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Ultrasonography and neurovascular pathologies

A novel risk index combining degree of stenosis and plaque morphology of the carotid artery: a multicenter study on asymptomatic 60-80% or symptomatic 50-69% carotid stenosis High resolution ultrasound is a useful tool to caracterise the structure of the carotid plaque. We developed a method based on a colour mapping of the grey-scale values of the whole plaque as well as of its surface. The purpose of the present study is to determine the predictive value of a novel risk index calculated on the ground of the degree of stenosis and of the proportion of the predominant colour at the surface of the plaque.
PET-CT and ultrasonography of the carotid plaque: a comparative study on symptomatic and asymptomatic patients
Vulnerable atherosclerotic plaques responsible for ischemic strokes are characterized by high numbers of inflammatory cells and proteins. The aim of our study is to evaluate whether PET co-registered with CT shows an increased accumulation of 18FDG in carotid artery plaques, with a higher uptake in symptomatic as compared with asymptomatic ones.
Morphological charactéristics of the patent foramen ovale and occurrence of cerebrovascular events : an MRI study in patients woth cryptogenic stroke. Patent foramen ovale (PFO) is a well established cause of ischemic stroke in young patients with cryptogenic stroke. A certain number of studies suggest that interatrial septal aneurysm which may be associated to the patent foramen increases the risk of stroke recurrence. Other studies however do not allow demonstrate any particular association between the size of the foramen ovale and the embolic risk. The aim of our study is to determine the correlation between the morphological characteristics of the PFO and the number as well as the distribution of lesions on MRI.
Etude TRUST : transcranial ultrasound enhanced thormbolysis) (PI: Prof R Baumgartner, University Hospital, Zurich). Thrombolysis with intravenous (iv) tissue plasminogen activator (t-PA) is the only effective and approved therapy for acute ischemic stroke. The most frequent cause of ischemic stroke is thrombosis of the middle cerebral artery (MCA).

Group's publications

Decompressive craniectomy for space occupying hemispheric and cerebellar ischemic strokes: Swiss recommendations.
INTERNATIONAL JOURNAL OF STROKE
2009 vol. 4(3) pp. 218-223
MICHEL P AND AL.

Incidence of atrial fibrillation after percutaneous closure of patent foramen ovale and small atrial septal defects in patients presenting with cryptogenic stroke.
INTERNATIONAL JOURNAL OF STROKE
2009 vol. 5(1) pp. 4-9
BONVINI R, SZTAJZEL R, DORSAZ PA, RIGHINI M, BONVIN C, ALIBEGOVIC J, SIGWART U, CAMENZIND E, VERIN VM, SZTAJZEL J

Consensus recommendations for transcranial color-coded duplex sonography for the assessment of intracranial arteries in clinical trials on acute stroke.
STROKE
2009 vol. 40(10) pp. 3238-3244
NEDELMANN M. AND AL.

Intravenous thrombolysis in stroke attributable to cervical artery dissection.
STROKE
2009 vol. 40(12) pp. 3772-3776
ENGELTER ST AND AL.

Factors influencing emergency delays in acute stroke management.
SWISS MEDICAL WEEKLY
2009 vol. 139(27-28) pp. 393-399
SEKORANJA L AND AL.

Isolated hemiataxia of the cerebellar type after a small internal capsular infarct.
CEREBROVASCULAR DISEASES (BASEL, SWITZERLAND)
2008 vol. 25(6) pp. 594-596
KAPINA V, SZTAJZEL R, MAYOR ISABELLE

Brueghel syndrome as a new manifestation of HIV encephalopathy.
EUROPEAN NEUROLOGY
2008 vol. 60(2) pp. 107-108
WICKI J, GERMANIER Y, SZTAJZEL R, BURKHARD PR

Neuro-imaging of cerebral ischemic stroke.
JOURNAL OF NEURORADIOLOGY. JOURNAL DE NEURORADIOLOGIE
2008 vol. 35(4) pp. 197-209
LOVBLAD KO, ALTRICHTER S, VIALLON M, SZTAJZEL R, DELAVELLE J, VARGAS MI, EL-KOUSSY M, FEDERSPIEL A, SEKORANJA

Microbubble potentiated transcranial duplex ultrasound enhances IV thrombolysis in acute stroke.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
2008 vol. 25(2) pp. 219-223
PERREN F, LOULIDI J, POGLIA D, LANDIS T, SZTAJZEL R

Levodopa-induced ocular dyskinesia in Parkinson's disease
EUROPEAN JOURNAL OF NEUROLOGY
2007 vol. 14 pp. 1124-1128
GROTZSCH H, SZTAJZEL R, BURKHARD PR

Is cerebral autoregulation impaired in Parkinson's disease? A transcranial Doppler study
JOURNAL OF THE NEUROLOGICAL SCIENCES
2007 vol. 254 pp. 49-53
VOKATCH N, GROTZSCH H, MERMILLOD B, BURKHARD PR, SZTAJZEL R

Vertebral artery hypoplasia: A predisposing factor for posterior circulation stroke?
NEUROLOGY
2007 vol. 68 pp. 65-67
PERREN F, POGLIA D, LANDIS T, SZTAJZEL R

Fonction sexuelle masculine après accident vasculaire cérébral
REVUE MÉDICALE SUISSE
2007 vol. 3(104) pp. 805-808
BIANCHI-DEMICHELI F, SEKORANJA L, TEMPERLI P, LÖVBLAD K-O, ORTIGUE S, SZTAJZEL R

Stroke may appear to be rare in Saudi-Arabian and Nigerian children with sickle cell disease, but not in Cameroonian sickle cell patients
BRITISH JOURNAL OF HAEMATOLOGY
2006 vol. 133 pp. 210-210
NJAMNSHI AK, WONKAM A, DJIENTCHEU VD, ONGOLO-ZOGO P, OBAMA MT, MUNA WFT, SZTAJZEL R

The epidemiology of stroke in sickle cell patients in Yaounde, Cameroon
JOURNAL OF THE NEUROLOGICAL SCIENCES
2006 vol. 250 pp. 79-84
NJAMNSHI AK, MBONG EN, WONKAM A, ONGOLO-ZOGO P, DJIENTCHEU VD, SUNJOH FL, WIYSONGE CS, SZTAJZEL R, MBANYA D, BLACKETT KN, DONGMO L, MUNA WFT

Combined IV-intra-arterial thrombolysis: A color-coded duplex pilot study
NEUROLOGY
2006 vol. 67 pp. 324-326
PERREN F, LOULIDI J, GRAVES R, YILMAZ H, RUEFENACHT D, LANDIS T, SZTAJZEL R

Neurodégénérescence et maladies cérébrovasculaires: coïncidences ou causalité ?
REVUE MEDICALE DE LA SUISSE ROMANDE
2006 vol. pp. 1180-1184
ASSAL F., SZTAJZEL R., CAROTA A., ANNONI J.-M., BOGOUSSLAVSKY J.

Correlation of cerebrovascular symptoms and microembolic signals with the stratified gray-scale median analysis and color mapping of the carotid plaque
STROKE
2006 vol. 37 pp. 824-829
SZTAJZEL R, MOMJIAN-MAYOR I, COMELLI M, MOMJIAN S

Intravenous versus combined (intravenous and intra-arterial) thrombolysis in acute ischemic stroke: a transcranial color-coded duplex sonography--guided pilot study
STROKE
2006 vol. 37(7) pp. 1805-1809
SEKORANJA LUCKA, YILMAZ HASAN, LOVBLAD KARL-OLOF, TEMPERLI PHILIPPE, COMELLI MARIO, SZTAJZEL ROMAN

Patent Foramen Ovale, a Possible Cause of Symptomatic Migraine : A Study of 74 Patients with Acute Ischemic Stroke. 102-106
CEREBROVASCULAR DISEASES (BASEL, SWITZERLAND)
2002 vol. 13 pp. 102-106
SZTAJZEL R, GENOUD D, ROTH S, MERMILLOD B, LE FLOCH-ROHR J

Research's domains




DATABASE-RESEARCH	GROUP OF CLINICAL PATIENT RESEARCH

R. SZTAJZEL - I. MOMJIAN-MAYOR	Head of group CV	Research subject	Members of the group


	Links about the group Prof. Roman SZTAJZEL HUG/ Dpt NEUCLID Serv Neurologie Rue Gabrielle-Perret-Gentil 4 1211 Genève 14 Suisse Roman.Sztajzel@hcuge.ch Tel.: 022 372 83 10 Fax: 022 372 83 32 Comments Pages updated the 17.11.2015		Reseach's subject \| Group's publications \| Research's domains Ultrasonography and neurovascular pathologies A novel risk index combining degree of stenosis and plaque morphology of the carotid artery: a multicenter study on asymptomatic 60-80% or symptomatic 50-69% carotid stenosis High resolution ultrasound is a useful tool to caracterise the structure of the carotid plaque. We developed a method based on a colour mapping of the grey-scale values of the whole plaque as well as of its surface. The purpose of the present study is to determine the predictive value of a novel risk index calculated on the ground of the degree of stenosis and of the proportion of the predominant colour at the surface of the plaque. PET-CT and ultrasonography of the carotid plaque: a comparative study on symptomatic and asymptomatic patients Vulnerable atherosclerotic plaques responsible for ischemic strokes are characterized by high numbers of inflammatory cells and proteins. The aim of our study is to evaluate whether PET co-registered with CT shows an increased accumulation of 18FDG in carotid artery plaques, with a higher uptake in symptomatic as compared with asymptomatic ones. Morphological charactéristics of the patent foramen ovale and occurrence of cerebrovascular events : an MRI study in patients woth cryptogenic stroke. Patent foramen ovale (PFO) is a well established cause of ischemic stroke in young patients with cryptogenic stroke. A certain number of studies suggest that interatrial septal aneurysm which may be associated to the patent foramen increases the risk of stroke recurrence. Other studies however do not allow demonstrate any particular association between the size of the foramen ovale and the embolic risk. The aim of our study is to determine the correlation between the morphological characteristics of the PFO and the number as well as the distribution of lesions on MRI. Etude TRUST : transcranial ultrasound enhanced thormbolysis) (PI: Prof R Baumgartner, University Hospital, Zurich). Thrombolysis with intravenous (iv) tissue plasminogen activator (t-PA) is the only effective and approved therapy for acute ischemic stroke. The most frequent cause of ischemic stroke is thrombosis of the middle cerebral artery (MCA). Group's publications Decompressive craniectomy for space occupying hemispheric and cerebellar ischemic strokes: Swiss recommendations. INTERNATIONAL JOURNAL OF STROKE 2009 vol. 4(3) pp. 218-223 MICHEL P AND AL. Incidence of atrial fibrillation after percutaneous closure of patent foramen ovale and small atrial septal defects in patients presenting with cryptogenic stroke. INTERNATIONAL JOURNAL OF STROKE 2009 vol. 5(1) pp. 4-9 BONVINI R, SZTAJZEL R, DORSAZ PA, RIGHINI M, BONVIN C, ALIBEGOVIC J, SIGWART U, CAMENZIND E, VERIN VM, SZTAJZEL J Consensus recommendations for transcranial color-coded duplex sonography for the assessment of intracranial arteries in clinical trials on acute stroke. STROKE 2009 vol. 40(10) pp. 3238-3244 NEDELMANN M. AND AL. Intravenous thrombolysis in stroke attributable to cervical artery dissection. STROKE 2009 vol. 40(12) pp. 3772-3776 ENGELTER ST AND AL. Factors influencing emergency delays in acute stroke management. SWISS MEDICAL WEEKLY 2009 vol. 139(27-28) pp. 393-399 SEKORANJA L AND AL. Isolated hemiataxia of the cerebellar type after a small internal capsular infarct. CEREBROVASCULAR DISEASES (BASEL, SWITZERLAND) 2008 vol. 25(6) pp. 594-596 KAPINA V, SZTAJZEL R, MAYOR ISABELLE Brueghel syndrome as a new manifestation of HIV encephalopathy. EUROPEAN NEUROLOGY 2008 vol. 60(2) pp. 107-108 WICKI J, GERMANIER Y, SZTAJZEL R, BURKHARD PR Neuro-imaging of cerebral ischemic stroke. JOURNAL OF NEURORADIOLOGY. JOURNAL DE NEURORADIOLOGIE 2008 vol. 35(4) pp. 197-209 LOVBLAD KO, ALTRICHTER S, VIALLON M, SZTAJZEL R, DELAVELLE J, VARGAS MI, EL-KOUSSY M, FEDERSPIEL A, SEKORANJA Microbubble potentiated transcranial duplex ultrasound enhances IV thrombolysis in acute stroke. JOURNAL OF THROMBOSIS AND THROMBOLYSIS 2008 vol. 25(2) pp. 219-223 PERREN F, LOULIDI J, POGLIA D, LANDIS T, SZTAJZEL R Levodopa-induced ocular dyskinesia in Parkinson's disease EUROPEAN JOURNAL OF NEUROLOGY 2007 vol. 14 pp. 1124-1128 GROTZSCH H, SZTAJZEL R, BURKHARD PR Is cerebral autoregulation impaired in Parkinson's disease? A transcranial Doppler study JOURNAL OF THE NEUROLOGICAL SCIENCES 2007 vol. 254 pp. 49-53 VOKATCH N, GROTZSCH H, MERMILLOD B, BURKHARD PR, SZTAJZEL R Vertebral artery hypoplasia: A predisposing factor for posterior circulation stroke? NEUROLOGY 2007 vol. 68 pp. 65-67 PERREN F, POGLIA D, LANDIS T, SZTAJZEL R Fonction sexuelle masculine après accident vasculaire cérébral REVUE MÉDICALE SUISSE 2007 vol. 3(104) pp. 805-808 BIANCHI-DEMICHELI F, SEKORANJA L, TEMPERLI P, LÖVBLAD K-O, ORTIGUE S, SZTAJZEL R Stroke may appear to be rare in Saudi-Arabian and Nigerian children with sickle cell disease, but not in Cameroonian sickle cell patients BRITISH JOURNAL OF HAEMATOLOGY 2006 vol. 133 pp. 210-210 NJAMNSHI AK, WONKAM A, DJIENTCHEU VD, ONGOLO-ZOGO P, OBAMA MT, MUNA WFT, SZTAJZEL R The epidemiology of stroke in sickle cell patients in Yaounde, Cameroon JOURNAL OF THE NEUROLOGICAL SCIENCES 2006 vol. 250 pp. 79-84 NJAMNSHI AK, MBONG EN, WONKAM A, ONGOLO-ZOGO P, DJIENTCHEU VD, SUNJOH FL, WIYSONGE CS, SZTAJZEL R, MBANYA D, BLACKETT KN, DONGMO L, MUNA WFT Combined IV-intra-arterial thrombolysis: A color-coded duplex pilot study NEUROLOGY 2006 vol. 67 pp. 324-326 PERREN F, LOULIDI J, GRAVES R, YILMAZ H, RUEFENACHT D, LANDIS T, SZTAJZEL R Neurodégénérescence et maladies cérébrovasculaires: coïncidences ou causalité ? REVUE MEDICALE DE LA SUISSE ROMANDE 2006 vol. pp. 1180-1184 ASSAL F., SZTAJZEL R., CAROTA A., ANNONI J.-M., BOGOUSSLAVSKY J. Correlation of cerebrovascular symptoms and microembolic signals with the stratified gray-scale median analysis and color mapping of the carotid plaque STROKE 2006 vol. 37 pp. 824-829 SZTAJZEL R, MOMJIAN-MAYOR I, COMELLI M, MOMJIAN S Intravenous versus combined (intravenous and intra-arterial) thrombolysis in acute ischemic stroke: a transcranial color-coded duplex sonography--guided pilot study STROKE 2006 vol. 37(7) pp. 1805-1809 SEKORANJA LUCKA, YILMAZ HASAN, LOVBLAD KARL-OLOF, TEMPERLI PHILIPPE, COMELLI MARIO, SZTAJZEL ROMAN Patent Foramen Ovale, a Possible Cause of Symptomatic Migraine : A Study of 74 Patients with Acute Ischemic Stroke. 102-106 CEREBROVASCULAR DISEASES (BASEL, SWITZERLAND) 2002 vol. 13 pp. 102-106 SZTAJZEL R, GENOUD D, ROTH S, MERMILLOD B, LE FLOCH-ROHR J Research's domains