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BASE DE DONNÉES-RECHERCHE | |
GROUPE DE RECHERCHE CLINIQUE ORIENTEE BIOLOGIE | ||||
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Dominique MULLER | CV du Chef de Groupe | Sujet de Recherche | Composition du Groupe | |||
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Coordonnées du groupe
Prof. D. MULLER CMU / Dpt NEUFO 1 rue Michel-Servet 1211 Genève 04 Suisse Dominique.Muller@unige.ch Tél.: 022 379 54 34 Fax: 022 379 54 52 Site web du groupe / département Commentaires Pages générées le 16.05.2012 |
Sujet de recherche
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Publications du groupe
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Domaines de recherche
Mécanismes impliqués dans les propriétés de plasticité des synapses excitatrices en utilisant un modèle de cultures organotypique de cortex d'hippocampe.
L'objectif principal de nos recherches est de comprendre les mécanismes impliqués dans les propriétés de plasticité des synapses excitatrices en utilisant un modèle de cultures organotypique de
cortex d'hippocampe. Les projets de recherche du laboratoire concerne les propriétés de la transmission synaptique, les mécanismes en affectant l'efficacité et la fonction, les événements moléculaires
participant à la formation de nouvelles épines dendritiques, à la synaptogenèse et la croissance de neurites. Une question importante abordée par ces expériences est de comprendre comment l'activité
neuronale contrôle et modifie l'organisation des réseaux synaptiques en situation physiologique mais aussi lors d'ischémie ou d'épilepsie. Ces questions sont étudiées à l'aide d'une approche
multidisciplinaire associant des techniques électrophysiologiques (enregistrements intracellulaires par la méthode de patch clamp), de l'imagerie confocale 2-photons de cellules vivantes à l'intérieur d'un réseau
complexe, de la microscopie électronique avec reconstruction tri-dimensionnelle de contacts synaptiques et des approches pharmacologiques et moléculaires.
Publications du groupe Dendritic spine formation and stabilization CURRENT OPINION IN NEUROBIOLOGY 2009 vol. 19(2) pp. 146-153 YOSHIHARA Y, DE ROO M, MULLER D Synaptic Potentiation Induces Increased Glial Coverage of Excitatory Synapses in CA1 Hippocampus HIPPOCAMPUS 2009 vol. 19(8) pp. 753-762 LUSHNIKOVA I, SKIBO G, MULLER D, NIKONENKO I Long-Term Plasticity in Mouse Sensorimotor Circuits after Rhythmic Whisker Stimulation JOURNAL OF NEUROSCIENCE 2009 vol. 29(16) pp. 5326-5335 MEGEVAND P, TRONCOSO E, QUAIRIAUX C, MULLER D, MICHEL CM, KISS J Anesthetics rapidly promote synaptogenesis during a critical period of brain development. PLOS ONE 2009 vol. 4(9) pp. 7043-7043 DE ROO M, KLAUSER P, BRINER A, NIKONENKO I, MENDEZ P, DAYER A, KISS JZ, MULLER D, VUTSKITS L Adverse effects of methylene blue on the central nervous system. ANESTHESIOLOGY 2008 vol. 108(4) pp. 684-692 VUTSKITS L, BRINER A, KLAUSER P, GASCON E, DAYER A, KISS JZ, MULLER D, LICKER MJ, MOREL D Activity-dependent PSD formation and stabilization of newly formed spines in hippocampal slice cultures. CEREBRAL CORTEX 2008 vol. 18(1) pp. 151-161 DE ROO M, KLAUSER P, MENDEZ P, POGLIA L, MULLER D Distinct, but compensatory roles of PAK1 and PAK3 in spine morphogenesis. HIPPOCAMPUS 2008 vol. 18(9) pp. 857-861 BODA B, JOURDAIN L, MULLER D PSD-95 promotes synaptogenesis and multiinnervated spine formation through nitric oxide signaling. JOURNAL OF CELL BIOLOGY 2008 vol. 183(6) pp. 1115-1127 NIKONENKO I, BODA B, STEEN S, KNOTT G, WELKER E, MULLER D SLC25A12 expression is associated with neurite outgrowth and is upregulated in the prefrontal cortex of autistic subjects. MOLECULAR PSYCHIATRY 2008 vol. 13(4) pp. 385-397 LEPAGNOL-BESTEL AM AND AL. LTP promotes a selective long-term stabilization and clustering of dendritic spines. PLOS BIOLOGY 2008 vol. ;6(9) pp. 219-219 DE ROO M, KLAUSER P, MULLER D Spine dynamics and synapse remodeling during LTP and memory processes. PROGRESS IN BRAIN RESEARCH 2008 vol. 169 pp. 199-207 DE ROO M, KLAUSER P, MENDEZ GARCIA P, POGLIA L, MULLER D The p21-activated kinase 3 implicated in mental retardation regulates spine morphogenesis through a Cdc42-dependent pathway. JOURNAL OF BIOLOGICAL CHEMISTRY 2007 vol. 282(29) pp. 21497-21506 KREIS P, THÉVENOT E, ROUSSEAU V, BODA B, MULLER D, BARNIER JV Interleukin-6 promotes sprouting and functional recovery in lesioned organotypic hippocampal slice cultures JOURNAL OF NEUROCHEMISTRY 2007 vol. 100 pp. 747-757 HAKKOUM D, STOPPINI L, MULLER D Glutamate receptor changes associated with transient anoxia/hypoglycaemia in hippocampal slice cultures EUROPEAN JOURNAL OF NEUROSCIENCE 2006 vol. 23(4) pp. 975-983 QUINTANA PATRICE, ALBERI STEFANO, HAKKOUM DAVID, MULLER DOMINIQUE Ischemia-induced modifications in hippocampal CA1 stratum radiatum excitatory synapses HIPPOCAMPUS 2006 vol. 16(10) pp. 814-825 KOVALENKO TATIANA, OSADCHENKO IRINA, NIKONENKO ALEXANDER, LUSHNIKOVA IRINA, VORONIN KIRILL, NIKONENKO IRINA, MULLER DOMINIQUE, SKIBO GALINA Sequential implication of the mental retardation proteins ARHGEF6 and PAK3 in spine morphogenesis JOURNAL OF CELL SCIENCE 2006 vol. 119(Pt 23) pp. 4986-4993 NODE-LANGLOIS ROXANNE, MULLER DOMINIQUE, BODA BERNADETT GABA regulates dendritic growth by stabilizing lamellipodia in newly generated interneurons of the olfactory bulb JOURNAL OF NEUROSCIENCE 2006 vol. 26 pp. 12956-12966 GASCON E, DAYER AG, SAUVAIN MO, POTTER G, JENNY B, DE ROO M, ZGRAGGEN E, DEMAUREX N, MULLER D, KISS JZ Central Nervous System Functions of PAK Protein Family: From Spine Morphogenesis to Mental Retardation MOLECULAR NEUROBIOLOGY 2006 vol. 34(1-2) pp. 67-80 BODA BERNADETT, NIKONENKO IRINA, ALBERI STEFANO, MULLER DOMINIQUE Long-term rearrangements of hippocampal mossy fiber terminal connectivity in the adult regulated by experience NEURON 2006 vol. 50(5) pp. 749-763 GALIMBERTI IVAN, GOGOLLA NADINE, ALBERI STEFANO, FERRAO SANTOS ALEXANDRE, MULLER DOMINIQUE Interactions between NEEP21, GRIP1 and GluR2 regulate sorting and recycling of the glutamate receptor subunit GluR2 EMBO JOURNAL 2005 vol. pp. 2873-2884 STEINER P., ET AL. Application of photoconversion technique for correlated confocal and ultrastructural studies in organotypic slice cultures MICROSCOPY RESEARCH AND TECHNIQUE 2005 vol. pp. 90-96 NIKONENKO IRINA, BODA BERNADETT, ALBERI STEFANO, MULLER DOMINIQUE The endosomal protein NEEP21 regulates AMPA receptor-mediated synaptic transmission and plasticity in the hippocampus MOLECULAR AND CELLULAR NEUROSCIENCE 2005 vol. pp. 313-319 ALBERI STEFANO, BODA BERNADETT, STEINER P., NIKONENKO IRINA, HIRLING H., MULLER DOMINIQUE Inhibition of T-type calcium channels protects neurons from delayed ischemia-induced damage MOLECULAR PHARMACOLOGY 2005 vol. pp. 84-89 NIKONENKO I., BANCILA M., BLOC A., MULLER DOMINIQUE, BIJLENGA PHILIPPE The mammalian central nervous synaptic cleft contains a high density of periodically organized complexes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2005 vol. pp. 19192-19197 ZUBER B., NIKONENKO IRINA, KLAUSER P., MULLER DOMINIQUE, DUBOCHET J. Sex and brain REVUE MEDICALE DE LA SUISSE ROMANDE 2005 vol. pp. 744-746 MULLER DOMINIQUE Recovery of evoked potentials, metabolic activity and behavior in a mouse model of somatosensory cortex lesion : role of the neural cell adhesion molecule (NCAM) CEREBRAL CORTEX 2004 vol. 14 pp. 332-341 TRONCOSO E, MULLER DOMINIQUE, KORODI K, STEIMER THIERRY, WELKER E, KISS JOZSEF Local gamma-aminobutyric acid and glutamate circuit control of hypophyseotrophic corticotropin-releasing factor neuron activity in the paraventricular nucleus of the hypothalamus EUROPEAN JOURNAL OF NEUROSCIENCE 2004 vol. 19 pp. 777-782 BARTANUSZ V, MULLER DOMINIQUE, GAILLARD RC, STREIT P, VUTSKITS LASZLO, KISS JOZSEF Zinc inhibits glutamate release via activation of pre-synaptic K channels and reduces ischaemic damage in rat hippocampus JOURNAL OF NEUROCHEMISTRY 2004 vol. 90 pp. 1243-1250 BANCILA VICTOR, NIKONENKO IRINA, DUNANT YVES, BLOC ALAIN Polysialylated neural cell adhesion molecule promotes remodeling and formation of hippocampal synapses JOURNAL OF NEUROSCIENCE 2004 vol. 24 pp. 9372-9382 DITYATEV A, DITYATEVA G, SYTNYK V, DELLING M, TONI NICOLAS, NIKONENKO IRINA, MULLER DOMINIQUE, SCHACHNER M The mental retardation protein PAK3 contributes to synapse formation and plasticity in hippocampus JOURNAL OF NEUROSCIENCE 2004 vol. 24 pp. 10816-10825 BODA BERNADETT, ALBERI STEFANO, NIKONENKO IRINA, JOURDAIN PASCAL, MOOSMAYER, PARISI-JOURDAIN, MULLER DOMINIQUE Calcium/calmodulin-dependent protein kinase II contributes to activity-dependent filopodia growth and spine formation. JOURNAL OF NEUROSCIENCE 2003 vol. pp. 10645-10649 JOURDAIN P, FUKUNAGA K, MULLER D Presynaptic remodeling contributes to activity-dependent synaptogenesis. JOURNAL OF NEUROSCIENCE 2003 vol. pp. 8498-8505 NIKONENKO I, JOURDAIN P, MULLER D Acute differential modulation of synaptic transmission and cell survival during exposure to pulsed and continuous radiofrequency energy. JOURNAL OF PAIN 2003 vol. 4 (4) pp. 197-202 CAHANA ALEX, VUTSKITS LASZLO, MULLER DOMINIQUE Dynamic presynaptic varicosities: a role in activity-dependent synaptogenesis. TRENDS IN NEUROSCIENCES 2003 vol. pp. 573-575 MULLER D, NIKONENKO I Cerebrospinal fluid concentrations of atracurium, laudanosine and vecuronium following clinical subarachnoid hemorrhage ACTA ANAESTHESIOLOGICA SCANDINAVICA 2002 vol. 46 pp. 1236-1241 TASSONYI E, FATHI M, HUGHES GJ, CHIODINI F, BERTRAND D, MULLER D, FUCHS-BUDER T The role of nicotinic acetylcholine receptors in the mechanisms of anesthesia BRAIN RESEARCH BULLETIN 2002 vol. 57 pp. 133-150 TASSONYI E, CHARPANTIER E, MULLER D, L. DUMONT, BERTRAND D. LTP, memory and structural plasticity CURRENT MOLECULAR MEDICINE 2002 vol. 2 pp. 605-611 MULLER D, NIKONENKO I, JOURDAIN P, ALBERI S A point mutant of GAP-43 induces enhanced short-term and long-term hippocampal plasticity EUROPEAN JOURNAL OF NEUROSCIENCE 2002 vol. 15 pp. 1976-1982 HULO S, ALBERI S, T. LAUX, P. CARONI, MULLER D Activity-induced changes of spine morphology HIPPOCAMPUS 2002 vol. 12 pp. 585-591 NIKONENKO I, P. JOURDAIN, ALBERI S, TONI N, MULLER D Remodeling of hippocampal synaptic networks by a brief anoxia-hypoglycemia JOURNAL OF NEUROSCIENCE 2002 vol. 15 pp. 3108-3116 P. JOURDAIN, NIKONENKO I, ALBERI S, MULLER D Activity-dependent regulation of genes implicated in X-linked non-specific mental retardation NEUROSCIENCE 2002 vol. 114 pp. 13-17 BODA B, MAS C, MULLER D Blockade and activation of the human neuronal incotinic acetylcholine receptors by atracurium and laudanosine ANESTHESIOLOGY 2001 vol. 94 pp. 643-651 CHIODINI F, CHARPANTIER E, MULLER D, TASSONYI E, FUCHS-BUDER T, BERTRAND D The role of neural cell adhesion molecules in plasticity and repair BRAIN RESEARCH BRAIN RESEARCH REVIEWS 2001 vol. 36 pp. 175-184 KISS JZ, TRONCOSO E, DJEBBARA Z, VUTSKITS L, MULLER D PSA-NCAM modulates BDNF-dependent survival and differentiation of cortical neurons EUROPEAN JOURNAL OF NEUROSCIENCE 2001 vol. 13 pp. 1391-1402 VUTSKITS L, DJEBBARA-HANNAS Z, ZHANG H, PACCAUD JP, DURBEC P, ROUGON G, MULLER D, KISS JZ Remodeling of synaptic membranes after induction of long-term potentiation JOURNAL OF NEUROSCIENCE 2001 vol. 21 pp. 6245-6251 TONI N, BUCHS PA, NIKONENKO I, POVILAITITE P, PARISI L, MULLER D Tetrodotoxin-sensitive enhancement of inhibition in CA1 pyramidal neurones by nicotine NEUROREPORT 2001 vol. 12 pp. 1351-1354 HULO S, MULLER D Transgenic mice with neuronal overexpression of bcl-2 gene present navigation disabilities in a water task NEUROSCIENCE 2001 vol. 104 pp. 207-215 RONDI-REIG L, LEMAIGRE-DUBREUIL Y, MONTECOT C, MULLER D, MARTINOU JC, CASTON J, MARIANI J Contribution of the neural cell adhesion molecule to neuronal and synaptic plasticity REVIEWS IN THE NEUROSCIENCES 2001 vol. 12 pp. 297-310 KISS JZ, MULLER D Domaines de recherche NEUROSCIENCES ISCHEMIE PLASTICITE CEREBRALE PHARMACOLOGIE ET PHARMACIE |