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Islet of Langerhans transplantation

Islet of Langerhans transplantation appears as a valid method for the treatment of type 1 diabetes. The publication in the year 2000 of the results of the Edmonton protocol showed that it was possible to achieve rates of insulin-independence of 80% at 1 year in transplanted patients, thanks to a steroid-free, islet-sparing immunosuppressive regimen and an increased implanted islet mass, by the utilization of 2-4 donors for each recipient. Nonetheless, several questions remain and several issues have to be addressed in order to improve this method. These constitute the topics of basic and clinical research of the group.
1. Islet engraftment is clearly suboptimal (as indicated by the need for multiple donors), as a result od pro-apoptotic and pro-inflammatory stimuli sustained during islet isolation and at the site of implantation. The group is developing a model of cell interaction between beta-cells and macrophages in order to study and prevent these phenomena. Moreover, the role of the pro-inflammatory MIF and anti-inflammatory IL-1Ra molecules is studied in murine models of islet transplantation using knock-out and transgenic animals. Finally, the role played by alpha-1-antitrypsine and cadherins on beta-cell apoptosis and destruction is studied in rodent models and on human islets in vitro.
2. Long-term islet graft function must be improved, since the rate of insulin-independence drops to 15% at 5 years post transplant, using the Edmonton protocol. Reasons for this progressive loss of islet graft function are not known and probably of multifactorial origin. Methods designed to monitor islet graft mass and/or function are critical tools that must be developed to better understand these phenomena. The group is developing techniques of islet graft imaging, using PET and MRI technology, in models of islet transplantation in the rat, in human islets in vitro, and in clinical protocols. Molecular monitoring of islet grafts, by measuring circulating levels of insulin mRNA as a marker of islet cell damage, are also developed in collaboration with Prof. Jacques Philippeżs group.
3. The immunosuppressive regimen currently used in clinical islet transplantation has several drawbacks in terms of side effects, notably kidney toxicity. New clinical immunosuppression protocols are being developed in collaboration with French University centers participating to the Swiss-French GRAGIL network (Grenoble, Lyon, Strasbourg, Besançon, Montpellier) and with other European Universities (Milan, Giessen, Uppsala, Brussels). The possibility of inducing immune tolerance by blockade of T-cell co-stimulatory signals (CD154, TRANCE) is studied on murine models of islet transplantation.

Group's publications

Immune monitoring of pancreatic islet graft: towards a better understanding, detection and treatment of harmful events.
EXPERT OPINION ON BIOLOGICAL THERAPY
2011 vol. 11(1) pp. 55-66
LACOTTE S, BERNEY T, SHAPIRO AJ, TOSO C

Combined pancreatic islet-lung transplantation: a novel approach to the treatment of end-stage cystic fibrosis.
AMERICAN JOURNAL OF TRANSPLANTATION
2010 vol. 10(7) pp. 1707-17012
KESSLER L AND AL.

Unique arrangement of alpha- and beta-cells in human islets of Langerhans.
DIABETES
2010 vol. 59(5) pp. 1202-1210
BOSCO D, ARMANET M, MOREL P, NICLAUSS N, SGROI A, MULLER Y, GIOVANNONI L, PARNAUD G, BERNEY T

Non-anesthesiologist administration of propofol for GI endoscopy.
ENDOSCOPY
2010 vol. 42(11) pp. 960-974
DUMONCEAU JM. AND AL.

Glucose inhibits angiogenesis of isolated human pancreatic islets.
JOURNAL OF MOLECULAR ENDOCRINOLOGY
2010 vol. 45(2) pp. 99-105
DUBOIS S, MADEC AM, MESNIER A, ARMANET M, CHIKH K, BERNEY T, THIVOLET CH

A map of open chromatin in human pancreatic islets.
NATURE GENETICS
2010 vol. 42(3) pp. 255-259
GAULTON KJ AND AL.

Type 2 diabetes susceptibility gene expression in normal or diabetic sorted human alpha and beta cells: correlations with age or BMI of islet donors.
PLOS ONE
2010 vol. 5(6) pp. 11053-11053
KIRKPATRICK C, MARCHETTI P, PURRELLO F, PIRO S, BUGLIANI M, BOSCO D, DE KONING EJ, ENGELSE MA, KERR-CONTE J, PATTOU F, WOLLHEIM CB

Liraglutide in islet transplantation: from bench to bedside.
TRANSPLANT INTERNATIONAL
2010 vol. 23(3) pp. 257-258
BERNEY T

Donor pancreata: evolving approaches to organ allocation for whole pancreas versus islet transplantation.
TRANSPLANTATION
2010 vol. 90(3) pp. 328-343
BERNEY T, JOHNSON PR

Combined pancreatic islets-lung transplantation in cystic fibrosis-related diabetes: case reports.
TRANSPLANTATION PROCEEDINGS
2010 vol. 42(10) pp. 4338-4340
KESSLER L, GREGET M, METIVIER AC, MOREAU F, ARMANET M, SANTELMO N, MASSARD G, BERNEY T, KESSLER R

Evidence for Humoral Rejection of a Pancreatic Islet Graft and Rescue with Rituximab and IV Immunoglobulin Therapy
AMERICAN JOURNAL OF TRANSPLANTATION
2009 vol. 9 pp. 1961-1966
KESSLER L AND AL.

Long-term insulin-independence after allogeneic islet transplantation for type 1 diabetes: over the 10-year mark.
AMERICAN JOURNAL OF TRANSPLANTATION
2009 vol. 9(2) pp. 419-423
BERNEY T, FERRARI-LACRAZ SYLVIE, BUEHLER LH, OBERHOLZER J, MARANGON NICOLA, PHILIPPE J, VILLARD J, MOREL P

Quality of life after islet transplantation: data from the GRAGIL 1 and 2 trials.
DIABETIC MEDICINE
2009 vol. 26(6) pp. 617-621
BENHAMOU PY AND AL.

Low- and High-Density Lipoproteins Modulate Function Apoptosis and Proliferation of Primary Human and Murine Pancreatic beta-Cells
ENDOCRINOLOGY
2009 vol. 150 pp. 4521-4530
RUTTI S, EHSES JA, SIBLER RA, PRAZAK R, ROHRER L, GEORGOPOULOS S, MEIER DT, NICLAUSS N, BERNEY T, DONATH M, VON ECKARDSTEIN A

Role of the Rho-ROCK (Rho-Associated Kinase) Signaling Pathway in the Regulation of Pancreatic beta-Cell Function
ENDOCRINOLOGY
2009 vol. 150 pp. 2072-2079
HAMMAR BOUVERET EVA, TOMAS A, BOSCO D, HALBAN PA

Regulated laminin-332 expression in human islets of Langerhans
FASEB JOURNAL
2009 vol. 23 pp. 4046-4055
ARMANET M, WOJTUSCISZYN A, MOREL P, PARNAUD G, ROUSSELLE P, SINIGAGLIA C, BERNEY T, BOSCO D

Cx36 makes channels coupling human pancreatic beta-cells and correlates with insulin expression
HUMAN MOLECULAR GENETICS
2009 vol. 18(3) pp. 428-439
SERRE-BEINIER V AND AL.

Signaling Pathways Implicated in the Stimulation of beta-Cell Proliferation by Extracellular Matrix
MOLECULAR ENDOCRINOLOGY
2009 vol. 23(8) pp. 1264-1271
PARNAUD G, HAMMAR BOUVERET EVA, RIBAUX P, DONATH M, BERNEY T, HALBAN PA

Immunomodulation by blockade of the TRANCE co-stimulatory pathway in murine allogeneic islet transplantation
TRANSPLANT INTERNATIONAL
2009 vol. 22(9) pp. 931-939
WOJTUSCISZYN A, ANDRES A, MOREL P, CHARVIER S, ARMANET M, TOSO C, CHOI Y, BOSCO D, BERNEY T

Islet culture and counter-culture
TRANSPLANT INTERNATIONAL
2009 vol. 22 pp. 531-533
BERNEY T

Rapamycin in islet transplantation: friend or foe?
TRANSPLANT INTERNATIONAL
2009 vol. 22(2) pp. 153-161
BERNEY T, SECCHI A

Immunosuppression in pancreas transplantation: the Euro SPK trials and beyond.
ACTA CHIRURGICA BELGICA
2008 vol. 108(6) pp. 673-678
MALAISE J AND AL.

Clinical magnetic resonance imaging of pancreatic islet grafts after iron nanoparticle labeling.
AMERICAN JOURNAL OF TRANSPLANTATION
2008 vol. 8(3) pp. 701-706
TOSO C, VALLEE JP, MOREL P, RIS F, DEMUYLDER-MISCHLER S, LEPETIT-COIFFE M, MARANGON NICOLA, SAUDEK F, JAMES SHAPIRO AM, BOSCO D, BERNEY T

Natural killer cell receptor repertoire and their ligands, and the risk of CMV infection after kidney transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
2008 vol. 8(12) pp. 2674-2683
HADAYA K, DE RHAM C, BANDELIER C, BANDELIER CH, FERRARI-LACRAZ SYLVIE, JENDLY S, BERNEY T, BUHLER L, KAISER L, SEEBACH J, TIERCY JM, MARTIN PY, VILLARD J

Organ preservation in pancreas and islet transplantation.
CURRENT OPINION IN ORGAN TRANSPLANTATION
2008 vol. 13(1) pp. 59-66
BAERTSCHIGER RM, BERNEY T, MOREL P

Insulin secretion from human beta cells is heterogeneous and dependent on cell-to-cell contacts.
DIABETOLOGIA
2008 vol. 51(10) pp. 1843-1852
WOJTUSCISZYN A, ARMANET M, MOREL P, BERNEY T, BOSCO D

Proliferation of sorted human and rat beta cells.
DIABETOLOGIA
2008 vol. 51(1) pp. 91-100
PARNAUD G, BOSCO D, BERNEY T, PATTOU F, KERR-CONTE J, DONATH MY, BRUUN C, MANDRUP-POULSEN T, BILLESTRUP N, HALBAN PA

The role of macrophage migration inhibitory factor on glucose metabolism and diabetes.
DIABETOLOGIA
2008 vol. 51(11) pp. 1937-1946
TOSO C, EMAMAULLEE JA, MERANI S, SHAPIRO AM

Glucose and leptin induce apoptosis in human beta-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases.
FASEB JOURNAL
2008 vol. 22(6) pp. 1905-1913
MAEDLER K, SCHULTHESS FT, BIELMAN C, BERNEY T, BONNY C, PRENTKI M, DONATH MY, RODUIT R

Beta-cell transplantation for diabetes therapy.
LANCET
2008 vol. 372(9632) pp. 28-29
SECCHI A, BERNEY T, BENHAMOU PY, BRENDEL M, KORSGREN O, PIPELEERS D, PATTOU F

Mesenchymal stem cells derived from human exocrine pancreas express transcription factors implicated in beta-cell development.
PANCREAS
2008 vol. 37(1) pp. 75-84
BAERTSCHIGER RM, BOSCO D, MOREL P, SERRE-BEINIER V, BERNEY T, BUHLER LH, GONELLE-GISPERT C

Interleukin-6 regulates pancreatic alpha-cell mass expansion.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2008 vol. 105(35) pp. 13163-13168
ELLINGSGAARD H AND AL.

Combined pancreatic islet-lung transplantation with islet percutaneous portal embolization in cystic fibrosis.
TRANSPLANTATION
2008 vol. 85(11) pp. 1670-1671
KESSLER L, GREGET M, METIVIER AC, MOREAU F, BOSCO D, SANTELMO N, HELMS O, PINGET M, BERNEY T, MASSARD G, KESSLER R

Computer-assisted digital image analysis to quantify the mass and purity of isolated human islets before transplantation.
TRANSPLANTATION
2008 vol. 86(11) pp. 1603-1609
NICLAUSS N, SGROI A, MOREL P, BAERTSCHIGER RETO, ARMANET M, WOJTUSCISZYN A, PARNAUD G, MULLER VIRGINIE, BERNEY T, BOSCO D

Low risk of anti-human leukocyte antigen antibody sensitization after combined kidney and islet transplantation.
TRANSPLANTATION
2008 vol. 86(2) pp. 357-359
FERRARI-LACRAZ SYLVIE, BERNEY T, MOREL P, MARANGON NICOLA, HADAYA K, DEMUYLDER-MISCHLER S, PONGRATZ G, PERNIN N, VILLARD J

The role of macrophage migration inhibitory factor in mouse islet transplantation.
TRANSPLANTATION
2008 vol. 86(10) pp. 1361-1369
TOSO C AND AL.

2008 Update from the Collaborative Islet Transplant Registry.
TRANSPLANTATION
2008 vol. 86(12) pp. 1783-1788
ALEJANDRO R AND AL.

Prospective study of 310 patients: can early CT predict the severity of acute pancreatitis?
ABDOMINAL IMAGING
2007 vol. 32(1) pp. 111-115
KNOEPFLI AS, KINKEL K, BERNEY T, MOREL P, BECKER CD, POLETTI PA

Invasive zygomycosis in transplant recipients
CLINICAL TRANSPLANTATION
2007 vol. 21 pp. 577-582
UCKAY I, CHALANDON Y, SARTORETTI P, ROHNER P, BERNEY T, HADAYA K, VAN DELDEN C

Differential expression of E-cadherin at the surface of rat beta-cells as a marker of functional heterogeneity
JOURNAL OF ENDOCRINOLOGY
2007 vol. 194 pp. 21-29
BOSCO, D, ROUILLER, DG, HALBAN, PA

The Fas pathway is involved in pancreatic beta cell secretory function
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2007 vol. 104 pp. 2861-2866
SCHUMANN DM, MAEDLER K, FRANKLIN I, KONRAD D, STORLING J, BONI-SCHNETZLER M, GJINOVCI A, KURRER MO, GAUTHIER BR, BOSCO D, ANDRES A, BERNEY T, GRETER M, BECHER B, CHERVONSKY AV, HALBAN PA, MANDRUP-POULSEN T, WOLLHEIM CB, DONATH MY

Expectations and strategies regarding islet transplantation: Metabolic data from the GRAGIL 2 trial
TRANSPLANTATION
2007 vol. 84 pp. 89-96
BADET, L, BENHAMOU, PY, WOJTUSCISZYN, A, BAERTSCHIGER, R, MILLIAT-GUITTARD, L, KESSLER, L, PENFORNIS, A, THIVOLET, C, RENARD, E, BOSCO, D, MOREL, P, MORELON, E, BAYLE, F, COLIN, C, BERNEY, T

Quality of life after islet transplant: impact of the number of islet infusions and metabolic outcome
TRANSPLANTATION
2007 vol. 84(5) pp. 664-666
TOSO CHRISTIAN, SHAPIRO A.M. JAMES, BOWKER SAMANTHA, DINYARI PARASTOO, PATY BREAY, RYAN EDMOND A., SENIOR PETER, JOHNSON JEFFREY

Acute humoral rejection in kidney allograft following a third-party arterial transplantation
AMERICAN JOURNAL OF TRANSPLANTATION
2006 vol. 6 pp. 3038-3039
FERRARI-LACRAZ S, BERNEY T, BEDNARKEWICZ M, BINET I, TIERCY JM, MARTIN PY, VILLARD J

Detection of insulin mRNA in the peripheral blood after human islet transplantion predicts deterioration of metabolic control
AMERICAN JOURNAL OF TRANSPLANTATION
2006 vol. 6 pp. 1704-1711
BERNEY T, MAMIN A, SHAPIRO AMJ, RITZ-LASER B, BRULHART MC, TOSO C, DEMUYLDER-MISCHLER S, ARMANET M, BAERTSCHIGER R, WOJTUSCISZYN A, BENHAMOU PY, BOSCO D, MOREL P, PHILIPPE J

Sequential kidney/islet transplantation: efficacy and safety assessment of a steroid-free immunosuppression protocol
AMERICAN JOURNAL OF TRANSPLANTATION
2006 vol. 6(5 Pt 1) pp. 1049-1058
TOSO C. ET AL.

Tetracycline-regulated expression of VEGF-A in beta cells induces angiogenesis: Improvement of engraftment following transplantation
CELL TRANSPLANTATION
2006 vol. 15 pp. 621-636
MATHE Z, DUPRAZ P, RINSCH C, THORENS B, BOSCO D, ZBINDEN M, MOREL P, BERNEY T, PEPPER MS

Aging correlates with decreased beta-cell proliferative capacity and enhanced sensitivity to apoptosis: a potential role for Fas and pancreatic duodenal homeobox-1
DIABETES
2006 vol. 55(9) pp. 2455-2462
MAEDLER KATHRIN, SCHUMANN DESIREE M, SCHULTHESS FABIENNE, OBERHOLZER JOSE, BOSCO DOMENICO, BERNEY THIERRY, DONATH MARC Y.

Blockade of beta 1 integrin-laminin-5 interaction affects spreading and insulin secretion of rat beta-cells attached on extracellular matrix
DIABETES
2006 vol. 55 pp. 1413-1420
PARNAUD G, HAMMAR E, ROUILLER DG, ARMANET M, HALBAN PA, BOSCO D

Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets
DIABETES
2006 vol. 55(10) pp. 2713-2722
MAEDLER KATHRIN ET AL.

Monitoring of the islet graft
DIABETES & METABOLISM
2006 vol. 32 pp. 503-512
BERNEY T, TOSO C

International trial of the Edmonton protocol for islet transplantation
NEW ENGLAND JOURNAL OF MEDICINE
2006 vol. 355(13 pp. 1318-1330
SHAPIRO JAMES ET AL.

Anti-HLA antibody repertoire after IVIg infusion in highly sensitised patients waiting for kidney transplantation
SWISS MEDICAL WEEKLY
2006 vol. 136 pp. 696-702
FERRARI-LACRAZ S, AUBERT V, BUHLER L, PASCUAL M, ANDRESEN I, BINET I, MARTIN PY, VILLARD J

Tacrolimus-associated optic neuropathy after pancreatic islet transplantation using a sirolimus/tacrolimus immunosuppressive regimen
TRANSPLANTATION
2006 vol. 81(4) pp. 636-637
KESSLER LAURENCE, LUCESCU CATALINA, PINGET MICHEL, CHARTON MARIE NOELLE, MUTSCHLER VERONIQUE, WOLF PHILIPPE, BERNEY THIERRY, BENHAMOU PIERRE YVES

Assessment of F-18-FDG-leucocyte imaging to monitor rejection after pancreatic islet transplantation
TRANSPLANTATION PROCEEDINGS
2006 vol. 38 pp. 3033-3034
TOSO C, ZAIDI H, MOREL P, ARMANET M, WOJTUSCISZYN A, MAI G, BAERTSCHIGER R, BUHLER L, BERNEY T

Epidural anaesthesia restores pancreatic microcirculation and decreases the severity of acute pancreatitis
WORLD JOURNAL OF GASTROENTEROLOGY
2006 vol. 12 pp. 915-920
DEMIRAG A, PASTOR CM, MOREL P, JEAN-CHRISTOPHE C, SIELENKAMPER AW, GUVENER N, MAI G, BERNEY T, FROSSARD JL, BUHLER LH

Soluble CD40 ligand in prediction of acute severe pancreatitis
WORLD JOURNAL OF GASTROENTEROLOGY
2006 vol. 12 pp. 1613-1616
FROSSARD JL, MOREL P, KWAK BR, PASTOR CM, BERNEY T, BUHLER L, VON LAUFEN A, DEMULDER S, MACH F

Effect of microcapsule composition and short-term immunosuppression on intraportal biocompatibility
CELL TRANSPLANTATION
2005 vol. 14 pp. 159-167
TOSO CHRISTIAN ET AL.

Expression and secretion of alpha1-proteinase inhibitor are regulated by proinflammatory cytokines in human pancreatic islet cells.
DIABETOLOGIA
2005 vol. 48 pp. 1523-1533
BOSCO DOMENICO, MEDA PAOLO, MOREL PHILIPPE, MATTHEY-DORET DAVID, CAILLE CHOFFAT DOROTHEE, TOSO CHRISTIAN, BUHLER LEO, BERNEY THIERRY

Impact of HLA matching on the outcome of simultaneous pancreas-kidney transplantation
NEPHROLOGY, DIALYSIS, TRANSPLANTATION : OFFICIAL PUBLICATION OF THE EUROPEAN DIALYSIS AND TRANSPLANT ASSOCIATION - EUROPEAN RENAL ASSOCIATION
2005 vol. 20 pp. 48-53
BERNEY THIERRY, MALAISE JACQUES, MOREL PHILIPPE, TOSO CHRISTIAN, DEMUYLDER-MISCHLER S, MAJNO PIETRO, BUHLER LEO, MENTHA GILLES, EURO-SPK STUDY GROUP

Impariment of renal function after islet transplant alone or islet-after-kidney transplantation using a sirolimus/tacrolimus-based immunosuppressive regimen
TRANSPLANT INTERNATIONAL
2005 vol. 18 pp. 1226-1230
ANDRES ALEX ET AL.

Microbial surveillance during human pancreatic islet isolation
TRANSPLANT INTERNATIONAL
2005 vol. 18 pp. 584-589
BUCHER PASCAL, OBERHOLZER JOSE, BOSCO DOMENICO, MATHE ZOLTAN, TOSO CHRISTIAN, BUHLER LEO, BERNEY THIERRY, MOREL PHILIPPE

Islet transplantation in a recipient presenting the factor V Leiden mutation
TRANSPLANTATION
2005 vol. 79 pp. 1771-1772
ANDRES AXEL, BOSCO DOMENICO, MOREL PHILIPPE, TOSO CHRISTIAN, BAERTSCHIGER RETO, MAJNO PIETRO, BUHLER LEO, BERNEY THIERRY

Logistics and transplant coordination activity in the GRAGIL Swiss-French multicenter network of islet transplantation
TRANSPLANTATION
2005 vol. 79 pp. 1200-1205
KEMPF MARIE-CLAUDE ET AL.

Macrophage depletion prolongs discordant but not concordant islet xenograft survival
TRANSPLANTATION
2005 vol. 79 pp. 543-549
ANDRES AXEL ET AL.

Positron-emission tomography imaging of early events after transplantation of islets of langerhans
TRANSPLANTATION
2005 vol. 79 pp. 353-355
TOSO CHRISTIAN, ZAIDI HABIB, MOREL PHILIPPE, ARMANET MATHIEU, ANDRES AXEL, PERNIN NADINE, BAERTSCHIGER RETO, SLOSMAN DANIEL, BUHLER LEO, BOSCO DOMENICO, BERNEY THIERRY

A comparison of cold storage solutions for pancreas preservation prior to islet isolation
TRANSPLANTATION PROCEEDINGS
2005 vol. 37 pp. 3396-3397
WOJTUSCISZYN A. ET AL.

Effect of HLA matching in simultaneous pancreas-kidney transplantation
TRANSPLANTATION PROCEEDINGS
2005 vol. 37 pp. 2846-2847
MALAISE J. ET AL.

Impact of a Sirolimus/Tacrolimus-based immunosuppressive regimen on kidney function after islet transplantation
TRANSPLANTATION PROCEEDINGS
2005 vol. 37 pp. 1326-1327
ANDRES A. ET AL.

Phylogenetic disparity influences the predominance of direct over indirect pathway of antigen presentation in islet xenotransplantation
TRANSPLANTATION PROCEEDINGS
2005 vol. 37 pp. 463-465
ANDRES A ET AL.

Management of hepatocellular adenoma: solitary-uncomplicated, multiple and ruptured tumors
WORLD JOURNAL OF GASTROENTEROLOGY
2005 vol. 11 pp. 5691-5695
TOSO CHRISTIAN, MAJNO PIETRO, ANDRES AXEL, RUBBIA BRANDT LAURA, BERNEY THIERRY, BUHLER LEO, MOREL PHILIPPE, MENTHA GILLES

Treatment of fulminant liver failure by transplantation of microencapsulated primary or immortalized xenogeneic hepatocypes
XENOTRANSPLANTATION
2005 vol. 12 pp. 457-464
MAI GANG ET AL.

Treatment of hepatocellular carcinoma at the dawn of the third millenium: liver transplantation and its alternatives.
ACTA GASTRO-ENTEROLOGICA BELGICA
2004 vol. 67 pp. 206-222
MAJNO P, MENTHA G, GIOSTRA E, TERRAZ S, RUBBIA-BRANDT L, BERNEY T, BUHLER L, TOSO C, HUBER O, SPAHR L, MORARD I, HADENGUE A, BECKER C, TERRIER F, MOREL P

Activation of human macrophages by allogeneic islets preparations: inhibition by AOP-RANTES and heparinoids
IMMUNOLOGY
2004 vol. 111 pp. 416-421
SIGRIST S, OBERHOLZER J, BOHBOT A, ESPOSITO G, MANDES K, LAMARTINE R, TOSO C, BUCHER P, PINGET M, KESSLER L

Islet of Langerhans allogeneic transplantation at the University of Geneva in the steroid free era in islet after kidney and simultaneous islet-kidney transplantations
TRANSPLANTATION PROCEEDINGS
2004 vol. 36 pp. 1121-1122
BERNEY T, BUCHER P, MATHE Z, ANDRES A, BOSCO D, MAGE R, TOSO C, OBERHOLZER J, BECKER C, PHILIPPE JACQUES, BUHLER L, MOREL P

Microbial surveillance during human pancreatic islet isolation
TRANSPLANTATION PROCEEDINGS
2004 vol. 36 pp. 1147-1148
BUCHER P, MATHE Z, BOSCO D, OBERHOLZER J, TOSO C, ANDRES A, BUHLER L, MOREL P, BERNEY T

Short-term immunosuppression reduces fibrotic cellular infiltration around barium-M-alginate microbeads injected intraportally
TRANSPLANTATION PROCEEDINGS
2004 vol. 36 pp. 1199-1200
MATHE Z, BUCHER P, BOSCO D, ANDRES A, FUX C, TOSO C, OBERHOLZER J, WANDREY C, SAINZ-VIDAL D, ESPINOSA D, BUHLER L, MOREL P, BERNEY T

Portal versus systemic drainage of small bowel allografts: comparative assessment of survival, function, rejection, and bacterial translocation
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
2002 vol. 195 pp. 804-813
BERNEY T, KATO T, NISHIDA S, TECTOR AJ, MITTAL NK, MADARIAGA J, NERY JR, CANTWELL GP, RUIZ P, TZAKIS AG

Indications et résultats de la transplantation intestinale
MEDECINE ET HYGIENE : JOURNAL SUISSE D'INFORMATIONS MEDICALES
2002 vol. 60 pp. 1199-1202
BERNEY T, BUHLER L, CHARBONNET P, MAJNO P, MENTHA G, MOREL P

Outcome of orthotopic liver transplantation in autoimmune hepatitis according to subtypes
TRANSPLANT INTERNATIONAL
2002 vol. 15 pp. 34-38
CATTAN P, BERNEY T, CONTI F, CALMUS Y, HOMBERG JC, HOUSSIN D, SOUBRANE O

Successful treatment of posttransplant lymphoproliferative disease with prolonged rituximab treatment in intestinal transplant recipients
TRANSPLANTATION
2002 vol. 74 pp. 1000-1006
BERNEY T, DELIS S, KATO T, NISHIDA S, MITTAL NK, MADARIAGA J, LEVI D, NERY JR, CIROCCO RE, GELMAN B, RUIZ P, TZAKIS AG

Systemic versus portal venous drainage of small bowel grafts: similar long-term outcome in spite of increased bacterial translocation
TRANSPLANTATION PROCEEDINGS
2002 vol. 34 pp. 961-962
BERNEY T, KATO T, NISHIDA S, MITTAL N, TECTOR AJ, LEVI D, MADARIAGA J, NERY JR, RUIZ P, TZAKIS AG

Neonatal porcine pancreatic cell clusters as a potential source for transplantation in humans: characterization of proliferation, apoptosis, xenoantigen expression and gene delivery with recombinant A AV
XENOTRANSPLANTATION
2002 vol. 9 pp. 14-24
VIZZARDELLI C, MOLANO RD, PILEGGI A, BERNEY T, CATTAN P, FENJVES ES, PEEL A, FRAKER C, RICORDI C, INVERARDI L

Transplantation of islets of Langerhans: new developments
SWISS MEDICAL WEEKLY
2001 vol. 131 pp. 671-680
BERNEY T, BUEHLER LH, CAULFIELD A, OBERHOLZER J, TOSO C, ALEJANDRO R, COOPER DK, RICORDI C, MOREL P

Research's domains




DATABASE-RESEARCH	GROUP OF CLINICAL PATIENT RESEARCH

Th. BERNEY et D. BOSCO	Head of group CV	Research subject	Members of the group