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BASE DE DONNÉES-RECHERCHE | |
GROUPE DE RECHERCHE CLINIQUE ORIENTEE BIOLOGIE | ||||
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Pedro HERRERA | CV du Chef de Groupe | Sujet de Recherche | Composition du Groupe | |||
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Coordonnées du groupe
Dr. P. HERRERA CMU / Dpt GEDEV Rue Michel-Servet 1 1211 Genève 4 Suisse Tél.: 022 379 52 25 Fax: 022 379 52 60 Commentaires Pages générées le 07.05.2013 |
Sujet de recherche
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Publications du groupe
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Domaines de recherche
Mécanismes impliqués dans la spécification et la détermination des différents types cellulaires pancréatiques pendant l'ontogenèse.
Nous étudions les mécanismes impliqués dans la spécification et la détermination des différents types cellulaires pancréatiques pendant l'ontogenèse. En particulier, nous sommes intéressés à
l'origine des cellules produisant l'insuline. Ces études sont réalisées grâce à la production de souris transgéniques, dans le cadre de 3 projets différents. 1) Dans le but d'étudier les lignages
cellulaires des îlots de Langerhans, nous marquons les cellules progénitrices, dans des souris doublement transgéniques, avec le système Cre / loxP. En effet, il est possible marquer des cellules souches
irréversiblement (génétiquement) avec l'activité de la recombinase Cre. Le gène rapporteur (portant les séquences loxP) ainsi modifié est ensuite analysé dans les îlots adultes. 2)Les cellules en voie de
différenciation doivent faire des choix qui sont déterminés, en partie au moins, par la voie de signalisation de Notch. Nous avons généré plusieurs lignées de souris dans lesquelles Notch1 a été
inactivé sélectivement dans un ou plusieurs types cellulaires pancréatiques. 3) La capacité de régénération de nouveaux îlots dans le pancréas adulte est étudiée et comparée aux processus, déjà connus en
partie, prenant place au cours du développement embryonnaire.
Publications du groupe Insulin Signaling in alpha Cells Modulates Glucagon Secretion In Vivo CELL METABOLISM 2009 vol. 9(4) pp. 350-361 KAWAMORI D, KURPAD AJ, HU H, SHIH JL, FORD E, HERRERA PL, POLONSKY KS, MCGUINESS OP, KULKARNI RN Pancreatic neurogenin 3-expressing cells are unipotent islet precursors DEVELOPMENT 2009 vol. 136(21) pp. 3567-3574 DESGRAZ R, HERRERA PL Transgenic and other experimental models of pancreas and islet damage. DIABETES, OBESITY AND METABOLISM 2009 vol. 11 pp. 91-96 HERRERA PL Pancreatic Inactivation of c-Myc Decreases Acinar Mass and Transdifferentiates Acinar Cells Into Adipocytes in Mice GASTROENTEROLOGY 2009 vol. 136(1) pp. 309-319 BONAL C, THOREL F, AITLOUNIS A, REITH W, TRUMMP A, HERRERA PL Deletion of Glutamate Dehydrogenase in beta-Cells Abolishes Part of the Insulin Secretory Response Not Required for Glucose Homeostasis JOURNAL OF BIOLOGICAL CHEMISTRY 2009 vol. 284(2) pp. 921-929 CAROBBIO S, FRIGERIO F, RUBI BLANCA, VETTERLI L, BLOKSGAARD M, GJINOVCI A, POURNOURMOHAMMADI S, HERRERA PL, REITH W, MANDRUP S, MAECHLER P Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice JOURNAL OF CLINICAL INVESTIGATION 2009 vol. 119(1) pp. 125-135 CANTLEY J AND AL. Experimental models of beta-cell regeneration. BIOCHEMICAL SOCIETY TRANSACTIONS 2008 vol. 36(Pt 3) pp. 286-289 BONAL C, AVRIL I, HERRERA PL A new conditional mouse mutant reveals specific expression and functions of connexin36 in neurons and pancreatic beta-cells. EXPERIMENTAL CELL RESEARCH 2008 vol. 314(5) pp. 997-1012 WELLERSHAUS K, DEGEN J, DEUCHARS J, THEIS M, CHAROLLAIS A, CAILLE D, GAUTHIER BENOIT, JANSSEN-BIENHOLD U, SONNTAG S, HERRERA PEDRO, MEDA P, WILLECKE K Peripheral tolerance limits CNS accumulation of CD8 T cells specific for an antigen shared by tumor cells and normal astrocytes. GLIA 2008 vol. 56(15) pp. 1625-1636 CALZASCIA T, LOH JM, DI BERARDINO-BESSON W, MASSON F, GUILLAUME P, BURKHARDT K, HERRERA PL, DIETRICH PY, WALKER PR Genes controlling pancreas ontogeny. INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY 2008 vol. 52(7) pp. 823-835 BONAL C, HERRERA PL Role of furin in granular acidification in the endocrine pancreas: identification of the V-ATPase subunit Ac45 as a candidate substrate. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2008 vol. 105(34) pp. 12319-12324 LOUAGIE T AND AL. Understanding the extrinsic and intrinsic signals involved in pancreas and beta-cell development: from endoderm to beta cells CURRENT OPINION IN ORGAN TRANSPLANTATION 2007 vol. 12 pp. 40-48 BONAL C, HERRERA PL Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas DEVELOPMENT 2007 vol. 134 pp. 2719-2725 STROM A, BONAL C, ASHERY-PADAN R, HASHIMOTO N, CAMPOS ML, TRUMPP A, NODA T, KIDO Y, REAL FX, THOREL F, HERRERA PL Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species DIABETOLOGIA 2007 vol. 50 pp. 84-93 PRODUIT-ZENGAFFINEN N, DAVIS-LAMELOISE N, PERRETEN H, BECARD D, GJINOVCI A, KELLER PA, WOLLHEIM CB, HERRERA P, MUZZIN P, ASSIMACOPOULOS-JEANNET F Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice DIABETOLOGIA 2007 vol. 50 pp. 1248-1256 CANTLEY J, CHOUDHURY AI, ASARE-ANANE H, SELMAN C, LINGARD S, HEFFRON H, HERRERA P, PERSAUD SJ, WITHERS DJ The GluCre-ROSA26EYFP mouse: A new model for easy identification of living pancreatic alpha-cells FEBS LETTERS 2007 vol. 581 pp. 4235-4240 QUOIX N, CHENG-XUE R, GUIOT Y, HERRERA PL, HENQUIN JC, GILON P Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression JOURNAL OF CLINICAL INVESTIGATION 2007 vol. 117 pp. 961-970 COLLOMBAT P, HECKSHER-SORENSEN J, KRULL J, BERGER J, RIEDEL D, HERRERA PL, SERUP P, MANSOURI A Activation of the Reg family genes by pancreatic-specific IGF-I gene deficiency and after streptozotocin-induced diabetes in mouse pancreas AMERICAN JOURNAL OF PHYSIOLOGY. ENDOCRINOLOGY AND METABOLISM 2006 vol. 291(1) pp. 50-58 LU Y, PONTON A, OKAMOTO H, TAKASAWA S, HERRERA PL, LIU JL Stabilization of beta-catenin impacts pancreas growth DEVELOPMENT 2006 vol. 133(10) pp. 2023-2032 HEISER P, LAU J, TAKETO MM, HERRERA PL, HEBROK M An amylase/Cre transgene marks the whole endoderm but the primordia of liver and ventral pancreas GENESIS 2006 vol. 44 pp. 287-296 KOCKEL L, STROM A, DELACOUR A, NEPOTE V, HAGENBUCHLE O, WELLAUER PK, HERRERA PL Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass NATURE GENETICS 2006 vol. 38(5) pp. 589-593 HASHIMOTO N. ET AL. Foxa2 is required for the differentiation of pancreatic alpha-cells DEVELOPMENTAL BIOLOGY 2005 vol. 278 pp. 484-495 LEE C.S., SUND N.J., BEHR R., HERRERA P.L., KAESTNER K.H. Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis. DIABETOLOGIA 2005 vol. 48(11) pp. 2313-2321 RIGGS AC, BERNAL-MIZRACHI E, OHSUGI M, WASSON J, FATRAI S, WELLING C, MURRAY J, SCHMIDT RE, HERRERA PL, PERMUTT MA Junctional Adhesion Molecule-C regulates the early influx of leukocytes into tissues during inflammation JOURNAL OF IMMUNOLOGY 2005 vol. 174 pp. 6406-6415 AURRAND-LIONS MICHEL, LAMAGNA CHRYSTELLE, DANGERFIELD JP, WANG S, HERRERA PEDRO, NOURSHARGH S, IMHOF BEAT Pax2 mutant mice display increased number and size of islets of Langerhans but no change in insulin and glucagon content. EUROPEAN JOURNAL OF ENDOCRINOLOGY 2004 vol. 150 pp. 389-395 ZAIKO MAIA, ANNE ESTREICHER, RITZ BEATE, HERRERA PEDRO, JACK FAVOR, MEDA PAOLO, PHILIPPE JACQUES Replacement by a lacZ reporter gene assigns mouse connexin36, 45 and 43 to distinct cell types in pancreatic islets. EXPERIMENTAL CELL RESEARCH 2004 vol. 294 pp. 18-29 MARTIN THEIS, MAS CHRISTOPHE, BRITTA DÖRING, JOACHIM DEGEN, CHRISTOPHER BRINK, DOROTHEE CAILLE, CHAROLLAIS ANNE, OLAF KRÜGER, ACHIM PLUM, NEPOTE VIRGINE, HERRERA PEDRO, MEDA PAOLO, KLAUS WILLECKE Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells. NATURE CELL BIOLOGY 2003 vol. 5 pp. 330-335 ISHIHARA H, MAECHLER P, GJINOVCI A, HERRERA PL, WOLLHEIM CB Reduced PTEN expression in the pancreas overexpressing transforming growth factor-beta 1. BRITISH JOURNAL OF CANCER 2002 vol. 86(2) pp. 257-262 EBERT MP, FEI G, SCHANDL L, MAWRIN C, DIETZMANN K, HERRERA PL, FRIESS H, GRESS T, MALFERTHEINER P Experimental models of transcription factor-associated maturity-onset diabetes of the young. DIABETES 2002 vol. 51 pp. 333-342 WANG H, HAGENFELDT-JOHANSSON K, LUC A. OTTEN, GAUTHIER BR, HERRERA PL, WOLLHEIM CB Pancreatic cell lineage analysis in mice ENDOCRINE 2002 vol. 19 pp. 267-278 HERRERA PL, NEPOTE V, DELACOUR A Generation of Smad4/Dpc4 conditional knockout mice. GENESIS 2002 vol. 32(2) pp. 80-81 YANG X, LI C, HERRERA PL, DENG CX Defining the cell lineages of the islets of Langerhans using transgenic mice. INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY 2002 vol. 46(1) pp. 97-103 HERRERA PL Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor. JOURNAL OF CLINICAL INVESTIGATION 2002 vol. 110(7) pp. 1011-1019 XUAN S, KITAMURA T, NAKAE J., POLITI K, KIDO Y, FISCHER P.E., MORRONI M, CINTI S, WHITE M.F., HERRERA PL, ACCILI D, EFSTRATIADIS A. ß-cell-targeted expression of a dominant-negative hepatocyte nuclear factor-1a induces a maturity-onset diabetes of the young (MODY)3-like phenotype in transgenic mice ENDOCRINOLOGY 2001 vol. 142 pp. 5311-5320 HAGENFELDT-JOHANSSON KA, HAGENFELDT J, HERRERA PL, WANG H, GJINOVCI A, ISHIHARA H, WOLLHEIM CB Two transgenic approaches to define the cell lineages in endocrine pancreas development MOLECULAR AND CELLULAR ENDOCRINOLOGY 1998 vol. 140 pp. 45-50 HERRERA PL, ORCI L, VASSALLI JD TGF-beta 1 influences the relative development of the exocrine and endocrine pancreas in vitro DEVELOPMENT 1994 vol. 120 pp. 3451-3462 SANVITO F, HERRERA PL, HUARTE J, NICHOLS A, ORCI L, VASSALLI JD A CD8+ T-lymphocyte-mediated and CD4+ T-lymphocyte-independent autoimmune diabetes of early onset in transgenic mice DIABETOLOGIA 1994 vol. 37 pp. 1277-1279 HERRERA PL, HARLAN DM, FOSSATI L, IZUI S, HUARTE J, ORCI L, VASSALLI JD, VASSALLI P Induction of diabetes is influenced by the infectious virus and local expression of MHC class I and tumor necrosis factor-alpha JOURNAL OF IMMUNOLOGY 1993 vol. 150 pp. 11- OHASHI PS, OEHEN S, AICHELE P, PIRCHER H, ODERMATT B, HERRERA PL, HIGUCHI Y, BUERKI K, HENGARTNER H, ZINKERNAGEL RM Domaines de recherche BIOLOGIE MOLECULAIRE EMBRYOGENESE ONTOGENESE METABOLISME |