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Functional anatomy of higher cognitive processes

The main research interests of the Psychiatric Neuroimaging Unit concern the functional anatomy of higher cognitive processes related to voluntary action, attention, and memory, and the study of cerebral dysfunction occurring in various frequent and incapacitating psychiatric disorders: psychosis (mainly schizophrenia), depression and neurodegenerative diseases (mainly Alzheimer disease). There are two leading themes:

1) Functional neuroanatomy of higher cognitive processes
We focus on the links between perception and action, in an attempt to understand human behavior and its alterations. The integration of the sensory signals (visual, somatosensory and auditory) and the covert processes underlying action are studied using electroencephalographic (EEG) and functional magnetic resonance imaging (fMRI) techniques. We plan to use neurofeedback techniques to test experimental hypothesis on sensorimotor control. On a clinical point of view, our objective is to test whether a dysfunction of perceptual processing, such as hallucinatory episodes in schizophrenic patients, is the result of abnormal integration of sensory signals, or could associate inadequate internal modeling of action.

Three projects utilizing fMRI and/or EEG techniques are part of this theme:

- The cortical network of voluntary action in schizophrenia: links between perception and action.
- The functional substrate of visuo-spatial attention in normal observers and in schizophrenic patients.
- The identification of early dysfunction of corticocortical circuits in mild cognitive impairment and Alzheimer's disease. In collaboration with Pr. Giannakopoulos (Principal Investigator), Psychogeriatric clinic, HUG.

2) Cerebral metabolism and neurotransmission in neuropsychiatric diseases
In neuropsychiatric disorders, it has been proposed that there is an abnormal regulation of different neurotransmitter systems. In mood disorders for example, the action mechanism of anti-depressive drugs is imperfectly known. A double methodological approach is used to study brain metabolism and neurotransmission dysfunction in neuropsychiatric diseases:
a) A fundamental approach in animal (rat or mouse) uses a new device, a beta probe similar to PET. This technique is applied to in vivo kinetic studies of serotonin receptors, evaluating their modifications under various experimental pharmacological conditions (mainly the action of Serotonin Reuptake Inhibitor drugs)
b) A clinical approach, using PET in humans, is employed to carry out kinetic studies and measure neurotransmitter receptor density in neuropsychiatric patients.

There are three ongoing projects :
- In vivo quantification of 5-HT1A receptors and their modulation after serotonin reuptake inhibitor drugs.
- Quantification and parametric mapping of GabaA receptor density using PET and SPECT.
- Brain metabolism in rats: in vivo measurement and comparison with autoradiography

Group's publications

Pluripotent stem cells as new drugs? The example of Parkinson's disease
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2009 vol. 381(2) pp. 113-121
PREYNAT-SEAUVE O, BURKHARD PR, VILLARD J, ZINGG W, GINOVART N, FEKI A, DUBOIS-DAUPHIN M, HURST S, MAURON A, JACONI M, KRAUSE KH

Abnormal-induced theta activity supports early directed-attention network deficits in progressive MCI.
NEUROBIOLOGY OF AGING
2009 vol. 30(9) pp. 1444-1452
DEIBER MP, IBANEZ V, MISSONNIER P, HERRMANN F, FAZIO-COSTA L, GOLD G, GIANNAKOPOULOS P

Acute and chronic effects of citalopram on 5-HT1A receptor-labeling by [18F]MPPF and -coupling to receptors-G proteins.
SYNAPSE [NEW YORK]
2009 vol. 63(2) pp. 106-116
MOULIN-SALLANON M, CHARNAY Y, GINOVART N, PERRET P, LANFUMEY L, HAMON M, HEN R, FAGRET D, IBANEZ V, MILLET P

In vivo quantification of 5-HT1A-[18F]MPPF interactions in rats using the YAP-(S)PET scanner and a beta-microprobe.
NEUROIMAGE
2008 vol. 41(3) pp. 823-834
MILLET P, MOULIN M, BARTOLI A, DEL GUERRA A, GINOVART N, LEMOUCHEUX L, BUONO S, FAGRET D, CHARNAY Y, IBANEZ V

Positron emission tomography quantification of [C-11]-(+)-PHNO binding in the human brain
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
2007 vol. 27 pp. 857-871
GINOVART N, WILLEIT M, RUSJAN P, GRAFF A, BLOOMFIELD PM, HOULE S, KAPUR S, WILSON AA

Distinction between perceptual and attentional processing in working memory tasks: A study of phase-locked and induced oscillatory brain dynamics
JOURNAL OF COGNITIVE NEUROSCIENCE
2007 vol. 19 pp. 158-172
DEIBER MP, MISSONNIER P, BERTRAND O, GOLD G, FAZIO-COSTA L, IBANEZ V, GIANNAKOPOULOS P

Working memory load-related electroencephalographic parameters can differentiate progressive from stable mild cognitive impairment.
NEUROSCIENCE
2007 vol. 150(2) pp. 346-356
MISSONNIER P, DEIBER MP, GOLD G, HERRMANN FR, MILLET P, MICHON A, FAZIO-COSTA LARA, IBAÑEZ V, GIANNAKOPOULOS P

Decreased theta event-related synchronization during working memory activation is associated with progressive mild cognitive impairment
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
2006 vol. 22 pp. 250-259
MISSONNIER P, GOLD G, HERRMANN FR, FAZIO-COSTA LARA, MICHEL JP, DEIBER MP, MICHON A, GIANNAKOPOULOS P

Frontal theta event-related synchronization: comparison of directed attention and working memory load effects
JOURNAL OF NEURAL TRANSMISSION
2006 vol. 113 pp. 1477-1486
MISSONNIER P, DEIBER MP, GOLD G, MILLET P, PUN MGF, FAZIO-COSTA L, GIANNAKOPOULOS P, IBANEZ V

SPECT quantification of benzodiazepine receptor concentration using a dual-ligand approach
JOURNAL OF NUCLEAR MEDICINE
2006 vol. 47 pp. 783-792
MILLET P, GRAF C, MOULIN M, IBANEZ V

Comparison of early cortical networks in efficient and inefficient visual search: an event-related potential study.
JOURNAL OF COGNITIVE NEUROSCIENCE
2003 vol. pp. 1039-1051
LEONARDS U, PALIX J., MICHEL CM, IBANEZ V

The role of stimulus type in age-related changes of visual working memory
EXPERIMENTAL BRAIN RESEARCH
2002 vol. 146 pp. 172-183
LEONARDS U, IBANEZ V, GIANNAKOPOULOS P

Evaluation of the reference tissue models for PET and SPECT benzodiazepine binding parameters
NEUROIMAGE
2002 vol. 17 pp. 928-942
MILLET P, GRAF C, BUCK A, WALDER B, IBANEZ V

Similarity and robustness of PET and SPECT binding parameters for benzodiazepine receptors
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM : OFFICIAL JOURNAL OF THE INTERNATIONAL SOCIETY OF CEREBRAL BLOOD FLOW AND METABOLISM
2000 vol. 20 pp. 1587-1603
MILLET PHILIPPE, GRAF CHRISTOPHE, BUCK A, WALDER BERNARD, WESTERA G, BROGGININ C, ARIGONI M, SLOSMAN DANIEL, BOURAS CONSTANTIN, IBANEZ VINCENT

Wavelet analysis of dynamic PET data: application to the parametric imaging of benzodiazepine receptor concentration
NEUROIMAGE
2000 vol. 11 pp. 458-472
MILLET PHILIPPE, IBANEZ VINCENT, DELFORGE J, PAPPATA S, GUIMON JOSE

Research's domains




DATABASE-RESEARCH	GROUP OF CLINICAL PATIENT RESEARCH

UNIP	Head of group CV	Research subject	Members of the group


	Links about the group Dr. V. IBANEZ HUG/ Dpt Psychiatrie Serv Neuropsychiatrie Ch-du Petit-Bel-Air 2 1225 Chêne-Bourg Suisse vicente.ibanez@hcuge.ch Tel.: 022/305.53.78 Fax: 022/305.53.75 Comments Pages updated the 17.11.2015		Reseach's subject \| Group's publications \| Research's domains Functional anatomy of higher cognitive processes The main research interests of the Psychiatric Neuroimaging Unit concern the functional anatomy of higher cognitive processes related to voluntary action, attention, and memory, and the study of cerebral dysfunction occurring in various frequent and incapacitating psychiatric disorders: psychosis (mainly schizophrenia), depression and neurodegenerative diseases (mainly Alzheimer disease). There are two leading themes: 1) Functional neuroanatomy of higher cognitive processes We focus on the links between perception and action, in an attempt to understand human behavior and its alterations. The integration of the sensory signals (visual, somatosensory and auditory) and the covert processes underlying action are studied using electroencephalographic (EEG) and functional magnetic resonance imaging (fMRI) techniques. We plan to use neurofeedback techniques to test experimental hypothesis on sensorimotor control. On a clinical point of view, our objective is to test whether a dysfunction of perceptual processing, such as hallucinatory episodes in schizophrenic patients, is the result of abnormal integration of sensory signals, or could associate inadequate internal modeling of action. Three projects utilizing fMRI and/or EEG techniques are part of this theme: - The cortical network of voluntary action in schizophrenia: links between perception and action. - The functional substrate of visuo-spatial attention in normal observers and in schizophrenic patients. - The identification of early dysfunction of corticocortical circuits in mild cognitive impairment and Alzheimer's disease. In collaboration with Pr. Giannakopoulos (Principal Investigator), Psychogeriatric clinic, HUG. 2) Cerebral metabolism and neurotransmission in neuropsychiatric diseases In neuropsychiatric disorders, it has been proposed that there is an abnormal regulation of different neurotransmitter systems. In mood disorders for example, the action mechanism of anti-depressive drugs is imperfectly known. A double methodological approach is used to study brain metabolism and neurotransmission dysfunction in neuropsychiatric diseases: a) A fundamental approach in animal (rat or mouse) uses a new device, a beta probe similar to PET. This technique is applied to in vivo kinetic studies of serotonin receptors, evaluating their modifications under various experimental pharmacological conditions (mainly the action of Serotonin Reuptake Inhibitor drugs) b) A clinical approach, using PET in humans, is employed to carry out kinetic studies and measure neurotransmitter receptor density in neuropsychiatric patients. There are three ongoing projects : - In vivo quantification of 5-HT1A receptors and their modulation after serotonin reuptake inhibitor drugs. - Quantification and parametric mapping of GabaA receptor density using PET and SPECT. - Brain metabolism in rats: in vivo measurement and comparison with autoradiography Group's publications Pluripotent stem cells as new drugs? The example of Parkinson's disease INTERNATIONAL JOURNAL OF PHARMACEUTICS 2009 vol. 381(2) pp. 113-121 PREYNAT-SEAUVE O, BURKHARD PR, VILLARD J, ZINGG W, GINOVART N, FEKI A, DUBOIS-DAUPHIN M, HURST S, MAURON A, JACONI M, KRAUSE KH Abnormal-induced theta activity supports early directed-attention network deficits in progressive MCI. NEUROBIOLOGY OF AGING 2009 vol. 30(9) pp. 1444-1452 DEIBER MP, IBANEZ V, MISSONNIER P, HERRMANN F, FAZIO-COSTA L, GOLD G, GIANNAKOPOULOS P Acute and chronic effects of citalopram on 5-HT1A receptor-labeling by [18F]MPPF and -coupling to receptors-G proteins. SYNAPSE [NEW YORK] 2009 vol. 63(2) pp. 106-116 MOULIN-SALLANON M, CHARNAY Y, GINOVART N, PERRET P, LANFUMEY L, HAMON M, HEN R, FAGRET D, IBANEZ V, MILLET P In vivo quantification of 5-HT1A-[18F]MPPF interactions in rats using the YAP-(S)PET scanner and a beta-microprobe. NEUROIMAGE 2008 vol. 41(3) pp. 823-834 MILLET P, MOULIN M, BARTOLI A, DEL GUERRA A, GINOVART N, LEMOUCHEUX L, BUONO S, FAGRET D, CHARNAY Y, IBANEZ V Positron emission tomography quantification of [C-11]-(+)-PHNO binding in the human brain JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 2007 vol. 27 pp. 857-871 GINOVART N, WILLEIT M, RUSJAN P, GRAFF A, BLOOMFIELD PM, HOULE S, KAPUR S, WILSON AA Distinction between perceptual and attentional processing in working memory tasks: A study of phase-locked and induced oscillatory brain dynamics JOURNAL OF COGNITIVE NEUROSCIENCE 2007 vol. 19 pp. 158-172 DEIBER MP, MISSONNIER P, BERTRAND O, GOLD G, FAZIO-COSTA L, IBANEZ V, GIANNAKOPOULOS P Working memory load-related electroencephalographic parameters can differentiate progressive from stable mild cognitive impairment. NEUROSCIENCE 2007 vol. 150(2) pp. 346-356 MISSONNIER P, DEIBER MP, GOLD G, HERRMANN FR, MILLET P, MICHON A, FAZIO-COSTA LARA, IBAÑEZ V, GIANNAKOPOULOS P Decreased theta event-related synchronization during working memory activation is associated with progressive mild cognitive impairment DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 2006 vol. 22 pp. 250-259 MISSONNIER P, GOLD G, HERRMANN FR, FAZIO-COSTA LARA, MICHEL JP, DEIBER MP, MICHON A, GIANNAKOPOULOS P Frontal theta event-related synchronization: comparison of directed attention and working memory load effects JOURNAL OF NEURAL TRANSMISSION 2006 vol. 113 pp. 1477-1486 MISSONNIER P, DEIBER MP, GOLD G, MILLET P, PUN MGF, FAZIO-COSTA L, GIANNAKOPOULOS P, IBANEZ V SPECT quantification of benzodiazepine receptor concentration using a dual-ligand approach JOURNAL OF NUCLEAR MEDICINE 2006 vol. 47 pp. 783-792 MILLET P, GRAF C, MOULIN M, IBANEZ V Comparison of early cortical networks in efficient and inefficient visual search: an event-related potential study. JOURNAL OF COGNITIVE NEUROSCIENCE 2003 vol. pp. 1039-1051 LEONARDS U, PALIX J., MICHEL CM, IBANEZ V The role of stimulus type in age-related changes of visual working memory EXPERIMENTAL BRAIN RESEARCH 2002 vol. 146 pp. 172-183 LEONARDS U, IBANEZ V, GIANNAKOPOULOS P Evaluation of the reference tissue models for PET and SPECT benzodiazepine binding parameters NEUROIMAGE 2002 vol. 17 pp. 928-942 MILLET P, GRAF C, BUCK A, WALDER B, IBANEZ V Similarity and robustness of PET and SPECT binding parameters for benzodiazepine receptors JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM : OFFICIAL JOURNAL OF THE INTERNATIONAL SOCIETY OF CEREBRAL BLOOD FLOW AND METABOLISM 2000 vol. 20 pp. 1587-1603 MILLET PHILIPPE, GRAF CHRISTOPHE, BUCK A, WALDER BERNARD, WESTERA G, BROGGININ C, ARIGONI M, SLOSMAN DANIEL, BOURAS CONSTANTIN, IBANEZ VINCENT Wavelet analysis of dynamic PET data: application to the parametric imaging of benzodiazepine receptor concentration NEUROIMAGE 2000 vol. 11 pp. 458-472 MILLET PHILIPPE, IBANEZ VINCENT, DELFORGE J, PAPPATA S, GUIMON JOSE Research's domains