|DATABASE-RESEARCH||GROUP OF CLINICAL PATIENT RESEARCH|
|UNIP||Head of group CV||Research subject||Members of the group|
Links about the group
Dr. V. IBANEZ
HUG/ Dpt Psychiatrie
Ch-du Petit-Bel-Air 2
Pages updated the 17.11.2015
Functional anatomy of higher cognitive processes
The main research interests of the Psychiatric Neuroimaging Unit concern the functional anatomy of higher cognitive processes related to voluntary action, attention, and memory, and the study of cerebral dysfunction occurring in various frequent and incapacitating psychiatric disorders: psychosis (mainly schizophrenia), depression and neurodegenerative diseases (mainly Alzheimer disease). There are two leading themes:
1) Functional neuroanatomy of higher cognitive processes
We focus on the links between perception and action, in an attempt to understand human behavior and its alterations. The integration of the sensory signals (visual, somatosensory and auditory) and the covert processes underlying action are studied using electroencephalographic (EEG) and functional magnetic resonance imaging (fMRI) techniques. We plan to use neurofeedback techniques to test experimental hypothesis on sensorimotor control. On a clinical point of view, our objective is to test whether a dysfunction of perceptual processing, such as hallucinatory episodes in schizophrenic patients, is the result of abnormal integration of sensory signals, or could associate inadequate internal modeling of action.
Three projects utilizing fMRI and/or EEG techniques are part of this theme:
- The cortical network of voluntary action in schizophrenia: links between perception and action.
- The functional substrate of visuo-spatial attention in normal observers and in schizophrenic patients.
- The identification of early dysfunction of corticocortical circuits in mild cognitive impairment and Alzheimer's disease. In collaboration with Pr. Giannakopoulos (Principal Investigator), Psychogeriatric clinic, HUG.
2) Cerebral metabolism and neurotransmission in neuropsychiatric diseases
In neuropsychiatric disorders, it has been proposed that there is an abnormal regulation of different neurotransmitter systems. In mood disorders for example, the action mechanism of anti-depressive drugs is imperfectly known. A double methodological approach is used to study brain metabolism and neurotransmission dysfunction in neuropsychiatric diseases:
a) A fundamental approach in animal (rat or mouse) uses a new device, a beta probe similar to PET. This technique is applied to in vivo kinetic studies of serotonin receptors, evaluating their modifications under various experimental pharmacological conditions (mainly the action of Serotonin Reuptake Inhibitor drugs)
b) A clinical approach, using PET in humans, is employed to carry out kinetic studies and measure neurotransmitter receptor density in neuropsychiatric patients.
There are three ongoing projects :
- In vivo quantification of 5-HT1A receptors and their modulation after serotonin reuptake inhibitor drugs.
- Quantification and parametric mapping of GabaA receptor density using PET and SPECT.
- Brain metabolism in rats: in vivo measurement and comparison with autoradiography
Pluripotent stem cells as new drugs? The example of Parkinson's disease
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2009 vol. 381(2) pp. 113-121
PREYNAT-SEAUVE O, BURKHARD PR, VILLARD J, ZINGG W, GINOVART N, FEKI A, DUBOIS-DAUPHIN M, HURST S, MAURON A, JACONI M, KRAUSE KH
Abnormal-induced theta activity supports early directed-attention network deficits in progressive MCI.
NEUROBIOLOGY OF AGING
2009 vol. 30(9) pp. 1444-1452
DEIBER MP, IBANEZ V, MISSONNIER P, HERRMANN F, FAZIO-COSTA L, GOLD G, GIANNAKOPOULOS P
Acute and chronic effects of citalopram on 5-HT1A receptor-labeling by [18F]MPPF and -coupling to receptors-G proteins.
SYNAPSE [NEW YORK]
2009 vol. 63(2) pp. 106-116
MOULIN-SALLANON M, CHARNAY Y, GINOVART N, PERRET P, LANFUMEY L, HAMON M, HEN R, FAGRET D, IBANEZ V, MILLET P
In vivo quantification of 5-HT1A-[18F]MPPF interactions in rats using the YAP-(S)PET scanner and a beta-microprobe.
2008 vol. 41(3) pp. 823-834
MILLET P, MOULIN M, BARTOLI A, DEL GUERRA A, GINOVART N, LEMOUCHEUX L, BUONO S, FAGRET D, CHARNAY Y, IBANEZ V
Positron emission tomography quantification of [C-11]-(+)-PHNO binding in the human brain
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
2007 vol. 27 pp. 857-871
GINOVART N, WILLEIT M, RUSJAN P, GRAFF A, BLOOMFIELD PM, HOULE S, KAPUR S, WILSON AA
Distinction between perceptual and attentional processing in working memory tasks: A study of phase-locked and induced oscillatory brain dynamics
JOURNAL OF COGNITIVE NEUROSCIENCE
2007 vol. 19 pp. 158-172
DEIBER MP, MISSONNIER P, BERTRAND O, GOLD G, FAZIO-COSTA L, IBANEZ V, GIANNAKOPOULOS P
Working memory load-related electroencephalographic parameters can differentiate progressive from stable mild cognitive impairment.
2007 vol. 150(2) pp. 346-356
MISSONNIER P, DEIBER MP, GOLD G, HERRMANN FR, MILLET P, MICHON A, FAZIO-COSTA LARA, IBAŅEZ V, GIANNAKOPOULOS P
Decreased theta event-related synchronization during working memory activation is associated with progressive mild cognitive impairment
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
2006 vol. 22 pp. 250-259
MISSONNIER P, GOLD G, HERRMANN FR, FAZIO-COSTA LARA, MICHEL JP, DEIBER MP, MICHON A, GIANNAKOPOULOS P
Frontal theta event-related synchronization: comparison of directed attention and working memory load effects
JOURNAL OF NEURAL TRANSMISSION
2006 vol. 113 pp. 1477-1486
MISSONNIER P, DEIBER MP, GOLD G, MILLET P, PUN MGF, FAZIO-COSTA L, GIANNAKOPOULOS P, IBANEZ V
SPECT quantification of benzodiazepine receptor concentration using a dual-ligand approach
JOURNAL OF NUCLEAR MEDICINE
2006 vol. 47 pp. 783-792
MILLET P, GRAF C, MOULIN M, IBANEZ V
Comparison of early cortical networks in efficient and inefficient visual search: an event-related potential study.
JOURNAL OF COGNITIVE NEUROSCIENCE
2003 vol. pp. 1039-1051
LEONARDS U, PALIX J., MICHEL CM, IBANEZ V
The role of stimulus type in age-related changes of visual working memory
EXPERIMENTAL BRAIN RESEARCH
2002 vol. 146 pp. 172-183
LEONARDS U, IBANEZ V, GIANNAKOPOULOS P
Evaluation of the reference tissue models for PET and SPECT benzodiazepine binding parameters
2002 vol. 17 pp. 928-942
MILLET P, GRAF C, BUCK A, WALDER B, IBANEZ V
Similarity and robustness of PET and SPECT binding parameters for benzodiazepine receptors
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM : OFFICIAL JOURNAL OF THE INTERNATIONAL SOCIETY OF CEREBRAL BLOOD FLOW AND METABOLISM
2000 vol. 20 pp. 1587-1603
MILLET PHILIPPE, GRAF CHRISTOPHE, BUCK A, WALDER BERNARD, WESTERA G, BROGGININ C, ARIGONI M, SLOSMAN DANIEL, BOURAS CONSTANTIN, IBANEZ VINCENT
Wavelet analysis of dynamic PET data: application to the parametric imaging of benzodiazepine receptor concentration
2000 vol. 11 pp. 458-472
MILLET PHILIPPE, IBANEZ VINCENT, DELFORGE J, PAPPATA S, GUIMON JOSE