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Nutrition

Project 1. Evaluation of the potential synergy between functional food administration and radio- or chemotherapy in different gastrointestinal cancer models.
Abstract: Recent findings suggest that functional foods, such as n-3 polyunsaturated fatty acids, may selectively sensitize tumor cells to radiation or certain drugs by increasing oxidative stress, while decreasing mucosal or epidermal radio- or chemotoxicity by downregulating cyclooxygenase II. We aim to evaluate the individual or combined potential of these functional foods to increase radio- or chemotherapy efficacy in different gastrointestinal cancer models.

Project 2. The Life-long Learning web-based educational programme in Clinical Nutrition.
Abstract: This European Union project is part of the Leonardo Da Vinci programme.

Project 3. Body composition evaluation.
Abstract: Establishment of methodologies and reference values (lean & fat masses, water distribution) in different pathologies.
br>Project 4. Effect of anabolic manipulations on the nutritional status of patients with chronic respiratory insufficiency.
Abstract: Impact of nutrients, hormones (testosterone) and/or physical activity on biological and physical (body composition) parameters.

Project 5. Micronutrient stability and pharmaco-economics in parenteral nutrition.
Abstract: Limiting factors in the use of ready-to-use total parenteral nutrition bags are the costs and the stability of micronutrients in the bag. These factors are evaluated and compared between different products and materials.

Group's publications

Differential effects of free versus imposed motor activity on alcohol consumption in C57BL/6J versus DBA/2J mice.
ALCOHOL
2009 vol. 43(8) pp. 593-601
PICHARD C, GORWOOD PA, HAMON M, COHEN-SALMON C

Decreased food intake is a risk factor for mortality in hospitalised patients: the NutritionDay survey 2006.
CLINICAL NUTRITION
2009 vol. 28(5) pp. 484-491
HIESMAYR M AND AL.

ESPEN Guidelines on Parenteral Nutrition: intensive care.
CLINICAL NUTRITION
2009 vol. 28(4) pp. 387-400
SINGER P, BERGER MM, VAN DEN BERGHE G, BIOLO G, PHILIP CALDER P, FORBES A, GRIFFITHS R, KREYMAN G, LEVERVE X, PICHARD C

Advancing from immunonutrition to a pharmaconutrition: a gigantic challenge.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
2009 vol. 12(4) pp. 398-403
DUPERTUIS YM, MEGUID MM, PICHARD C

Dichotomic actions of glutamine in host versus tumour: an emerging concept.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
2009 vol. 12(4) pp. 372-377
BELABED L, DARMON P, THADIKKARAN L, DUPERTUIS YM, PICHARD C

Nutritional care: from the dark ages to the renaissance, to the age of enlightenment.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
2009 vol. 12(4) pp. 364-365
MEGUID M, LAVIANO A, PICHARD C

Do obese patients have specific nutrition goals in cases of cancer?
JPEN . JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
2009 vol. 33(4) pp. 442-443
GENTON L, PICHARD C

Neural control of the anorexia-cachexia syndrome.
AMERICAN JOURNAL OF PHYSIOLOGY. ENDOCRINOLOGY AND METABOLISM
2008 vol. 295(5) pp. 1000-1008
LAVIANO A, INUI A, MARKS DL, MEGUID MM, PICHARD C, ROSSI FANELLI F, SEELAENDER M

Clinical relevance of parenteral nutrition prescription and administration in 200 hospitalized patients: a quality control study.
CLINICAL NUTRITION
2008 vol. ;27(6) pp. 858-864
NARDO P, DUPERTUIS YM, JETZER J, KOSSOVSKI MP, DARMON P, PICHARD C

Inspired by the pioneers: the lesson of the Judy Taylor story.
CLINICAL NUTRITION
2008 vol. 27(3) pp. 319-320
LJUNGQVIST O, PICHARD C

Nutrition in care homes and home care: how to implement adequate strategies (report of the Brussels Forum (22-23 November 2007)).
CLINICAL NUTRITION
2008 vol. 27(4) pp. 481-488
ARVANITAKIS M AND AL.

Oral nutritional supplements and taste preferences: 545 days of clinical testing in malnourished in-patients.
CLINICAL NUTRITION
2008 vol. 27(4) pp. 660-665
DARMON P, KARSEGARD LV, NARDO P, DUPERTUIS YM, PICHARD C

Prognostic impact of disease-related malnutrition.
CLINICAL NUTRITION
2008 vol. 27(1) pp. 5-15
NORMAN K, PICHARD C, LOCHS H, PIRLICH M

Economic impact and quality of life as endpoints of nutritional therapy.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
2008 vol. ;11(4) pp. 452-458
DARMON P, LOCHS H, PICHARD C

Of autoantibodies and single nucleotide polymorphisms: a brave new world?
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
2008 vol. 11(4) pp. 398-399
PICHARD C, LAVIANO A, MEGUID MM

Enteral vs. parenteral nutrition for the critically ill patient: a combined support should be preferred.
CURRENT OPINION IN CRITICAL CARE
2008 vol. 14(4) pp. 408-414
HEIDEGGER CLAUDIA, DARMON P, PICHARD C

Injury stimulates an innate respiratory immunoglobulin a immune response in humans.
JOURNAL OF TRAUMA
2008 vol. 64(2) pp. 316-323
KUDSK KA, HERMSEN JL, GENTON L, FAUCHER L, GOMEZ FE

Comparison of equations for estimating resting metabolic rate in healthy subjects over 70 years of age
CLINICAL NUTRITION
2007 vol. 26 pp. 498-505
MELZER K, KARSEGARD WL, GENTON L, KOSSOVSKY MP, KAYSER B, PICHARD C

New legal regulations for clinical trials: An opportunity for the future of Clinical Nutrition research
CLINICAL NUTRITION
2007 vol. 26 pp. 510-513
DEUTZ NEP, KOLETZKO B, PICHARD C

Nutritional intervention and quality of life in adult oncology patients
CLINICAL NUTRITION
2007 vol. 26 pp. 289-301
MARIN CARO MM, LAVIANO A, PICHARD C

Colon cancer therapy: new perspectives of nutritional manipulations using polyunsaturated fatty acids
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
2007 vol. 10(4) pp. 427-432
DUPERTUIS YM, MEGUID MM, PICHARD C

mpact of nutrition on quality of life during cancer
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
2007 vol. 10(4) pp. 480-487
MARÍN CARO MM, LAVIANO A, PICHARD C

Is it now time to promote mixed enteral and parenteral nutrition for the critically ill patient?
INTENSIVE CARE MEDICINE
2007 vol. 33 pp. 963-969
HEIDEGGER CP, ROMAND JA, TREGGIARI MM, PICHARD C

Relationship between nutritional intervention and quality of life in cancer patients
NUTRICION HOSPITALARIA : ORGANO OFICIAL DE LA SOCIEDAD ESPANOLA DE NUTRICION PARENTERAL Y ENTERAL
2007 vol. 22(3) pp. 337-350
CARO MM, LAVIANO A, PICHARD C, CANDELA CG

Effect of an immunonutrient mix on human colorectal adenocarcinoma cell growth and viability
NUTRITION
2007 vol. 23 pp. 672-680
DUPERTUIS YM, BENAIS-PONT G, BUCHEGGER F, PICHARD C

Overweight and obesity in a Swiss city: 10-year trends
PUBLIC HEALTH NUTRITION
2007 vol. 10 pp. 914-919
KYLE UG, KOSSOVSKY MP, GENTON L, PICHARD C

A 3-year longitudinal study on body composition changes in the elderly: Role of physical exercise
CLINICAL NUTRITION
2006 vol. 25 pp. 573-580
RAGUSO CA, KYLE U, KOSSOVSKY MP, ROYNETTE C, PAOLONI-GIACOBINO A, HANS D, GENTON L, PICHARD C

Comparison of body weight and composition measured by two different dual energy X-ray absorptiometry devices and three acquisition modes in obese women
CLINICAL NUTRITION
2006 vol. 25 pp. 428-437
GENTON L, KARSEGARD VL, ZAWADYNSKI S, KYLE UG, PICHARD C, GOLAY A, HANS DB

Comparison of tools for nutritional assessment and screening at hospital admission: A population study
CLINICAL NUTRITION
2006 vol. 25 pp. 409-417
KYLE UG, KOSSOVSKY MP, KARSEGARD VL, PICHARD C

ESPEN guidelines on enteral nutrition: Intensive care
CLINICAL NUTRITION
2006 vol. 25 pp. 210-223
KREYMANN KG, BERGER MM, DEUTZ NEP, HIESMAYR M, NITENBERG G, VAN DEN BERGHE G, WERNERMAN J, EBNER C, HARTL W, HEYMANN C, SPIES C, JOLLIET P, KAZANDJIEV G

Evidence supports nutritional support
CLINICAL NUTRITION
2006 vol. 25(2) pp. 177-179
LOCHS H, PICHARD C, ALLISON SP

Hospitalized mechanically ventilated patients are at higher risk of enteral underfeeding than non-ventilated patients
CLINICAL NUTRITION
2006 vol. 25 pp. 727-735
KYLE UG, GENTON L, HEIDEGGER CP, MAISONNEUVE N, KARSEGARD VL, HUBER O, MENSI N, ROMAND JA, JOLLIET P, PICHARD C

Introductory to the ESPEN guidelines on enteral nutrition: Terminology, definitions and general topics
CLINICAL NUTRITION
2006 vol. 25 pp. 180-186
LOCHS H, ALLISON SP, MEIER R, PIRLICH M, KONDRUP J, SCHNEIDER S, VAN DEN BERGHE G, PICHARD C

Did it all start with Delilah?
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
2006 vol. 9 pp. 386-387
MEGUID MM, PICHARD C

Ergonomic and economic aspects of total parenteral nutrition
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
2006 vol. 9 pp. 149-154
GENTON L, MUHLEBACH S, DUPERTUIS YM, PICHARD C

The Dutch Famine of 1944-1945: a pathophysiological model of long-term consequences of wasting disease
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
2006 vol. 9 pp. 388-394
KYLE UG, PICHARD C

Eight-year longitudinal changes in body composition in healthy Swiss adults
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
2006 vol. 25(6) pp. 493-501
KYLE URSULA G, MELZER KATARINA, KAYSER BENGT, PICARD-KOSSOVSKY MICHEL, GREMION GERALD, PICHARD CLAUDE

Longitudinal study of body composition changes associated with weight change and physical activity
NUTRITION
2006 vol. 22 pp. 1103-1111
KYLE UG, ZHANG FF, MORABIA A, PICHARD C

omega-3 Polyunsaturated fatty acids and ionizing radiation: combined cytotoxicity on human colorectal. adenocarcinoma cells
NUTRITION
2006 vol. 22 pp. 931-939
BENAIS-PONT G, DUPERTUIS YM, KOSSOVSKY MP, NOUET P, ALLAL AS, BUCHEGGER F, PICHARD C

Body composition in patients with chronic hypercapnic respiratory failure
RESPIRATORY MEDICINE
2006 vol. 100 pp. 244-252
KYLE UG, JANSSENS JP, ROCHAT T, RAGUSO CA, PICHARD C

Diet and ageing: critical influence of genetype and gene expression profile.
NUTRITION RESEARCH
2003 vol. 23 pp. 1727-1738
PAOLONI GIACOBINO A, PICHARD C

Research's domains




DATABASE-RESEARCH	GROUP OF CLINICAL PATIENT RESEARCH

C. PICHARD - Y. DUPERTUIS	Head of group CV	Research subject	Members of the group


	Links about the group Dr. Cl. PICHARD HUG/Spécialités de Médecine Serv Endo. Diabet. Nutrit. Rue Gabrielle-Perret-Gentil 4 1211 Genève 14 Suisse secretariat.nutrition@hcuge.ch Tel.: 022 372 93 49 Fax: 022 372 93 63 Comments Pages updated the 17.11.2015		Reseach's subject \| Group's publications \| Research's domains Nutrition Project 1. Evaluation of the potential synergy between functional food administration and radio- or chemotherapy in different gastrointestinal cancer models. Abstract: Recent findings suggest that functional foods, such as n-3 polyunsaturated fatty acids, may selectively sensitize tumor cells to radiation or certain drugs by increasing oxidative stress, while decreasing mucosal or epidermal radio- or chemotoxicity by downregulating cyclooxygenase II. We aim to evaluate the individual or combined potential of these functional foods to increase radio- or chemotherapy efficacy in different gastrointestinal cancer models. Project 2. The Life-long Learning web-based educational programme in Clinical Nutrition. Abstract: This European Union project is part of the Leonardo Da Vinci programme. Project 3. Body composition evaluation. Abstract: Establishment of methodologies and reference values (lean & fat masses, water distribution) in different pathologies. br>Project 4. Effect of anabolic manipulations on the nutritional status of patients with chronic respiratory insufficiency. Abstract: Impact of nutrients, hormones (testosterone) and/or physical activity on biological and physical (body composition) parameters. Project 5. Micronutrient stability and pharmaco-economics in parenteral nutrition. Abstract: Limiting factors in the use of ready-to-use total parenteral nutrition bags are the costs and the stability of micronutrients in the bag. These factors are evaluated and compared between different products and materials. Group's publications Differential effects of free versus imposed motor activity on alcohol consumption in C57BL/6J versus DBA/2J mice. ALCOHOL 2009 vol. 43(8) pp. 593-601 PICHARD C, GORWOOD PA, HAMON M, COHEN-SALMON C Decreased food intake is a risk factor for mortality in hospitalised patients: the NutritionDay survey 2006. CLINICAL NUTRITION 2009 vol. 28(5) pp. 484-491 HIESMAYR M AND AL. ESPEN Guidelines on Parenteral Nutrition: intensive care. CLINICAL NUTRITION 2009 vol. 28(4) pp. 387-400 SINGER P, BERGER MM, VAN DEN BERGHE G, BIOLO G, PHILIP CALDER P, FORBES A, GRIFFITHS R, KREYMAN G, LEVERVE X, PICHARD C Advancing from immunonutrition to a pharmaconutrition: a gigantic challenge. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE 2009 vol. 12(4) pp. 398-403 DUPERTUIS YM, MEGUID MM, PICHARD C Dichotomic actions of glutamine in host versus tumour: an emerging concept. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE 2009 vol. 12(4) pp. 372-377 BELABED L, DARMON P, THADIKKARAN L, DUPERTUIS YM, PICHARD C Nutritional care: from the dark ages to the renaissance, to the age of enlightenment. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE 2009 vol. 12(4) pp. 364-365 MEGUID M, LAVIANO A, PICHARD C Do obese patients have specific nutrition goals in cases of cancer? JPEN . JOURNAL OF PARENTERAL AND ENTERAL NUTRITION 2009 vol. 33(4) pp. 442-443 GENTON L, PICHARD C Neural control of the anorexia-cachexia syndrome. AMERICAN JOURNAL OF PHYSIOLOGY. ENDOCRINOLOGY AND METABOLISM 2008 vol. 295(5) pp. 1000-1008 LAVIANO A, INUI A, MARKS DL, MEGUID MM, PICHARD C, ROSSI FANELLI F, SEELAENDER M Clinical relevance of parenteral nutrition prescription and administration in 200 hospitalized patients: a quality control study. CLINICAL NUTRITION 2008 vol. ;27(6) pp. 858-864 NARDO P, DUPERTUIS YM, JETZER J, KOSSOVSKI MP, DARMON P, PICHARD C Inspired by the pioneers: the lesson of the Judy Taylor story. CLINICAL NUTRITION 2008 vol. 27(3) pp. 319-320 LJUNGQVIST O, PICHARD C Nutrition in care homes and home care: how to implement adequate strategies (report of the Brussels Forum (22-23 November 2007)). CLINICAL NUTRITION 2008 vol. 27(4) pp. 481-488 ARVANITAKIS M AND AL. Oral nutritional supplements and taste preferences: 545 days of clinical testing in malnourished in-patients. CLINICAL NUTRITION 2008 vol. 27(4) pp. 660-665 DARMON P, KARSEGARD LV, NARDO P, DUPERTUIS YM, PICHARD C Prognostic impact of disease-related malnutrition. CLINICAL NUTRITION 2008 vol. 27(1) pp. 5-15 NORMAN K, PICHARD C, LOCHS H, PIRLICH M Economic impact and quality of life as endpoints of nutritional therapy. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE 2008 vol. ;11(4) pp. 452-458 DARMON P, LOCHS H, PICHARD C Of autoantibodies and single nucleotide polymorphisms: a brave new world? CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE 2008 vol. 11(4) pp. 398-399 PICHARD C, LAVIANO A, MEGUID MM Enteral vs. parenteral nutrition for the critically ill patient: a combined support should be preferred. CURRENT OPINION IN CRITICAL CARE 2008 vol. 14(4) pp. 408-414 HEIDEGGER CLAUDIA, DARMON P, PICHARD C Injury stimulates an innate respiratory immunoglobulin a immune response in humans. JOURNAL OF TRAUMA 2008 vol. 64(2) pp. 316-323 KUDSK KA, HERMSEN JL, GENTON L, FAUCHER L, GOMEZ FE Comparison of equations for estimating resting metabolic rate in healthy subjects over 70 years of age CLINICAL NUTRITION 2007 vol. 26 pp. 498-505 MELZER K, KARSEGARD WL, GENTON L, KOSSOVSKY MP, KAYSER B, PICHARD C New legal regulations for clinical trials: An opportunity for the future of Clinical Nutrition research CLINICAL NUTRITION 2007 vol. 26 pp. 510-513 DEUTZ NEP, KOLETZKO B, PICHARD C Nutritional intervention and quality of life in adult oncology patients CLINICAL NUTRITION 2007 vol. 26 pp. 289-301 MARIN CARO MM, LAVIANO A, PICHARD C Colon cancer therapy: new perspectives of nutritional manipulations using polyunsaturated fatty acids CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE 2007 vol. 10(4) pp. 427-432 DUPERTUIS YM, MEGUID MM, PICHARD C mpact of nutrition on quality of life during cancer CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE 2007 vol. 10(4) pp. 480-487 MARÍN CARO MM, LAVIANO A, PICHARD C Is it now time to promote mixed enteral and parenteral nutrition for the critically ill patient? INTENSIVE CARE MEDICINE 2007 vol. 33 pp. 963-969 HEIDEGGER CP, ROMAND JA, TREGGIARI MM, PICHARD C Relationship between nutritional intervention and quality of life in cancer patients NUTRICION HOSPITALARIA : ORGANO OFICIAL DE LA SOCIEDAD ESPANOLA DE NUTRICION PARENTERAL Y ENTERAL 2007 vol. 22(3) pp. 337-350 CARO MM, LAVIANO A, PICHARD C, CANDELA CG Effect of an immunonutrient mix on human colorectal adenocarcinoma cell growth and viability NUTRITION 2007 vol. 23 pp. 672-680 DUPERTUIS YM, BENAIS-PONT G, BUCHEGGER F, PICHARD C Overweight and obesity in a Swiss city: 10-year trends PUBLIC HEALTH NUTRITION 2007 vol. 10 pp. 914-919 KYLE UG, KOSSOVSKY MP, GENTON L, PICHARD C A 3-year longitudinal study on body composition changes in the elderly: Role of physical exercise CLINICAL NUTRITION 2006 vol. 25 pp. 573-580 RAGUSO CA, KYLE U, KOSSOVSKY MP, ROYNETTE C, PAOLONI-GIACOBINO A, HANS D, GENTON L, PICHARD C Comparison of body weight and composition measured by two different dual energy X-ray absorptiometry devices and three acquisition modes in obese women CLINICAL NUTRITION 2006 vol. 25 pp. 428-437 GENTON L, KARSEGARD VL, ZAWADYNSKI S, KYLE UG, PICHARD C, GOLAY A, HANS DB Comparison of tools for nutritional assessment and screening at hospital admission: A population study CLINICAL NUTRITION 2006 vol. 25 pp. 409-417 KYLE UG, KOSSOVSKY MP, KARSEGARD VL, PICHARD C ESPEN guidelines on enteral nutrition: Intensive care CLINICAL NUTRITION 2006 vol. 25 pp. 210-223 KREYMANN KG, BERGER MM, DEUTZ NEP, HIESMAYR M, NITENBERG G, VAN DEN BERGHE G, WERNERMAN J, EBNER C, HARTL W, HEYMANN C, SPIES C, JOLLIET P, KAZANDJIEV G Evidence supports nutritional support CLINICAL NUTRITION 2006 vol. 25(2) pp. 177-179 LOCHS H, PICHARD C, ALLISON SP Hospitalized mechanically ventilated patients are at higher risk of enteral underfeeding than non-ventilated patients CLINICAL NUTRITION 2006 vol. 25 pp. 727-735 KYLE UG, GENTON L, HEIDEGGER CP, MAISONNEUVE N, KARSEGARD VL, HUBER O, MENSI N, ROMAND JA, JOLLIET P, PICHARD C Introductory to the ESPEN guidelines on enteral nutrition: Terminology, definitions and general topics CLINICAL NUTRITION 2006 vol. 25 pp. 180-186 LOCHS H, ALLISON SP, MEIER R, PIRLICH M, KONDRUP J, SCHNEIDER S, VAN DEN BERGHE G, PICHARD C Did it all start with Delilah? CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE 2006 vol. 9 pp. 386-387 MEGUID MM, PICHARD C Ergonomic and economic aspects of total parenteral nutrition CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE 2006 vol. 9 pp. 149-154 GENTON L, MUHLEBACH S, DUPERTUIS YM, PICHARD C The Dutch Famine of 1944-1945: a pathophysiological model of long-term consequences of wasting disease CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE 2006 vol. 9 pp. 388-394 KYLE UG, PICHARD C Eight-year longitudinal changes in body composition in healthy Swiss adults JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION 2006 vol. 25(6) pp. 493-501 KYLE URSULA G, MELZER KATARINA, KAYSER BENGT, PICARD-KOSSOVSKY MICHEL, GREMION GERALD, PICHARD CLAUDE Longitudinal study of body composition changes associated with weight change and physical activity NUTRITION 2006 vol. 22 pp. 1103-1111 KYLE UG, ZHANG FF, MORABIA A, PICHARD C omega-3 Polyunsaturated fatty acids and ionizing radiation: combined cytotoxicity on human colorectal. adenocarcinoma cells NUTRITION 2006 vol. 22 pp. 931-939 BENAIS-PONT G, DUPERTUIS YM, KOSSOVSKY MP, NOUET P, ALLAL AS, BUCHEGGER F, PICHARD C Body composition in patients with chronic hypercapnic respiratory failure RESPIRATORY MEDICINE 2006 vol. 100 pp. 244-252 KYLE UG, JANSSENS JP, ROCHAT T, RAGUSO CA, PICHARD C Diet and ageing: critical influence of genetype and gene expression profile. NUTRITION RESEARCH 2003 vol. 23 pp. 1727-1738 PAOLONI GIACOBINO A, PICHARD C Research's domains