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Functionnal cardiac imaging.

Using a translational approach, our research groupżs interests are in MR imaging of molecular and cellular processes. Our uniqueness lies in the development of an imaging strategy based on clinical MRI systems for examining small animals, as well as using the same tools, systems and protocols for patients.

Cardiac Imaging

One long-standing area of research concerns cardiac imaging. We have developed several models of occlusion / reperfusion in rats to be able to image by MRI the effect and consequences of ischemia. We showed that it was possible to measure the area at risk in rat using manganese and to view, noninvasively, migration of monocytes to the site of a myocardial infarction. After validating a method for measuring function and size of myocardial infarction in mice, we investigate the potential of new contrast-based MRI with iron oxide for the evaluation of the inflammatory response in myocardial infarction.

Arthritis: NanoDiaRA project

A second line of research concerns molecular imaging with iron particles in MR imaging in rheumatoid arthritis based on the European project NanoDiaRA (FP7-NMP-2008-LARGE-2). This project aims to develop new contrast agents and diagnostic derivatives of iron oxide particles for the early diagnosis of rheumatoid arthritis and osteoarthritis. Our group leads the imaging component (Work Package 2) validating the development of new iron particles produced by the European partners of the consortium (The group is also partner in a European Commission 7th Framework Programme for Research project. The main objective of this large-scale integrating project is the development of modified superparamagnetic nanoparticles as a diagnostic tool for the detection of early stages of arthritis. In addition to research, the project will consider the social, ethical and legal aspects of applying nanotechnology for medical purposes. The University of Geneva is responsible for in-vivo imaging of the disease in small animal models using MRI and uCT. The detections and quantification of new iron oxide nanoparticle contrast agents, both non-specific and specific, are investigated to help with early diagnostics and possible drug delivery methods.)

Group's publications

Noninvasive stress testing of myocardial perfusion defects: head-to-head comparison of thallium-201 SPECT to MRI perfusion.
JOURNAL OF NUCLEAR CARDIOLOGY : OFFICIAL PUBLICATION OF THE AMERICAN SOCIETY OF NUCLEAR CARDIOLOGY
2009 vol. 16(4) pp. 549-561
VINCENTI G, NKOULOU R, STEINER C, IMPERIANO H, AMBROSIO G, MACH F, RATIB O, VALLEE JP, SCHINDLER TH

SNR enhancement of highly-accelerated real-time cardiac MRI acquisitions based on non-local means algorithm
MEDICAL IMAGE ANALYSIS
2009 vol. 13(4) pp. 598-608
NAEGEL B, CERNICANU A, HYACINTHE JN, TOGNOLINI M, VALLEE JP

The viability of kidneys tested by gadolinium-perfusion MRI during ex vivo perfusion
PROGRES EN UROLOGIE : JOURNAL DE L'ASSOCIATION FRANCAISE D'UROLOGIE ET DE LA SOCIETE FRANCAISE D'UROLOGIE
2009 vol. 19(5) pp. 307-312
BUCHS JB, LAZEYRAS F, BUHLER L, VALLEE JP, NASTASI A, RUTTIMANN R, MOREL P

Clinical magnetic resonance imaging of pancreatic islet grafts after iron nanoparticle labeling.
AMERICAN JOURNAL OF TRANSPLANTATION
2008 vol. 8(3) pp. 701-706
TOSO C, VALLEE JP, MOREL P, RIS F, DEMUYLDER-MISCHLER S, LEPETIT-COIFFE M, MARANGON NICOLA, SAUDEK F, JAMES SHAPIRO AM, BOSCO D, BERNEY T

Cine and tagged cardiovascular magnetic resonance imaging in normal rat at 1.5 T: a rest and stress study.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
2008 vol. 10(1) pp. 48-48
DAIRE JL, JACOB JP, HYACINTHE JN, CROISILLE P, MONTET-ABOU K, RICHTER S, BOTSIKAS D, LEPETIT-COIFFE M, MOREL D, VALLEE JP

In vivo myocardial infarct area at risk assessment in the rat using manganese enhanced magnetic resonance imaging (MEMRI) at 1.5T.
MAGNETIC RESONANCE IN MEDICINE : OFFICIAL JOURNAL OF THE SOCIETY OF MAGNETIC RESONANCE IN MEDICINE / SOCIETY OF MAGNETIC RESONANCE IN MEDICINE
2008 vol. 59(6) pp. 1422-1430
DAIRE JL, HYACINTHE JN, TATAR I, MONTET-ABOU K, IVANCEVIC MK, MASTERSON K, JORGE-COSTA M, MOREL DR, VALLEE JP

Feasibility of complementary spatial modulation of magnetization tagging in the rat heart after manganese injection.
NMR IN BIOMEDICINE
2008 vol. 21(1) pp. 15-21
HYACINTHE JN, IVANCEVIC MK, DAIRE JL, VALLEE JP

High-resolution complementary spatial modulation of magnetization (CSPAMM) rat heart tagging on a 1.5 Tesla Clinical Magnetic Resonance System: a preliminary feasibility study
INVESTIGATIVE RADIOLOGY
2007 vol. 42(3) pp. 204-210
IVANCEVIC MK, DAIRE JL, HYACINTHE JN, CRELIER G, KOZERKE S, MONTET-ABOU K, GUNES-TATAR I, MOREL DR, VALLEE JP

Improved visualization of vessels and hepatic tumors by micro-computed tomography (CT) using iodinated liposomes
INVESTIGATIVE RADIOLOGY
2007 vol. 42 pp. 652-658
MONTET X, PASTOR CM, VALLEE JP, BECKER CD, GEISSBUHLER A, MOREL DR, MEDA P

Comparative evaluation of active contour model extensions for automated cardiac MR image segmentation by regional error assessment
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
2007 vol. 20 pp. 69-82
NGUYEN, D, MASTERSON, K, VALLEE, JP

Coarctation of the aorta: pre and postoperative evaluation with MRI and MR angiography; correlation with echocardiography and surgery
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
2006 vol. 22 pp. 457-475
DIDIER D, SAINT-MARTIN C, LAPIERRE C, TRINDADE PT, LAHALAIDI N, VALLEE JP, KALANGOS A, FRIEDLI B, BEGHETTI M

Analysis of contrast-enhanced MR images to assess renal function
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
2006 vol. 19 pp. 167-179
MICHOUX N, VALEE JP, PECHERE-BERTSCHI A, MONTET X, BUEHLER L, VAN BEERS BE

Optimization of cardiac cine in the rat on a clinical 1.5-T MR system
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
2006 vol. 19 pp. 144-151
MONTET-ABOU K, DAIRE JL, IVANCEVIC MK, HYACINTHE JN, NGUYEN D, JORGE-COSTA M, MOREL DR, VALLEE JP

Bone motion analysis from dynamic MRI : acquisition and tracking
ACADEMIC RADIOLOGY
2005 vol. 12 pp. 1285-1292
B. GILLES, R. PERRIN, N. MAGNENAT-THALMANN, VALLEE JEAN-PAUL

Casimage project - A digital teaching file authoring environment
JOURNAL OF THORACIC IMAGING
2004 vol. 19 pp. 103-108
ROSSET A, MULLER H, MARTINS M, DFOUNI N, VALLEE JEAN-PAUL, RATIB OSMAN

Use of high flip angle in T1-prepared FAST sequences for myocardial perfusion quantification.
EUROPEAN RADIOLOGY
2003 vol. 13 pp. 507-514
VALLEE JP, IVANCEVIC MK, LAZEYRAS F, KASUBOSKI L., CHATELAIN P, RIGHETTI A, DIDIER D

Improvement in the quantification of myocardial perfusion using an automatic spline-based registration algorithm.
JOURNAL OF MAGNETIC RESONANCE IMAGING
2003 vol. 18 pp. 160-168
IVANCEVIC M.K., THEVENAZ P., VALLEE JP

Inflow effect in first-pass cardiac and renal MRI.
JOURNAL OF MAGNETIC RESONANCE IMAGING
2003 vol. 18 pp. 372-376
IVANCEVIC M.K., ZIMINE I., FOXALL D., LOCOQ G., RIGHETTI A, DIDIER D, VALLEE JP

Quantification of myocardial perfusion by MRI after coronary occlusion
MAGNETIC RESONANCE IN MEDICINE : OFFICIAL JOURNAL OF THE SOCIETY OF MAGNETIC RESONANCE IN MEDICINE / SOCIETY OF MAGNETIC RESONANCE IN MEDICINE
1998 vol. 40 pp. 287-297
VALLEE

Research's domains

ISCHEMIA
MRI
perfusion
IMAGE ANALYSE
HEART




DATABASE-RESEARCH	GROUP OF CLINICAL PATIENT RESEARCH

Jean-Paul VALLEE	Head of group CV	Research subject	Members of the group


	Links about the group Dr. J.-P.VALLEE HUG/ Dpt Radiologie Serv Radiodiagnostic Rue Gabrielle-Perret-Gentil 4 1211 Genève 14 Suisse jean-paul.vallee@hcuge.ch Tel.: 022/372.70.35 Fax: 022/372.70.72 Comments Pages updated the 17.11.2015		Reseach's subject \| Group's publications \| Research's domains Functionnal cardiac imaging. Using a translational approach, our research groupżs interests are in MR imaging of molecular and cellular processes. Our uniqueness lies in the development of an imaging strategy based on clinical MRI systems for examining small animals, as well as using the same tools, systems and protocols for patients. Cardiac Imaging One long-standing area of research concerns cardiac imaging. We have developed several models of occlusion / reperfusion in rats to be able to image by MRI the effect and consequences of ischemia. We showed that it was possible to measure the area at risk in rat using manganese and to view, noninvasively, migration of monocytes to the site of a myocardial infarction. After validating a method for measuring function and size of myocardial infarction in mice, we investigate the potential of new contrast-based MRI with iron oxide for the evaluation of the inflammatory response in myocardial infarction. Arthritis: NanoDiaRA project A second line of research concerns molecular imaging with iron particles in MR imaging in rheumatoid arthritis based on the European project NanoDiaRA (FP7-NMP-2008-LARGE-2). This project aims to develop new contrast agents and diagnostic derivatives of iron oxide particles for the early diagnosis of rheumatoid arthritis and osteoarthritis. Our group leads the imaging component (Work Package 2) validating the development of new iron particles produced by the European partners of the consortium (The group is also partner in a European Commission 7th Framework Programme for Research project. The main objective of this large-scale integrating project is the development of modified superparamagnetic nanoparticles as a diagnostic tool for the detection of early stages of arthritis. In addition to research, the project will consider the social, ethical and legal aspects of applying nanotechnology for medical purposes. The University of Geneva is responsible for in-vivo imaging of the disease in small animal models using MRI and uCT. The detections and quantification of new iron oxide nanoparticle contrast agents, both non-specific and specific, are investigated to help with early diagnostics and possible drug delivery methods.) Group's publications Noninvasive stress testing of myocardial perfusion defects: head-to-head comparison of thallium-201 SPECT to MRI perfusion. JOURNAL OF NUCLEAR CARDIOLOGY : OFFICIAL PUBLICATION OF THE AMERICAN SOCIETY OF NUCLEAR CARDIOLOGY 2009 vol. 16(4) pp. 549-561 VINCENTI G, NKOULOU R, STEINER C, IMPERIANO H, AMBROSIO G, MACH F, RATIB O, VALLEE JP, SCHINDLER TH SNR enhancement of highly-accelerated real-time cardiac MRI acquisitions based on non-local means algorithm MEDICAL IMAGE ANALYSIS 2009 vol. 13(4) pp. 598-608 NAEGEL B, CERNICANU A, HYACINTHE JN, TOGNOLINI M, VALLEE JP The viability of kidneys tested by gadolinium-perfusion MRI during ex vivo perfusion PROGRES EN UROLOGIE : JOURNAL DE L'ASSOCIATION FRANCAISE D'UROLOGIE ET DE LA SOCIETE FRANCAISE D'UROLOGIE 2009 vol. 19(5) pp. 307-312 BUCHS JB, LAZEYRAS F, BUHLER L, VALLEE JP, NASTASI A, RUTTIMANN R, MOREL P Clinical magnetic resonance imaging of pancreatic islet grafts after iron nanoparticle labeling. AMERICAN JOURNAL OF TRANSPLANTATION 2008 vol. 8(3) pp. 701-706 TOSO C, VALLEE JP, MOREL P, RIS F, DEMUYLDER-MISCHLER S, LEPETIT-COIFFE M, MARANGON NICOLA, SAUDEK F, JAMES SHAPIRO AM, BOSCO D, BERNEY T Cine and tagged cardiovascular magnetic resonance imaging in normal rat at 1.5 T: a rest and stress study. JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE 2008 vol. 10(1) pp. 48-48 DAIRE JL, JACOB JP, HYACINTHE JN, CROISILLE P, MONTET-ABOU K, RICHTER S, BOTSIKAS D, LEPETIT-COIFFE M, MOREL D, VALLEE JP In vivo myocardial infarct area at risk assessment in the rat using manganese enhanced magnetic resonance imaging (MEMRI) at 1.5T. MAGNETIC RESONANCE IN MEDICINE : OFFICIAL JOURNAL OF THE SOCIETY OF MAGNETIC RESONANCE IN MEDICINE / SOCIETY OF MAGNETIC RESONANCE IN MEDICINE 2008 vol. 59(6) pp. 1422-1430 DAIRE JL, HYACINTHE JN, TATAR I, MONTET-ABOU K, IVANCEVIC MK, MASTERSON K, JORGE-COSTA M, MOREL DR, VALLEE JP Feasibility of complementary spatial modulation of magnetization tagging in the rat heart after manganese injection. NMR IN BIOMEDICINE 2008 vol. 21(1) pp. 15-21 HYACINTHE JN, IVANCEVIC MK, DAIRE JL, VALLEE JP High-resolution complementary spatial modulation of magnetization (CSPAMM) rat heart tagging on a 1.5 Tesla Clinical Magnetic Resonance System: a preliminary feasibility study INVESTIGATIVE RADIOLOGY 2007 vol. 42(3) pp. 204-210 IVANCEVIC MK, DAIRE JL, HYACINTHE JN, CRELIER G, KOZERKE S, MONTET-ABOU K, GUNES-TATAR I, MOREL DR, VALLEE JP Improved visualization of vessels and hepatic tumors by micro-computed tomography (CT) using iodinated liposomes INVESTIGATIVE RADIOLOGY 2007 vol. 42 pp. 652-658 MONTET X, PASTOR CM, VALLEE JP, BECKER CD, GEISSBUHLER A, MOREL DR, MEDA P Comparative evaluation of active contour model extensions for automated cardiac MR image segmentation by regional error assessment MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE 2007 vol. 20 pp. 69-82 NGUYEN, D, MASTERSON, K, VALLEE, JP Coarctation of the aorta: pre and postoperative evaluation with MRI and MR angiography; correlation with echocardiography and surgery INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING 2006 vol. 22 pp. 457-475 DIDIER D, SAINT-MARTIN C, LAPIERRE C, TRINDADE PT, LAHALAIDI N, VALLEE JP, KALANGOS A, FRIEDLI B, BEGHETTI M Analysis of contrast-enhanced MR images to assess renal function MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE 2006 vol. 19 pp. 167-179 MICHOUX N, VALEE JP, PECHERE-BERTSCHI A, MONTET X, BUEHLER L, VAN BEERS BE Optimization of cardiac cine in the rat on a clinical 1.5-T MR system MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE 2006 vol. 19 pp. 144-151 MONTET-ABOU K, DAIRE JL, IVANCEVIC MK, HYACINTHE JN, NGUYEN D, JORGE-COSTA M, MOREL DR, VALLEE JP Bone motion analysis from dynamic MRI : acquisition and tracking ACADEMIC RADIOLOGY 2005 vol. 12 pp. 1285-1292 B. GILLES, R. PERRIN, N. MAGNENAT-THALMANN, VALLEE JEAN-PAUL Casimage project - A digital teaching file authoring environment JOURNAL OF THORACIC IMAGING 2004 vol. 19 pp. 103-108 ROSSET A, MULLER H, MARTINS M, DFOUNI N, VALLEE JEAN-PAUL, RATIB OSMAN Use of high flip angle in T1-prepared FAST sequences for myocardial perfusion quantification. EUROPEAN RADIOLOGY 2003 vol. 13 pp. 507-514 VALLEE JP, IVANCEVIC MK, LAZEYRAS F, KASUBOSKI L., CHATELAIN P, RIGHETTI A, DIDIER D Improvement in the quantification of myocardial perfusion using an automatic spline-based registration algorithm. JOURNAL OF MAGNETIC RESONANCE IMAGING 2003 vol. 18 pp. 160-168 IVANCEVIC M.K., THEVENAZ P., VALLEE JP Inflow effect in first-pass cardiac and renal MRI. JOURNAL OF MAGNETIC RESONANCE IMAGING 2003 vol. 18 pp. 372-376 IVANCEVIC M.K., ZIMINE I., FOXALL D., LOCOQ G., RIGHETTI A, DIDIER D, VALLEE JP Quantification of myocardial perfusion by MRI after coronary occlusion MAGNETIC RESONANCE IN MEDICINE : OFFICIAL JOURNAL OF THE SOCIETY OF MAGNETIC RESONANCE IN MEDICINE / SOCIETY OF MAGNETIC RESONANCE IN MEDICINE 1998 vol. 40 pp. 287-297 VALLEE Research's domains ISCHEMIA MRI perfusion IMAGE ANALYSE HEART