Welcome in the research database

Acute pulmonary diseases and congenital cardiac pathologies

In our Neonatal and Pediatric Intensive Care Unit research activities are chiefly concentrated on two major fields: 1. acute pulmonary diseases, particularly in relation to artificial mechanical ventilation and 2. congenital cardiac pathologies, whose principal axe is centered on cardiopulmonary interactions in relation to new modes and strategies of mechanical ventilation for children and neonates.

Several studies are actually underway or in preparation:
1. Work of Breathing study in children under non-invasive ventilation suffering from acute bronchiolitis:
This prospective study aims to analyze the respiratory mechanics and gas exchange under non-invasive ventilation (nasal CPAP) in relation to the various levels of CPAP-pressure applied. Respiratory mechanics will be assessed by measuring work of breathing, thoraco-abdominal synchronization, and gas exchange parameters. The object of this study is to try to define the optimal pressure level for supporting spontaneous breathing .
2. Study of non-invasive nasal high frequency oscillation in neonates with moderate respiratory insufficiency:
Prospective study aiming to study the feasibility of nasal high frequency oscillation in the neonate or premature infant suffering from infant respiratory distress syndrome.
3. Study aiming at the optimization of pulmonary recruitment during conventional mechanical ventilation:
This prospective study, which is currently under preparation for submission to the Ethical Committee, will focus on functional lung recruitment in patients with an acute pulmonary pathology. For many years, we have worked in the field of lung recruitment using conventional ventilation modes mainly in the animal laboratories. We use for many years with great success, in terms of patient outcomes, lung recruitment strategies during high-frequency oscillation. With this study we will now investigate the integration of recruitment in a structured way in patients under conventional mechanical ventilation. The aim is to be able to define simple physiological bedside parameters, which could be useful for finding optimal lung volumes (point of best recruitment and least over-distention) for each individual patient.
4. Study: Utility of non-invasive measurements to monitor bedside cardio-pulmonary interactions in patients under mechanical ventilation:
This study, in collaboration with the Pediatric Cardiology Unit, aims at evaluating the value of clinical and non-invasively measured parameters, validated by invasive hemodynamic parameters, for estimation of intra-vascular volume in relation of ventilator settings and changes of ventilator parameters.

Studies in collaboration with other international centers:
1. Study: Development of an Electrical Impedance Tomography system suitable for bedside application in neonates:
This study of the development of a simplified method of EIT method is done in collaboration with Prof. Simbrunner of the University of Innsbruck, Austria. This research activity will be centered on two fields: 1. development and application of the method in the animal model and 2. validation of this new method in the newborn child under spontaneous ventilation as well as under mechanical ventilation.
2. PALIVE-1 Study.
Epidemiological study on an international scale in collaboration with the PALISI Group (Pediatric Acute Lung Injury and Sepsis Investigation Group). The object of this study is to analyze the attitudes and the methods for ventilating patients with acute pulmonary lesions on a global level, that is to say in the United States and in Europe.
3. European Neonatal Ventilation Survey Study

Group's publications

Regional tidal ventilation and compliance during a stepwise vital capacity manoeuvre.
INTENSIVE CARE MEDICINE
2010 vol. 36(11) pp. 1953-1961
DARGAVILLE PA, RIMENSBERGER PC, FRERICHS I

Surfactant use based on the oxygenation response to lung recruitment during HFOV in VLBW infants.
INTENSIVE CARE MEDICINE
2010 vol. 36(7) pp. 1164-1170
TISSIERES P, MYERS PO, BEGHETTI M, BERNER M, RIMENSBERGER PC

Ventilation practices in the neonatal intensive care unit: a cross-sectional study.
JOURNAL OF PEDIATRICS
2010 vol. 157(5) pp. 767-771
VAN KAAM AH. AND AL.

Acute lung injury in children: therapeutic practice and feasibility of international clinical trials.
PEDIATRIC CRITICAL CARE MEDICINE : A JOURNAL OF THE SOCIETY OF CRITICAL CARE MEDICINE AND THE WORLD FEDERATION OF PEDIATRIC INTENSIVE AND CRITICAL CARE SOCIETIES
2010 vol. 11(6) pp. 681-689
SANTSCHI M AND AL.

Pseudomonas aeruginosa outbreak in a pediatric intensive care unit linked to a humanitarian organization residential center.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
2010 vol. 29(3) pp. 233-237
LONGTIN Y, TROILLET N, TOUVENEAU S, BOILLAT N, RIMENSBERGER PC, DHARAN S, GERVAIX A, PITTET D, HARBARTH S

Use of analgesic and sedative drugs in the NICU: integrating clinical trials and laboratory data.
PEDIATRIC RESEARCH : AN INTERNATIONAL JOURNAL OF CLINICAL, LABORATORY AND DEVELOPMENTAL INVESTIGATION
2010 vol. 67(2) pp. 117-127
DURRMEYER X, VUTSKITS L, ANAND KJ, RIMENSBERGER PC

Mechanical ventilation in paediatric intensive care.
ANNALES FRANCAISES D'ANESTHESIE ET DE REANIMATION
2009 vol. 28(7-8) pp. 682-684
RIMENSBERGER PC

Children with chronic conditions in pediatric intensive care units located in predominantly French-speaking regions: Prevalence and implications on rehabilitation care need and utilization.
CRITICAL CARE MEDICINE
2009 vol. 37(4) pp. 1456-1462
CREMER R AND AL.

Prospective population-based study of RSV-related intermediate care and intensive care unit admissions in Switzerland over a 4-year period (2001-2005).
INFECTION
2009 vol. 37(2) pp. 109-116
BERGER TM AND AL.

VGAM induced high-flow congestive heart failure responsive to PGE1 infusion.
INTERNATIONAL JOURNAL OF CARDIOLOGY
2009 vol. 132(2) pp. 60-62
KARAM O, DA CRUZ E, RIMENSBERGER PC

To intubate or not to intubate at birth, this is still the question! Will experimental studies give us the answer?: commentary on the article by Polglase et al. on page 67.
PEDIATRIC RESEARCH : AN INTERNATIONAL JOURNAL OF CLINICAL, LABORATORY AND DEVELOPMENTAL INVESTIGATION
2009 vol. 65(1) pp. 19-20
RIMENSBERGER PC

Noise levels during nCPAP are flow-dependent but not device-dependent.
ARCHIVES OF DISEASE IN CHILDHOOD : THE JOURNAL OF THE ROYAL COLLEGE OF PAEDIATRICS AND CHILD HEALTH. FETAL AND NEONATAL EDITION
2008 vol. 93(2) pp. 132-134
KARAM O, DONATIELLO C, VAN LANCKER E, CHRITIN V, PFISTER RE, RIMENSBERGER PETER

Factors effecting adoption of new neonatal and pediatric respiratory technologies.
INTENSIVE CARE MEDICINE
2008 vol. 34(1) pp. 174-178
BACHMAN TE, MARKS NE, RIMENSBERGER PC

High frequency oscillatory ventilation for respiratory failure due to RSV bronchiolitis.
INTENSIVE CARE MEDICINE
2008 vol. 34(9) pp. 1698-1702
BERNER M, HANQUINET SYLVIANE, RIMENSBERGER PC

Mechanical support availability in pediatric cardiac surgery: program size should not matter.
INTERNATIONAL JOURNAL OF CARDIOLOGY
2008 vol. 129(2) pp. 282-284
DA CRUZ EM, BEGHETTI M, KALANGOS A, BERNER M, SIERRA J, AGGOUN Y, TISSOT C, PELLEGRINI M, SAUDAN S, HABRE W, RIMENSBERGER PC

Ventilation strategies and adjunctive therapy in severe lung disease.
PEDIATRIC CLINICS OF NORTH AMERICA
2008 vol. 55(3) pp. 709-733
KISSOON N, RIMENSBERGER PC, BOHN D

Partial liquid ventilation: is it really time to give it a go?
PEDIATRIC CRITICAL CARE MEDICINE : A JOURNAL OF THE SOCIETY OF CRITICAL CARE MEDICINE AND THE WORLD FEDERATION OF PEDIATRIC INTENSIVE AND CRITICAL CARE SOCIETIES
2008 vol. 9(6) pp. 664-666
RIMENSBERGER PC

Food poisoning as a cause of acute liver failure.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
2008 vol. 27(9) pp. 846-847
POSFAY-BARBE KLARA, SCHRENZEL J, FREY J, STUDER R, KORFF CM, BELLI DC, PARVEX P, RIMENSBERGER PC, SCHAPPI MG

Lung-protective ventilation strategies in neonatology: What do we know - What do we need to know?
CRITICAL CARE MEDICINE
2007 vol. 35 pp. 925-931
VAN KAAM AH, RIMENSBERGER PC

Left ventricular epicardial VVI pacing for a congenital complete heart block with severe myocardial dysfunction: shall epicardial pacing wires be positioned left?
INTERNATIONAL JOURNAL OF CARDIOLOGY
2007 vol. 116(1) pp. 7-9
TISSOT CECILE, AGGOUN YACINE, RIMENSBERGER PETER C., SIERRA JORGE, KALANGOS AFKSENDYIOS, BEGHETTI MAURICE, DA CRUZ EDUARDO

Tissue plasminogen activator for a left atrial thrombus after Senning repair.
PEDIATRIC CRITICAL CARE MEDICINE : A JOURNAL OF THE SOCIETY OF CRITICAL CARE MEDICINE AND THE WORLD FEDERATION OF PEDIATRIC INTENSIVE AND CRITICAL CARE SOCIETIES
2007 vol. 8(3) pp. 279-281
TISSOT C, RIMENSBERGER PC, AGGOUN Y, KALANGOS A, OZSAHIN H, BEGHETTI M, DA CRUZ E

Lung volume recruitment after surfactant administration modifies spatial distribution of ventilation
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
2006 vol. 174(7) pp. 772-779
FRERICHS I, DARGAVILLE PA, VAN GENDERINGEN H, MOREL DR, RIMENSBERGER PC

Allowing for spontaneous breathing during high-frequency oscillation: the key for final success?
CRITICAL CARE
2006 vol. 10(4) pp. 155-
RIMENSBERGER PETER

Fatal GvHD as a complication of liver transplantation for undetermined fulminant hepatic failure and associated aplastic anemia
LIVER TRANSPLANTATION : OFFICIAL PUBLICATION OF THE AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES AND THE INTERNATIONAL LIVER TRANSPLANTATION SOCIETY
2006 vol. 12(11) pp. 1693-1697
SCHAEPPI MICHELA, BELLI DOMINIQUE, RIMENSBERGER PETER, CHARDOT CHRISTOPHE, GÜRKAN KAYA, TIERCY JEAN-MARIE, OZSAHIN HULYA

Intravenous adenosine for refractory pulmonary hypertension in a low-weight premature newborn: a potential new drug for rescue therapy
PEDIATRIC CRITICAL CARE MEDICINE : A JOURNAL OF THE SOCIETY OF CRITICAL CARE MEDICINE AND THE WORLD FEDERATION OF PEDIATRIC INTENSIVE AND CRITICAL CARE SOCIETIES
2006 vol. 7(4) pp. 380-382
MOTTI ALESSANDRO, TISSOT CECILE, RIMENSBERGER PETER C., PRINA-ROUSSO ALINE, AGGOUN YACINE, BERNER MICHEL, BEGHETTI MAURICE, DA CRUZ EDUARDO

Prenatal diagnostic indicators of paternal uniparental disomy 14
PRENATAL DIAGNOSIS
2006 vol. 26 pp. 662-666
CURTIS L, ANTONEILLI E, VIAL Y, RIMENSBERGER P, LE MERRERS M, HINARD C, BOTTANI A, FOKSTUEN S

National ethical directives and practical aspects of forgoing life-sustaining treatment in newborn infants in a Swiss intensive care unit
SWISS MEDICAL WEEKLY
2006 vol. 136 pp. 597-602
BERNER ME, RIMENSBERGER PC, HUPPI PS, PFISTER RE

Effects of inhaled nitric oxide and intravenous magnesium sulphate, alone and in combination, in a porcine model of hypoxic pulmonary hypertension
MEDICAL SCIENCE MONITOR : INTERNATIONAL MEDICAL JOURNAL OF EXPERIMENTAL AND CLINICAL RESEARCH
2003 vol. 9 pp. 193-198
BEGHETTI MAURICE, SPAHR-SCHOPFER ISABELLE, MENSI NOURY, MOREL DENIS, RIMENSBERGER PETER

Neonatal respiratory failure
CURRENT OPINION IN PEDIATRICS
2002 vol. 14 pp. 315-321
RIMENSBERGER PC

Aerosolized iloprost induces a mild but sustained inhibition of platelet aggregation
EUROPEAN RESPIRATORY JOURNAL
2002 vol. 19 pp. 518-524
BEGHETTI M, REBER G, DE MOERLOOSE P, VADAS L, CHIAPPE A, SPAHR-SCHOPFER I, RIMENSBERGER PC

Research's domains




DATABASE-RESEARCH	GROUP OF CLINICAL PATIENT RESEARCH

Peter RIMENSBERGER	Head of group CV	Research subject	Members of the group


	Links about the group Dr. Peter RIMENSBERGER HUG/ Dpt Pédiatrie Serv Néonatologie Willy-Donzé 6 1211 Genève 14 Suisse Peter.Rimensberger@hcuge.ch Tel.: 022 372 47 30 Fax: 022 382 54 88 Comments Pages updated the 17.11.2015		Reseach's subject \| Group's publications \| Research's domains Acute pulmonary diseases and congenital cardiac pathologies In our Neonatal and Pediatric Intensive Care Unit research activities are chiefly concentrated on two major fields: 1. acute pulmonary diseases, particularly in relation to artificial mechanical ventilation and 2. congenital cardiac pathologies, whose principal axe is centered on cardiopulmonary interactions in relation to new modes and strategies of mechanical ventilation for children and neonates. Several studies are actually underway or in preparation: 1. Work of Breathing study in children under non-invasive ventilation suffering from acute bronchiolitis: This prospective study aims to analyze the respiratory mechanics and gas exchange under non-invasive ventilation (nasal CPAP) in relation to the various levels of CPAP-pressure applied. Respiratory mechanics will be assessed by measuring work of breathing, thoraco-abdominal synchronization, and gas exchange parameters. The object of this study is to try to define the optimal pressure level for supporting spontaneous breathing . 2. Study of non-invasive nasal high frequency oscillation in neonates with moderate respiratory insufficiency: Prospective study aiming to study the feasibility of nasal high frequency oscillation in the neonate or premature infant suffering from infant respiratory distress syndrome. 3. Study aiming at the optimization of pulmonary recruitment during conventional mechanical ventilation: This prospective study, which is currently under preparation for submission to the Ethical Committee, will focus on functional lung recruitment in patients with an acute pulmonary pathology. For many years, we have worked in the field of lung recruitment using conventional ventilation modes mainly in the animal laboratories. We use for many years with great success, in terms of patient outcomes, lung recruitment strategies during high-frequency oscillation. With this study we will now investigate the integration of recruitment in a structured way in patients under conventional mechanical ventilation. The aim is to be able to define simple physiological bedside parameters, which could be useful for finding optimal lung volumes (point of best recruitment and least over-distention) for each individual patient. 4. Study: Utility of non-invasive measurements to monitor bedside cardio-pulmonary interactions in patients under mechanical ventilation: This study, in collaboration with the Pediatric Cardiology Unit, aims at evaluating the value of clinical and non-invasively measured parameters, validated by invasive hemodynamic parameters, for estimation of intra-vascular volume in relation of ventilator settings and changes of ventilator parameters. Studies in collaboration with other international centers: 1. Study: Development of an Electrical Impedance Tomography system suitable for bedside application in neonates: This study of the development of a simplified method of EIT method is done in collaboration with Prof. Simbrunner of the University of Innsbruck, Austria. This research activity will be centered on two fields: 1. development and application of the method in the animal model and 2. validation of this new method in the newborn child under spontaneous ventilation as well as under mechanical ventilation. 2. PALIVE-1 Study. Epidemiological study on an international scale in collaboration with the PALISI Group (Pediatric Acute Lung Injury and Sepsis Investigation Group). The object of this study is to analyze the attitudes and the methods for ventilating patients with acute pulmonary lesions on a global level, that is to say in the United States and in Europe. 3. European Neonatal Ventilation Survey Study Group's publications Regional tidal ventilation and compliance during a stepwise vital capacity manoeuvre. INTENSIVE CARE MEDICINE 2010 vol. 36(11) pp. 1953-1961 DARGAVILLE PA, RIMENSBERGER PC, FRERICHS I Surfactant use based on the oxygenation response to lung recruitment during HFOV in VLBW infants. INTENSIVE CARE MEDICINE 2010 vol. 36(7) pp. 1164-1170 TISSIERES P, MYERS PO, BEGHETTI M, BERNER M, RIMENSBERGER PC Ventilation practices in the neonatal intensive care unit: a cross-sectional study. JOURNAL OF PEDIATRICS 2010 vol. 157(5) pp. 767-771 VAN KAAM AH. AND AL. Acute lung injury in children: therapeutic practice and feasibility of international clinical trials. PEDIATRIC CRITICAL CARE MEDICINE : A JOURNAL OF THE SOCIETY OF CRITICAL CARE MEDICINE AND THE WORLD FEDERATION OF PEDIATRIC INTENSIVE AND CRITICAL CARE SOCIETIES 2010 vol. 11(6) pp. 681-689 SANTSCHI M AND AL. Pseudomonas aeruginosa outbreak in a pediatric intensive care unit linked to a humanitarian organization residential center. PEDIATRIC INFECTIOUS DISEASE JOURNAL 2010 vol. 29(3) pp. 233-237 LONGTIN Y, TROILLET N, TOUVENEAU S, BOILLAT N, RIMENSBERGER PC, DHARAN S, GERVAIX A, PITTET D, HARBARTH S Use of analgesic and sedative drugs in the NICU: integrating clinical trials and laboratory data. PEDIATRIC RESEARCH : AN INTERNATIONAL JOURNAL OF CLINICAL, LABORATORY AND DEVELOPMENTAL INVESTIGATION 2010 vol. 67(2) pp. 117-127 DURRMEYER X, VUTSKITS L, ANAND KJ, RIMENSBERGER PC Mechanical ventilation in paediatric intensive care. ANNALES FRANCAISES D'ANESTHESIE ET DE REANIMATION 2009 vol. 28(7-8) pp. 682-684 RIMENSBERGER PC Children with chronic conditions in pediatric intensive care units located in predominantly French-speaking regions: Prevalence and implications on rehabilitation care need and utilization. CRITICAL CARE MEDICINE 2009 vol. 37(4) pp. 1456-1462 CREMER R AND AL. Prospective population-based study of RSV-related intermediate care and intensive care unit admissions in Switzerland over a 4-year period (2001-2005). INFECTION 2009 vol. 37(2) pp. 109-116 BERGER TM AND AL. VGAM induced high-flow congestive heart failure responsive to PGE1 infusion. INTERNATIONAL JOURNAL OF CARDIOLOGY 2009 vol. 132(2) pp. 60-62 KARAM O, DA CRUZ E, RIMENSBERGER PC To intubate or not to intubate at birth, this is still the question! Will experimental studies give us the answer?: commentary on the article by Polglase et al. on page 67. PEDIATRIC RESEARCH : AN INTERNATIONAL JOURNAL OF CLINICAL, LABORATORY AND DEVELOPMENTAL INVESTIGATION 2009 vol. 65(1) pp. 19-20 RIMENSBERGER PC Noise levels during nCPAP are flow-dependent but not device-dependent. ARCHIVES OF DISEASE IN CHILDHOOD : THE JOURNAL OF THE ROYAL COLLEGE OF PAEDIATRICS AND CHILD HEALTH. FETAL AND NEONATAL EDITION 2008 vol. 93(2) pp. 132-134 KARAM O, DONATIELLO C, VAN LANCKER E, CHRITIN V, PFISTER RE, RIMENSBERGER PETER Factors effecting adoption of new neonatal and pediatric respiratory technologies. INTENSIVE CARE MEDICINE 2008 vol. 34(1) pp. 174-178 BACHMAN TE, MARKS NE, RIMENSBERGER PC High frequency oscillatory ventilation for respiratory failure due to RSV bronchiolitis. INTENSIVE CARE MEDICINE 2008 vol. 34(9) pp. 1698-1702 BERNER M, HANQUINET SYLVIANE, RIMENSBERGER PC Mechanical support availability in pediatric cardiac surgery: program size should not matter. INTERNATIONAL JOURNAL OF CARDIOLOGY 2008 vol. 129(2) pp. 282-284 DA CRUZ EM, BEGHETTI M, KALANGOS A, BERNER M, SIERRA J, AGGOUN Y, TISSOT C, PELLEGRINI M, SAUDAN S, HABRE W, RIMENSBERGER PC Ventilation strategies and adjunctive therapy in severe lung disease. PEDIATRIC CLINICS OF NORTH AMERICA 2008 vol. 55(3) pp. 709-733 KISSOON N, RIMENSBERGER PC, BOHN D Partial liquid ventilation: is it really time to give it a go? PEDIATRIC CRITICAL CARE MEDICINE : A JOURNAL OF THE SOCIETY OF CRITICAL CARE MEDICINE AND THE WORLD FEDERATION OF PEDIATRIC INTENSIVE AND CRITICAL CARE SOCIETIES 2008 vol. 9(6) pp. 664-666 RIMENSBERGER PC Food poisoning as a cause of acute liver failure. PEDIATRIC INFECTIOUS DISEASE JOURNAL 2008 vol. 27(9) pp. 846-847 POSFAY-BARBE KLARA, SCHRENZEL J, FREY J, STUDER R, KORFF CM, BELLI DC, PARVEX P, RIMENSBERGER PC, SCHAPPI MG Lung-protective ventilation strategies in neonatology: What do we know - What do we need to know? CRITICAL CARE MEDICINE 2007 vol. 35 pp. 925-931 VAN KAAM AH, RIMENSBERGER PC Left ventricular epicardial VVI pacing for a congenital complete heart block with severe myocardial dysfunction: shall epicardial pacing wires be positioned left? INTERNATIONAL JOURNAL OF CARDIOLOGY 2007 vol. 116(1) pp. 7-9 TISSOT CECILE, AGGOUN YACINE, RIMENSBERGER PETER C., SIERRA JORGE, KALANGOS AFKSENDYIOS, BEGHETTI MAURICE, DA CRUZ EDUARDO Tissue plasminogen activator for a left atrial thrombus after Senning repair. PEDIATRIC CRITICAL CARE MEDICINE : A JOURNAL OF THE SOCIETY OF CRITICAL CARE MEDICINE AND THE WORLD FEDERATION OF PEDIATRIC INTENSIVE AND CRITICAL CARE SOCIETIES 2007 vol. 8(3) pp. 279-281 TISSOT C, RIMENSBERGER PC, AGGOUN Y, KALANGOS A, OZSAHIN H, BEGHETTI M, DA CRUZ E Lung volume recruitment after surfactant administration modifies spatial distribution of ventilation AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2006 vol. 174(7) pp. 772-779 FRERICHS I, DARGAVILLE PA, VAN GENDERINGEN H, MOREL DR, RIMENSBERGER PC Allowing for spontaneous breathing during high-frequency oscillation: the key for final success? CRITICAL CARE 2006 vol. 10(4) pp. 155- RIMENSBERGER PETER Fatal GvHD as a complication of liver transplantation for undetermined fulminant hepatic failure and associated aplastic anemia LIVER TRANSPLANTATION : OFFICIAL PUBLICATION OF THE AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES AND THE INTERNATIONAL LIVER TRANSPLANTATION SOCIETY 2006 vol. 12(11) pp. 1693-1697 SCHAEPPI MICHELA, BELLI DOMINIQUE, RIMENSBERGER PETER, CHARDOT CHRISTOPHE, GÜRKAN KAYA, TIERCY JEAN-MARIE, OZSAHIN HULYA Intravenous adenosine for refractory pulmonary hypertension in a low-weight premature newborn: a potential new drug for rescue therapy PEDIATRIC CRITICAL CARE MEDICINE : A JOURNAL OF THE SOCIETY OF CRITICAL CARE MEDICINE AND THE WORLD FEDERATION OF PEDIATRIC INTENSIVE AND CRITICAL CARE SOCIETIES 2006 vol. 7(4) pp. 380-382 MOTTI ALESSANDRO, TISSOT CECILE, RIMENSBERGER PETER C., PRINA-ROUSSO ALINE, AGGOUN YACINE, BERNER MICHEL, BEGHETTI MAURICE, DA CRUZ EDUARDO Prenatal diagnostic indicators of paternal uniparental disomy 14 PRENATAL DIAGNOSIS 2006 vol. 26 pp. 662-666 CURTIS L, ANTONEILLI E, VIAL Y, RIMENSBERGER P, LE MERRERS M, HINARD C, BOTTANI A, FOKSTUEN S National ethical directives and practical aspects of forgoing life-sustaining treatment in newborn infants in a Swiss intensive care unit SWISS MEDICAL WEEKLY 2006 vol. 136 pp. 597-602 BERNER ME, RIMENSBERGER PC, HUPPI PS, PFISTER RE Effects of inhaled nitric oxide and intravenous magnesium sulphate, alone and in combination, in a porcine model of hypoxic pulmonary hypertension MEDICAL SCIENCE MONITOR : INTERNATIONAL MEDICAL JOURNAL OF EXPERIMENTAL AND CLINICAL RESEARCH 2003 vol. 9 pp. 193-198 BEGHETTI MAURICE, SPAHR-SCHOPFER ISABELLE, MENSI NOURY, MOREL DENIS, RIMENSBERGER PETER Neonatal respiratory failure CURRENT OPINION IN PEDIATRICS 2002 vol. 14 pp. 315-321 RIMENSBERGER PC Aerosolized iloprost induces a mild but sustained inhibition of platelet aggregation EUROPEAN RESPIRATORY JOURNAL 2002 vol. 19 pp. 518-524 BEGHETTI M, REBER G, DE MOERLOOSE P, VADAS L, CHIAPPE A, SPAHR-SCHOPFER I, RIMENSBERGER PC Research's domains