Catherine PASTOR  Head of group CV  Members of the group

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Dr. C. PASTOR
HUG/ Dpt Radiologie
Serv RadioDiag. Radio Interv
Rue Gabrielle-Perret-Gentil 4
1211 Genève
Suisse

Catherine.Pastor@hcuge.ch

Tel.: +41 22 382 38 36
Fax: +41 22 347 59 79




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Pages updated the 17.11.2015
Reseach's subject | Group's publications | Research's domains

Regulation of hepatic blood flow and functions

Our research is focused on the regulation of hepatic blood flow and functions in various experimental models, including biliary cirrhosis in rats and liver transplantation in pigs. Our main interests are the vascular reactivity and the regulation of the endothelial NO synthase. The laboratory also investigates the physiopathology of acute pancreatitis and pancreatitis-associated lung injury. Finally, we recently studied the transport mechanisms of Magnetic Resonance Imaging (MRI) contrast agents. This new subject will be extensively developed in the following years.




Group's publications

Hepatopulmonary syndrome
GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE
2009 vol. 33(6-7) pp. 565-579
THEVENOT T AND AL.

Hepatic regeneration is decreased in a rat model of sinusoidal obstruction syndrome.
JOURNAL OF SURGICAL ONCOLOGY
2009 vol. 99(7) pp. 439-446
SCHIFFER E, FROSSARD JL, RUBBIA-BRANDT L, MENTHA G, PASTOR CM

Experimental evidence of obesity as a risk factor for severe acute pancreatitis.
WORLD JOURNAL OF GASTROENTEROLOGY
2009 vol. 15(42) pp. 5260-5265
FROSSARD JL, LESCUYER P, PASTOR CM

Laparoscopic colon surgery: unreliability of end-tidal CO2 monitoring.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
2008 vol. 52(5) pp. 700-707
KLOPFENSTEIN CE, SCHIFFER E, PASTOR CM, BEAUSSIER M, FRANCIS K, SORAVIA C, HERRMANN FR

Acute pancreatitis.
LANCET
2008 vol. 371(9607) pp. 143-152
FROSSARD JL, STEER M, PASTOR CM

Proteomic profiling in an animal model of acute pancreatitis.
PROTEOMICS
2008 vol. 8(17) pp. 3621-3631
FETAUD V, FROSSARD JL, FARINA A, PASTOR CM, BUHLER L, DUMONCEAU JM, HADENGUE A, HOCHSTRASSER DENIS, LESCUYER P

Concomitant autoimmune and genetic pancreatitis leads to severe inflammatory conditions.
WORLD JOURNAL OF GASTROENTEROLOGY
2008 vol. 14(16) pp. 2596-2598
FROSSARD JL, DUMONCEAU JM, PASTOR CATHERINE, SPAHR L, HADENGUE A

Opposite regulation of endothelial NO synthase by HSP90 and caveolin in liver and lungs of rats with hepatopulmonary syndrome
AMERICAN JOURNAL OF PHYSIOLOGY
2007 vol. 293(4) pp. 867-870
FROSSARD JL, SCHIFFER E, CIKIRIKCIOGLU B, BOURQUIN J, MOREL DR, PASTOR CM

Improved visualization of vessels and hepatic tumors by micro-computed tomography (CT) using iodinated liposomes
INVESTIGATIVE RADIOLOGY
2007 vol. 42 pp. 652-658
MONTET X, PASTOR CM, VALLEE JP, BECKER CD, GEISSBUHLER A, MOREL DR, MEDA P

Model-based analysis of Gd-BOPTA-induced MR signal intensity changes in cirrhotic rat livers
INVESTIGATIVE RADIOLOGY
2007 vol. 42 pp. 513-521
PLANCHAMP C, GEX-FABRY M, BECKER CD, PASTOR CM

Function of both sinusoidal and canalicular transporters controls the concentration of organic anions within hepatocytes
MOLECULAR PHARMACOLOGY
2007 vol. 71 pp. 1089-1097
PLANCHAMP C, HADENGUE A, STIEGER B, BOURQUIN J, VONLAUFEN A, FROSSARD JL, QUADRI R, BECKER CD, PASTOR CM

Therapy insight: hepatopulmonary syndrome and orthotopic liver transplantation
NATURE CLINICAL PRACTICE GASTROENTEROLOGY & HEPATOLOGY
2007 vol. 4 pp. 614-621
PASTOR CM, SCHIFFER E

Hepatopulmonary syndrome increases the postoperative mortality rate following liver transplantation: a prospective study in 90 patients
AMERICAN JOURNAL OF TRANSPLANTATION
2006 vol. 6(6) pp. 1430-1437
SCHIFFER E. ET AL.

Time course of lung injury in rats with acute pancreatitis
INTENSIVE CARE MEDICINE
2006 vol. 32(11) pp. 1872-1880
MOREL DENIS R, FROSSARD JEAN-LOUIS, CIKIRICIOGLU BANU, TAPPONNIER MAXIME, PASTOR CATHERINE M.

The role of junctional adhesion molecule C (JAM-C) in acute pancreatitis
JOURNAL OF PATHOLOGY
2006 vol. 209 pp. 540-548
VONLAUFEN A, AURRAND-LIONS M, PASTOR CM, LAMAGNA C, HADENGUE A, IMHOF BA, FROSSARD JL

Endothelial nitric oxide synthase regulation is altered in pancreas from cirrhotic rats
WORLD JOURNAL OF GASTROENTEROLOGY
2006 vol. 12 pp. 228-233
FROSSARD JL, PASTOR CM, QUADRI R, HADENGUE A, MOREI P

Epidural anaesthesia restores pancreatic microcirculation and decreases the severity of acute pancreatitis
WORLD JOURNAL OF GASTROENTEROLOGY
2006 vol. 12 pp. 915-920
DEMIRAG A, PASTOR CM, MOREL P, JEAN-CHRISTOPHE C, SIELENKAMPER AW, GUVENER N, MAI G, BERNEY T, FROSSARD JL, BUHLER LH

Neutrophil depletion--but not prevention of Kupffer cell activation--decreases the severity of cerulein-induced acute pancreatitis
WORLD JOURNAL OF GASTROENTEROLOGY
2006 vol. 12(8) pp. 1219-1224
PASTOR CATHERINE, VONLAUFEN ALAIN, GREGORI F, HADENGUE ANTOINE, MOREL PHILIPPE, FROSSARD JEAN-LOUIS

Soluble CD40 ligand in prediction of acute severe pancreatitis
WORLD JOURNAL OF GASTROENTEROLOGY
2006 vol. 12 pp. 1613-1616
FROSSARD JL, MOREL P, KWAK BR, PASTOR CM, BERNEY T, BUHLER L, VON LAUFEN A, DEMULDER S, MACH F

Direct evidence of the temperature dependence of Gd-BOPTA transport in the intact rat liver
APPLIED RADIATION AND ISOTOPES : INCLUDING DATA, INSTRUMENTATION AND METHODS FOR USE IN AGRICULTURE, INDUSTRY AND MEDICINE
2005 vol. 62 pp. 943-949
PLANCHAMP MESSEILLER CORINNE, BEYER GERD-JURGEN, SLOSMAN DANIEL, TERRIER FRANCOIS, PASTOR CATHERINE

Magnetic resonance imaging with hepatospecific contrast agents in cirrhotic rat livers
INVESTIGATIVE RADIOLOGY
2005 vol. 40 pp. 187-194
PLANCHAMP CAROLINE, MONTET XAVIER, FROSSARD JEAN-LOUIS, QUADRI DEFILIPPIS RAFAEL, STIEGER BRUNO, MEIER PETER, IVANCEVIC MARKO, VALLEE JEAN-PAUL, TERRIER FRANCOIS, PASTOR CATHERINE

Quantification of Gd-BOPTA uptake and biliary excretion from dynamic MRI in rat livers : model validation with 153 Gd-BOPTA
INVESTIGATIVE RADIOLOGY
2005 vol. 40 pp. 705-714
PLANCHAMP MESSEILLER CORINNE, PASTOR CATHERINE, BALANT LUC, BECKER CHRISTOPH, TERRIER FRANCOIS, GEX-FABRY PUN MARIANNE

Tracking mesenchymal stem cells in the liver by magnetic resonance imaging
JOURNAL OF HEPATOLOGY
2005 vol. 43 pp. 915-916
PASTOR CATHERINE

Hsp70 does not mediate the hyperthermia-associated hyporesponsiveness to angiotensin in isolated rat portal veins
LIFE SCIENCES
2005 vol. 78 pp. 41-46
FROSSARD JEAN-LOUIS, MASTRANGELO DOMINIQUE, HADENGUE ANTOINE, PASTOR CATHERINE

Hollow fiber bioreactor: new development for the study of contrast agent transport into hepatocytes by magnetic resonance imaging
BIOTECHNOLOGY AND BIOENGINEERING
2004 vol. 85 pp. 656-665
PLANCHAMP C, IVANCEVIC MK, PASTOR CM, VALLEE JP, POCHON S, TERRIER F, MAYER JM, REIST M

Role of Toll-like receptor 4 on pancreatic and pulmonary injury in a mice model of acute pancreatitis associated with endotoxemia
CRITICAL CARE MEDICINE
2004 vol. 32 pp. 1759-1763
PASTOR CM, PUGIN J, KWAK BR, CHANSON M, MACH F, HADENGUE A, FROSSARD JL

Hyperthermia decreases the response to vasoconstrictor in rat portal veins
EUROPEAN JOURNAL OF PHARMACOLOGY
2004 vol. 494 pp. 191-197
PASTOR CATHERINE

Gd-BOPTA transport into rat hepatocytes: pharmacokinetic analysis of dynamic magnetic resonance images using a hollow-fiber bioreactor
INVESTIGATIVE RADIOLOGY
2004 vol. 39 pp. 506-515
PLANCHAMP C, GEX-FABRY M, DORNIER C, QUADRI R, REIST M, IVANCEVIC MK, VALLEE JP, POCHON S, TERRIER F, BALANT L, STIEGER B, MEIER PJ, PASTOR CM

Perioperative management of patients with increased risk of laparoscopy-induced hepatic hypoperfusion
SWISS MEDICAL WEEKLY
2004 vol. 134 pp. 39-43
CLERGUE F, MOREL P, PASTOR CM

Kinetics of gadobenate dimeglumine in isolated perfused rat liver: MR imaging evaluation
RADIOLOGY
2003 vol. 229 pp. 119-125
PASTOR CM, PLANCHAMP CORINNE, POCHON SYLVIE, LORUSSO VITTORIO, MONTET X, MAYER JOACHIM, TERRIER F, VALLEE JP

Effect of hyperthermic preconditioning on cold preserved rat portal veins
JOURNAL OF HEPATOLOGY
2002 vol. 37 pp. 640-647
PASTOR CM, FROSSARD JL, MENTHA G, MASTRANGELO D, QUADRI R, HADENGUE A

Are genetically modified mice useful for the understanding of acute pancreatitis ?
FASEB JOURNAL
2001 vol. 15(6) pp. 893-897
PASTOR CM, FROSSARD JL

Shear stress modulates the vascular tone in perfused livers isolated from normal rats
HEPATOLOGY
2000 vol. 32 pp. 786-791
PASTOR CM, HADENGUE A

Sepsis decreases the spontaneous and agonist-induced contractile activities in the rat portal vein.
JOURNAL OF HEPATOLOGY
2000 vol. 33 pp. 933-940
MASTRANGELO D, FROSSARD JL, HADENGUE A, PASTOR CM


Research's domains