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Born and nutrition

Calcium and bone growth
Bone mass and bone size are of crucial importance to determine the future risk of fractures occurring in advanced age. Calcium salt supplements administered to young girls enhance bone mineral gain but also tend to stimulate the gain in bone size in girls having a low spontaneous calcium intake. Protein supplements markedly increase plasma IGF-I in animals fed a low protein diet. This research project is aimed first to set up an animal model able to detect modification of bone mineral mass, bone size and architecture in growing rats in relation with protein and calcium intake, then to investigate the effect of calcium salts and protein intakes on bone mineral mass acquisition, in prepubertal children.
Dietary protein and bone
Dietary protein intake plays a role in both bone mass acquisition and bone loss. Low protein intake contributes to a marked uncoupling between bone formation and bone resorption. The research project aims at investigating how dietary proteins are influencing the coupling process between bone formation and resorption, by studying the cellular and molecular mechanisms implicated. Using experimental models of rats and mice, and various transgenic mice, we are further characterizing, in terms of skeletal site specificity, bone remodeling rate, microarchitectural alterations, bone envelop selectivity, the process leading to decreased bone strength induced by a low protein isocaloric diet. The role of protein undernutrition on bone mass, bone architecture, bone remodeling, and bone strength should be better understood. These aspects will be of major importance for the nutritional prevention and treatment of osteoporosis and of its complications.
Osteoporosis epidemiology
Femoral neck and vertebral fractures are associated with considerable pain and disability, and have considerable impact on public health in elderly populations. Optimal treatment and prevention of osteoporosis require knowledge on incidence, socio-economic impact and on effects of modifiable risk factors of osteoporosis. The goal of the project is to estimate the incidence of osteoporotic fractures, their risk factors and their outcome, including mortality rate. This belongs to a more than 15 years collaboration with the orthopedic department.
Glucocorticoids and bone
Glucocorticoid therapy is associated with accelerated bone loss and frequent low energy fracture. A paradigm of corticosteroid-induced osteoporosis is represented by patients with organ transplantation, in whom immunosuppressive therapy adds its deleterious effects to the negative influence of the underlying disease. In collaboration with the medical teams involved in transplant recipients management, systematic assessment of those patients is applied together with prevention measures under the form of bone resorption inhibitors administration.
Bone microstructure
During infancy and adolescence, very little is known regarding the changes in bone microarchitecture, another important determinant of bone strength, and thereby of fracture risk. There is a variety of evidences indicating that weight bearing exercise before and/or during puberty contributes to favor bone mineral mass accumulation, but the role in influencing microarchitecture is unknown. We are studying competition sport men and women at the end of the second decade of life, and comparing sports with weight bearing, non weight bearing and healthy non sport competitors of both genders. Bone microarchitecture will be assessed at the level of the distal tibia and distal radius by high resolution pQCT, a protoype lent in the frame of a European community/European space agency sponsored research project.

Group's publications

Bisphosphonate-associated osteonecrosis of the jaw: A key role of inflammation?
BONE
2009 vol. 45 pp. 843-852
LESCLOUS P, ABI NAJM S, CARREL JP, BAROUKH B, LOMBARDI T, WILLI JP, RIZZOLI R, SAFFAR JL, SAMSON J

Management of osteoporosis in the elderly.
CURRENT MEDICAL RESEARCH AND OPINION
2009 vol. 25(10) pp. 2373-2387
RIZZOLI R, BRUYERE O, CANNATA-ANDIA JB, DEVOGELAER JP, LYRITIS G, RINGE JD, VELLAS B, REGINSTER JY

Beta-Arrestin2 regulates RANKL and ephrins gene expression in response to bone remodeling in mice.
JOURNAL OF BONE AND MINERAL RESEARCH
2009 vol. 24(5) pp. 775-784
PIERROZ DD, RUFO A, BIANCHI E, GLATT V, CAPULLI M, RUCCI N, CAVAT F, RIZZOLI R, TETI A, BOUXSEIN ML, FERRARI SL

Deleterious effect of late menarche on distal tibia microstructure in healthy 20-year-old and premenopausal middle-aged women.
JOURNAL OF BONE AND MINERAL RESEARCH
2009 vol. 24(1) pp. 144-152
CHEVALLEY T, BONJOUR JP, FERRARI SL, RIZZOLI R

Selective modification of bone quality by PTH, pamidronate, or raloxifene.
JOURNAL OF BONE AND MINERAL RESEARCH
2009 vol. 24(5) pp. 800-808
BRENNAN T, RIZZOLI R, AMMANN P

The influence of pubertal timing on bone mass acquisition: a predetermined trajectory detectable five years before menarche.
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
2009 vol. 94(9) pp. 3424-3431
CHEVALLEY T, BONJOUR JP, FERRARI SL, RIZZOLI R

Remaining lifetime and absolute 10-year probabilities of osteoporotic fracture in Swiss men and women.
OSTEOPOROSIS INTERNATIONAL
2009 vol. 20(7) pp. 1131-1140
LIPPUNER K, JOHANSSON H, KANIS JA, RIZZOLI R

The International Osteoporosis Foundation: history, objectives and achievements.
OSTEOPOROSIS INTERNATIONAL
2009 vol. 20 pp. 241-242
COOPER C, RIZZOLI R, REGINSTER JY

Age and gender distribution of primary hyperparathyroidism and incidence of surgical treatment in a European country with a particularly high life expectancy.
SWISS MEDICAL WEEKLY
2009 vol. 139(27-28) pp. 400-404
RICHERT L, TROMBETTI A, HERRMANN FR, TRIPONEZ F, MEIER C, ROBERT JH, RIZZOLI R

Zinc increases the effects of essential amino acids-whey protein supplements in frail elderly.
THE JOURNAL OF NUTRITION, HEALTH & AGING
2009 vol. 13(6) pp. 491-497
RODONDI A, AMMANN P, GHILARDI-BEURET S, RIZZOLI R

How does teriparatide compare with alendronate for the treatment of glucocorticoid-induced osteoporosis?
NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM
2008 vol. 4(7) pp. 372-373
RIZZOLI R

Contribution of gender-specific genetic factors to osteoporosis risk.
ANNALS OF HUMAN GENETICS
2008 vol. 72(Pt 5) pp. 696-714
KARASIK D, FERRARI SERGE LIVIO

Guidance on the use of bisphosphonates in solid tumours: recommendations of an international expert panel.
ANNALS OF ONCOLOGY
2008 vol. 19(3) pp. 420-432
AAPRO M AND AL.

Dietary protein and bone health: roles of amino acid-sensing receptors in the control of calcium metabolism and bone homeostasis.
ANNUAL REVIEW OF NUTRITION
2008 vol. 28 pp. 131-155
CONIGRAVE AD, BROWN EM, RIZZOLI R

Effects of long-term strontium ranelate treatment on the risk of nonvertebral and vertebral fractures in postmenopausal osteoporosis: Results of a five-year, randomized, placebo-controlled trial.
ARTHRITIS AND RHEUMATISM --
2008 vol. 58(6) pp. 1687-1695
REGINSTER JY, FELSENBERG D, BOONEN S, DIEZ-PEREZ A, RIZZOLI R, BRANDI ML, SPECTOR TD, BRIXEN K, GOEMAERE S, CORMIER C, BALOGH A, DELMAS PD, MEUNIER PJ

Human genetics of osteoporosis.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
2008 vol. 22(5) pp. 723-735
FERRARI SL

Nutrition: its role in bone health.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
2008 vol. 22(5) pp. 813-829
RIZZOLI R

Evaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system.
BMC MUSCULOSKELETAL DISORDERS [COMPUTER FILE]
2008 vol. 9 pp. 165-165
BRUYÈRE O, BURLET N, DELMAS PD, RIZZOLI R, COOPER C, REGINSTER JY

Clinical evaluation of medicinal products for acceleration of fracture healing in patients with osteoporosis.
BONE
2008 vol. 43(2) pp. 343-347
GOLDHAHN J AND AL.

Osteonecrosis of the jaw and bisphosphonate treatment for osteoporosis.
BONE
2008 vol. 42(5) pp. 841-847
RIZZOLI R AND AL.

Strontium ranelate promotes osteoblastic cell replication through at least two different mechanisms.
BONE
2008 vol. 42(6) pp. 1131-1136
CAVERZASIO J

The role of calcium and vitamin D in the management of osteoporosis.
BONE
2008 vol. 42(2) pp. 246-249
RIZZOLI R, BOONEN S, BRANDI ML, BURLET N, DELMAS P, REGINSTER JY

Inhibition of bone turnover by milk intake in postmenopausal women.
BRITISH JOURNAL OF NUTRITION
2008 vol. 100(4) pp. 866-874
BONJOUR JP, BRANDOLINI-BUNLON, BOIRIE Y, MOREL-LAPORTE F, BRAESCO V, BERTIÈRE MC, SOUBERBIELLE JC

Bone reactions to controlled loading of endosseous implants: a pilot study.
CLINICAL ORAL IMPLANTS RESEARCH
2008 vol. 19(11) pp. 1093-1102
WISKOTT HW, CUGNONI J, SCHERRER S, AMMANN P, BOTSIS J, BELSER UC

Post-fracture management of patients with hip fracture: a perspective.
CURRENT MEDICAL RESEARCH AND OPINION
2008 vol. 24(10) pp. 2841-2851
BRUYERE O, BRANDI ML, BURLET N, HARVEY N, LYRITIS G, MINNE H, BOONEN S, REGINSTER JY, RIZZOLI R, AKESSON K

Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis.
JAMA
2008 vol. 299(11) pp. 1277-1290
VAN MEURS JB AND AL.

Prophylactic injection of methylmetacrylate in vertebrae located between two previously cemented levels does not prevent a subsequent compression fracture in a patient with bone fragility.
JOINT BONE SPINE
2008 vol. 75(3) pp. 322-324
UEBELHART B, CASEZ P, RIZZOLI R, LOUIS-SIMONET M

Critical issues in translational and clinical research for the study of new technologies to enhance bone repair.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
2008 vol. 90 pp. 43-47
GOLDHAHN J, MITLAK B, ASPENBERG P, KANIS JA, RIZZOLI R, REGINSTER JY

High-protein intake enhances the positive impact of physical activity on BMC in prepubertal boys.
JOURNAL OF BONE AND MINERAL RESEARCH
2008 vol. 23(1) pp. 131-142
CHEVALLEY T, BONJOUR JP, FERRARI SL, RIZZOLI R

PPARG by dietary fat interaction influences bone mass in mice and humans.
JOURNAL OF BONE AND MINERAL RESEARCH
2008 vol. 23(9) pp. 1398-1408
ACKERT-BICKNELL CL AND AL.

Prevention of trabecular bone loss induced by estrogen deficiency by a selective p38alpha inhibitor.
JOURNAL OF BONE AND MINERAL RESEARCH
2008 vol. 23(9) pp. 1389-1397
CAVERZASIO J, HIGGINS L, AMMANN P

Influence of age at menarche on forearm bone microstructure in healthy young women.
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
2008 vol. 93(7) pp. 2594-2601
CHEVALLEY T, BONJOUR JP, FERRARI SL, RIZZOLI R

European guidance for the diagnosis and management of osteoporosis in postmenopausal women.
OSTEOPOROSIS INTERNATIONAL
2008 vol. 19(4) pp. 399-428
KANIS JA, BURLET N, COOPER C, DELMAS PD, REGINSTER JY, BORGSTROM F, RIZZOLI R

Leptin and the sympathetic connection of fat to bone.
OSTEOPOROSIS INTERNATIONAL
2008 vol. 19(7) pp. 905-912
HAMRICK MW, FERRARI SERGE LIVIO

Recommendations for the registration of agents for prevention and treatment of glucocorticoid-induced osteoporosis: an update from the Group for the Respect of Ethics and Excellence in Science.
OSTEOPOROSIS INTERNATIONAL
2008 vol. 19(9) pp. 1247-1250
COMPSTON J AND AL.

Reversal of the hip fracture secular trend is related to a decrease in the incidence in institution-dwelling elderly women.
OSTEOPOROSIS INTERNATIONAL
2008 vol. 19(12) pp. 1741-1747
GUILLEY E, CHEVALLEY T, HERRMANN F, BACCINO D, HOFFMEYER P, RAPIN CH, RIZZOLI R

Weight-bearing bones are more sensitive to physical exercise in boys than in girls during pre- and early puberty: a cross-sectional study.
OSTEOPOROSIS INTERNATIONAL
2008 vol. 19(12) pp. 1749-1758
KRIEMLER S, ZAHNER L, PUDER JJ, BRAUN-FAHRLÄNDER C, SCHINDLER C, FARPOUR-LAMBERT N, KRÄNZLIN M, RIZZOLI R

Cervical Paget disease of bone with spinal cord compression due to atlanto-axial instability: a case report and review of the literature.
SPINE
2008 vol. 33(3) pp. 85-89
TESSITORE E, LUZI M, LOBRINUS JOHANNES, SAMARAS N, RIZZOLI R

Secondary prevention of osteoporotic fractures: why not apply the evidence?
SWISS MEDICAL WEEKLY
2008 vol. 138(45-46) pp. 656-657
FERRARI SL

Nutrition and aging. The Carla Workshop.
THE JOURNAL OF NUTRITION, HEALTH & AGING
2008 vol. 12(6) pp. 355-364
ABELLAN VAN KAN G AND AL.

A randomized double-blind placebo-controlled trial to investigate the effects of nasal calcitonin on bone microarchitecture measured by high-resolution peripheral quantitative computerized tomography in postmenopausal women - Study protocol.
TRIALS
2008 vol. 9 pp. 19-19
RICHERT L, UEBELHART B, ENGELHARDT M, AZRIA M, RIZZOLI R

Increase in bone mineral density after successful parathyroidectomy for tertiary hyperparathyroidism after renal transplantation.
WORLD JOURNAL OF SURGERY
2008 vol. 32(8) pp. 1795-1801
COLLAUD S, STAUB-ZÄHNER T, TROMBETTI A, CLERICI T, MARANGON NICOLA, BINET I, MYERS PO, RIZZOLI R, MARTIN PY, ROBERT J, TRIPONEZ F

Evidences for a role of p38 MAP kinase in the stimulation of alkaline phosphatase and matrix mineralization induced by parathyroid hormone in osteoblastic cells
BONE
2007 vol. 41 pp. 59-67
REY A, MANEN D, RIZZOLI R, FERRARI SL, CAVERZASIO J

Incidence of hip fracture over a 10-year period (1991-2000): Reversal of a secular trend
BONE
2007 vol. 40 pp. 1284-1289
CHEVALLEY, T, GUILLEY, E, HERRMANN, FR, HOFFINEYER, P, RAPIN, CH, RIZZOLI, R

Osteoporosis: non-hormonal treatment.
CLIMACTERIC : THE JOURNAL OF THE INTERNATIONAL MENOPAUSE SOCIETY
2007 vol. 10 pp. 74-78
RIZZOLI R

International society of geriatric oncology (SIOG) clinical practice recommendations for the use of bisphosphonates in elderly patients
EUROPEAN JOURNAL OF CANCER
2007 vol. 43 pp. 852-858
BODY JJ, COLEMAN R, CLEZARDIN P, RIPAMONTI C, RIZZOLI R, AAPRO M

Long-term strategy in the management of postmenopausal osteoporosis.
JOINT BONE SPINE
2007 vol. 74(6) pp. 540-543
RIZZOLI R

Defective implant osseointegration under protein undernutrition: Prevention by PTH or pamidronate
JOURNAL OF BONE AND MINERAL RESEARCH
2007 vol. 22 pp. 1526-1533
DAYER R, BADOUD I, RIZZOLI R, AMMANN P

Different responsiveness of alveolar and tibial bone to bone loss stimuli
JOURNAL OF BONE AND MINERAL RESEARCH
2007 vol. 22 pp. 403-410
MAVROPOULOS A, RIZZOLI R, AMMANN P

Strontium ranelate treatment improves trabecular and cortical intrinsic bone tissue quality, a determinant of bone strength
JOURNAL OF BONE AND MINERAL RESEARCH
2007 vol. 22 pp. 1419-1425
AMMANN P, BADOUD I, BARRAUD S, DAYER R, RIZZOLI R

Bone mass in prepubertal boys is associated with a Gln223Arg amino acid substitution in the leptin receptor
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
2007 vol. 92 pp. 4380-4386
RICHERT L, CHEVALLEY T, MANEN D, BONJOUR JP, RIZZOLI R, FERRARI S

A tribute to Herbert Fleisch.
OSTEOPOROSIS INTERNATIONAL
2007 vol. 18(9) pp. 1151-1151
RIZZOLI R

Adherence to treatment of osteoporosis: a need for study.
OSTEOPOROSIS INTERNATIONAL
2007 vol. 18(10) pp. 1311-1317
LEKKERKERKER F AND AL

Pamidronate and osteoporosis prevention in liver transplant recipients
RHEUMATOLOGY INTERNATIONAL
2007 vol. 27 pp. 251-256
PENNISI, P, TROMBETTI, A, GIOSTRA, E, MENTHA, G, RIZZOLI, R, FIORE, CE

Survival after parathyroidectomy in patients with end-stage renal disease and severe hyperparathyroidism
WORLD JOURNAL OF SURGERY
2007 vol. 31 pp. 1014-1021
TROMBETTI, A, STOERMANN, C, ROBERT, JH, HERRMANN, FR, PENNISI, P, MARTIN, PY, RIZZOLI, R

Determinants of peak bone mass
ANNALES D'ENDOCRINOLOGIE
2006 vol. 67 pp. 114-115
RIZZOLI RENE

Journées Internationales d'Endocrinologie Clinique
ANNALES D'ENDOCRINOLOGIE
2006 vol. 67 pp. 109-
BODY JJ, RIZZOLI R

Combined treatment with a beta-blocker and intermittent PTH improves bone mass and microarchitecture in ovariectomized mice
BONE
2006 vol. 39 pp. 260-267
PIERROZ DD, BOUXSEIN ML, RIZZOLI R, FERRARI SL

Gluclocorticoid-induced osteoporosis and its treatment
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
2006 vol. 0 pp. 39-47
PENNISI P, TROMBETTI A, RIZZOLI R

Long-term outcome of weekly bisphosphonates
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
2006 vol. 443 pp. 61-65
RIZZOLI RENE

Long-term experience with alendronate in the treatment of osteoporosis
EXPERT OPINION ON PHARMACOTHERAPY
2006 vol. 7 pp. 1201-1210
HOCHBERG MC, RIZZOLI R

Risk factors for vitamin D inadequacy among women with osteoporosis: an international epidemiological study
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
2006 vol. 60(8) pp. 1013-1019
RIZZOLI R, EISMAN JA, NORQUIST J, LJUNGGREN O, KRISHNARAJAH G, LIM SK, CHANDLER J

Proline-rich motifs in the parathyroid hormone (PTH)/PTH-related protein receptor C terminus mediate scaffolding of c-Src with beta-arrestin2 for ERK1/2 activation
JOURNAL OF BIOLOGICAL CHEMISTRY
2006 vol. 281 pp. 38181-38188
REY A, MANEN D, RIZZOLI R, CAVERZASIO J, FERRARI SL

Childhood fractures are associated with decreased bone mass gain during puberty: An early marker of persistent bone fragility?
JOURNAL OF BONE AND MINERAL RESEARCH
2006 vol. 21 pp. 501-507
FERRARI SL, CHEVALLEY T, BONJOUR JP, RIZZOLI R

Low protein intake is associated with impaired titanium implant osseointegration
JOURNAL OF BONE AND MINERAL RESEARCH
2006 vol. 21 pp. 258-264
DAYER R, RIZZOLI R, KAELIN A, AMMANN P

Prediction of hip fracture risk by quantitative ultrasound in more than 7000 Swiss women > or =70 years of age: comparison of three technologically different bone ultrasound devices in the SEMOF study
JOURNAL OF BONE AND MINERAL RESEARCH
2006 vol. 21(9) pp. 1457-1463
KRIEG MA ET AL.

The perspective of the international osteoporosis foundation on the official positions of the international society for clinical densitometry
JOURNAL OF CLINICAL DENSITOMETRY
2006 vol. 9(1) pp. 128-129
KANIS JA, SEEMAN E, JOHNELL O, RIZZOLI R, DELMAS P

Recommendations for an update of the current (2001) regulatory requirements for registration of drugs to be used in the treatment of osteoporosis in postmenopausal women and in men
OSTEOPOROSIS INTERNATIONAL
2006 vol. 17 pp. 1-7
REGINSTER JY, ABADIE E, DELMAS P, RIZZOLI R, DERE W, DER AUWERA P, AVOUAC B, BRANDI ML, DAIFOTIS A, DIEZ-PEREZ A, CALVO G, JOHNELL O, KAUFMAN JM, KREUTZ G, LASLOP A, LEKKERKERKER F, MITLAK B

Targeted education improves the very low recognition of vertebral fractures and osteoporosis management by general internists
OSTEOPOROSIS INTERNATIONAL
2006 vol. 17 pp. 965-970
CASEZ P, UEBELHART B, GASPOZ JM, FERRARI S, LOUIS-SIMONET M, RIZZOLI R

The perspective of the International Osteoporosis Foundation on the official positions of the International Society for Clinical Densitometry
OSTEOPOROSIS INTERNATIONAL
2006 vol. 17(3) pp. 492-494
KANIS JA, SEEMAN E, JOHNELL O, RIZZOLI R, DELMAS P

Traitement de l'ostéoporose
REVUE MEDICALE DE LA SUISSE ROMANDE
2006 vol. 2(47) pp. 47-51
UEBELHART BRIGITTE, RIZZOLI RENE

LRP5 gene polymorphisms and idiopathic osteoporosis in men.
BONE
2005 vol. 37(6) pp. 770-775
FERRARI SERGE LIVIO, DEUTSCH ESCALANTE SAMUEL, BAUDOIN C, COHEN-SOLAL M, OSTERTAG A, ANTONARAKIS STYLIANOS, DE VERNEJOUL MC, RIZZOLI RENE

A rapid self-administrated food frequency questionnaire for the evaluation of dietary protein intake
CLINICAL NUTRITION
2005 vol. 24 pp. 768-774
MORIN PATRICIA, HERRMANN FRANCOIS, AMMANN PATRICK, UEBELHART-DOMENECH B, RIZZOLI RENE

Pamidonate prevents bone loss and decreased bone strength in adult female and male rats fed an isocaloric low-protein diet
JOURNAL OF BONE AND MINERAL RESEARCH
2005 vol. 20 pp. 1365-1371
MEKRALDI SAMIA, TOROMANOFF ANNE, RIZZOLI RENE, AMMANN PATRICK

A new treatment for post-menopausal osteoporosis: strontium ranelate
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
2005 vol. 28 pp. 50-57
RIZZOLI RENE

The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis.
OBSTETRICAL AND GYNECOLOGICAL SURVEY
2004 vol. 59 pp. 526-527
MEUNIER PJ, ROUX C, SEEMAN E, ORTOLANI S, BADURSKI JE, SPECTOR TD, CANNATA J, BALOGH A, LEMMEL E-M, PORS-NIELSEN S, RIZZOLI R, GENANT HK, REGINSTER J-Y

Dietary essential amino acid supplements increase bone strength by influencing bone mass and bone microarchitecture in ovariectomized adult rats fed an isocaloric low-protein diet
JOURNAL OF BONE AND MINERAL RESEARCH
2002 vol. 17 pp. 1264-1272
AMMANN P, LAIB A, BONJOUR JP, MEYER JM, RÜEGSEGGER P, RIZZOLI R

An osteoporosis clinical pathway for the medical management of patients with low-trauma fracture
OSTEOPOROSIS INTERNATIONAL
2002 vol. 13 pp. 450-455
CHEVALLEY T, HOFFMEYER P, BONJOUR JP, RIZZOLI R

Gain in bone mineral mass in prepubertal girls 3.5 years after discontinuation of calcium supplementation: a follow-up study
LANCET
2001 vol. 358(9289) pp. 1208-1212
BONJOUR JEAN-PHILIPPE, CHEVALLEY THIERRY, AMMANN PATRICK, SLOSMAN DANIEL, RIZZOLI RENE

Protein supplements increase serum insulin-like growth factor-I levels and attenuate proximal femur bone loss in patients with recent hip fracture. A randomized, double-blind, placebo-controlled trial
ANNALS OF INTERNAL MEDICINE
1998 vol. 128(10) pp. 801-809
SCHURCH MARC, RIZZOLI RENE, SLOSMAN DANIEL, VADAS LASZLO, VERGNAUD P, BONJOUR JEAN-PHILIPPE

Research's domains

MOLECULAR ENDOCRINOLOGY
NUTRITION
GROWTH
OSTEOPOROSIS




DATABASE-RESEARCH	GROUP OF CLINICAL PATIENT RESEARCH

René RIZZOLI	Head of group CV	Research subject	Members of the group