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Régulation traductionnelle dans les cellules de mammifère

L'initiation de la traduction des protéines représente une étape clé dans la régulation de la croissance cellulaire. Par conséquence, les dysfonctionnements de la machinerie traductionnelle sont associés avec plusieurs tumeurs humaines. Notre groupe étudie la régulation globale et spécifique dans les cellules mammifères. Le but est de caractérisé les éléments cis et trans qui régulent le recrutement d'un ARNm sur les polysomes.

Publications du groupe

Transcriptional and post-transcriptional profile of human chromosome 21
GENOME RESEARCH
2009 vol. 19(8) pp. 1471-1479
NIKOLAEV S AND AL.

De novo generation of a non-segmented negative strand RNA virus with a bicistronic gene.
VIRUS RESEARCH
2009 vol. 140(1-2) pp. 40-48
TOUZELET O, LOUKILI N, PELET T, FAIRLEY D, CURRAN J, POWER UF

The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases.
CELL DEATH AND DIFFERENTIATION
2008 vol. 15(11) pp. 1804-1811
REBSAMEN MC, MEYLAN E, CURRAN J, TSCHOPP J

TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
IMMUNITY
2008 vol. 28(5) pp. 651-661
MICHALLET MC AND AL.

Nonsegmented negative-strand RNA virus RNA synthesis in vivo.
VIROLOGY
2008 vol. 371(2) pp. 227-230
CURRAN J, KOLAKOFSKY D

Alternatively spliced isoforms of the human elk-1 mRNA within the 5 ' UTR: implications for ELK-1 expression
NUCLEIC ACIDS RESEARCH
2007 vol. 35 pp. 4649-4663
ARAUD, T, GENOLET, R, JAQUIER-GUBLER, P, CURRAN, J

Phosphorylated extracellular signal-regulated kinases are significantly increased in malignant mesothelioma
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
2006 vol. 54 pp. 855-861
DE MELO M, GERBASE MW, CURRAN J, PACHE JC

Intracellular processing of the Sendai virus C' protein leads to the generation of a Y protein module : Structure-functional implications
FEBS LETTERS
2005 vol. 579 pp. 5685-5690
DE BREYNE SYLVAIN, STALDER MONNEY ROMAINE, CURRAN JOSEPH

Cardif is a novel adaptor protein for RIG-I-mediated antiviral responses targeted by hepatitis C virus.
NATURE
2005 vol. 437 pp. 1167-1172
MEYLAN E, CURRAN JOSEPH, HOFFMAN K, MORADPOOR D, TSCHOPP J

The protein kinase PKR: a molecular clock that sequentially activates survival and death programs
EMBO JOURNAL
2004 vol. 23 pp. 564-571
DONZE OLIVIER, DENG JING, CURRAN JOSEPH, SLADEK ROBERT, PICARD DIDIER, SONENBERG NAHUM

Proteolytic processing and translation initiation: two independent mechanisms for the expression of the Sendai virus Y proteins.
JOURNAL OF BIOLOGICAL CHEMISTRY
2004 vol. 279 pp. 16571-16580
DE BREYNE SYLVAIN, STALDER MONNEY ROMAINE, CURRAN JOSEPH

Identification of a cis-acting element required for shunt-mediated initiation of the Sendai virus Y proteins.
NUCLEIC ACIDS RESEARCH
2003 vol. 31 pp. 608-618
DE BREYNE S, SIMONET V, PELLET T, CURRAN J

Sendai virus Y proteins are initiated by a ribosomal shunt.
MOLECULAR AND CELLULAR BIOLOGY : MCB
1998 vol. 18 pp. 5021-5031
LATORRE P, KOLAKOFSKY D, CURRAN J

Domaines de recherche

REGULATION TRANSLATIONNELLE
GENE EXPRESSION




BASE DE DONNÉES-RECHERCHE	GROUPE DE RECHERCHE FONDAMENTALE

Joseph CURRAN	CV du Chef de Groupe	Sujet de Recherche	Composition du Groupe


	Coordonnées du groupe Dr. J. CURRAN CMU/ Dpt MIMOL Rue Michel-Servet 1 1211 Genève 4 Suisse Joseph.Curran@unige.ch Tél.: 022 379 56 74 / 73 Fax: 022 379 57 02 Commentaires Pages générées le 10.02.2012		Sujet de recherche \| Publications du groupe \| Domaines de recherche Régulation traductionnelle dans les cellules de mammifère L'initiation de la traduction des protéines représente une étape clé dans la régulation de la croissance cellulaire. Par conséquence, les dysfonctionnements de la machinerie traductionnelle sont associés avec plusieurs tumeurs humaines. Notre groupe étudie la régulation globale et spécifique dans les cellules mammifères. Le but est de caractérisé les éléments cis et trans qui régulent le recrutement d'un ARNm sur les polysomes. Publications du groupe Transcriptional and post-transcriptional profile of human chromosome 21 GENOME RESEARCH 2009 vol. 19(8) pp. 1471-1479 NIKOLAEV S AND AL. De novo generation of a non-segmented negative strand RNA virus with a bicistronic gene. VIRUS RESEARCH 2009 vol. 140(1-2) pp. 40-48 TOUZELET O, LOUKILI N, PELET T, FAIRLEY D, CURRAN J, POWER UF The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases. CELL DEATH AND DIFFERENTIATION 2008 vol. 15(11) pp. 1804-1811 REBSAMEN MC, MEYLAN E, CURRAN J, TSCHOPP J TRADD protein is an essential component of the RIG-like helicase antiviral pathway. IMMUNITY 2008 vol. 28(5) pp. 651-661 MICHALLET MC AND AL. Nonsegmented negative-strand RNA virus RNA synthesis in vivo. VIROLOGY 2008 vol. 371(2) pp. 227-230 CURRAN J, KOLAKOFSKY D Alternatively spliced isoforms of the human elk-1 mRNA within the 5 ' UTR: implications for ELK-1 expression NUCLEIC ACIDS RESEARCH 2007 vol. 35 pp. 4649-4663 ARAUD, T, GENOLET, R, JAQUIER-GUBLER, P, CURRAN, J Phosphorylated extracellular signal-regulated kinases are significantly increased in malignant mesothelioma JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 2006 vol. 54 pp. 855-861 DE MELO M, GERBASE MW, CURRAN J, PACHE JC Intracellular processing of the Sendai virus C' protein leads to the generation of a Y protein module : Structure-functional implications FEBS LETTERS 2005 vol. 579 pp. 5685-5690 DE BREYNE SYLVAIN, STALDER MONNEY ROMAINE, CURRAN JOSEPH Cardif is a novel adaptor protein for RIG-I-mediated antiviral responses targeted by hepatitis C virus. NATURE 2005 vol. 437 pp. 1167-1172 MEYLAN E, CURRAN JOSEPH, HOFFMAN K, MORADPOOR D, TSCHOPP J The protein kinase PKR: a molecular clock that sequentially activates survival and death programs EMBO JOURNAL 2004 vol. 23 pp. 564-571 DONZE OLIVIER, DENG JING, CURRAN JOSEPH, SLADEK ROBERT, PICARD DIDIER, SONENBERG NAHUM Proteolytic processing and translation initiation: two independent mechanisms for the expression of the Sendai virus Y proteins. JOURNAL OF BIOLOGICAL CHEMISTRY 2004 vol. 279 pp. 16571-16580 DE BREYNE SYLVAIN, STALDER MONNEY ROMAINE, CURRAN JOSEPH Identification of a cis-acting element required for shunt-mediated initiation of the Sendai virus Y proteins. NUCLEIC ACIDS RESEARCH 2003 vol. 31 pp. 608-618 DE BREYNE S, SIMONET V, PELLET T, CURRAN J Sendai virus Y proteins are initiated by a ribosomal shunt. MOLECULAR AND CELLULAR BIOLOGY : MCB 1998 vol. 18 pp. 5021-5031 LATORRE P, KOLAKOFSKY D, CURRAN J Domaines de recherche REGULATION TRANSLATIONNELLE GENE EXPRESSION