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Tissue compatibility and clinical transplantation

* In clinical transplantation tissue compatibility is determined by genes of the major histocompatibility complex, the HLA sytem in man (Human Leucocyte Antigens). HLA class I (A, B, C) and class II (DR, DQ, DP) antigens are cell surface glycoproteins caracterized by a high degree of allelic polymorphism. Immune responses to incompatible HLA antigens are a major barrier to organ and hematopoietic stem cell transplantation. Polymorphism of the HLA system, initially analysed by serology (~100 serotypes), turned out to be much larger when molecular typing techniques were applied (> 1500 alleles defined by DNA sequencing). Thus two unrelated individuals that would be considered as HLA-compatible by serology might in fact differ by one or multiple HLA alleles when high resolution molecular typing is applied. These allelic incompatibilities are recognized by T lymphocytes and are therefore clinically relevant, particularly in transplantation with HSC from unrelated donors. Indeed post-transplant complications and mortality risk increase with the degree of patient/donor HLA mismatching.

Our research projects concern the following five main areas :
1. Allelic polymorphism and haplotypic diversity of the HLA system
The laboratory contributes to the caracterization of allelic polymorphism of the different HLA genes by cloning and sequencing new variants. Blood samples are provided by the LNRH (National Reference Laboratory for Histocompatibility, HUG) and by the Swiss Bone Marrow Donor Registry (Berne). Our major interest concerns the diversity of associations of HLA antigens (haplotypes) in the population, with a particular emphasis on HLA-B-Cw haplotypes. Since that diversity varies wih the serotypes and within different populations, there are important implications for the selection of HLA-compatible HSC donors. We are developping a database comprising the HLA-A/B/C/DRB1/B3/B5 haplotypes, with a priority given to the HLA-B serotypes that account for the most frequent incompatibilities (e.g. B35, B39, B44, B51).
2. HLA incompatibilities and hematopoietic stem cell transplantation (HSCT)
The studies from our laboratory as well as those from other centers have shown the importance of HLA class I and II compatibility at the allelic level for allogenic HSCT. However the relative importance of each of the individual loci remains an unresolved issue. Based on the HLA incompatibilities detectd by molecular typing a clinical study of all allografts of HSC from unrelated donors performed in Switzerland is underway in collaboration with the transplant centers of Geneva (Pr. B. Chapuis), Basel (Pr. A. Gratwohl, Pr. J. Passweg), Zürich (Dr. U. Schanz) and Zürich-Kinderspital (Pr. R. Seger).
3. Other immunogenetic factors and HSCT
Non-HLA immunogenetic factors, such as cytokine and cytokine receptor genes, and KIR genes (killer immunoglobulin-like receptor) (a collaboration with Pr. D. Middleton, Belfast) are analysed in the unrelated HSCT patient/donor combinations. The polymorphisms (SNPs and microsatellites) of TNF, IL-10, IL-1¿, IL-1Ra, and IL-4R are analysed. The HLA class I incompatibilities are recognized by CD8+ cytotoxic T lymphocytes (CTL), and this alloreactivity is measured in vitro by the CTLpf (CTL precursor frequency) assay. Non classical co-stimulation pathways (LIGHT, ICOS, CD134, CD137) that are potentially involved in recognition of HLA incompatibilities will be caracterized by RT-PCR on alloreactive lymphocytes.
4. Microchimerism and liver transplantation
5. HLA and population genetics

Group's publications

Cord blood banks collect units with different HLA alleles and haplotypes to volunteer donor banks: a comparative report from Swiss Blood stem cells.
BONE MARROW TRANSPLANTATION
2009 vol. 43(10) pp. 771-778
MEYER-MONARD S AND AL.

Modified tumour antigen-encoding mRNA facilitates the analysis of naturally occurring and vaccine-induced CD4 and CD8 T cells in cancer patients.
CANCER IMMUNOLOGY IMMUNOTHERAPY
2009 vol. 58(3) pp. 325-338
KNIGHTS AJ, NUBER N, THOMSON CW, DE LA ROSA O, JÄGER E, TIERCY JM, VAN DEN BROEK M, PASCOLO S, KNUTH A, ZIPPELIUS A

Tumor antigen-specific FOXP3+ CD4 T cells identified in human metastatic melanoma: peptide vaccination results in selective expansion of Th1-like counterparts.
CANCER RESEARCH
2009 vol. 69(20) pp. 8085-8093
JANDUS C AND AL.

Relationship between gamma-interferon and interleukin-17 in Chlamydia trachomatis reactive arthritis.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
2009 vol. 27(5) pp. 885-886
BAS S, NEFF L, VIATTE S, VUILLET M, SPENATO U, GUERNE PA, MICHEL M, TIERCY JM, BUTRIMIENE I, GABAY C

HLA allele and haplotype frequencies in the Albanian population and their relationship with the other European populations.
INTERNATIONAL JOURNAL OF IMMUNOGENETICS
2009 vol. 36(6) pp. 337-343
SULCEBE G, SANCHEZ-MAZAS A, TIERCY JM, SHYTI E, MONE I, YLLI Z, KARDHASHI V

A bioinformatics approach to ascertaining the rarity of HLA alleles.
TISSUE ANTIGENS
2009 vol. 74(6) pp. 480-485
MIDDLETON D AND AL.

HLA-B51 and haplotypic diversity of B-Cw associations: implications for matching in unrelated hematopoietic stem cell transplantation.
TISSUE ANTIGENS
2009 vol. 73(4) pp. 316-325
BETTENS F, NICOLOSO DE FAVERI G, TIERCY JM

Sequence of a novel HLA-A2 allele in a haematopoietic stem cell donor of the international registry.
TISSUE ANTIGENS
2009 vol. 74(3) pp. 248-249
KERVAIRE B, SCHMIDT AH, VILLARD J, TIERCY JM

Natural killer cell receptor repertoire and their ligands, and the risk of CMV infection after kidney transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
2008 vol. 8(12) pp. 2674-2683
HADAYA K, DE RHAM C, BANDELIER C, BANDELIER CH, FERRARI-LACRAZ SYLVIE, JENDLY S, BERNEY T, BUHLER L, KAISER L, SEEBACH J, TIERCY JM, MARTIN PY, VILLARD J

A new HLA-DR4 allele, DRB1*0474, with an unusual residue at position 77.
TISSUE ANTIGENS
2008 vol. 72(5) pp. 500-501
DESAULES C, VILLARD J, TIERCY JM

DNA typing by microbead arrays and PCR-SSP: apparent false-negative or -positive hybridization or amplification signals disclose new HLA-B and -DRB1 alleles.
TISSUE ANTIGENS
2008 vol. 71(3) pp. 238-241
RAHAL M, KERVAIRE B, VILLARD J, TIERCY JM

The proinflammatory cytokines IL-2, IL-15 and IL-21 modulate the repertoire of mature human natural killer cell receptors
ARTHRITIS RESEARCH & THERAPY
2007 vol. 9(6) pp. 25-25
DE RHAM C, FERRARI-LACRAZ SYLVIE, JENDLY S, SCHNEITER G, DAYER JM, VILLARD J

The probability of identifying a 10/10 HLA allele-matched unrelated donor is highly predictable
BONE MARROW TRANSPLANTATION
2007 vol. 40 pp. 515-522
TIERCY JM, NICOLOSO G, PASSWEG J, SCHANZ U, SEGER R, CHALANDON Y, HEIM D, GUNGOR T, SCHNEIDER P, SCHWABE R, GRATWOHL A

Investigation of alloreactive NK cells in mixed lymphocyte reactions using paraformaldehyde-silenced target cells
JOURNAL OF IMMUNOLOGICAL METHODS
2007 vol. 321 pp. 196-199
ZENHAEUSERN G, GASSER O, SALEH L, VILLARD J, TIERCY JM, HESS C

Quality control for registry HLA data
TISSUE ANTIGENS
2007 vol. 69 pp. 13-14
TIERCY JM, FISCHER G, SETTERHOLM M

HLA and KIR polymorphisms affect NK-cell anti-tumor activity
TRENDS IN IMMUNOLOGY
2007 vol. 28 pp. 437-441
PASSWEG JR, HUARD B, TIERCY JM, ROOSNEK E

Acute humoral rejection in kidney allograft following a third-party arterial transplantation
AMERICAN JOURNAL OF TRANSPLANTATION
2006 vol. 6 pp. 3038-3039
FERRARI-LACRAZ S, BERNEY T, BEDNARKEWICZ M, BINET I, TIERCY JM, MARTIN PY, VILLARD J

Combined antiviral-immunosuppressive treatment in human T-lymphotrophic virus 1-Sjogren-associated myelopathy
ARCHIVES OF NEUROLOGY
2006 vol. 63 pp. 1318-1320
POT C, CHIZZOLINI C, VOKATCH N, TIERCY JM, RIBI C, LANDIS T, PERREN F

Human leukocyte antigen DR15 is associated with reduced relapse rate and improved survival after human leukocyte antigen-identical sibling hematopoietic stem cell transplantation
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
2006 vol. 12 pp. 1169-1175
STERN M, PASSWEG J, TIERCY JM, GENITSCH A, MEYER-MONARD S, HEIM D, TICHELLI A, GRATWOHL A, NISSEN-DRUEY C

Impact of high-resolution matching in allogeneic unrelated donor stem cell transplantation in Switzerland
BONE MARROW TRANSPLANTATION
2006 vol. 37 pp. 909-916
CHALANDON Y, TIERCY JM, SCHANZ U, GUNGOR T, SEGER R, HALTER J, HELG C, CHAPUIS B, GRATWOHL A, TICHELLI A, DE FAVERI GN, ROOSNEK E, PASSWEG J

Melan-A/MART-1-specific CD4 T cells in melanoma patients: identification of new epitopes and ex vivo visualization of specific T cells by MHC class II tetramers
JOURNAL OF IMMUNOLOGY
2006 vol. 177 pp. 6769-6779
BIOLEY G, JANDUS C, TUYAERTS S, RIMOLDI D, KWOK WW, SPEISER DE, TIERCY JM, THIELEMANS K, CEROTTINI JC, ROMERO P

Spontaneous CD8 T cell responses against the melanocyte differentiation antigen RAB38/NY-MEL-1 in melanoma patients
JOURNAL OF IMMUNOLOGY
2006 vol. 177 pp. 8212-8218
WALTON SM, GERLINGER M, DE LA ROSA O, NUBER N, KNIGHTS A, GATI A, LAUMER M, STRAUSS L, EXNER C, SCHAFER N, UROSEVIC M, DUNUNER R, TIERCY JM, MACKENSEN A, JAEGER E, LEVY F, KNUTH A

Fatal GvHD as a complication of liver transplantation for undetermined fulminant hepatic failure and associated aplastic anemia
LIVER TRANSPLANTATION : OFFICIAL PUBLICATION OF THE AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES AND THE INTERNATIONAL LIVER TRANSPLANTATION SOCIETY
2006 vol. 12(11) pp. 1693-1697
SCHAEPPI MICHELA, BELLI DOMINIQUE, RIMENSBERGER PETER, CHARDOT CHRISTOPHE, GÜRKAN KAYA, TIERCY JEAN-MARIE, OZSAHIN HULYA

HLA-C molecular characterization of a Lebanese population and genetic structure of 39 populations from Europe to India-Pakistan
TISSUE ANTIGENS
2006 vol. 68 pp. 44-57
BUHLER S, MEGARBANE A, LEFRANC G, TIERCY JM, SANCHEZ-MAZAS A

Association of TNFd and IL-10 polymorphisms with mortality in unrelated hematopoietic stem cell transplantation
TRANSPLANTATION
2006 vol. 81(9) pp. 1261-1267
BETTENS FLORENCE ET AL.

Isolated HLA-C mismatches in unrelated donor transplantation for CML
BONE MARROW TRANSPLANTATION
2004 vol. 34 pp. 249-255
TIERCY JEAN-MARIE, J. PASSWEG, A. VAN BIEZEN, A. ZANDER, N. KROGER, A. GRATWOHL, CHAPUIS BERNARD, HELG CLAUDINE, L. BRINCH, J. CORNELISSEN, M. OUDSHOORN, T. RUUTU, L.VOLIN, D. NIEDERWIESER, ROOSNEK EDDY

Polymorphic tumor necrosis factors microsatellite TNFa4 is associated with resistance of Hodgkin lymphoma to chemotherapy with replapses after therapy
ANTICANCER RESEARCH
2002 vol. 22 pp. 921-926
LIBURA J, BETTENS F, RADKOWSKI A, TIERCY JM, PIGUET PF

PCR-SSOP molecular typing of HLA-C alleles in an Iranian population
TISSUE ANTIGENS
2002 vol. 59 pp. 525-530
BUHLER S, SANCHEZ-MAZAS A, ZANONE R, DJAVAD N, TIERCY JM

Selection of unrelated bone marrow donors by serology, molecular typing, and cellular assays
TRANSPLANT IMMUNOLOGY
2002 vol. 10 pp. 215-221
TIERCY JM, VILLARD J, ROOSNEK E

Sequence of a new class I null allele within the HLA-B44 specificity
TISSUE ANTIGENS
2000 vol. 56 pp. 441-445
BETTENS F, TIERCY JEAN-MARIE

The molecular determination of HLA-Cw alleles in the Mandenka (West Africa) reveals a close genetic relationship between Africans and Europeans
TISSUE ANTIGENS
2000 vol. 56 pp. 303-312
SANCHEZ-MAZAS A, STEINER QUYNH-GIAO, GRUNDSCHOBER C, TIERCY JEAN-MARIE

Research's domains




DATABASE-RESEARCH	GROUP OF CLINICAL PATIENT RESEARCH

Jean-Marie TIERCY	Head of group CV	Research subject	Members of the group


	Links about the group Dr.J.-M. TIERCY CMU/ Dpt DEMED Lab. Immunologie Transplant. 1 rue Michel Servet 1211 Genève 4 Suisse Jean-marie.tiercy@unige.ch Tel.: 022/372.94.01 / 022/372.33.82 Fax: 022/372.93.90 Comments Pages updated the 17.11.2015		Reseach's subject \| Group's publications \| Research's domains Tissue compatibility and clinical transplantation * In clinical transplantation tissue compatibility is determined by genes of the major histocompatibility complex, the HLA sytem in man (Human Leucocyte Antigens). HLA class I (A, B, C) and class II (DR, DQ, DP) antigens are cell surface glycoproteins caracterized by a high degree of allelic polymorphism. Immune responses to incompatible HLA antigens are a major barrier to organ and hematopoietic stem cell transplantation. Polymorphism of the HLA system, initially analysed by serology (~100 serotypes), turned out to be much larger when molecular typing techniques were applied (> 1500 alleles defined by DNA sequencing). Thus two unrelated individuals that would be considered as HLA-compatible by serology might in fact differ by one or multiple HLA alleles when high resolution molecular typing is applied. These allelic incompatibilities are recognized by T lymphocytes and are therefore clinically relevant, particularly in transplantation with HSC from unrelated donors. Indeed post-transplant complications and mortality risk increase with the degree of patient/donor HLA mismatching. Our research projects concern the following five main areas : 1. Allelic polymorphism and haplotypic diversity of the HLA system The laboratory contributes to the caracterization of allelic polymorphism of the different HLA genes by cloning and sequencing new variants. Blood samples are provided by the LNRH (National Reference Laboratory for Histocompatibility, HUG) and by the Swiss Bone Marrow Donor Registry (Berne). Our major interest concerns the diversity of associations of HLA antigens (haplotypes) in the population, with a particular emphasis on HLA-B-Cw haplotypes. Since that diversity varies wih the serotypes and within different populations, there are important implications for the selection of HLA-compatible HSC donors. We are developping a database comprising the HLA-A/B/C/DRB1/B3/B5 haplotypes, with a priority given to the HLA-B serotypes that account for the most frequent incompatibilities (e.g. B35, B39, B44, B51). 2. HLA incompatibilities and hematopoietic stem cell transplantation (HSCT) The studies from our laboratory as well as those from other centers have shown the importance of HLA class I and II compatibility at the allelic level for allogenic HSCT. However the relative importance of each of the individual loci remains an unresolved issue. Based on the HLA incompatibilities detectd by molecular typing a clinical study of all allografts of HSC from unrelated donors performed in Switzerland is underway in collaboration with the transplant centers of Geneva (Pr. B. Chapuis), Basel (Pr. A. Gratwohl, Pr. J. Passweg), Zürich (Dr. U. Schanz) and Zürich-Kinderspital (Pr. R. Seger). 3. Other immunogenetic factors and HSCT Non-HLA immunogenetic factors, such as cytokine and cytokine receptor genes, and KIR genes (killer immunoglobulin-like receptor) (a collaboration with Pr. D. Middleton, Belfast) are analysed in the unrelated HSCT patient/donor combinations. The polymorphisms (SNPs and microsatellites) of TNF, IL-10, IL-1¿, IL-1Ra, and IL-4R are analysed. The HLA class I incompatibilities are recognized by CD8+ cytotoxic T lymphocytes (CTL), and this alloreactivity is measured in vitro by the CTLpf (CTL precursor frequency) assay. Non classical co-stimulation pathways (LIGHT, ICOS, CD134, CD137) that are potentially involved in recognition of HLA incompatibilities will be caracterized by RT-PCR on alloreactive lymphocytes. 4. Microchimerism and liver transplantation 5. HLA and population genetics Group's publications Cord blood banks collect units with different HLA alleles and haplotypes to volunteer donor banks: a comparative report from Swiss Blood stem cells. BONE MARROW TRANSPLANTATION 2009 vol. 43(10) pp. 771-778 MEYER-MONARD S AND AL. Modified tumour antigen-encoding mRNA facilitates the analysis of naturally occurring and vaccine-induced CD4 and CD8 T cells in cancer patients. CANCER IMMUNOLOGY IMMUNOTHERAPY 2009 vol. 58(3) pp. 325-338 KNIGHTS AJ, NUBER N, THOMSON CW, DE LA ROSA O, JÄGER E, TIERCY JM, VAN DEN BROEK M, PASCOLO S, KNUTH A, ZIPPELIUS A Tumor antigen-specific FOXP3+ CD4 T cells identified in human metastatic melanoma: peptide vaccination results in selective expansion of Th1-like counterparts. CANCER RESEARCH 2009 vol. 69(20) pp. 8085-8093 JANDUS C AND AL. Relationship between gamma-interferon and interleukin-17 in Chlamydia trachomatis reactive arthritis. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 2009 vol. 27(5) pp. 885-886 BAS S, NEFF L, VIATTE S, VUILLET M, SPENATO U, GUERNE PA, MICHEL M, TIERCY JM, BUTRIMIENE I, GABAY C HLA allele and haplotype frequencies in the Albanian population and their relationship with the other European populations. INTERNATIONAL JOURNAL OF IMMUNOGENETICS 2009 vol. 36(6) pp. 337-343 SULCEBE G, SANCHEZ-MAZAS A, TIERCY JM, SHYTI E, MONE I, YLLI Z, KARDHASHI V A bioinformatics approach to ascertaining the rarity of HLA alleles. TISSUE ANTIGENS 2009 vol. 74(6) pp. 480-485 MIDDLETON D AND AL. HLA-B51 and haplotypic diversity of B-Cw associations: implications for matching in unrelated hematopoietic stem cell transplantation. TISSUE ANTIGENS 2009 vol. 73(4) pp. 316-325 BETTENS F, NICOLOSO DE FAVERI G, TIERCY JM Sequence of a novel HLA-A2 allele in a haematopoietic stem cell donor of the international registry. TISSUE ANTIGENS 2009 vol. 74(3) pp. 248-249 KERVAIRE B, SCHMIDT AH, VILLARD J, TIERCY JM Natural killer cell receptor repertoire and their ligands, and the risk of CMV infection after kidney transplantation. AMERICAN JOURNAL OF TRANSPLANTATION 2008 vol. 8(12) pp. 2674-2683 HADAYA K, DE RHAM C, BANDELIER C, BANDELIER CH, FERRARI-LACRAZ SYLVIE, JENDLY S, BERNEY T, BUHLER L, KAISER L, SEEBACH J, TIERCY JM, MARTIN PY, VILLARD J A new HLA-DR4 allele, DRB1*0474, with an unusual residue at position 77. TISSUE ANTIGENS 2008 vol. 72(5) pp. 500-501 DESAULES C, VILLARD J, TIERCY JM DNA typing by microbead arrays and PCR-SSP: apparent false-negative or -positive hybridization or amplification signals disclose new HLA-B and -DRB1 alleles. TISSUE ANTIGENS 2008 vol. 71(3) pp. 238-241 RAHAL M, KERVAIRE B, VILLARD J, TIERCY JM The proinflammatory cytokines IL-2, IL-15 and IL-21 modulate the repertoire of mature human natural killer cell receptors ARTHRITIS RESEARCH & THERAPY 2007 vol. 9(6) pp. 25-25 DE RHAM C, FERRARI-LACRAZ SYLVIE, JENDLY S, SCHNEITER G, DAYER JM, VILLARD J The probability of identifying a 10/10 HLA allele-matched unrelated donor is highly predictable BONE MARROW TRANSPLANTATION 2007 vol. 40 pp. 515-522 TIERCY JM, NICOLOSO G, PASSWEG J, SCHANZ U, SEGER R, CHALANDON Y, HEIM D, GUNGOR T, SCHNEIDER P, SCHWABE R, GRATWOHL A Investigation of alloreactive NK cells in mixed lymphocyte reactions using paraformaldehyde-silenced target cells JOURNAL OF IMMUNOLOGICAL METHODS 2007 vol. 321 pp. 196-199 ZENHAEUSERN G, GASSER O, SALEH L, VILLARD J, TIERCY JM, HESS C Quality control for registry HLA data TISSUE ANTIGENS 2007 vol. 69 pp. 13-14 TIERCY JM, FISCHER G, SETTERHOLM M HLA and KIR polymorphisms affect NK-cell anti-tumor activity TRENDS IN IMMUNOLOGY 2007 vol. 28 pp. 437-441 PASSWEG JR, HUARD B, TIERCY JM, ROOSNEK E Acute humoral rejection in kidney allograft following a third-party arterial transplantation AMERICAN JOURNAL OF TRANSPLANTATION 2006 vol. 6 pp. 3038-3039 FERRARI-LACRAZ S, BERNEY T, BEDNARKEWICZ M, BINET I, TIERCY JM, MARTIN PY, VILLARD J Combined antiviral-immunosuppressive treatment in human T-lymphotrophic virus 1-Sjogren-associated myelopathy ARCHIVES OF NEUROLOGY 2006 vol. 63 pp. 1318-1320 POT C, CHIZZOLINI C, VOKATCH N, TIERCY JM, RIBI C, LANDIS T, PERREN F Human leukocyte antigen DR15 is associated with reduced relapse rate and improved survival after human leukocyte antigen-identical sibling hematopoietic stem cell transplantation BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 2006 vol. 12 pp. 1169-1175 STERN M, PASSWEG J, TIERCY JM, GENITSCH A, MEYER-MONARD S, HEIM D, TICHELLI A, GRATWOHL A, NISSEN-DRUEY C Impact of high-resolution matching in allogeneic unrelated donor stem cell transplantation in Switzerland BONE MARROW TRANSPLANTATION 2006 vol. 37 pp. 909-916 CHALANDON Y, TIERCY JM, SCHANZ U, GUNGOR T, SEGER R, HALTER J, HELG C, CHAPUIS B, GRATWOHL A, TICHELLI A, DE FAVERI GN, ROOSNEK E, PASSWEG J Melan-A/MART-1-specific CD4 T cells in melanoma patients: identification of new epitopes and ex vivo visualization of specific T cells by MHC class II tetramers JOURNAL OF IMMUNOLOGY 2006 vol. 177 pp. 6769-6779 BIOLEY G, JANDUS C, TUYAERTS S, RIMOLDI D, KWOK WW, SPEISER DE, TIERCY JM, THIELEMANS K, CEROTTINI JC, ROMERO P Spontaneous CD8 T cell responses against the melanocyte differentiation antigen RAB38/NY-MEL-1 in melanoma patients JOURNAL OF IMMUNOLOGY 2006 vol. 177 pp. 8212-8218 WALTON SM, GERLINGER M, DE LA ROSA O, NUBER N, KNIGHTS A, GATI A, LAUMER M, STRAUSS L, EXNER C, SCHAFER N, UROSEVIC M, DUNUNER R, TIERCY JM, MACKENSEN A, JAEGER E, LEVY F, KNUTH A Fatal GvHD as a complication of liver transplantation for undetermined fulminant hepatic failure and associated aplastic anemia LIVER TRANSPLANTATION : OFFICIAL PUBLICATION OF THE AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES AND THE INTERNATIONAL LIVER TRANSPLANTATION SOCIETY 2006 vol. 12(11) pp. 1693-1697 SCHAEPPI MICHELA, BELLI DOMINIQUE, RIMENSBERGER PETER, CHARDOT CHRISTOPHE, GÜRKAN KAYA, TIERCY JEAN-MARIE, OZSAHIN HULYA HLA-C molecular characterization of a Lebanese population and genetic structure of 39 populations from Europe to India-Pakistan TISSUE ANTIGENS 2006 vol. 68 pp. 44-57 BUHLER S, MEGARBANE A, LEFRANC G, TIERCY JM, SANCHEZ-MAZAS A Association of TNFd and IL-10 polymorphisms with mortality in unrelated hematopoietic stem cell transplantation TRANSPLANTATION 2006 vol. 81(9) pp. 1261-1267 BETTENS FLORENCE ET AL. Isolated HLA-C mismatches in unrelated donor transplantation for CML BONE MARROW TRANSPLANTATION 2004 vol. 34 pp. 249-255 TIERCY JEAN-MARIE, J. PASSWEG, A. VAN BIEZEN, A. ZANDER, N. KROGER, A. GRATWOHL, CHAPUIS BERNARD, HELG CLAUDINE, L. BRINCH, J. CORNELISSEN, M. OUDSHOORN, T. RUUTU, L.VOLIN, D. NIEDERWIESER, ROOSNEK EDDY Polymorphic tumor necrosis factors microsatellite TNFa4 is associated with resistance of Hodgkin lymphoma to chemotherapy with replapses after therapy ANTICANCER RESEARCH 2002 vol. 22 pp. 921-926 LIBURA J, BETTENS F, RADKOWSKI A, TIERCY JM, PIGUET PF PCR-SSOP molecular typing of HLA-C alleles in an Iranian population TISSUE ANTIGENS 2002 vol. 59 pp. 525-530 BUHLER S, SANCHEZ-MAZAS A, ZANONE R, DJAVAD N, TIERCY JM Selection of unrelated bone marrow donors by serology, molecular typing, and cellular assays TRANSPLANT IMMUNOLOGY 2002 vol. 10 pp. 215-221 TIERCY JM, VILLARD J, ROOSNEK E Sequence of a new class I null allele within the HLA-B44 specificity TISSUE ANTIGENS 2000 vol. 56 pp. 441-445 BETTENS F, TIERCY JEAN-MARIE The molecular determination of HLA-Cw alleles in the Mandenka (West Africa) reveals a close genetic relationship between Africans and Europeans TISSUE ANTIGENS 2000 vol. 56 pp. 303-312 SANCHEZ-MAZAS A, STEINER QUYNH-GIAO, GRUNDSCHOBER C, TIERCY JEAN-MARIE Research's domains