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Evidence-Based Perioperative Medicine

What is Evidence-Based Perioperative Medicine?

Perioperative medicine includes anaesthesia, acute postoperative pain treatment, labour pain treatment, surgical intensive care, resuscitation, emergency medicine, and trauma medicine. Evidence-based Medicine is the process of systematically finding, appraising, and using contemporaneous research findings as the basis for clinical decisions. Thus, Evidence-based Perioperative Medicine is about rational decision making in perioperative medicine: What should be recommended to patients? Which interventions should be purchased? What are the research priorities?

Our main activities:

We produce data: We are performing high quality systematic reviews and meta-analyses that are relevant to health care providers and patients. Thus, we are creating new best evidence knowledge, based on the critical analysis and review of historical (published and unpublished) data. Although our main focus is on perioperative medicine, we provide our expertise for projects that go beyond our clinical speciality. We are also conducting randomised controlled trials.

We disseminate data: We are publishing our products in paper-print and electronic peer reviewed medical journals. We are organising EBM workshops for anaesthesiologists and surgeons. We are organising scientific congresses. Finally, we are publishing the first book on Evidence-based perioperative medicine. The first edition was published in 2000, the second edition in August 2003.

We implement data: Valid clinical guidelines for prevention, treatment and diagnosis should be based on best-evidence data from the scientific literature. We are constantly working on such guidelines that are relevant to the practice of perioperative medicine. An example is the rational approach to the control of postoperative nausea and vomiting.

Group's publications

Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials.
ANESTHESIOLOGY
2009 vol. 111(2) pp. 406-415
PÖPPING DM, ELIA N, MARRET E, WENK M, TRAMER M

Susceptibility to fraud in systematic reviews: lessons from the Reuben case.
ANESTHESIOLOGY
2009 vol. 111(6) pp. 1279-1289
MARRET E, ELIA N, DAHL JB, MCQUAY HJ, MOINICHE S, MOORE RA, STRAUBE S, TRAMER M

Mortality with upper gastrointestinal bleeding and perforation: effects of time and NSAID use.
BMC GASTROENTEROLOGY
2009 vol. 9 pp. 41-41
STRAUBE S, TRAMER M, MOORE RA, DERRY S, MCQUAY HJ

Benefit and risk of intrathecal morphine without local anaesthetic in patients undergoing major surgery: meta-analysis of randomized trials
BRITISH JOURNAL OF ANAESTHESIA.
2009 vol. 102(2) pp. 156-167
MEYLAN N, ELIA N, LYSAKOWSKI C, TRAMER M

Bispectral and spectral entropy indices at propofol-induced loss of consciousness in young and elderly patients
BRITISH JOURNAL OF ANAESTHESIA.
2009 vol. 103(3) pp. 387-393
LYSAKOWSKI C, ELIA N, CZARNETZKI C, DUMONT L, HALLER G, COMBESCURE C, TRAMER M

Protective effects of epidural analgesia on pulmonary complications after abdominal and thoracic surgery: a meta-analysis.
ARCHIVES OF SURGERY (DES 1960)
2008 vol. 143(10) pp. 990-999
PÖPPING DM, ELIA NADIA, MARRET E, REMY C, TRAMER MR

Nefopam for the prevention of postoperative pain: quantitative systematic review.
BRITISH JOURNAL OF ANAESTHESIA.
2008 vol. 101(5) pp. 610-617
EVANS M, LYSAKOWSKI C, TRAMER MR

Dexamethasone and risk of nausea and vomiting and postoperative bleeding after tonsillectomy in children: a randomized trial.
JAMA
2008 vol. 300(22) pp. 2621-2630
CZARNETZKI C, ELIA N, LYSAKOWSKI C, DUMONT L, LANDIS BN, GIGER R, DULGUEROV P, DESMEULES J, TRAMER MR

Primer: strengths and weaknesses of meta-analysis.
NATURE CLINICAL PRACTICE RHEUMATOLOGY
2008 vol. 4(3) pp. 146-152
FINCKH A, TRAMER MR

Plasma concentrations of brain-derived neurotrophic factor in patients undergoing minor surgery: a randomized controlled trial.
NEUROCHEMICAL RESEARCH
2008 vol. 33(7) pp. 1325-1331
VUTSKITS L, LYSAKOWSKI C, CZARNETZKI C, JENNY B, COPIN JC, TRAMER MR

Clonidine as an adjuvant to intrathecal local anesthetics for surgery: systematic review of randomized trials.
REGIONAL ANESTHESIA AND PAIN MEDICINE
2008 vol. 33(2) pp. 159-167
ELIA NADIA, CULEBRAS X, MAZZA C, SCHIFFER E, TRAMER MR

Impact of the intubation model on the efficacy of rocuronium during rapid sequence intubation: systematic review of randomized trials
ACTA ANAESTHESIOLOGICA SCANDINAVICA
2007 vol. 51 pp. 848-857
LYSAKOWSKI C, SUPPAN L, CZARNETZKI C, TASSONYI E, TRAMER MR

Postoperative nausea and vomiting
ANAESTHESIST (DER)
2007 vol. 56(7) pp. 679-685
TRAMER MR

An evaluation of a single dose of magnesium to supplement analgesia after ambulatory surgery: Randomized controlled trial
ANESTHESIA AND ANALGESIA
2007 vol. 104 pp. 1374-1379
TRAMER MR, GLYNN CJ

Magnesium as an adjuvant to postoperative analgesia: A systematic review of randomized trials
ANESTHESIA AND ANALGESIA
2007 vol. 104 pp. 1532-1539
LYSAKOWSKI C, DUMONT L, CZARNETZKI C, TRAMER MR

Society for ambulatory anesthesia guidelines for the management of postoperative nausea and vomiting
ANESTHESIA AND ANALGESIA
2007 vol. 105 pp. 1615-1628
GAN TJ, MEYER TA, APFEL CC, CHUNG F, DAVIS PJ, HABIB AS, HOOPER VD, KOVAC AL, KRANKE P, MYLES P, PHILIP BK, SAMSA G, SESSLER DI, TEMO J, TRAMER MR, KOLK CV, WATCHA M

Prevention and treatment of postoperative nausea and vomiting in children. An evidence-based approach
ANNALES FRANCAISES D'ANESTHESIE ET DE REANIMATION
2007 vol. 26 pp. 529-534
TRAMER MR

Algorithms for the prevention of postoperative nausea and vomiting: an efficacy and efficiency simulation
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
2007 vol. 24 pp. 856-867
KRANKE P, EBERHART LH, GAN TJ, ROEWER N, TRAMER MR

Are self-collected samples comparable to physician-collected cervical specimens for human papillomavirus DNA testing? A systematic review and meta-analysis
GYNECOLOGIC ONCOLOGY
2007 vol. 105 pp. 530-535
PETIGNAT P, FALTIN DL, BRUCHIM I, TRAMER MR, FRANCO EL, COUTLEE F

The effect of cigarette smoking on the hypnotic efficacy of propofol
ANAESTHESIA
2006 vol. 61 pp. 826-831
LYSAKOWSKI C, DUMONT L, CZARNETZKI C, BERTRAND D, TASSONYI E, TRAMER MR

Pharmacological prevention of serious anaphylactic reactions due to iodinated contrast media: systematic review
BRITISH MEDICAL JOURNAL
2006 vol. 333 pp. 675-679
TRAMER MR, VON ELM E, LOUBEYRE P, HAUSER C

Respiratory physiotherapy to prevent pulmonary complications after abdominal surgery - A systematic review
CHEST
2006 vol. 130 pp. 1887-1899
PASQUINA P, TRAMER MR, GRANIER JM, WALDER B

Pharmacologic myocardial protection in patients undergoing non-cardiac surgery: a quantitative systematic review
ANESTHESIA AND ANALGESIA
2003 vol. 97 pp. 623-633
STEVENS R, BURRI H, TRAMER MR

Efficacy of low-dose acetazolamide for the prophylaxis of acute mountain sickness.
HIGH ALTITUDE MEDICINE & BIOLOGY
2003 vol. 4 pp. 399-399
DUMONT LIONEL, TRAMER MARTIN, LYSAKOWSKI CHRISTOPHER, MARDIROSOFF C, KAYSER BENGT

Complications of central venous catheters: Internal jugular versus subclavian access - A systematic review
CRITICAL CARE MEDICINE
2002 vol. 30 pp. 454-460
RUESCH S, WALDER B, TRAMER MR

Seizure-like phenomena and propofol: a systematic review
NEUROLOGY
2002 vol. 58 pp. 1327-1332
WALDER B, TRAMER MR, SEECK M

Cannabinoids for control of chemotherapy induced nausea and vomiting
BRITISH MEDICAL JOURNAL
2001 vol. 323 pp. 16-21
TRAMER MARTIN, CARROLL D, CAMPBELL F, REYNOLDS DJM, MOORE RA, MCQUAY HJ

Transcranial doppler versus angiography in patients with vasospasm due to a ruptured cerebral aneurysm
STROKE
2001 vol. 32 pp. 2292-2298
LYSAKOWSKI C, WALDER B, COSTANZA MC, TRAMER MARTIN

Research's domains




DATABASE-RESEARCH	GROUP OF CLINICAL PATIENT RESEARCH

Martin TRAMÈR	Head of group CV	Research subject	Members of the group


	Links about the group Prof. M. TRAMÈR HUG/ Dpt APSI Serv Anesthésiologie Rue Gabrielle-Perret-Gentil 4 1211 Genève 14 Suisse martin.tramer@hcuge.ch Tel.: +41 22 372 74 01 Comments Pages updated the 17.11.2015		Reseach's subject \| Group's publications \| Research's domains Evidence-Based Perioperative Medicine What is Evidence-Based Perioperative Medicine? Perioperative medicine includes anaesthesia, acute postoperative pain treatment, labour pain treatment, surgical intensive care, resuscitation, emergency medicine, and trauma medicine. Evidence-based Medicine is the process of systematically finding, appraising, and using contemporaneous research findings as the basis for clinical decisions. Thus, Evidence-based Perioperative Medicine is about rational decision making in perioperative medicine: What should be recommended to patients? Which interventions should be purchased? What are the research priorities? Our main activities: We produce data: We are performing high quality systematic reviews and meta-analyses that are relevant to health care providers and patients. Thus, we are creating new best evidence knowledge, based on the critical analysis and review of historical (published and unpublished) data. Although our main focus is on perioperative medicine, we provide our expertise for projects that go beyond our clinical speciality. We are also conducting randomised controlled trials. We disseminate data: We are publishing our products in paper-print and electronic peer reviewed medical journals. We are organising EBM workshops for anaesthesiologists and surgeons. We are organising scientific congresses. Finally, we are publishing the first book on Evidence-based perioperative medicine. The first edition was published in 2000, the second edition in August 2003. We implement data: Valid clinical guidelines for prevention, treatment and diagnosis should be based on best-evidence data from the scientific literature. We are constantly working on such guidelines that are relevant to the practice of perioperative medicine. An example is the rational approach to the control of postoperative nausea and vomiting. Group's publications Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials. ANESTHESIOLOGY 2009 vol. 111(2) pp. 406-415 PÖPPING DM, ELIA N, MARRET E, WENK M, TRAMER M Susceptibility to fraud in systematic reviews: lessons from the Reuben case. ANESTHESIOLOGY 2009 vol. 111(6) pp. 1279-1289 MARRET E, ELIA N, DAHL JB, MCQUAY HJ, MOINICHE S, MOORE RA, STRAUBE S, TRAMER M Mortality with upper gastrointestinal bleeding and perforation: effects of time and NSAID use. BMC GASTROENTEROLOGY 2009 vol. 9 pp. 41-41 STRAUBE S, TRAMER M, MOORE RA, DERRY S, MCQUAY HJ Benefit and risk of intrathecal morphine without local anaesthetic in patients undergoing major surgery: meta-analysis of randomized trials BRITISH JOURNAL OF ANAESTHESIA. 2009 vol. 102(2) pp. 156-167 MEYLAN N, ELIA N, LYSAKOWSKI C, TRAMER M Bispectral and spectral entropy indices at propofol-induced loss of consciousness in young and elderly patients BRITISH JOURNAL OF ANAESTHESIA. 2009 vol. 103(3) pp. 387-393 LYSAKOWSKI C, ELIA N, CZARNETZKI C, DUMONT L, HALLER G, COMBESCURE C, TRAMER M Protective effects of epidural analgesia on pulmonary complications after abdominal and thoracic surgery: a meta-analysis. ARCHIVES OF SURGERY (DES 1960) 2008 vol. 143(10) pp. 990-999 PÖPPING DM, ELIA NADIA, MARRET E, REMY C, TRAMER MR Nefopam for the prevention of postoperative pain: quantitative systematic review. BRITISH JOURNAL OF ANAESTHESIA. 2008 vol. 101(5) pp. 610-617 EVANS M, LYSAKOWSKI C, TRAMER MR Dexamethasone and risk of nausea and vomiting and postoperative bleeding after tonsillectomy in children: a randomized trial. JAMA 2008 vol. 300(22) pp. 2621-2630 CZARNETZKI C, ELIA N, LYSAKOWSKI C, DUMONT L, LANDIS BN, GIGER R, DULGUEROV P, DESMEULES J, TRAMER MR Primer: strengths and weaknesses of meta-analysis. NATURE CLINICAL PRACTICE RHEUMATOLOGY 2008 vol. 4(3) pp. 146-152 FINCKH A, TRAMER MR Plasma concentrations of brain-derived neurotrophic factor in patients undergoing minor surgery: a randomized controlled trial. NEUROCHEMICAL RESEARCH 2008 vol. 33(7) pp. 1325-1331 VUTSKITS L, LYSAKOWSKI C, CZARNETZKI C, JENNY B, COPIN JC, TRAMER MR Clonidine as an adjuvant to intrathecal local anesthetics for surgery: systematic review of randomized trials. REGIONAL ANESTHESIA AND PAIN MEDICINE 2008 vol. 33(2) pp. 159-167 ELIA NADIA, CULEBRAS X, MAZZA C, SCHIFFER E, TRAMER MR Impact of the intubation model on the efficacy of rocuronium during rapid sequence intubation: systematic review of randomized trials ACTA ANAESTHESIOLOGICA SCANDINAVICA 2007 vol. 51 pp. 848-857 LYSAKOWSKI C, SUPPAN L, CZARNETZKI C, TASSONYI E, TRAMER MR Postoperative nausea and vomiting ANAESTHESIST (DER) 2007 vol. 56(7) pp. 679-685 TRAMER MR An evaluation of a single dose of magnesium to supplement analgesia after ambulatory surgery: Randomized controlled trial ANESTHESIA AND ANALGESIA 2007 vol. 104 pp. 1374-1379 TRAMER MR, GLYNN CJ Magnesium as an adjuvant to postoperative analgesia: A systematic review of randomized trials ANESTHESIA AND ANALGESIA 2007 vol. 104 pp. 1532-1539 LYSAKOWSKI C, DUMONT L, CZARNETZKI C, TRAMER MR Society for ambulatory anesthesia guidelines for the management of postoperative nausea and vomiting ANESTHESIA AND ANALGESIA 2007 vol. 105 pp. 1615-1628 GAN TJ, MEYER TA, APFEL CC, CHUNG F, DAVIS PJ, HABIB AS, HOOPER VD, KOVAC AL, KRANKE P, MYLES P, PHILIP BK, SAMSA G, SESSLER DI, TEMO J, TRAMER MR, KOLK CV, WATCHA M Prevention and treatment of postoperative nausea and vomiting in children. An evidence-based approach ANNALES FRANCAISES D'ANESTHESIE ET DE REANIMATION 2007 vol. 26 pp. 529-534 TRAMER MR Algorithms for the prevention of postoperative nausea and vomiting: an efficacy and efficiency simulation EUROPEAN JOURNAL OF ANAESTHESIOLOGY 2007 vol. 24 pp. 856-867 KRANKE P, EBERHART LH, GAN TJ, ROEWER N, TRAMER MR Are self-collected samples comparable to physician-collected cervical specimens for human papillomavirus DNA testing? A systematic review and meta-analysis GYNECOLOGIC ONCOLOGY 2007 vol. 105 pp. 530-535 PETIGNAT P, FALTIN DL, BRUCHIM I, TRAMER MR, FRANCO EL, COUTLEE F The effect of cigarette smoking on the hypnotic efficacy of propofol ANAESTHESIA 2006 vol. 61 pp. 826-831 LYSAKOWSKI C, DUMONT L, CZARNETZKI C, BERTRAND D, TASSONYI E, TRAMER MR Pharmacological prevention of serious anaphylactic reactions due to iodinated contrast media: systematic review BRITISH MEDICAL JOURNAL 2006 vol. 333 pp. 675-679 TRAMER MR, VON ELM E, LOUBEYRE P, HAUSER C Respiratory physiotherapy to prevent pulmonary complications after abdominal surgery - A systematic review CHEST 2006 vol. 130 pp. 1887-1899 PASQUINA P, TRAMER MR, GRANIER JM, WALDER B Pharmacologic myocardial protection in patients undergoing non-cardiac surgery: a quantitative systematic review ANESTHESIA AND ANALGESIA 2003 vol. 97 pp. 623-633 STEVENS R, BURRI H, TRAMER MR Efficacy of low-dose acetazolamide for the prophylaxis of acute mountain sickness. HIGH ALTITUDE MEDICINE & BIOLOGY 2003 vol. 4 pp. 399-399 DUMONT LIONEL, TRAMER MARTIN, LYSAKOWSKI CHRISTOPHER, MARDIROSOFF C, KAYSER BENGT Complications of central venous catheters: Internal jugular versus subclavian access - A systematic review CRITICAL CARE MEDICINE 2002 vol. 30 pp. 454-460 RUESCH S, WALDER B, TRAMER MR Seizure-like phenomena and propofol: a systematic review NEUROLOGY 2002 vol. 58 pp. 1327-1332 WALDER B, TRAMER MR, SEECK M Cannabinoids for control of chemotherapy induced nausea and vomiting BRITISH MEDICAL JOURNAL 2001 vol. 323 pp. 16-21 TRAMER MARTIN, CARROLL D, CAMPBELL F, REYNOLDS DJM, MOORE RA, MCQUAY HJ Transcranial doppler versus angiography in patients with vasospasm due to a ruptured cerebral aneurysm STROKE 2001 vol. 32 pp. 2292-2298 LYSAKOWSKI C, WALDER B, COSTANZA MC, TRAMER MARTIN Research's domains