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Children with bronchial hyperresponsiveness (BHR)

The principal subject of my research activity is anaesthesia management of children with bronchial hyperresponsiveness (BHR). The choices of the optimal anaesthetic agent and its interaction with respiratory mechanics have been investigated both clinically and experimentally. My research projects have been focused on respiratory mechanics and implemented in Geneva the technique of partitioning lung mechanics into airway and tissue components by using the low-frequency forced oscillatory technique (LFFOT). This technique was first applied experimentally in rodents with healthy and diseased lungs. My group then developed 2 models of BHR in guinea pigs and in rabbits. These models have been validated and allow the investigation of the action of different anaesthetic agents on both the airways and the parenchymal mechanical parameters under wide variety of conditions encountered in clinical practice. The LFFOT was also used in healthy children, and in children with BHR and congenital heart disease. The application of this technique to both experimental and clinical studies and the accomplishment of these research projects have been achieved with a strong collaboration with Professor Z. Hantos, from the Dept of Medical Informatics at the University of Szeged-Hungary, and Professor P. D. Sly, from the Institute for Child Health Research at the University of Western Australia.
The new ongoing research programs are aiming at extending these previous investigations towards 2 new areas:
- To combine respiratory mechanical measurements with an in vivo moprohological technique using synchrotron radiation imaging. With the combination of state-of-the-art lung functional and structural measurements, this project has a promise to better characterize the pathophysiological mechanisms leading to BHR.
- To better understand diseases such as pulmonary hypertension, acute lung injury and left ventricular failure, that all lead to a serious imbalance between the lung mechanics and pulmonary haemodynamics.

Group's publications

Methacholine and ovalbumin challenges assessed by forced oscillations and synchrotron lung imaging.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
2009 vol. 180(4) pp. 296-303
BAYAT S, STRENGELL S, PORRA L, JANOSI T, PETAK F, SUHONEN H, SUORTTI P, HANTOS Z, SOVIJÄRVI AR, HABRE W

The impact of oral premedication with midazolam on respiratory function in children.
ANESTHESIA AND ANALGESIA
2009 vol. 108(6) pp. 1771-1776
VON UNGERN-STERNBERG BS, ERB TO, HABRE W, SLY PD, HANTOS Z

Changes in Functional Residual Capacity and Lung Mechanics during Surgical Repair of Congenital Heart Diseases Effects of Preoperative Pulmonary Hemodynamics
ANESTHESIOLOGY
2009 vol. 110(6) pp. 1348-1355
VON UNGERN-STERNBERG BS, PETAK F, HANTOS Z, HABRE W

Does implicit memory during anaesthesia persist in children?
BRITISH JOURNAL OF ANAESTHESIA.
2009 vol. 102(3) pp. 379-384
LOPEZ U, HABRE W, LAURENCON M, WILLEMS SJ, SCHMIDT C, VAN DER LINDEN M, ISELIN-CHAVES IA

Impact of elevated pulmonary blood flow and capillary pressure on lung responsiveness
JOURNAL OF APPLIED PHYSIOLOGY
2009 vol. 107 pp. 780-786
PETAK F, JANOSI T, MYERS C, FONTAO F, HABRE W

Lung mechanical and vascular changes during positive- and negative-pressure lung inflations: importance of reference pressures in the pulmonary vasculature
JOURNAL OF APPLIED PHYSIOLOGY
2009 vol. 106(3) pp. 935-942
PETAK F, ALBU G, LELE E, HANTOS Z, MOREL DR, FONTAO F, HABRE W

Biosafety in Ex Vivo Gene Therapy and Conditional Ablation of Lentivirally Transduced Hepatocytes in Nonhuman Primates
MOLECULAR THERAPY
2009 vol. 17(10) pp. 1754-1760
MENZEL O, BIRRAUX J, WILDHABER B, JOND C, LASNE F, HABRE W, TRONO D, NGUYEN TH, CHARDOT C

Evaluation of intraoperative memory and postoperative behavior in children: are we really measuring what we intend to measure?
PEDIATRIC ANESTHESIA
2009 vol. 19(12) pp. 1147-1151
LOPEZ U, HABRE W

Hypnosis as an alternative to avoid general anesthesia in a child with severe pulmonary arterial hypertension.
PEDIATRIC ANESTHESIA
2009 vol. 19(2) pp. 182-183
VON UNGERN-STERNBERG BS, HABRE W

Salbutamol premedication in children with a recent respiratory tract infection.
PEDIATRIC ANESTHESIA
2009 vol. 19(11) pp. 1064-1069
VON UNGERN-STERNBERG BS, HABRE W, ERB TO, HEANEY M

Does anesthesia affect cerebral development
PRESSE MEDICALE (DES 1983)
2009 vol. 38(11) pp. 1591-1596
VUTSKITS L, HABRE W

Intra-operative awareness in children and post-traumatic stress disorder.
ANAESTHESIA
2008 vol. 63(5) pp. 474-481
LOPEZ U, HABRE W, VAN DER LINDEN MARTIAL, ISELIN-CHAVES IRENE ANNE JULIE

The involvement of histaminic and muscarinic receptors in the bronchoconstriction induced by myorelaxant administration in sensitized rabbits.
ANESTHESIA AND ANALGESIA
2008 vol. 107(6) pp. 1899-1906
HABRE W, ADAMICZA A, LELE E, NOVÁK T, SLY PD, PETAK F

Desflurane but not sevoflurane impairs airway and respiratory tissue mechanics in children with susceptible airways.
ANESTHESIOLOGY
2008 vol. 108(2) pp. 216-224
VON UNGERN-STERNBERG BS, SAUDAN SONJA, PETAK F, HANTOS Z, HABRE W

Imaging of lung function using synchrotron radiation computed tomography: what's new?
EUROPEAN JOURNAL OF RADIOLOGY
2008 vol. 68 pp. 78-83
BAYAT S, PORRA L, SUHONEN H, JANOSI T, STRENGELL S, HABRE W, PETAK F, HANTOS Z, SUORTTI P, SOVIJÄRVI A

Differential roles of endothelin-1 ETA and ETB receptors and vasoactive intestinal polypeptide in regulation of the airways and the pulmonary vasculature in isolated rat lung.²
EXPERIMENTAL PHYSIOLOGY
2008 vol. 93(11) pp. 1210-1219
JANOSI T, PETAK F, FONTAO F, MOREL DR, BEGHETTI M, HABRE W

Value of brain natriuretic peptide in the perioperative follow-up of children with valvular disease.
INTENSIVE CARE MEDICINE
2008 vol. 34(6) pp. 1109-1113
TISSIERES P, DA CRUZ E, HABRE W, AGGOUN Y, MENSI N, KALANGOS A, BEGHETTI M

Safety and efficacy of patient controlled epidural analgesia following pediatric spinal surgery.
PEDIATRIC ANESTHESIA
2008 vol. 18(2) pp. 132-139
SAUDAN S, HABRE W, CERONI D, MEYER PA, GREENBERG RS, KAELIN A, VON UNGERN-STERNBERG BS

Mechanisms of airway hyper-responsiveness after coronary ischemia.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
2008 vol. 162(3) pp. 176-183
ALBU G, PETAK F, FONTAO F, BITON C, PACHE JC, HABRE W

Impact of Trendelenburg positioning on functional residual capacity and ventilation homogeneity in anaesthetised children
ANAESTHESIA
2007 vol. 62 pp. 451-455
REGLI A, HABRE W, SAUDAN S, MAMIE C, ERB TO, VON UMGERN-STERNBERG BS

Intra-operative awareness in children: the value of an interview adapted to their cognitive abilities
ANAESTHESIA
2007 vol. 62 pp. 778-789
LOPEZ U, HABRE W, LAURENCON M, HALLER G, VAN DER LINDEN M, ISELIN-CHAVES IA

Laryngeal mask airway is associated with an increased incidence of adverse respiratory events in children with recent upper respiratory tract infections
ANESTHESIOLOGY
2007 vol. 107 pp. 714-719
VON UNGERN-STEMBERG BS, BODA K, SCHWAB C, SIMS C, JOHNSON C, HABRE W

Actualities in paediatric anaesthesia and critical care medicine
ANNALES FRANCAISES D'ANESTHESIE ET DE REANIMATION
2007 vol. 26(6) pp. 483-487
HABRE W, PAUT O

Pharmacokinetics of tramadol in children
ANNALES FRANCAISES D'ANESTHESIE ET DE REANIMATION
2007 vol. 26(6) pp. 483-487
SAUDAN S, HABRE W

Multimodality imaging for focus localization in pediatric pharmacoresistant epilepsy
EPILEPTIC DISORDERS : INTERNATIONAL EPILEPSY JOURNAL WITH VIDEOTAPE
2007 vol. 9(1) pp. 20-31
KURIAN M, SPINELLI L, DELAVELLE J, WILLI JP, VELAZQUEZ M, CHAVES V, HABRE W, MEAGHER-VILLEMURE K, ROULET E, VILLENEUVE JG, SEECK M

Mechanical support availability in pediatric cardiac surgery: program size should not matter
INTERNATIONAL JOURNAL OF CARDIOLOGY
2007 vol. 129(2) pp. 282-284
DA CRUZ EM, BEGHETTI M, KALANGOS A, BERNER M, SIERRA J, AGGOUN Y, TISSOT C, PELLEGRINI M, SAUDAN S, HABRE W, RIMENSBERGER PC

Effect of cardiopulmonary bypass and aortic clamping on functional residual capacity and ventilation distribution in children
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
2007 vol. 134(5) pp. 1193-1198
VON UNGERN-STERNBERG BS, PETAK F, SAUDAN S, PELLEGRINI M, ERB TO, HABRE W

Cardiac rhythm and left ventricular function of infants at 1 MAC sevoflurane and halothane
PEDIATRIC ANESTHESIA
2007 vol. 17(6) pp. 540-546
SAUDAN S, BEGHETTI M, SPAHR-SCHOPFER I, MAMIE C, HABRE W

Influence of anesthesia on immune responses and its effect on vaccination in children: review of evidence
PEDIATRIC ANESTHESIA
2007 vol. 17 pp. 410-420
SIEBERT JN, POSFAY-BARBE KM, HABRE W, SIEGRIST CA

Midazolam as premedication: is the emperor naked or just half-dressed? Reply
PEDIATRIC ANESTHESIA
2007 vol. 17 pp. 401-401
LONNQVISTT PA, HABRE W

Pediatric anesthesia - potential risks and their assessment: part I
PEDIATRIC ANESTHESIA
2007 vol. 17 pp. 206-215
VON UNGERN-STERNBERG BS, HABRE W

Pediatric anesthesia--potential risks and their assessment: part II
PEDIATRIC ANESTHESIA
2007 vol. 17(4) pp. 311-320
VON UNGERN-STERNBERG BS, HABRE W

Should the use of modified Jackson Rees T-piece breathing system be abandoned in preschool children?
PEDIATRIC ANESTHESIA
2007 vol. 17 pp. 654-660
VON UNGERN-STERNBERG BS, SAUDAN S, REGLI A, SCHAUB E, ERB TO, HABRE W

Vaccination and anesthesia: the precautionary principle is to vaccinate
PEDIATRIC ANESTHESIA
2007 vol. 17 pp. 1218-1220
SIEBERT J, POSFAY-BARBE KM, HABRE W, SIEGRIST CA

The contribution of the pulmonary microvascular pressure in the maintenance of an open lung during mechanical ventilation
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
2007 vol. 157 pp. 262-269
ALBU G, HABRE W, FONTAO F, MOREL DR, PETAK F

Protective effects of volatile agents against acetylcholine-induced bronchoconstriction in isolated perfused rat lungs
ACTA ANAESTHESIOLOGICA SCANDINAVICA
2006 vol. 50(9) pp. 1145-1151
LELE E., PETAK F., FONTAO F., MOREL D.R., HABRE W.

Value of eosinophil cationic protein and tryptase levels in bronchoalveolar lavage fluid for predicting lung function impairment in anaesthetised, asthmatic children
ANAESTHESIA
2006 vol. 61(12) pp. 1149-1154
VON UNGERN-STERNBERG BS, SLY PD, LOH RKS, ISIDORO A, HABRE W

Development of bronchoconstriction after administration of muscle relaxants in rabbits with normal or hyperreactive airways
ANESTHESIA AND ANALGESIA
2006 vol. 103(1) pp. 103-109
PETÁK F, HANTOS Z, ADAMICZA A, GALITY H, HABRE W

Evaluation pour anesthésie de l'enfant avec cardiopathie congénitale
ARCHIVES DE PEDIATRIE : ORGANE OFFICIEL DE LA SOCIETE FRANCAISE DE PEDIATRIE
2006 vol. 13(6) pp. 754-757
HABRE WALID

Intraoperative awareness in children: myth or reality?
CURRENT OPINION IN ANAESTHESIOLOGY
2006 vol. 19(3) pp. 309-314
ISELIN-CHAVES I, LOPEZ U, HABRE W

Crackle-sound recording to monitor airway closure and recruitment in ventilated pigs
EUROPEAN RESPIRATORY JOURNAL
2006 vol. 27(4) pp. 808-816
PETAK F, HABRE W, BABIK B, TOLNAI J, HANTOS Z

Anesthesia management in a young child with aromatic L-amino acid decarboxylase deficiency
PEDIATRIC ANESTHESIA
2006 vol. 16(1) pp. 82-84
VUTSKITS L, MENACHE C, MANZANO S, HAENGGELI CA, KISS J

Near-death experience in a boy undergoing uneventful elective surgery under general anesthesia
PEDIATRIC ANESTHESIA
2006 vol. 16 pp. 85-88
LOPEZ U, FORSTER A, ANNONI JM, HABRE W, ISELIN-CHAVES IA

Population pharmacokinetic/pharmacodynamic modelling of the analgesic effects of tramadol in pediatrics
PHARMACEUTICAL RESEARCH
2006 vol. 23(9) pp. 2014-2023
GARRIDO MJ, HABRE W, ROMBOUT F, TROCONIZ IF

Measuring end-expiratory lung volume and pulmonary mechanics to detect early lung function impairment in rabbits
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
2006 vol. 152(1) pp. 72-82
HABRE WALID, SCALFARO PIETRO, SCHÜTZ NATHALIE, STUCKI PASCAL, PETAK FERENC

The role of endothelin-I in hyperoxia-induced lung injury in mice
RESPIRATORY RESEARCH
2006 vol. 7(1) pp. 45-0
HABRE W, PETAK F, RUCHONNET-METRAILLER I, DONATI Y, TOLSA JF, LELE E, ALBU G, BEGHETTI M, BARAZZONE-ARGIROFFO C

Time and tidal volume dependent ventilator-induced lung injury in healthy rats
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
2005 vol. 22 pp. 785-794
WALDER BERNARD, FONTAO FABIENNE, TOTSCH M, MOREL DENIS

Effects of pulmonary vascular pressures and flow on airway and parenchymal mechanics in isolated rat lungs
JOURNAL OF APPLIED PHYSIOLOGY
2002 vol. 92 pp. 169-178
PETAK F, HABRE W, HANTOS Z, SLY PD, MOREL DR

Research's domains




DATABASE-RESEARCH	GROUP OF CLINICAL PATIENT RESEARCH

Professeur Walid HABRE	Head of group CV	Research subject	Members of the group


	Links about the group Prof. Walid HABRE HUG/ Dpt APSI Serv. Anesthésiologie Rue Gabrielle-Perret-Gentil 4 1211 Genève 14 Suisse Walid.Habre@hcuge.ch Tel.: +41 22 372 75 04 Fax: 022/372.75.11 Comments Pages updated the 17.11.2015		Reseach's subject \| Group's publications \| Research's domains Children with bronchial hyperresponsiveness (BHR) The principal subject of my research activity is anaesthesia management of children with bronchial hyperresponsiveness (BHR). The choices of the optimal anaesthetic agent and its interaction with respiratory mechanics have been investigated both clinically and experimentally. My research projects have been focused on respiratory mechanics and implemented in Geneva the technique of partitioning lung mechanics into airway and tissue components by using the low-frequency forced oscillatory technique (LFFOT). This technique was first applied experimentally in rodents with healthy and diseased lungs. My group then developed 2 models of BHR in guinea pigs and in rabbits. These models have been validated and allow the investigation of the action of different anaesthetic agents on both the airways and the parenchymal mechanical parameters under wide variety of conditions encountered in clinical practice. The LFFOT was also used in healthy children, and in children with BHR and congenital heart disease. The application of this technique to both experimental and clinical studies and the accomplishment of these research projects have been achieved with a strong collaboration with Professor Z. Hantos, from the Dept of Medical Informatics at the University of Szeged-Hungary, and Professor P. D. Sly, from the Institute for Child Health Research at the University of Western Australia. The new ongoing research programs are aiming at extending these previous investigations towards 2 new areas: - To combine respiratory mechanical measurements with an in vivo moprohological technique using synchrotron radiation imaging. With the combination of state-of-the-art lung functional and structural measurements, this project has a promise to better characterize the pathophysiological mechanisms leading to BHR. - To better understand diseases such as pulmonary hypertension, acute lung injury and left ventricular failure, that all lead to a serious imbalance between the lung mechanics and pulmonary haemodynamics. Group's publications Methacholine and ovalbumin challenges assessed by forced oscillations and synchrotron lung imaging. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2009 vol. 180(4) pp. 296-303 BAYAT S, STRENGELL S, PORRA L, JANOSI T, PETAK F, SUHONEN H, SUORTTI P, HANTOS Z, SOVIJÄRVI AR, HABRE W The impact of oral premedication with midazolam on respiratory function in children. ANESTHESIA AND ANALGESIA 2009 vol. 108(6) pp. 1771-1776 VON UNGERN-STERNBERG BS, ERB TO, HABRE W, SLY PD, HANTOS Z Changes in Functional Residual Capacity and Lung Mechanics during Surgical Repair of Congenital Heart Diseases Effects of Preoperative Pulmonary Hemodynamics ANESTHESIOLOGY 2009 vol. 110(6) pp. 1348-1355 VON UNGERN-STERNBERG BS, PETAK F, HANTOS Z, HABRE W Does implicit memory during anaesthesia persist in children? BRITISH JOURNAL OF ANAESTHESIA. 2009 vol. 102(3) pp. 379-384 LOPEZ U, HABRE W, LAURENCON M, WILLEMS SJ, SCHMIDT C, VAN DER LINDEN M, ISELIN-CHAVES IA Impact of elevated pulmonary blood flow and capillary pressure on lung responsiveness JOURNAL OF APPLIED PHYSIOLOGY 2009 vol. 107 pp. 780-786 PETAK F, JANOSI T, MYERS C, FONTAO F, HABRE W Lung mechanical and vascular changes during positive- and negative-pressure lung inflations: importance of reference pressures in the pulmonary vasculature JOURNAL OF APPLIED PHYSIOLOGY 2009 vol. 106(3) pp. 935-942 PETAK F, ALBU G, LELE E, HANTOS Z, MOREL DR, FONTAO F, HABRE W Biosafety in Ex Vivo Gene Therapy and Conditional Ablation of Lentivirally Transduced Hepatocytes in Nonhuman Primates MOLECULAR THERAPY 2009 vol. 17(10) pp. 1754-1760 MENZEL O, BIRRAUX J, WILDHABER B, JOND C, LASNE F, HABRE W, TRONO D, NGUYEN TH, CHARDOT C Evaluation of intraoperative memory and postoperative behavior in children: are we really measuring what we intend to measure? PEDIATRIC ANESTHESIA 2009 vol. 19(12) pp. 1147-1151 LOPEZ U, HABRE W Hypnosis as an alternative to avoid general anesthesia in a child with severe pulmonary arterial hypertension. PEDIATRIC ANESTHESIA 2009 vol. 19(2) pp. 182-183 VON UNGERN-STERNBERG BS, HABRE W Salbutamol premedication in children with a recent respiratory tract infection. PEDIATRIC ANESTHESIA 2009 vol. 19(11) pp. 1064-1069 VON UNGERN-STERNBERG BS, HABRE W, ERB TO, HEANEY M Does anesthesia affect cerebral development PRESSE MEDICALE (DES 1983) 2009 vol. 38(11) pp. 1591-1596 VUTSKITS L, HABRE W Intra-operative awareness in children and post-traumatic stress disorder. ANAESTHESIA 2008 vol. 63(5) pp. 474-481 LOPEZ U, HABRE W, VAN DER LINDEN MARTIAL, ISELIN-CHAVES IRENE ANNE JULIE The involvement of histaminic and muscarinic receptors in the bronchoconstriction induced by myorelaxant administration in sensitized rabbits. ANESTHESIA AND ANALGESIA 2008 vol. 107(6) pp. 1899-1906 HABRE W, ADAMICZA A, LELE E, NOVÁK T, SLY PD, PETAK F Desflurane but not sevoflurane impairs airway and respiratory tissue mechanics in children with susceptible airways. ANESTHESIOLOGY 2008 vol. 108(2) pp. 216-224 VON UNGERN-STERNBERG BS, SAUDAN SONJA, PETAK F, HANTOS Z, HABRE W Imaging of lung function using synchrotron radiation computed tomography: what's new? EUROPEAN JOURNAL OF RADIOLOGY 2008 vol. 68 pp. 78-83 BAYAT S, PORRA L, SUHONEN H, JANOSI T, STRENGELL S, HABRE W, PETAK F, HANTOS Z, SUORTTI P, SOVIJÄRVI A Differential roles of endothelin-1 ETA and ETB receptors and vasoactive intestinal polypeptide in regulation of the airways and the pulmonary vasculature in isolated rat lung.² EXPERIMENTAL PHYSIOLOGY 2008 vol. 93(11) pp. 1210-1219 JANOSI T, PETAK F, FONTAO F, MOREL DR, BEGHETTI M, HABRE W Value of brain natriuretic peptide in the perioperative follow-up of children with valvular disease. INTENSIVE CARE MEDICINE 2008 vol. 34(6) pp. 1109-1113 TISSIERES P, DA CRUZ E, HABRE W, AGGOUN Y, MENSI N, KALANGOS A, BEGHETTI M Safety and efficacy of patient controlled epidural analgesia following pediatric spinal surgery. PEDIATRIC ANESTHESIA 2008 vol. 18(2) pp. 132-139 SAUDAN S, HABRE W, CERONI D, MEYER PA, GREENBERG RS, KAELIN A, VON UNGERN-STERNBERG BS Mechanisms of airway hyper-responsiveness after coronary ischemia. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY 2008 vol. 162(3) pp. 176-183 ALBU G, PETAK F, FONTAO F, BITON C, PACHE JC, HABRE W Impact of Trendelenburg positioning on functional residual capacity and ventilation homogeneity in anaesthetised children ANAESTHESIA 2007 vol. 62 pp. 451-455 REGLI A, HABRE W, SAUDAN S, MAMIE C, ERB TO, VON UMGERN-STERNBERG BS Intra-operative awareness in children: the value of an interview adapted to their cognitive abilities ANAESTHESIA 2007 vol. 62 pp. 778-789 LOPEZ U, HABRE W, LAURENCON M, HALLER G, VAN DER LINDEN M, ISELIN-CHAVES IA Laryngeal mask airway is associated with an increased incidence of adverse respiratory events in children with recent upper respiratory tract infections ANESTHESIOLOGY 2007 vol. 107 pp. 714-719 VON UNGERN-STEMBERG BS, BODA K, SCHWAB C, SIMS C, JOHNSON C, HABRE W Actualities in paediatric anaesthesia and critical care medicine ANNALES FRANCAISES D'ANESTHESIE ET DE REANIMATION 2007 vol. 26(6) pp. 483-487 HABRE W, PAUT O Pharmacokinetics of tramadol in children ANNALES FRANCAISES D'ANESTHESIE ET DE REANIMATION 2007 vol. 26(6) pp. 483-487 SAUDAN S, HABRE W Multimodality imaging for focus localization in pediatric pharmacoresistant epilepsy EPILEPTIC DISORDERS : INTERNATIONAL EPILEPSY JOURNAL WITH VIDEOTAPE 2007 vol. 9(1) pp. 20-31 KURIAN M, SPINELLI L, DELAVELLE J, WILLI JP, VELAZQUEZ M, CHAVES V, HABRE W, MEAGHER-VILLEMURE K, ROULET E, VILLENEUVE JG, SEECK M Mechanical support availability in pediatric cardiac surgery: program size should not matter INTERNATIONAL JOURNAL OF CARDIOLOGY 2007 vol. 129(2) pp. 282-284 DA CRUZ EM, BEGHETTI M, KALANGOS A, BERNER M, SIERRA J, AGGOUN Y, TISSOT C, PELLEGRINI M, SAUDAN S, HABRE W, RIMENSBERGER PC Effect of cardiopulmonary bypass and aortic clamping on functional residual capacity and ventilation distribution in children JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY 2007 vol. 134(5) pp. 1193-1198 VON UNGERN-STERNBERG BS, PETAK F, SAUDAN S, PELLEGRINI M, ERB TO, HABRE W Cardiac rhythm and left ventricular function of infants at 1 MAC sevoflurane and halothane PEDIATRIC ANESTHESIA 2007 vol. 17(6) pp. 540-546 SAUDAN S, BEGHETTI M, SPAHR-SCHOPFER I, MAMIE C, HABRE W Influence of anesthesia on immune responses and its effect on vaccination in children: review of evidence PEDIATRIC ANESTHESIA 2007 vol. 17 pp. 410-420 SIEBERT JN, POSFAY-BARBE KM, HABRE W, SIEGRIST CA Midazolam as premedication: is the emperor naked or just half-dressed? Reply PEDIATRIC ANESTHESIA 2007 vol. 17 pp. 401-401 LONNQVISTT PA, HABRE W Pediatric anesthesia - potential risks and their assessment: part I PEDIATRIC ANESTHESIA 2007 vol. 17 pp. 206-215 VON UNGERN-STERNBERG BS, HABRE W Pediatric anesthesia--potential risks and their assessment: part II PEDIATRIC ANESTHESIA 2007 vol. 17(4) pp. 311-320 VON UNGERN-STERNBERG BS, HABRE W Should the use of modified Jackson Rees T-piece breathing system be abandoned in preschool children? PEDIATRIC ANESTHESIA 2007 vol. 17 pp. 654-660 VON UNGERN-STERNBERG BS, SAUDAN S, REGLI A, SCHAUB E, ERB TO, HABRE W Vaccination and anesthesia: the precautionary principle is to vaccinate PEDIATRIC ANESTHESIA 2007 vol. 17 pp. 1218-1220 SIEBERT J, POSFAY-BARBE KM, HABRE W, SIEGRIST CA The contribution of the pulmonary microvascular pressure in the maintenance of an open lung during mechanical ventilation RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY 2007 vol. 157 pp. 262-269 ALBU G, HABRE W, FONTAO F, MOREL DR, PETAK F Protective effects of volatile agents against acetylcholine-induced bronchoconstriction in isolated perfused rat lungs ACTA ANAESTHESIOLOGICA SCANDINAVICA 2006 vol. 50(9) pp. 1145-1151 LELE E., PETAK F., FONTAO F., MOREL D.R., HABRE W. Value of eosinophil cationic protein and tryptase levels in bronchoalveolar lavage fluid for predicting lung function impairment in anaesthetised, asthmatic children ANAESTHESIA 2006 vol. 61(12) pp. 1149-1154 VON UNGERN-STERNBERG BS, SLY PD, LOH RKS, ISIDORO A, HABRE W Development of bronchoconstriction after administration of muscle relaxants in rabbits with normal or hyperreactive airways ANESTHESIA AND ANALGESIA 2006 vol. 103(1) pp. 103-109 PETÁK F, HANTOS Z, ADAMICZA A, GALITY H, HABRE W Evaluation pour anesthésie de l'enfant avec cardiopathie congénitale ARCHIVES DE PEDIATRIE : ORGANE OFFICIEL DE LA SOCIETE FRANCAISE DE PEDIATRIE 2006 vol. 13(6) pp. 754-757 HABRE WALID Intraoperative awareness in children: myth or reality? CURRENT OPINION IN ANAESTHESIOLOGY 2006 vol. 19(3) pp. 309-314 ISELIN-CHAVES I, LOPEZ U, HABRE W Crackle-sound recording to monitor airway closure and recruitment in ventilated pigs EUROPEAN RESPIRATORY JOURNAL 2006 vol. 27(4) pp. 808-816 PETAK F, HABRE W, BABIK B, TOLNAI J, HANTOS Z Anesthesia management in a young child with aromatic L-amino acid decarboxylase deficiency PEDIATRIC ANESTHESIA 2006 vol. 16(1) pp. 82-84 VUTSKITS L, MENACHE C, MANZANO S, HAENGGELI CA, KISS J Near-death experience in a boy undergoing uneventful elective surgery under general anesthesia PEDIATRIC ANESTHESIA 2006 vol. 16 pp. 85-88 LOPEZ U, FORSTER A, ANNONI JM, HABRE W, ISELIN-CHAVES IA Population pharmacokinetic/pharmacodynamic modelling of the analgesic effects of tramadol in pediatrics PHARMACEUTICAL RESEARCH 2006 vol. 23(9) pp. 2014-2023 GARRIDO MJ, HABRE W, ROMBOUT F, TROCONIZ IF Measuring end-expiratory lung volume and pulmonary mechanics to detect early lung function impairment in rabbits RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY 2006 vol. 152(1) pp. 72-82 HABRE WALID, SCALFARO PIETRO, SCHÜTZ NATHALIE, STUCKI PASCAL, PETAK FERENC The role of endothelin-I in hyperoxia-induced lung injury in mice RESPIRATORY RESEARCH 2006 vol. 7(1) pp. 45-0 HABRE W, PETAK F, RUCHONNET-METRAILLER I, DONATI Y, TOLSA JF, LELE E, ALBU G, BEGHETTI M, BARAZZONE-ARGIROFFO C Time and tidal volume dependent ventilator-induced lung injury in healthy rats EUROPEAN JOURNAL OF ANAESTHESIOLOGY 2005 vol. 22 pp. 785-794 WALDER BERNARD, FONTAO FABIENNE, TOTSCH M, MOREL DENIS Effects of pulmonary vascular pressures and flow on airway and parenchymal mechanics in isolated rat lungs JOURNAL OF APPLIED PHYSIOLOGY 2002 vol. 92 pp. 169-178 PETAK F, HABRE W, HANTOS Z, SLY PD, MOREL DR Research's domains