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Evaluation and treatment of depression

Several ongoing research projects take place within the context of a clinical research group of the Clinic of Adult Psychiatry (GRETTHA - Groupe de Recherche sur les Thérapeutiques des Troubles de l'Humeur et de l'Anxiété). This group is co-directed by Drs G. Bondolfi and J.-M. Aubry and benefits from the contributions of a network of young doctors and clinical psychologists in the clinic. The group continually networks in order to establish relations with research groups in the basic sciences (pharmacokinetics, neurobiology, genetics).At the heart of GRETTHA's research, the implication of the party concerned deals more particularly with the evaluation and treatment of depression, the depressive relapse prevention, the relapse risk factors detection and pathological gambling through an integrative viewpoint of psychopathology and biological psychiatry (neurosciences, psychopharmacology, transcranial magnetic stimulation, cognitive psychotherapy).

Group's publications

Current status of brain imaging in anxiety disorders
CURRENT OPINION IN PSYCHIATRY
2009 vol. 22(1) pp. 96-110
DAMSA C, KOSEL M, MOUSSALLY J

Performance of the Mood Disorder Questionnaire (MDQ) according to bipolar subtype and symptom severity.
EUROPEAN PSYCHIATRY : THE JOURNAL OF THE ASSOCIATION OF EUROPEAN PSYCHIATRISTS
2009 vol. 24(5) pp. 341-344
GERVASONI N, WEBER ROUGET B, MIGUEZ M, DUBUIS V, BIZZINI V, GEX-FABRY M, BONDOLFI G, AUBRY JM

Does the Form or the Amount of Exposure Make a Difference in the Cognitive-Behavioral Therapy Treatment of Social Phobia?
JOURNAL OF NERVOUS AND MENTAL DISEASE
2009 vol. 197(7) pp. 507-513
BORGEAT F, STANKOVIC M, KHAZAAL Y, ROUGET BW, BAUMANN MC, RIQUIER F, O'CONNOR K, JERMANN F, ZULLINO D, BONDOLFI G

Nicotine-induced and depolarisation-induced glutamate release from hippocampus mossy fibre synaptosomes: two distinct mechanisms
JOURNAL OF NEUROCHEMISTRY
2009 vol. 110(2) pp. 570-580
BANCILA V, CORDEIRO JM, BLOC A, DUNANT Y

Anatomy of the White Bear Suppression Inventory (WBSI): a review of previous findings and a new approach.
JOURNAL OF PERSONALITY ASSESSMENT
2009 vol. 91(4) pp. 323-330
SCHMIDT RE, GAY P, COURVOISIER D, JERMANN F, CESCHI G, DAVID M, BRINKMANN K, VAN DER LINDEN M

Is there a place for tricyclic antidepressants and subsequent augmentation strategies in obtaining remission for patients with treatment resistant depression?
PHARMACOLOGICAL REVIEWS
2009 vol. 59(3) pp. 202-206
GERVASONI N, AUBRY JM, GEX-FABRY M, BERTSCHY G, BONDOLFI G

Mindful Attention Awareness Scale (MAAS): Psychometric Properties of the French Translation and Exploration of Its Relations With Emotion Regulation Strategies
PSYCHOLOGICAL ASSESSMENT
2009 vol. 21(4) pp. 506-514
JERMANN F, BILLIEUX J, LAROI F, D'ARGEMBEAU A, BONDOLFI G, ZERMATTEN ARIANE, VAN DER LINDEN M

Prevalence of pathological gambling in Switzerland after the opening of casinos and the introduction of new preventive legislation.
ACTA PSYCHIATRICA SCANDINAVICA
2008 vol. 117(3) pp. 236-239
BONDOLFI G, JERMANN F, FERRERO F, ZULLINO D, OSIEK C

CYP2D6 and ABCB1 genetic variability: influence on paroxetine plasma level and therapeutic response.
THERAPEUTIC DRUG MONITORING
2008 vol. 30(4) pp. 474-482
GEX-FABRY M, EAP CB, ONEDA B, GERVASONI N, AUBRY JM, BONDOLFI G, BERTSCHY G

The DEX/CRH neuroendocrine test and the prediction of depressive relapse in remitted depressed outpatients
JOURNAL OF PSYCHIATRIC RESEARCH
2007 vol. 41 pp. 290-294
AUBRY JM, GERVASONI N, OSIEK C, PERRET G, ROSSIER MF, BERTSCHY G, BONDOLFI G

Time course of response to paroxetine: Influence of plasma level
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
2007 vol. 31 pp. 892-900
GEX-FABRY M, GERVASONI N, EAP CB, AUBRY JM, BONDOLFI G, BERTSCHY G

No human tryptophan hydroxylase-2 gene R441H mutation in a large cohort of psychiatric patients and control subjects
BIOLOGICAL PSYCHIATRY
2006 vol. 60 pp. 202-203
DELORME R, DURAND CM, BETANCUR C, WAGNER M, RUHRMANN S, GRABE HJ, NYGREN G, GILLBERG C, LEBOYER M, BOURGERON T, COURTET P, JOLLANT F, BURESI C, AUBRY JM, BAUD P, BONDOLFI G, BERTSCHY G

Body dysmorphic disorder, psychosis and insight: A report of four cases
PSYCHOPATHOLOGY
2006 vol. 39 pp. 130-135
LUCCHELLI JP, BONDOLFI G, BERTSCHY G

A stepwise drug treatment algorithm to obtain complete remission in depression: a Geneva study
SWISS MEDICAL WEEKLY
2006 vol. 136 pp. 78-85
BONDOLFI G, AUBRY JM, GOLAZ J, GEX-FABRY M, GERVASONI N, BERTSCHY G

Induction of a mixed depressive episode during rTMS treatment in a patient with refractory major depression
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
2006 vol. 7 pp. 261-264
RACHID F, GOLAZ J, BONDOLFI G, BERTSCHY G

Lithium dose prediction based on 24 hours single dose levels : a prospective evaluation
PHARMACOLOGICAL RESEARCH
2003 vol. 48 pp. 649-653
GERVASONI N, OSIEK C, ROTH L, BONDOLFI G, BERTSCHY G

The effect of fluoxetine on the pharmacokinetics and safety of risperidone in psychiatric patients
PHARMACOPSYCHIATRY
2002 vol. 35 pp. 50-56
BONDOLFI G, EAP CB, BERTSCHY G, ZULLINO D, VERMEULEN A, BAUMANN P

Decreased serum brain-derived neurotrophic factor levels in major depressed patients
PSYCHIATRY RESEARCH
2002 vol. 109 pp. 143-148
KAREGE F, PERRET G, BONDOLFI G, SCHWALD M, BERTSCHY G, AUBRY JM

Prevalence estimates of pathological gambling in Switzerland
ACTA PSYCHIATRICA SCANDINAVICA
2000 vol. 101 pp. 473-475
BONDOLFI GUIDO-X, OSEIK CH, FERRERO FRANCOIS

Fluoxetine augmentation in citalopram non-responders: pharmacokinetic and clinical consequences
THE INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY / OFFICIAL SCIENTIFIC JOURNAL OF THE COLLEGIUM INTERNATIONALE NEUROPSYCHOPHARMACOLOGICUM (CINP)
2000 vol. 3 pp. 55-60
BONDOLFI GUIDO-X, LISSNER C, KOSEL M, EAP C.B, BAUMANN PHILIPPE

Research's domains




DATABASE-RESEARCH	GROUP OF CLINICAL PATIENT RESEARCH

GRETTHA (GROUPE DE G BONDOLFI)	Head of group CV	Research subject	Members of the group


	Links about the group Dr. G. BONDOLFI HUG/ Dpt Psychiatrie Consultation Jonction Bd Saint-Georges 16-18 1205 Genève guido.bondolfi@hcuge.ch Tel.: + 41 22 327 75 54 Fax: + 41 22 327 75 75 Comments Pages updated the 17.11.2015		Reseach's subject \| Group's publications \| Research's domains Evaluation and treatment of depression Several ongoing research projects take place within the context of a clinical research group of the Clinic of Adult Psychiatry (GRETTHA - Groupe de Recherche sur les Thérapeutiques des Troubles de l'Humeur et de l'Anxiété). This group is co-directed by Drs G. Bondolfi and J.-M. Aubry and benefits from the contributions of a network of young doctors and clinical psychologists in the clinic. The group continually networks in order to establish relations with research groups in the basic sciences (pharmacokinetics, neurobiology, genetics).At the heart of GRETTHA's research, the implication of the party concerned deals more particularly with the evaluation and treatment of depression, the depressive relapse prevention, the relapse risk factors detection and pathological gambling through an integrative viewpoint of psychopathology and biological psychiatry (neurosciences, psychopharmacology, transcranial magnetic stimulation, cognitive psychotherapy). Group's publications Current status of brain imaging in anxiety disorders CURRENT OPINION IN PSYCHIATRY 2009 vol. 22(1) pp. 96-110 DAMSA C, KOSEL M, MOUSSALLY J Performance of the Mood Disorder Questionnaire (MDQ) according to bipolar subtype and symptom severity. EUROPEAN PSYCHIATRY : THE JOURNAL OF THE ASSOCIATION OF EUROPEAN PSYCHIATRISTS 2009 vol. 24(5) pp. 341-344 GERVASONI N, WEBER ROUGET B, MIGUEZ M, DUBUIS V, BIZZINI V, GEX-FABRY M, BONDOLFI G, AUBRY JM Does the Form or the Amount of Exposure Make a Difference in the Cognitive-Behavioral Therapy Treatment of Social Phobia? JOURNAL OF NERVOUS AND MENTAL DISEASE 2009 vol. 197(7) pp. 507-513 BORGEAT F, STANKOVIC M, KHAZAAL Y, ROUGET BW, BAUMANN MC, RIQUIER F, O'CONNOR K, JERMANN F, ZULLINO D, BONDOLFI G Nicotine-induced and depolarisation-induced glutamate release from hippocampus mossy fibre synaptosomes: two distinct mechanisms JOURNAL OF NEUROCHEMISTRY 2009 vol. 110(2) pp. 570-580 BANCILA V, CORDEIRO JM, BLOC A, DUNANT Y Anatomy of the White Bear Suppression Inventory (WBSI): a review of previous findings and a new approach. JOURNAL OF PERSONALITY ASSESSMENT 2009 vol. 91(4) pp. 323-330 SCHMIDT RE, GAY P, COURVOISIER D, JERMANN F, CESCHI G, DAVID M, BRINKMANN K, VAN DER LINDEN M Is there a place for tricyclic antidepressants and subsequent augmentation strategies in obtaining remission for patients with treatment resistant depression? PHARMACOLOGICAL REVIEWS 2009 vol. 59(3) pp. 202-206 GERVASONI N, AUBRY JM, GEX-FABRY M, BERTSCHY G, BONDOLFI G Mindful Attention Awareness Scale (MAAS): Psychometric Properties of the French Translation and Exploration of Its Relations With Emotion Regulation Strategies PSYCHOLOGICAL ASSESSMENT 2009 vol. 21(4) pp. 506-514 JERMANN F, BILLIEUX J, LAROI F, D'ARGEMBEAU A, BONDOLFI G, ZERMATTEN ARIANE, VAN DER LINDEN M Prevalence of pathological gambling in Switzerland after the opening of casinos and the introduction of new preventive legislation. ACTA PSYCHIATRICA SCANDINAVICA 2008 vol. 117(3) pp. 236-239 BONDOLFI G, JERMANN F, FERRERO F, ZULLINO D, OSIEK C CYP2D6 and ABCB1 genetic variability: influence on paroxetine plasma level and therapeutic response. THERAPEUTIC DRUG MONITORING 2008 vol. 30(4) pp. 474-482 GEX-FABRY M, EAP CB, ONEDA B, GERVASONI N, AUBRY JM, BONDOLFI G, BERTSCHY G The DEX/CRH neuroendocrine test and the prediction of depressive relapse in remitted depressed outpatients JOURNAL OF PSYCHIATRIC RESEARCH 2007 vol. 41 pp. 290-294 AUBRY JM, GERVASONI N, OSIEK C, PERRET G, ROSSIER MF, BERTSCHY G, BONDOLFI G Time course of response to paroxetine: Influence of plasma level PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 2007 vol. 31 pp. 892-900 GEX-FABRY M, GERVASONI N, EAP CB, AUBRY JM, BONDOLFI G, BERTSCHY G No human tryptophan hydroxylase-2 gene R441H mutation in a large cohort of psychiatric patients and control subjects BIOLOGICAL PSYCHIATRY 2006 vol. 60 pp. 202-203 DELORME R, DURAND CM, BETANCUR C, WAGNER M, RUHRMANN S, GRABE HJ, NYGREN G, GILLBERG C, LEBOYER M, BOURGERON T, COURTET P, JOLLANT F, BURESI C, AUBRY JM, BAUD P, BONDOLFI G, BERTSCHY G Body dysmorphic disorder, psychosis and insight: A report of four cases PSYCHOPATHOLOGY 2006 vol. 39 pp. 130-135 LUCCHELLI JP, BONDOLFI G, BERTSCHY G A stepwise drug treatment algorithm to obtain complete remission in depression: a Geneva study SWISS MEDICAL WEEKLY 2006 vol. 136 pp. 78-85 BONDOLFI G, AUBRY JM, GOLAZ J, GEX-FABRY M, GERVASONI N, BERTSCHY G Induction of a mixed depressive episode during rTMS treatment in a patient with refractory major depression WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY 2006 vol. 7 pp. 261-264 RACHID F, GOLAZ J, BONDOLFI G, BERTSCHY G Lithium dose prediction based on 24 hours single dose levels : a prospective evaluation PHARMACOLOGICAL RESEARCH 2003 vol. 48 pp. 649-653 GERVASONI N, OSIEK C, ROTH L, BONDOLFI G, BERTSCHY G The effect of fluoxetine on the pharmacokinetics and safety of risperidone in psychiatric patients PHARMACOPSYCHIATRY 2002 vol. 35 pp. 50-56 BONDOLFI G, EAP CB, BERTSCHY G, ZULLINO D, VERMEULEN A, BAUMANN P Decreased serum brain-derived neurotrophic factor levels in major depressed patients PSYCHIATRY RESEARCH 2002 vol. 109 pp. 143-148 KAREGE F, PERRET G, BONDOLFI G, SCHWALD M, BERTSCHY G, AUBRY JM Prevalence estimates of pathological gambling in Switzerland ACTA PSYCHIATRICA SCANDINAVICA 2000 vol. 101 pp. 473-475 BONDOLFI GUIDO-X, OSEIK CH, FERRERO FRANCOIS Fluoxetine augmentation in citalopram non-responders: pharmacokinetic and clinical consequences THE INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY / OFFICIAL SCIENTIFIC JOURNAL OF THE COLLEGIUM INTERNATIONALE NEUROPSYCHOPHARMACOLOGICUM (CINP) 2000 vol. 3 pp. 55-60 BONDOLFI GUIDO-X, LISSNER C, KOSEL M, EAP C.B, BAUMANN PHILIPPE Research's domains