAVIS BG, FEIZI T, MATTHEWS S

Hijacking of host cellular functions by the Apicomplexa.
ANNUAL REVIEW OF MICROBIOLOGY
2008 vol. 62 pp. 471-487
PLATTNER FABIENNE, SOLDATI-FAVRE D

Targeting the transcriptional and translational machinery of the endosymbiotic organelle in apicomplexans.
CURRENT DRUG TARGETS
2008 vol. 9(11) pp. 948-956
FLEIGE T, SOLDATI-FAVRE D

Structural insights into microneme protein assembly reveal a new mode of EGF domain recognition.
EMBO REPORTS
2008 vol. 9(11) pp. 1149-1155
SAWMYNADEN K, SAOUROS S, FRIEDRICH N, MARCHANT J, SIMPSON P, BLEIJLEVENS B,, BLACKMAN MJ, SOLDATI-FAVRE D, MATTHEWS S

Microneme protein 8--a new essential invasion factor in Toxoplasma gondii.
JOURNAL OF CELL SCIENCE
2008 vol. 121(Pt 7) pp. 947-956
KESSLER H, HERM-GÖTZ A, HEGGE S, RAUCH M, SOLDATI-FAVRE D, FRISCHKNECHT F, MEISSNER M

Molecular dissection of host cell invasion by the apicomplexans: the glideosome.
PARASITE (PARIS, FRANCE)
2008 vol. 15(3) pp. 197-205
SOLDATI-FAVRE D

RIG-I and dsRNA-induced IFNbeta activation.
PLOS ONE
2008 vol. 3(12) pp. 3965-3965
HAUSMANN S, MARQ JB, TAPPAREL C, KOLAKOFSKY D, GARCIN D

Dedication.
SUB-CELLULAR BIOCHEMISTRY
2008 vol. 47 pp. 7-8
BURLEIGH B, SOLDATI-FAVRE D

Roles of proteases during invasion and egress by Plasmodium and Toxoplasma.
SUB-CELLULAR BIOCHEMISTRY
2008 vol. 47 pp. 121-139
DOWSE TJ, KOUSSIS K, BLACKMAN MJ, SOLDATI-FAVRE D

Identification of trafficking determinants for polytopic rhomboid proteases in Toxoplasma gondii.
TRAFFIC
2008 vol. 9(5) pp. 665-677
SHEINER L, DOWSE TJ, SOLDATI-FAVRE D

Protein trafficking inside Toxoplasma gondii.
TRAFFIC
2008 vol. 9(5) pp. 636-646
SHEINER L, SOLDATI-FAVRE D

Apicomplexan mitochondrial metabolism: a story of gains, losses and retentions.
TRENDS IN PARASITOLOGY
2008 vol. 24(10) pp. 468-478
SEEBER F, LIMENITAKIS J, SOLDATI-FAVRE D

Atomic resolution insight into host cell recognition by Toxoplasma gondii
EMBO JOURNAL
2007 vol. 26 pp. 2808-2820
BLUMENSCHEIN, TMA, FRIEDRICH, N, CHILDS, RA, SAOUROS, S, CARPENTER, EP, CAMPANERO-RHODES, MA, SIMPSON, P, CHAI, WG, KOUTROUKIDES, T, BLACKMAN, MJ, FEIZI, T, SOLDATI-FAVRE, D, MATTHEWS, S

Dual targeting of antioxidant and metabolic enzymes to the mitochondrion and the apicoplast of Toxoplasma gondii
PLOS PATHOGENS
2007 vol. 3 pp. 1092-1108
PINO P, FOTH BJ, KWOK LY, SHEINER L, SCHEPERS R, SOLDATI T, SOLDATI-FAVRE D

Dual targeting of antioxidant and metabolic enzymes to the mitochondrion and the apicoplast of Toxoplasma gondii.
PLOS PATHOGENS
2007 vol. 3(8) pp. 115-115
PINO P, FOTH BJ, KWOK LY, SHEINER L, SCHEPERS R, SOLDATI T, SOLDATI-FAVRE D

A family of aspartic proteases and a novel, dynamic and cell-cycle-dependent protease localization in the secretory pathway of Toxoplasma gondii
TRAFFIC
2007 vol. 8 pp. 1018-1034
SHEA, M, JAKLE, U, LIU, Q, BERRY, C, JOINER, KA, SOLDATI-FAVRE, D

Functional and biophysical analyses of the class XIV Toxoplasma gondii Myosin D
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
2006 vol. 27 pp. 139-151
HERM-GOTZ A, DELBAC F, WEISS S, NYITRAI M, STRATMANN R, TOMAVO S, SIBLEY LD, GEEVES MA, SOLDATI D

New insights into myosin evolution and classification
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2006 vol. 103 pp. 3681-3686
FOTH BJ, GOEDECKE MC, SOLDATI D

Apicomplexan rhomboids have a potential role in microneme protein cleavage during host cell invasion
INTERNATIONAL JOURNAL FOR PARASITOLOGY
2005 vol. 35 pp. 747-756
TIMOTHY J. DOWSE, JOHN C. PASCALL, KENNETH D. BROWN, SOLDATI-FAVRE DOMINIQUE

A novel galectin-like domain from Toxoplasma gondii micronemal protein 1 assists the folding, assembly, and transport of a cell adhesion complex
JOURNAL OF BIOLOGICAL CHEMISTRY
2005 vol. 280 pp. 38583-38591
SAVVAS SAOUROS ET AL.

Complete resonance assignments of the C-terminal domain from MIC1 : A micronemal protein from Toxoplasma gondii
JOURNAL OF BIOMOLECULAR NMR
2005 vol. 31 pp. 177-178
SAOUROS SAVVAS, CHEN HO AN, SIMPSON PETER, COTA ERNESTO, EDWARDS-JONES BRYN, SOLDATI-FAVRE DOMINIQUE, MATTHEWS STEPHEN

The transcription machinery and the molecular toolbox to control gene expression in Toxoplasma gondii and other protozoan parasites
MICROBES AND INFECTION : A JOURNAL ON INFECTIOUS AGENTS AND HOST DEFENSES
2005 vol. pp. 1376-1384
MEISSNER MARKUS, SOLDATI-FAVRE DOMINIQUE

Conditional expression of Toxoplasma gondii apical membrane antigen-1 (TgAMA1) demonstrates that tgAMA1 plays a critical role in host cell invasion
MOLECULAR BIOLOGY OF THE CELL
2005 vol. 16 pp. 4341-4349
JEFFREY MITAL, MARKUS MEISSNER, SOLDATI-FAVRE DOMINIQUE, GARY E. WARD

The human malaria parasite Plasmodium falciparum possesses two distinct dihydrolipoamide dehydrogenases
MOLECULAR MICROBIOLOGY
2005 vol. 55(1) pp. 27-38
PAUL J. MCMILLAN, LUCIANA M. STIMMLER, BERNARDO J. FOTH, GEOFFREY I. MCFADDEN, SYLKE MULLER

The malaria parasite Plasmodium falciparum has only one pyruvate dehydrogenase complex, which is located in the apicoplast
MOLECULAR MICROBIOLOGY
2005 vol. 55(1) pp. 39-53
BERNARDO J. FOTH, LUCIANA M. STIMMLER, EMANUELA HANDMAN, BRENDAN S. CRABB, ANTHONY N. HODDER, GEOFFREY I. MCFADDEN

Tetracycline analogue-regulated transgene expression in Plasmodium falciparum blood stages using Toxoplasma gondii transactivators
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2005 vol. 102 pp. 2980-2985
MARKUS MEISSNER, EFROSINIA KREJANY, PAUL R. GILSON, TANIA F. DE KONING-WARD, SOLDATI-FAVRE DOMINIQUE, BRENDAN S. CRABB

Rhomboid-like proteins in apicomplexa : phylogeny and nomenclature
TRENDS IN PARASITOLOGY
2005 vol. 21 pp. 254-258
TIMOTHY J DOWSE, SOLDATI-FAVRE DOMINIQUE

Trans-genera reconstitution and complementation of an adhesion complex in Toxoplasma gondii
CELLULAR MICROBIOLOGY
2004 vol. 6(8) pp. 771-782
HUYNH MY-HANG, OPITZ CORINNA, KWOK LAI YU, TOMLEY FIONA M, CARRUTHERS VERN B, SOLDATI-FAVRE DOMINIQUE

Toxoplasma as a novel system for motility.
CURRENT OPINION IN CELL BIOLOGY
2004 vol. 16 pp. 32-40
MEISSNER M, SOLDATI-FAVRE DOMINIQUE

Host cell invasion by the apicomplexans: the significance of microneme protein proteolysis.
CURRENT OPINION IN MICROBIOLOGY
2004 vol. 7 pp. 388-396
DOWSE T, SOLDATI-FAVRE DOMINIQUE

The antioxidant systems in Toxoplasma gondii and the role of cytosolic catalase in defence against oxidative injury.
MOLECULAR MICROBIOLOGY
2004 vol. 51 pp. 47-61
KWOK LAI YU, SCHLUTER D, CLAYTON C, SOLDATI-FAVRE DOMINIQUE

The glideosome: a molecular machine powering motility and host-cell invasion by Apicomplexa.
TRENDS IN CELL BIOLOGY
2004 vol. 14 pp. 528-532
KEELEY A, SOLDATI-FAVRE DOMINIQUE

Molecular and functional aspects of parasite invasion.
TRENDS IN PARASITOLOGY
2004 vol. 20 pp. 567-574
SOLDATI-FAVRE DOMINIQUE, FOTH BERNARDO, COWMAN AF.

The induction and kinetics of antigen-specific CD8 T cells are defined by the stage specificity and compartmentalization of the antigen in murine toxoplasmosis.
JOURNAL OF IMMUNOLOGY
2003 vol. 70(4) pp. 1949-1957
KWOK L-Y, LÜTJEN SONJA, SOLTEK SABINE, SOLDATI-FAVRE D, BUSCH DIRK, DECKERT M, SCHLÜTER DIRK

Free in PMC Intramembrane cleavage of microneme proteins at the surface of the apicomplexan parasite Toxoplasma gondii
EMBO JOURNAL
2002 vol. 21(7) pp. 1577-1585
OPITZ C, DI CRISTINA M, REISS M, RUPPERT T, CRISANTI A, SOLDATI-FAVRE D

Toxoplasma gondii myosin A and its light chain: a fast, single-headed, plus-end-directed motor
EMBO JOURNAL
2002 vol. 21(9) pp. 2149-2158
HERM-GOTZ A, WEISS S, STRATMANN R, FUJITA-BECKER S, RUFF C, MEYHOFER E, SOLDATI T, MANSTEIN DJ, GEEVES MA, SOLDATI-FAVRE D

A family of transmembrane microneme proteins of Toxoplasma gondii contain EGF-like domains and function as escorters
JOURNAL OF CELL SCIENCE
2002 vol. 115(Pt 3) pp. 563-574
MEISSNER M, REISS M, VIEBIG N, CARRUTHERS VB, TOURSEL C, TOMAVO S, AJIOKA JW, SOLDATI-FAVRE D

Role of Toxoplasma gondii myosin A in powering parasite gliding and host cell invasion
SCIENCE
2002 vol. 298(5594) pp. 837-840
MEISSNER M, SCHLUTER D, SOLDATI-FAVRE D


Domaines de recherche