DATABASE-RESEARCH | GROUP OF CLINICAL PATIENT RESEARCH | ||||||
L. BUHLER et Ph. MOREL | Head of group CV | Research subject | Members of the group |
Links about the group
Pr. L. BÜHLER HUG/ Dpt Chirurgie Serv. Chirurgie Viscérale Rue Gabrielle-Perret-Gentil 4 1211 Genève 14 Suisse Leo.Buhler@hcuge.ch Tel.: 022/ 372 76 98 Fax: 022/ 372 76 89 Comments Pages updated the 17.11.2015 |
Reseach's subject
|
Group's publications
|
Research's domains
Cell cultures and transplantation
Availability of human organ donors has become extremely limited and other sources of organs must be investigated. Cell transplantation could become an alternative for the metabolic support of
patients with acute or chronic liver failure. The aims of our projects are i) to evaluate the potential of primary or immortalized hepatocyte transplantation for treatment of acute liver failure, by using
micro-encapsulation methods, and ii) to evaluate the potential of adult mesenchymal stem cell transdifferentiation into hepatocytes for treatment of chronic liver failure.Based on the extensive research
and clinical experience in the field of islet cell transplantation performed at our laboratory, we have developed rodent and human hepatocyte isolation, microencapsulation and transplantation. In
collaboration with the laboratory of Didier Trono, human hepatocytes were immortalized using lentiviral vectors. Primary rat or immortalized human hepatocytes were encapsulated and transplanted into mice
with acetaminophen-induced acute liver failure, allowing significant increase of survival. We plan to test function and survival of encapsulated hepatocyte transplantation in large animal models of
acute liver failure.
We have established isolation and culture of mouse and human adult mesenchymal stem cells. We will test new culture conditions of mesenchymal stem cells to improve the expansion capacity and
differentiation into hepatocyte-like cells. We plan to measure gene expression of mouse and human mesenchymal stem cells during in vitro differentiation into hepatocyte-like cells by RNA-microarrays.
Hepatocyte-like cells will be transplanted into Fumaryl-acetoacetate-hydroalse deficient mice to study engraftment and regeneration of chronic liver failure. Furthermore, we will investigate the capacity of
immunoregulation in vitro by performing mixed lymphocyte reactions with co-cultures of antigen presenting cells, T cells and mesenchymal stem cells at various time points of differentiation into
hepatocyte-like cells. Finally, we will study the immumodulatory characteristics of mesenchymal stem cells in vivo by performing allo and xenotransplantation experiments into immunodeficient and
immunocompetent mice.These projects have the potential of developing new strategies to treat liver failure and will evaluate new sources of tissues for transplantation.
Group's publications Natural killer cell receptor--repertoire and functions after induction therapy by polyclonal rabbit anti-thymocyte globulin in unsensitized kidney transplant recipients. CLINICAL IMMUNOLOGY 2010 vol. 137(2) pp. 250-260 HADAYA K, AVILA Y, VALLOTON L, DE RHAM C, BANDELIER C, FERRARI-LACRAZ S, PASCUAL M, PANTALEO G, MARTIN PY, BUHLER L, VILLARD J Peroxisome proliferator-activated receptor alpha (PPARalpha) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism. DIABETOLOGIA 2010 vol. 53(2) pp. 331-340 FRIGERIO F, BRUN T, BARTLEY C, USARDI A, BOSCO D, RAVNSKJAER K, MANDRUP S, MAECHLER P HVEM/LIGHT/BTLA/CD160 cosignaling pathways as targets for immune regulation. JOURNAL OF LEUKOCYTE BIOLOGY 2010 vol. 87(2) pp. 223-235 DEL RIO ML, LUCAS CL, BUHLER LH, RAYAT G, RODRIGUEZ-BARBOSA JI Hepatitis C virus infection after liver transplantation is associated with lower levels of activated CD4(+)CD25(+)CD45RO(+)IL-7ralpha(high) T cells. LIVER TRANSPLANTATION : OFFICIAL PUBLICATION OF THE AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES AND THE INTERNATIONAL LIVER TRANSPLANTATION SOCIETY 2010 vol. 16(1) pp. 49-55 CIUFFREDA D, CODARRI L, BUHLER L, VALLOTTON L, GIOSTRA E, MENTHA G, MOREL P, PANTALEO G, PASCUAL M Expression of the hepatic Niemann-Pick C1 like 1 protein gene is sensitive to rosuvastatin treatment of primary human hepatocytes. PHARMACOGENETICS AND GENOMICS 2010 vol. 20(7) pp. 455-458 BRULHART, DEAKIN S, SGROI A, BUHLER L, JAMES RW Anti-CD154 mAb and rapamycin induce T regulatory cell mediated tolerance in rat-to-mouse islet transplantation. PLOS ONE 2010 vol. 5(4) pp. 10352-10352 MULLER YD AND AL. Magnetic resonance imaging as the sole radiological assessment for living donor nephrectomy. UROLOGIA INTERNATIONALIS 2010 vol. 84(1) pp. 56-60 FLEURY N, VALLEE JP, HADAYA K, BUHLER LH, MARTIN PY, ISELIN C Vascular invasion in pancreatic cancer: Imaging modalities, preoperative diagnosis and surgical management. WORLD JOURNAL OF GASTROENTEROLOGY 2010 vol. 16(7) pp. 818-831 BUCHS NC, CHILCOTT M, POLETTI PA, BUHLER LH, MOREL P Transplantation of mouse embryonic stem cells induces hematopoietic and tissue chimerism in rats. XENOTRANSPLANTATION 2010 vol. 17(5) pp. 362-369 BAERTSCHIGER RM, GONELLE-GISPERT C, MOREL P, SGROI A, SERRE-BEINIER V, STOUFFS M, JACONI M, BUHLER LH Long-term insulin-independence after allogeneic islet transplantation for type 1 diabetes: over the 10-year mark. AMERICAN JOURNAL OF TRANSPLANTATION 2009 vol. 9(2) pp. 419-423 BERNEY T, FERRARI-LACRAZ SYLVIE, BUEHLER LH, OBERHOLZER J, MARANGON NICOLA, PHILIPPE J, VILLARD J, MOREL P Renal and cardiac endothelial heterogeneity impact acute vascular rejection in pig-to-baboon xenotransplantation. AMERICAN JOURNAL OF TRANSPLANTATION 2009 vol. 9(5) pp. 1006-1016 KNOSALLA C AND AL. Improved survival of fulminant liver failure by transplantation of microencapsulated cryopreserved porcine hepatocytes in mice. CELL TRANSPLANTATION 2009 vol. 18(1) pp. 101-110 MEI J, SGROI A, MAI G, BAERTSCHIGER RM, GONELLE-GISPERT C, SERRE-BEINIER V, MOREL P, BUHLER LH Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes. HEPATOLOGY 2009 vol. 49(4) pp. 1176-1184 VINCIGUERRA M, SGROI A, VEYRAT-DUREBEX C, RUBBIA-BRANDT L, BUHLER LH, FOTI M Cx36 makes channels coupling human pancreatic beta-cells and correlates with insulin expression HUMAN MOLECULAR GENETICS 2009 vol. 18(3) pp. 428-439 SERRE-BEINIER V AND AL. Fibrogenic potential of human multipotent mesenchymal stromal cells in injured liver. PLOS ONE 2009 vol. 4(8) pp. 6657-6657 BAERTSCHIGER RM, SERRE-BEINIER V, MOREL P, BOSCO D, PEYROU M, CLEMENT S, SGROI A, KAELIN A, BUHLER LH, GONELLE-GISPERT C The viability of kidneys tested by gadolinium-perfusion MRI during ex vivo perfusion PROGRES EN UROLOGIE : JOURNAL DE L'ASSOCIATION FRANCAISE D'UROLOGIE ET DE LA SOCIETE FRANCAISE D'UROLOGIE 2009 vol. 19(5) pp. 307-312 BUCHS JB, LAZEYRAS F, BUHLER L, VALLEE JP, NASTASI A, RUTTIMANN R, MOREL P Immunomodulation by blockade of the TRANCE co-stimulatory pathway in murine allogeneic islet transplantation TRANSPLANT INTERNATIONAL 2009 vol. 22(9) pp. 931-939 WOJTUSCISZYN A, ANDRES A, MOREL P, CHARVIER S, ARMANET M, TOSO C, CHOI Y, BOSCO D, BERNEY T What clinical alternatives to whole liver transplantation? Current status of artificial devices and hepatocyte transplantation. TRANSPLANTATION 2009 vol. 87(4) pp. 457-466 SGROI A, SERRE-BEINIER V, MOREL P, BUHLER LH T regulatory cells in xenotransplantation. XENOTRANSPLANTATION 2009 vol. 16(3) pp. 121-128 MULLER Y, GOLSHAYAN D, EHIRCHIOU D, WEKERLE T, SEEBACH JD, BUHLER LH Natural killer cell receptor repertoire and their ligands, and the risk of CMV infection after kidney transplantation. AMERICAN JOURNAL OF TRANSPLANTATION 2008 vol. 8(12) pp. 2674-2683 HADAYA K, DE RHAM C, BANDELIER C, BANDELIER CH, FERRARI-LACRAZ SYLVIE, JENDLY S, BERNEY T, BUHLER L, KAISER L, SEEBACH J, TIERCY JM, MARTIN PY, VILLARD J Polyfunctional HCV-specific T-cell responses are associated with effective control of HCV replication. EUROPEAN JOURNAL OF IMMUNOLOGY 2008 vol. 38(10) pp. 2665-2677 CIUFFREDA D AND AL. Monocyte chemoattractant protein-1 secreted by adipose tissue induces direct lipid accumulation in hepatocytes. HEPATOLOGY 2008 vol. 48(3) pp. 799-807 CLEMENT S, JUGE-AUBRY CRISTIANA, SGROI A, CONZELMAN S, PAZIENZA VALERIO, PITTET-CUENOD B, MEIER CA, NEGRO F The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1. HUMAN MOLECULAR GENETICS 2008 vol. 17(4) pp. 478-489 BRUN T, HE KH, LUPI R, BOEHM B, WOJTUSCISZYN A, SAUTER N, DONATH M, MARCHETTI P, MAEDLER K, GAUTHIER BR Mesenchymal stem cells derived from human exocrine pancreas express transcription factors implicated in beta-cell development. PANCREAS 2008 vol. 37(1) pp. 75-84 BAERTSCHIGER RM, BOSCO D, MOREL P, SERRE-BEINIER V, BERNEY T, BUHLER LH, GONELLE-GISPERT C Proteomic profiling in an animal model of acute pancreatitis. PROTEOMICS 2008 vol. 8(17) pp. 3621-3631 FETAUD V, FROSSARD JL, FARINA A, PASTOR CM, BUHLER L, DUMONCEAU JM, HADENGUE A, HOCHSTRASSER DENIS, LESCUYER P PD-1/PD-L1, PD-1/PD-L2, and other co-inhibitory signaling pathways in transplantation. TRANSPLANT INTERNATIONAL 2008 vol. 21(11) pp. 1015-1028 DEL RIO ML, BUHLER LH, GIBBONS C, TIAN J, RODRIGUEZ-BARBOSA JI Computer-assisted digital image analysis to quantify the mass and purity of isolated human islets before transplantation. TRANSPLANTATION 2008 vol. 86(11) pp. 1603-1609 NICLAUSS N, SGROI A, MOREL P, BAERTSCHIGER RETO, ARMANET M, WOJTUSCISZYN A, PARNAUD G, MULLER VIRGINIE, BERNEY T, BOSCO D Xenotransplantation literature update January-February, 2008. XENOTRANSPLANTATION 2008 vol. 15(3) pp. 200-204 BAERTSCHIGER RM, BUHLER L Xenotransplantation literature update March-April, 2008. XENOTRANSPLANTATION 2008 vol. 15(4) pp. 277-280 BAERTSCHIGER RM, BUHLER L Xenotransplantation literature update November-December, 2007. XENOTRANSPLANTATION 2008 vol. 15(2) pp. 145-149 BAERTSCHIGER RM, BUHLER L Xenotransplantation literature update September-October, 2007. XENOTRANSPLANTATION 2008 vol. 15(1) pp. 64-67 BAERTSCHIGER RM, BUHLER L Le Vacuum Assisted Closure : utilité dans le traitement des plaies abdomino-périnéales complexes JOURNAL DE CHIRURGIE 2007 vol. 144(3) pp. 209-213 DURMISHI Y, GERVAZ P, BÜHLER L, BUCHER P, ZUFFEREY G, AL-MAZROUEI A, MOREL PH Expansion and tissue infiltration of an allospecific CD4(+)CD25(+)CD45RO(+)IL-7R alpha(high) cell population in solid organ transplant recipients JOURNAL OF EXPERIMENTAL MEDICINE 2007 vol. 204 pp. 1533-1541 CODARRI, L, VALLOTTON, L, CIUFFREDA, D, VENETZ, JP, GARCIA, M, HADAYA, K, BUHLER, L, ROTMAN, S, PASCUAL, M, PANTALEO, G Characterization of endothelial-like cells derived from human mesenchymal stem cells JOURNAL OF THROMBOSIS AND HAEMOSTASIS 2007 vol. 5 pp. 826-834 LIU JW, DUNOYER-GEINDRE S, SERRE-BEINIER V, MAI G, LAMBERT JF, FISH RJ, PERNOD G, BUEHLER L, BOUNAMEAUX H, KRUITHOF EKO Microarray analyses and molecular profiling of steatosis induction in immortalized human hepatocytes LABORATORY INVESTIGATION 2007 vol. 87 pp. 792-806 DE GOTTARDI, A, VINCIGUERRA, M, SGROI, A, MOUKIL, M, RAVIER-DALL'ANTONIA, F, PAZIENZA, V, PUGNALE, P, FOTI, M, HADENGUE, A Renal ischaemic injuries during the use of zolmitriptan for treatment of migraines in a transplanted patient under tacrolimus therapy NEPHROLOGY DIALYSIS TRANSPLANTATION 2007 vol. 22 pp. 3341-3343 MALACARNE S, MOLL S, HADAYA K, BUHLER L, MARTIN PY Vascular invasion in pancreatic cancer - Evaluation of endoscopic ultrasonography, computed tomography, ultrasonography, and angiography SWISS MEDICAL WEEKLY 2007 vol. 137 pp. 286-291 BUCHS NC, FROSSARD JL, ROSSET A, CHILCOTT M, KOUTNY-FONG P, CHASSOT G, FASEL JHD, POLETTI PA, BECKER CD, MENTHA G, BÜHLER L, MOREL P From current immunosuppressive strategies to clinical tolerance of allografts TRANSPLANT INTERNATIONAL 2007 vol. 20 pp. 12-24 GOLSHAYAN, D, BUHLER, L, LECHLER, RI, PASCUAL, M Successful treatment of recurrent focal segmental glomerulosclerosis after kidney transplantation by plasmapheresis and rituximab TRANSPLANT INTERNATIONAL 2007 vol. 20 pp. 102-105 HRISTEA, D, HADAYA, K, MARANGON, N, BUHLER, L, VILLARD, J, MOREL, P, MARTIN, PY Blockade of the PD-1/PD-1L pathway reverses the protective effect of anti-CD40L therapy in a rat to mouse concordant islet xenotransplantation model XENOTRANSPLANTATION 2007 vol. 14 pp. 243-248 MAI, G, DEL RIO, ML, TIAN, J, RAMIREZ, P, BUHLER, L, RODRIGUEZ-BARBOSA, JI Xenotransplantation literature update, March-April 2007 XENOTRANSPLANTATION 2007 vol. 14 pp. 360-365 BAERTSCHIGER, RM, BUHLER, LH Xenotransplantation literature update January-February, 2007 XENOTRANSPLANTATION 2007 vol. 14 pp. 273-277 BAERTSCHIGER, RM, BUHLER, LH Xenotransplantation literature update May-August, 2007 XENOTRANSPLANTATION 2007 vol. 14 pp. 642-652 BAERTSCHIGER, RM, BUHLER, LH Xenotransplantation literature update November-December 2006 XENOTRANSPLANTATION 2007 vol. 14 pp. 166-170 BAERTSCHIGER, RM, BUHLER, LH Xenotransplantation literature update September-October 2006 XENOTRANSPLANTATION 2007 vol. 14(1) pp. 83-88 BAERTSCHIGER RM, BUHLER LH Detection of insulin mRNA in the peripheral blood after human islet transplantion predicts deterioration of metabolic control AMERICAN JOURNAL OF TRANSPLANTATION 2006 vol. 6 pp. 1704-1711 BERNEY T, MAMIN A, SHAPIRO AMJ, RITZ-LASER B, BRULHART MC, TOSO C, DEMUYLDER-MISCHLER S, ARMANET M, BAERTSCHIGER R, WOJTUSCISZYN A, BENHAMOU PY, BOSCO D, MOREL P, PHILIPPE J Sequential kidney/islet transplantation: efficacy and safety assessment of a steroid-free immunosuppression protocol AMERICAN JOURNAL OF TRANSPLANTATION 2006 vol. 6(5 Pt 1) pp. 1049-1058 TOSO C. ET AL. Pig-to-nonhuman primate islet xenotransplantation: A review of current problems CELL TRANSPLANTATION 2006 vol. 15 pp. 89-104 ROOD PPM, BUHLER LH, BOTTINO R, TRUCCO M, COOPER DKC Tetracycline-regulated expression of VEGF-A in beta cells induces angiogenesis: Improvement of engraftment following transplantation CELL TRANSPLANTATION 2006 vol. 15 pp. 621-636 MATHE Z, DUPRAZ P, RINSCH C, THORENS B, BOSCO D, ZBINDEN M, MOREL P, BERNEY T, PEPPER MS Aging correlates with decreased beta-cell proliferative capacity and enhanced sensitivity to apoptosis: a potential role for Fas and pancreatic duodenal homeobox-1 DIABETES 2006 vol. 55(9) pp. 2455-2462 MAEDLER KATHRIN, SCHUMANN DESIREE M, SCHULTHESS FABIENNE, OBERHOLZER JOSE, BOSCO DOMENICO, BERNEY THIERRY, DONATH MARC Y. Blockade of beta 1 integrin-laminin-5 interaction affects spreading and insulin secretion of rat beta-cells attached on extracellular matrix DIABETES 2006 vol. 55 pp. 1413-1420 PARNAUD G, HAMMAR E, ROUILLER DG, ARMANET M, HALBAN PA, BOSCO D Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets DIABETES 2006 vol. 55(10) pp. 2713-2722 MAEDLER KATHRIN ET AL. An audit of surgical management of gastrointestinal stromal tumours (GIST) EJSO 2006 vol. 32 pp. 310-314 BUCHER P, EGGER JF, GERVAZ P, RIS F, WEINTRAUB D, VILLIGER P, BUHLER LH, MOREL P Analysis of antibiotic resistance gene expression in Pseudomonas aeruginosa by quantitative real-time-PCR FEMS MICROBIOLOGY LETTERS 2006 vol. 254 pp. 217-225 DUMAS JL, VAN DELDEN C, PERRON K, KOHLER T Analysis of contrast-enhanced MR images to assess renal function MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE 2006 vol. 19 pp. 167-179 MICHOUX N, VALEE JP, PECHERE-BERTSCHI A, MONTET X, BUEHLER L, VAN BEERS BE Anti-HLA antibody repertoire after IVIg infusion in highly sensitised patients waiting for kidney transplantation SWISS MEDICAL WEEKLY 2006 vol. 136 pp. 696-702 FERRARI-LACRAZ S, AUBERT V, BUHLER L, PASCUAL M, ANDRESEN I, BINET I, MARTIN PY, VILLARD J Assessment of F-18-FDG-leucocyte imaging to monitor rejection after pancreatic islet transplantation TRANSPLANTATION PROCEEDINGS 2006 vol. 38 pp. 3033-3034 TOSO C, ZAIDI H, MOREL P, ARMANET M, WOJTUSCISZYN A, MAI G, BAERTSCHIGER R, BUHLER L, BERNEY T Abdominal plain film in patients admitted with clinical suspicion of renal colic: Should it be replaced by low-dose computed tomography? UROLOGY 2006 vol. 67 pp. 64-68 POLETTI PA, PLATON A, RUTSCHMANN OT, VERDUN FR, SCHMIDLIN FR, ISELIN CE, VERMEULEN B, SARASIN FOP, BUHLER LH, BECKER CD Epidural anaesthesia restores pancreatic microcirculation and decreases the severity of acute pancreatitis WORLD JOURNAL OF GASTROENTEROLOGY 2006 vol. 12 pp. 915-920 DEMIRAG A, PASTOR CM, MOREL P, JEAN-CHRISTOPHE C, SIELENKAMPER AW, GUVENER N, MAI G, BERNEY T, FROSSARD JL, BUHLER LH Soluble CD40 ligand in prediction of acute severe pancreatitis WORLD JOURNAL OF GASTROENTEROLOGY 2006 vol. 12 pp. 1613-1616 FROSSARD JL, MOREL P, KWAK BR, PASTOR CM, BERNEY T, BUHLER L, VON LAUFEN A, DEMULDER S, MACH F International inventory of xenotransplantation practices in humans XENOTRANSPLANTATION 2006 vol. 13 pp. 482-482 BUHLER L, SGROI A, SYKES M, NOEL L PERV Methodology XENOTRANSPLANTATION 2006 vol. 13(3) pp. 171- COOPER DAVID KC, BUHLER LEO Treatment of fulminant liver failure by transplantation of microencapsulated primary or immortalized xenogeneic hepatocytes (vol 12, pg 457, 2005) XENOTRANSPLANTATION 2006 vol. 13 pp. 89-89 MAI G, NGUYEN TH, MOREL P, MEI J, ANDRES A, BOSCO D, BAERTSCHIGER R, TOSO C, BERNEY T, MAJNO P, MENTHA G, TRONO D, BUHLER LH Xenotransplantation literature update January-February, 2006 XENOTRANSPLANTATION 2006 vol. 13 pp. 272-276 BAERTSCHIGER RM, BUHLER LH Xenotransplantation literature update July-August, 2006 XENOTRANSPLANTATION 2006 vol. 13 pp. 571-575 BAERTSCHIGER RM, BUHLER LH Xenotransplantation literature update March-April 2006 XENOTRANSPLANTATION 2006 vol. 13 pp. 368-370 BAERTSCHIGER RM, BUHLER LH Xenotransplantation literature update May-June 2006 XENOTRANSPLANTATION 2006 vol. 13 pp. 475-480 BAERTSCHIGER RM, BUHLER LH Xenotransplantation literature update November-December 2005 XENOTRANSPLANTATION 2006 vol. 13 pp. 96-99 BAERTSCHIGER RM, BUHLER LH Xenotransplantation literature update September-October, 2005 XENOTRANSPLANTATION 2006 vol. 13 pp. 86-88 BAERTSCHIGER RM, BUHLER LH Effect of microcapsule composition and short-term immunosuppression on intraportal biocompatibility CELL TRANSPLANTATION 2005 vol. 14 pp. 159-167 TOSO CHRISTIAN ET AL. Expression and secretion of alpha1-proteinase inhibitor are regulated by proinflammatory cytokines in human pancreatic islet cells. DIABETOLOGIA 2005 vol. 48 pp. 1523-1533 BOSCO DOMENICO, MEDA PAOLO, MOREL PHILIPPE, MATTHEY-DORET DAVID, CAILLE CHOFFAT DOROTHEE, TOSO CHRISTIAN, BUHLER LEO, BERNEY THIERRY Impact of HLA matching on the outcome of simultaneous pancreas-kidney transplantation NEPHROLOGY, DIALYSIS, TRANSPLANTATION : OFFICIAL PUBLICATION OF THE EUROPEAN DIALYSIS AND TRANSPLANT ASSOCIATION - EUROPEAN RENAL ASSOCIATION 2005 vol. 20 pp. 48-53 BERNEY THIERRY, MALAISE JACQUES, MOREL PHILIPPE, TOSO CHRISTIAN, DEMUYLDER-MISCHLER S, MAJNO PIETRO, BUHLER LEO, MENTHA GILLES, EURO-SPK STUDY GROUP Impariment of renal function after islet transplant alone or islet-after-kidney transplantation using a sirolimus/tacrolimus-based immunosuppressive regimen TRANSPLANT INTERNATIONAL 2005 vol. 18 pp. 1226-1230 ANDRES ALEX ET AL. Microbial surveillance during human pancreatic islet isolation TRANSPLANT INTERNATIONAL 2005 vol. 18 pp. 584-589 BUCHER PASCAL, OBERHOLZER JOSE, BOSCO DOMENICO, MATHE ZOLTAN, TOSO CHRISTIAN, BUHLER LEO, BERNEY THIERRY, MOREL PHILIPPE Islet transplantation in a recipient presenting the factor V Leiden mutation TRANSPLANTATION 2005 vol. 79 pp. 1771-1772 ANDRES AXEL, BOSCO DOMENICO, MOREL PHILIPPE, TOSO CHRISTIAN, BAERTSCHIGER RETO, MAJNO PIETRO, BUHLER LEO, BERNEY THIERRY Macrophage depletion prolongs discordant but not concordant islet xenograft survival TRANSPLANTATION 2005 vol. 79 pp. 543-549 ANDRES AXEL ET AL. Positron-emission tomography imaging of early events after transplantation of islets of langerhans TRANSPLANTATION 2005 vol. 79 pp. 353-355 TOSO CHRISTIAN, ZAIDI HABIB, MOREL PHILIPPE, ARMANET MATHIEU, ANDRES AXEL, PERNIN NADINE, BAERTSCHIGER RETO, SLOSMAN DANIEL, BUHLER LEO, BOSCO DOMENICO, BERNEY THIERRY Effect of HLA matching in simultaneous pancreas-kidney transplantation TRANSPLANTATION PROCEEDINGS 2005 vol. 37 pp. 2846-2847 MALAISE J. ET AL. Impact of a Sirolimus/Tacrolimus-based immunosuppressive regimen on kidney function after islet transplantation TRANSPLANTATION PROCEEDINGS 2005 vol. 37 pp. 1326-1327 ANDRES A. ET AL. Phylogenetic disparity influences the predominance of direct over indirect pathway of antigen presentation in islet xenotransplantation TRANSPLANTATION PROCEEDINGS 2005 vol. 37 pp. 463-465 ANDRES A ET AL. Treatment of fulminant liver failure by transplantation of microencapsulated primary or immortalized xenogeneic hepatocypes XENOTRANSPLANTATION 2005 vol. 12 pp. 457-464 MAI GANG ET AL. Treatment of hepatocellular carcinoma at the dawn of the third millenium: liver transplantation and its alternatives. ACTA GASTRO-ENTEROLOGICA BELGICA 2004 vol. 67 pp. 206-222 MAJNO P, MENTHA G, GIOSTRA E, TERRAZ S, RUBBIA-BRANDT L, BERNEY T, BUHLER L, TOSO C, HUBER O, SPAHR L, MORARD I, HADENGUE A, BECKER C, TERRIER F, MOREL P Islet of Langerhans allogeneic transplantation at the University of Geneva in the steroid free era in islet after kidney and simultaneous islet-kidney transplantations TRANSPLANTATION PROCEEDINGS 2004 vol. 36 pp. 1121-1122 BERNEY T, BUCHER P, MATHE Z, ANDRES A, BOSCO D, MAGE R, TOSO C, OBERHOLZER J, BECKER C, PHILIPPE JACQUES, BUHLER L, MOREL P Microbial surveillance during human pancreatic islet isolation TRANSPLANTATION PROCEEDINGS 2004 vol. 36 pp. 1147-1148 BUCHER P, MATHE Z, BOSCO D, OBERHOLZER J, TOSO C, ANDRES A, BUHLER L, MOREL P, BERNEY T Short-term immunosuppression reduces fibrotic cellular infiltration around barium-M-alginate microbeads injected intraportally TRANSPLANTATION PROCEEDINGS 2004 vol. 36 pp. 1199-1200 MATHE Z, BUCHER P, BOSCO D, ANDRES A, FUX C, TOSO C, OBERHOLZER J, WANDREY C, SAINZ-VIDAL D, ESPINOSA D, BUHLER L, MOREL P, BERNEY T Cryopreservation and mycophenolate therapy are detrimental to hematopoietic progenitor cells TRANSPLANTATION 2002 vol. 74 pp. 1159-1166 BUEHLER LH, KURILLA-MAHON B, CHANG Q, ABRAHAM S, ALWAYN IP, APPEL JZ, NEWMAN D, AWWAD M, WHITE-SCHARP ME, SACKSTEIN R, SACHS DH, COOPER DK, DOWN JD Depletion of anti-gal, antibodies in baboons by intravenous therapy with bovine serum albumin conjugated to gal oligosaccharides TRANSPLANTATION 2002 vol. 73 pp. 129-139 TERANISHI K, GOLLACKNER B, BUEHLER LH, KNOSALLA C, CORREA L, DOWN JD, WHITE-SCHARF ME, SACHS DH, AWWAD M, COOPER DKC Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease TRANSPLANTATION 2002 vol. 74 pp. 1405-1409 BUEHLER LH, SPITZER TR, SYKES M, SACHS DH, DELMONICO FL, TOLKOFF-RUBIN N, SAIDMAN SL, SACKSTEIN R, MCAFEE S, DEY B, COLBY C, COSIMI AB Adult porcine islet transplantation in baboons treated with conventional immunosuppression or a non-myeloablative regimen and CD 154 blockade XENOTRANSPLANTATION 2002 vol. 9 pp. 3-13 BUEHLER LH, DENG S, O'NEIL J, KITAMURA H, KOULMANDA M, BALDI A, RAHIER J, ALWAYN IP, APPEL JZ, AWWAD M, SACHS DH, WEIR G, SQUIFFLET JP, COOPER DK, MOREL P Porcine hematopoietic cell xenotransplantation in nonhuman primates is complicated by thrombotic microangiopathy BONE MARROW TRANSPLANTATION 2001 vol. 27 pp. 1227-1236 BUHLER L, GOEPFERT C, KITAMURA H, BASKER M, GOJO S, ALWAYN IP, CHANG Q, DOWN JD, TSAI H, WISE R, SACHS DH, COOPER DKC Pig kidney transplantation in baboons: anti-gal a 1-3gal igm alone is associated with acute humoral xenograft rejection and disseminated intravascular coagulation TRANSPLANTATION 2001 vol. 72 pp. 1743-1752 BUHLER L, YAMADA K, KITAMURA H, ALWAYN IPJ, BASKER M, APPEL JZ, COLVIN RB, WHITE-SCHARF ME, SACHS DH, ROBSON SC, AWWAD M, COOPER DKC Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates. TRANSPLANTATION 2000 vol. 70(9) pp. 1323-1331 BUHLER L, BASKER M, ALWAYN I.P.J., GOEPFERT C, KITAMURA H, KAWAI T, GOJO S, KOZLOWSKI T, LERINO F.L, AWWAD M, SACHS D.H, SACKSTEIN R, ROBSON S.C, COOPER D.K.C. A nonmyeloabaltive regimen with CD40L blockade leads to humoral and cellular hyporesponsiveness to pig hematopoietic cells in baboon. TRANSPLANTATION PROCEEDINGS 2000 vol. 32 pp. 1100-1100 BUHLER L, AWWAD M, BASKER M, GOJO S, THALL A, DOWN JD, SYKES M, ANDREWS D, SACKSTEIN R, WHITE-SCHARF ME, SACHS DH, COOPER DK Research's domains DIABETE REGENERATION IMMUNITARY TOLERANCE HEPATIC INSUFISANCE XENOTRANSPLANTATION |