Bienvenue dans la base de données-recherche

Migration cellulaire

Nous cherchons à comprendre les méchanismes qui contrôlent la migration cellulaire. Notre but est de comprendre comment les facteurs de croissance, via leurs présentation et distribution spécifiques, contrôlent l'adhésion et la migration cellulaires liées aux récepteurs de la famille des intégrines. Nous utilisons des cellules de la ligne des mélanocytes, qui incluent notamment des mélanomes. Les informations obtenuent grâce à notre recherche iront au bénéfice des patients présentant des mélanomes mais aussi des cancers en général. Nous sommes spécifiquement attirés par le problème de la dissémination des cellules tumorales qui aboutit à la formation des métastases, mais aussi par le problème de l'induction de la vascularisation par des tumeurs en croissance.

Publications du groupe

Dimerization of Kit-ligand and efficient cell-surface presentation requires a conserved Ser-Gly-Gly-Tyr motif in its transmembrane domain
FASEB JOURNAL
2009 vol. 23(9) pp. 3037-3048
PAULHE F, WEHRLE-HALLER M, JACQUIER M, IMHOF B, TABONE-EGLINGER S, WEHRLE-HALLER B

Dimerization of Kit-ligand and efficient cell-surface presentation requires a conserved Ser-Gly-Gly-Tyr motif in its transmembrane domain.
FASEB JOURNAL
2009 vol. 23(9) pp. 3037-3048
PAULHE F, WEHRLE-HALLER M, JACQUIER MC, IMHOF BA, TABONE-EGLINGER S, WEHRLE-HALLER B

New PI(45)P-2- and membrane proximal integrin-binding motifs in the talin head control beta 3-integrin clustering
JOURNAL OF CELL BIOLOGY
2009 vol. 187(5) pp. 715-731
SALTEL F, MORTIER E, HYTONEN VP, JACQUIER MC, ZIMMERMANN P, VOGEL V, LIU W, WEHRLE-HALLER B

Multiscale Modeling of Form and Function
SCIENCE
2009 vol. 324(5924) pp. 208-212
ENGLER AJ, HUMBERT P, WEHRLE-HALLER B, WEAVER VM

Multiscale modeling of form and function.
SCIENCE
2009 vol. 324(5924) pp. 208-212
ENGLER AJ, HUMBERT PO, WEHRLE-HALLER B, WEAVER VM

Synaptotagmin VII splice variants alpha, beta, and delta are expressed in pancreatic beta-cells and regulate insulin exocytosis.
FASEB JOURNAL
2008 vol. 22(1) pp. 194-206
GAUTHIER BR, DUHAMEL DL, IEZZI M, THEANDER S, SALTEL FREDERIC, FUKUDA M, WEHRLE-HALLER B, WOLLHEIM CB

Cell-matrix adhesion complexes: master control machinery of cell migration.
SEMINARS IN CANCER BIOLOGY
2008 vol. 18(1) pp. 65-76
LOCK JG, WEHRLE-HALLER B, STRÖMBLAD S

Urokinase receptor (CD87) clustering in detergent-insoluble adhesion patches leads to cell adhesion independently of Integrins
CELL COMMUNICATION AND ADHESION
2007 vol. 14 pp. 137-155
PETZINGER J, SALTEL F, HERSEMEYER K, DANIEL JM, PREISSNER KT, WEHRLE-HALLER B, KANSE SM

Analysis of integrin dynamics by fluorescence recovery after photobleaching
METHODS IN MOLECULAR BIOLOGY (CLIFTON, N.J.)
2007 vol. 370 pp. 173-202
WEHRLE-HALLER BERNHARD

CD44 and beta 3 integrin organize two functionally distinct actin-based domains in osteoclasts
MOLECULAR BIOLOGY OF THE CELL
2007 vol. 18 pp. 4899-4910
CHABADEL, A, BANON-RODRIGUEZ, I, CLUET, D, RUDKIN, BB, WEHRLE-HALLER, B, GENOT, E, JURDIC, P, ANTON, IM, SALTEL, F

An adhesion molecule in free-living Dictyostelium amoebae with integrin beta features
EMBO REPORTS
2006 vol. 7(6) pp. 617-621
CORNILLON SOPHIE ET AL.

Intracellular interleukin-1 receptor antagonist type 1 antagonizes the stimulatory effect of interleukin-1 alpha precursor on cell motility.
CYTOKINE
2005 vol. 32 pp. 163-170
MERHI-SOUSSI F, WEHRLE-HALLER BERNHARD, GABAY CEM

The mechanisms and dynamics of alphavbeta3 integrin clustering in living cells
JOURNAL OF CELL BIOLOGY
2005 vol. 171 pp. 383-392
CLUZEL CAROLINE, SALTEL FREDERIC, LUSSI JOST, PAULHE FREDERIQUE, IMHOF BEAT, WEHRLE-HALLER BERNHARD

Severe congenital hyperinsulinism caused by a mutation in the Kir6.2 subunit of the adenosine triphosphate-sensitive potassium channel impairing trafficking and function.
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
2005 vol. 90 pp. 5401-5406
MARTHINET ERIC, BLOC ALAIN, OKA YOSHIMOTO, TANIZAWA YUKIO, WEHRLE-HALLER BERNHARD, BANCILA VICTOR, DUBUIS JEAN-MICHEL, PHILIPPE JACQUES, SCHWITZGEBEL LUSCHER VALERIE

Role of Gas6 receptors in platelet signaling during thrombus stabilisation and implications for antitrhombotic therapy
JOURNAL OF CLINICAL INVESTIGATION
2005 vol. 2 pp. 237-246
ANGELILLO-SCHERRER A, SAVI PIERRE, DEMOL MARIA, SCHAEFFER PAUL, HERBERT JEAN-MARC, GOFF STEPHEN P, LEMKE GREG, MATSUSHIMA GLENN K., EARP H. SHELTON, VESIN CHRISTIAN, HOYLAERTS MARC F., PLAISANCE STPHANE, COLLEN DÉSIRÉ, CONWAY EDWARD M., WEHRLE-HALLER BERNHARD, CARMELIET PETER

A specific endoplasmic reticulum export signal drives transport of stem cell factor (Kitl) to the cell surface
JOURNAL OF BIOLOGICAL CHEMISTRY
2004 vol. 279 pp. 55545-55555
PAULHE F, IMHOF BA, WEHRLE-HALLER B

Cell behaviour on micropatterned substrata: limits of extracellular matrix geometry for spreading and adhesion
JOURNAL OF CELL SCIENCE
2004 vol. 117 pp. 41-52
LEHNERT D, WEHRLE-HALLER B, DAVID C, WEILAND U, BALLESTREM C, IMHOF BA, BASTMEYER M

Molecular identification of distinct neurogenic and melanogenic neural crest sublineages
DEVELOPMENT
2003 vol. 130 pp. 321-330
LUO R, GAO J, WEHRLE-HALLER B, HENION PD

Actin, microtubules and focal adhesion dynamics during cell migration
INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND CELL BIOLOGY
2003 vol. 35 pp. 39-50
WEHRLE-HALLER B, IMHOF BA

Integrin-dependent pathologies
JOURNAL OF PATHOLOGY
2003 vol. 200 pp. 481-487
WEHRLE-HALLER B, IMHOF BA

alpha-smooth muscle actin is crucial for focal adhesion maturation in myofibroblasts
MOLECULAR BIOLOGY OF THE CELL
2003 vol. 14 pp. 2508-2519
HINZ B, DUGINA V, BALLESTREM C, WEHRLE-HALLER B, CHAPONNIER C

IL-04 The role of kit-ligand presentation in the development of the epidermal melanocyte niche
PIGMENT CELL RESEARCH
2003 vol. 16 pp. 572-572
WEHRLE-HALLER B, PAULHE F, JACQUIER M, ROSSIER C, IMHOF BA, WEHRLE-HALLER M

The role of kit-ligand in melanocyte development and epidermal homeostasis
PIGMENT CELL RESEARCH
2003 vol. 16 pp. 287-296
WEHRLE-HALLER B

Molecular identification of distinct neurogenic and melanogenic neural crest sublineages
DEVELOPMENT
2002 vol. 130 pp. 321-330
LUO R, GAO J, WEHRLE-HALLER B, HENION PD

The inner lives of focal adhesions
TRENDS IN CELL BIOLOGY
2002 vol. 12 pp. 382-389
WEHRLE-HALLER B, IMHOF BA

Domaines de recherche




BASE DE DONNÉES-RECHERCHE	GROUPE DE RECHERCHE CLINIQUE ORIENTEE BIOLOGIE

WEHRLE-HALLER BERNHARD	CV du Chef de Groupe	Sujet de Recherche	Composition du Groupe


	Coordonnées du groupe Dr. B. WEHRLE-HALLER CMU / Dpt PHYM 1 rue Michel-Servet 1211 Genève 4 SUISSE Bernhard.Wehrle-Haller@unige.ch Tél.: 022 379 52 91 Fax: 022 379 53 38 Site web du groupe / département Commentaires Pages générées le 20.06.2013		Sujet de recherche \| Publications du groupe \| Domaines de recherche Migration cellulaire Nous cherchons à comprendre les méchanismes qui contrôlent la migration cellulaire. Notre but est de comprendre comment les facteurs de croissance, via leurs présentation et distribution spécifiques, contrôlent l'adhésion et la migration cellulaires liées aux récepteurs de la famille des intégrines. Nous utilisons des cellules de la ligne des mélanocytes, qui incluent notamment des mélanomes. Les informations obtenuent grâce à notre recherche iront au bénéfice des patients présentant des mélanomes mais aussi des cancers en général. Nous sommes spécifiquement attirés par le problème de la dissémination des cellules tumorales qui aboutit à la formation des métastases, mais aussi par le problème de l'induction de la vascularisation par des tumeurs en croissance. Publications du groupe Dimerization of Kit-ligand and efficient cell-surface presentation requires a conserved Ser-Gly-Gly-Tyr motif in its transmembrane domain FASEB JOURNAL 2009 vol. 23(9) pp. 3037-3048 PAULHE F, WEHRLE-HALLER M, JACQUIER M, IMHOF B, TABONE-EGLINGER S, WEHRLE-HALLER B Dimerization of Kit-ligand and efficient cell-surface presentation requires a conserved Ser-Gly-Gly-Tyr motif in its transmembrane domain. FASEB JOURNAL 2009 vol. 23(9) pp. 3037-3048 PAULHE F, WEHRLE-HALLER M, JACQUIER MC, IMHOF BA, TABONE-EGLINGER S, WEHRLE-HALLER B New PI(45)P-2- and membrane proximal integrin-binding motifs in the talin head control beta 3-integrin clustering JOURNAL OF CELL BIOLOGY 2009 vol. 187(5) pp. 715-731 SALTEL F, MORTIER E, HYTONEN VP, JACQUIER MC, ZIMMERMANN P, VOGEL V, LIU W, WEHRLE-HALLER B Multiscale Modeling of Form and Function SCIENCE 2009 vol. 324(5924) pp. 208-212 ENGLER AJ, HUMBERT P, WEHRLE-HALLER B, WEAVER VM Multiscale modeling of form and function. SCIENCE 2009 vol. 324(5924) pp. 208-212 ENGLER AJ, HUMBERT PO, WEHRLE-HALLER B, WEAVER VM Synaptotagmin VII splice variants alpha, beta, and delta are expressed in pancreatic beta-cells and regulate insulin exocytosis. FASEB JOURNAL 2008 vol. 22(1) pp. 194-206 GAUTHIER BR, DUHAMEL DL, IEZZI M, THEANDER S, SALTEL FREDERIC, FUKUDA M, WEHRLE-HALLER B, WOLLHEIM CB Cell-matrix adhesion complexes: master control machinery of cell migration. SEMINARS IN CANCER BIOLOGY 2008 vol. 18(1) pp. 65-76 LOCK JG, WEHRLE-HALLER B, STRÖMBLAD S Urokinase receptor (CD87) clustering in detergent-insoluble adhesion patches leads to cell adhesion independently of Integrins CELL COMMUNICATION AND ADHESION 2007 vol. 14 pp. 137-155 PETZINGER J, SALTEL F, HERSEMEYER K, DANIEL JM, PREISSNER KT, WEHRLE-HALLER B, KANSE SM Analysis of integrin dynamics by fluorescence recovery after photobleaching METHODS IN MOLECULAR BIOLOGY (CLIFTON, N.J.) 2007 vol. 370 pp. 173-202 WEHRLE-HALLER BERNHARD CD44 and beta 3 integrin organize two functionally distinct actin-based domains in osteoclasts MOLECULAR BIOLOGY OF THE CELL 2007 vol. 18 pp. 4899-4910 CHABADEL, A, BANON-RODRIGUEZ, I, CLUET, D, RUDKIN, BB, WEHRLE-HALLER, B, GENOT, E, JURDIC, P, ANTON, IM, SALTEL, F An adhesion molecule in free-living Dictyostelium amoebae with integrin beta features EMBO REPORTS 2006 vol. 7(6) pp. 617-621 CORNILLON SOPHIE ET AL. Intracellular interleukin-1 receptor antagonist type 1 antagonizes the stimulatory effect of interleukin-1 alpha precursor on cell motility. CYTOKINE 2005 vol. 32 pp. 163-170 MERHI-SOUSSI F, WEHRLE-HALLER BERNHARD, GABAY CEM The mechanisms and dynamics of alphavbeta3 integrin clustering in living cells JOURNAL OF CELL BIOLOGY 2005 vol. 171 pp. 383-392 CLUZEL CAROLINE, SALTEL FREDERIC, LUSSI JOST, PAULHE FREDERIQUE, IMHOF BEAT, WEHRLE-HALLER BERNHARD Severe congenital hyperinsulinism caused by a mutation in the Kir6.2 subunit of the adenosine triphosphate-sensitive potassium channel impairing trafficking and function. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 2005 vol. 90 pp. 5401-5406 MARTHINET ERIC, BLOC ALAIN, OKA YOSHIMOTO, TANIZAWA YUKIO, WEHRLE-HALLER BERNHARD, BANCILA VICTOR, DUBUIS JEAN-MICHEL, PHILIPPE JACQUES, SCHWITZGEBEL LUSCHER VALERIE Role of Gas6 receptors in platelet signaling during thrombus stabilisation and implications for antitrhombotic therapy JOURNAL OF CLINICAL INVESTIGATION 2005 vol. 2 pp. 237-246 ANGELILLO-SCHERRER A, SAVI PIERRE, DEMOL MARIA, SCHAEFFER PAUL, HERBERT JEAN-MARC, GOFF STEPHEN P, LEMKE GREG, MATSUSHIMA GLENN K., EARP H. SHELTON, VESIN CHRISTIAN, HOYLAERTS MARC F., PLAISANCE STPHANE, COLLEN DÉSIRÉ, CONWAY EDWARD M., WEHRLE-HALLER BERNHARD, CARMELIET PETER A specific endoplasmic reticulum export signal drives transport of stem cell factor (Kitl) to the cell surface JOURNAL OF BIOLOGICAL CHEMISTRY 2004 vol. 279 pp. 55545-55555 PAULHE F, IMHOF BA, WEHRLE-HALLER B Cell behaviour on micropatterned substrata: limits of extracellular matrix geometry for spreading and adhesion JOURNAL OF CELL SCIENCE 2004 vol. 117 pp. 41-52 LEHNERT D, WEHRLE-HALLER B, DAVID C, WEILAND U, BALLESTREM C, IMHOF BA, BASTMEYER M Molecular identification of distinct neurogenic and melanogenic neural crest sublineages DEVELOPMENT 2003 vol. 130 pp. 321-330 LUO R, GAO J, WEHRLE-HALLER B, HENION PD Actin, microtubules and focal adhesion dynamics during cell migration INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND CELL BIOLOGY 2003 vol. 35 pp. 39-50 WEHRLE-HALLER B, IMHOF BA Integrin-dependent pathologies JOURNAL OF PATHOLOGY 2003 vol. 200 pp. 481-487 WEHRLE-HALLER B, IMHOF BA alpha-smooth muscle actin is crucial for focal adhesion maturation in myofibroblasts MOLECULAR BIOLOGY OF THE CELL 2003 vol. 14 pp. 2508-2519 HINZ B, DUGINA V, BALLESTREM C, WEHRLE-HALLER B, CHAPONNIER C IL-04 The role of kit-ligand presentation in the development of the epidermal melanocyte niche PIGMENT CELL RESEARCH 2003 vol. 16 pp. 572-572 WEHRLE-HALLER B, PAULHE F, JACQUIER M, ROSSIER C, IMHOF BA, WEHRLE-HALLER M The role of kit-ligand in melanocyte development and epidermal homeostasis PIGMENT CELL RESEARCH 2003 vol. 16 pp. 287-296 WEHRLE-HALLER B Molecular identification of distinct neurogenic and melanogenic neural crest sublineages DEVELOPMENT 2002 vol. 130 pp. 321-330 LUO R, GAO J, WEHRLE-HALLER B, HENION PD The inner lives of focal adhesions TRENDS IN CELL BIOLOGY 2002 vol. 12 pp. 382-389 WEHRLE-HALLER B, IMHOF BA Domaines de recherche