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Fonction de l'îlot de Langerhans

Ce groupe étudie la fonction de l'îlot de Langerhans afin de mieux comprendre la défaillance fonctionnelle des îlots chez les patients diabétiques. Nous nous intéressons également à la thérapie cellulaire du diabète Nous avons deux principaux projets: 1. La synthèse et la sécrétion de l'insuline: La Proinsuline est acheminée vers l'aire de Golgi (TGN) où elle est triée afin d' être emballée dans les granules sécrétoires. Par la suite, la proinsuline est transformée à l'intérieur des granules en insuline et C-peptide. Nous nous intéressons au mécanisme du tri dans le TGN ainsi qu'à celui de la rétention sélective de l'insuline dans les granules. Nous étudions également les différentes étapes de l'exocytose et notamment le rôle des protéines SNARE et du cytosquelette. Ces études in vitro nous aident à mieux comprendre les anomalies fonctionnnelles des cellules bêta dans les divers états pathologiques. Ils sont associés à l'dentification par "microarray" de gènes essentiels au bon fonctionnement de cette cellule. 2. La sauvegarde de la masse des cellules bêta et le développement d'une thérapie cellulaire du diabète En collaboration avec le département de Chirurgie et des groupes à Lausanne et à Zürich, nous aimerions élaborer une stratégie pour une thérapie cellulaire du diabète en remplaçant les cellules bêta défaillantes ou absentes par des cellules de remplacement. Notre groupe cherche à améliorer la survie des cellules bêta humaines en culture. Ces cellules sont particulièrement sujettes à la mort par apoptose. Nous tentons de comprendre les voies de signalisation de cette apoptose et de la prévenir, soit à l'aide d'inhibiteurs solubles, soit par l'expression de gènes appropriés. De telles interventions pourront également servir à préserver la masse de cellules bêta chez l'homme dans des conditions d'apoptose élevée.

Publications du groupe

Role of the Rho-ROCK (Rho-Associated Kinase) Signaling Pathway in the Regulation of Pancreatic beta-Cell Function
ENDOCRINOLOGY
2009 vol. 150 pp. 2072-2079
HAMMAR BOUVERET EVA, TOMAS A, BOSCO D, HALBAN PA

Silencing Mitogen-activated Protein 4 Kinase 4 (MAP4K4) Protects Beta Cells from Tumor Necrosis Factor-alpha-induced Decrease of IRS-2 and Inhibition of Glucose-stimulated Insulin Secretion
JOURNAL OF BIOLOGICAL CHEMISTRY
2009 vol. 284(41) pp. 27892-27898
BOUZAKRI K, RIBAUX P, HALBAN PA

Signaling Pathways Implicated in the Stimulation of beta-Cell Proliferation by Extracellular Matrix
MOLECULAR ENDOCRINOLOGY
2009 vol. 23(8) pp. 1264-1271
PARNAUD G, HAMMAR BOUVERET EVA, RIBAUX P, DONATH M, BERNEY T, HALBAN PA

The right stuff: beta-cell channels, cycles, and sensors.
AMERICAN JOURNAL OF PHYSIOLOGY. ENDOCRINOLOGY AND METABOLISM
2008 vol. 295(6) pp. 1277-1278
HALBAN PA

Increasing GLP-1-induced beta-cell proliferation by silencing the negative regulators of signaling cAMP response element modulator-alpha and DUSP14.
DIABETES
2008 vol. 57(3) pp. 584-593
KLINGER S, POUSSIN C, DEBRIL MB, DOLCI W, HALBAN PA, THORENS B

Rab GTPase-activating protein AS160 is a major downstream effector of protein kinase B/Akt signaling in pancreatic beta-cells.
DIABETES
2008 vol. 57(5) pp. 1195-1204
BOUZAKRI K, RIBAUX P, TOMAS A, PARNAUD G, RICKENBACH K, HALBAN PA

Cell therapy for type 2 diabetes: is it desirable and can we get it?
DIABETES, OBESITY AND METABOLISM
2008 vol. 10 pp. 205-211
HALBAN PA

Order! Order! Order in the House! DIAMAP: a road map for European diabetes research.
DIABETOLOGIA
2008 vol. 51(10) pp. 1765-1767
HALBAN PA, SMITH U

Proliferation of sorted human and rat beta cells.
DIABETOLOGIA
2008 vol. 51(1) pp. 91-100
PARNAUD G, BOSCO D, BERNEY T, PATTOU F, KERR-CONTE J, DONATH MY, BRUUN C, MANDRUP-POULSEN T, BILLESTRUP N, HALBAN PA

Dual effect of cell-cell contact disruption on cytosolic calcium and insulin secretion.
ENDOCRINOLOGY
2008 vol. 149(5) pp. 2494-2505
JAQUES F, JOUSSET H, TOMAS A, PROST AL, WOLLHEIM CB, IRMINGER JC, DEMAUREX N, HALBAN P

Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation.
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
2008 vol. 93(10) pp. 4065-4074
BÖNI-SCHNETZLER M, THORNE J, PARNAUD G, MARSELLI L, EHSES JA, KERR-CONTE J, PATTOU F, HALBAN PA, WEIR GC, DONATH MY

Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture.
LE DIABETE
2008 vol. 57(11) pp. 3045-3055
MARZBAN L, TOMAS A, BECKER TC, ROSENBERG L, OBERHOLZER J, FRASER PE, HALBAN PA, VERCHERE CB

Interleukin-6 regulates pancreatic alpha-cell mass expansion.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2008 vol. 105(35) pp. 13163-13168
ELLINGSGAARD H AND AL.

Munc 18-1 and granuphilin collaborate during insulin granule exocytosis.
TRAFFIC
2008 vol. 9(5) pp. 813-832
TOMAS A, MEDA P, REGAZZI R, PESSIN JE, HALBAN PA

Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice
DIABETES
2007 vol. 56(5) pp. 1268-1276
HERBACH NADJA ET AL.

Pro-survival role of gelsolin in mouse beta-cells
DIABETES
2007 vol. 56 pp. 80-87
YERMEN, B, TOMAS, A, HALBAN, PA

The innovative medicines initiative (IMI): a shot in the arm for European diabetes research?
DIABETOLOGIA
2007 vol. 50 pp. 1791-1794
HALBAN, PA

Induction of CXCL1 by extracellular matrix and autocrine enhancement by interleukin-1 in rat pancreatic beta-cells
ENDOCRINOLOGY
2007 vol. 148 pp. 5582-5590
RIBAUX, P, EHSES, JA, LIN-MARQ, N, CARROZZINO, F, BONI-SCHNETZLER, M, HAMMAR, E, IRMINGER, JC, DONATH, MY, HALBAN, PA

Dynamin is functionally coupled to insulin granule exocytosis
JOURNAL OF BIOLOGICAL CHEMISTRY
2007 vol. 282 pp. 33530-33536
MIN, L, LEUNG, YM, TOMAS, A, WATSON, RT, GAISANO, HY, HALBAN, PA, PESSIN, JE, HOU, JC

Differential expression of E-cadherin at the surface of rat beta-cells as a marker of functional heterogeneity
JOURNAL OF ENDOCRINOLOGY
2007 vol. 194 pp. 21-29
BOSCO, D, ROUILLER, DG, HALBAN, PA

The Fas pathway is involved in pancreatic beta cell secretory function
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2007 vol. 104 pp. 2861-2866
SCHUMANN DM, MAEDLER K, FRANKLIN I, KONRAD D, STORLING J, BONI-SCHNETZLER M, GJINOVCI A, KURRER MO, GAUTHIER BR, BOSCO D, ANDRES A, BERNEY T, GRETER M, BECHER B, CHERVONSKY AV, HALBAN PA, MANDRUP-POULSEN T, WOLLHEIM CB, DONATH MY

Blockade of beta 1 integrin-laminin-5 interaction affects spreading and insulin secretion of rat beta-cells attached on extracellular matrix
DIABETES
2006 vol. 55 pp. 1413-1420
PARNAUD G, HAMMAR E, ROUILLER DG, ARMANET M, HALBAN PA, BOSCO D

Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death
DIABETES
2006 vol. 55(8) pp. 2192-2201
MARZBAN LUCY, RHODES CHRISTOPHER J, STEINER DONALD F, HAATAJA LEENA, HALBAN PHILIPPE A, VERCHERE C. BRUCE

Islet Inflammation and Fibrosis in a Spontaneous Model of Type 2 Diabetes, the GK Rat
DIABETES
2006 vol. 55(6) pp. 1625-1633
HOMO-DELARCHE FRANCOISE ET AL.

Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor
JOURNAL OF BIOLOGICAL CHEMISTRY
2006 vol. 281(16) pp. 11050-11057
UGLEHOLDT RANDI ET AL.

Regulation of pancreatic beta-cell insulin secretion by actin cytoskeleton remodelling: role of gelsolin and cooperation with the MAPK signalling pathway
JOURNAL OF CELL SCIENCE
2006 vol. 119(Pt 10) pp. 2156-2167
TOMAS ALEJANDRA, YERMEN BARBARA, LE MIN, PESSIN JEFFREY E, HALBAN PHILIPPE A

Diabetes research investment in the European union
NATURE MEDICINE
2006 vol. 12 pp. 70-72
HALBAN PA, FERRANNINI E, NERUP J

Inhibition of calpain blocks pancreatic beta-cell spreading and insulin secretion
AMERICAN JOURNAL OF PHYSIOLOGY. ENDOCRINOLOGY AND METABOLISM
2005 vol. 289 pp. 313-321
PARNAUD GERALDINE, HAMMAR BOUVERET EVA, ROUILLER DOMINIQUE, BOSCO DOMENICO

Restitution of defective glucose-stimulated insulin secretion in diabetic GK rat by acetylcholine uncovers paradoxical stimulatory effect of beta-cell muscarinic receptor activation on cAMP production .
DIABETES
2005 vol. 54 pp. 3229-3237
DOLZ M, BAILBE D, GIROIX MH, CALDERARI S, GANGNERAU MN, SERRADAS P, RICKENBACH KATHARINA, IRMINGER JEAN-CLAUDE

Suppression of Pdx-1 perturbs proinsulin processing, insulin secretion and GLP-1 signalling in INS-1 cells.
DIABETOLOGIA
2005 vol. 48 pp. 720-731
WANG HAIYAN, IEZZI-BAKHTIARI MARIELLA, THEANDER STEN, ANTINOZZI PETER, GAUTHIER BENOIT, HALBAN PHILIPPE A., WOLLHEIM CLAES

10th EASD/JDRF Oxford Workshop. What is a beta-cell and can we improve it?
DIABETOLOGIA
2005 vol. 48 pp. 93-101
SCHUIT F, HALBAN PHILIPPE A., RHODES C

Activation of NF-kappaB by extracellular matric is involved in spreading and glucose-stimulated insulin secretion of pancreatic beta cells
JOURNAL OF BIOLOGICAL CHEMISTRY
2005 vol. 280 pp. 30630-30637
HAMMAR EB, IRMINGER JEAN-CLAUDE, RICKENBACH KATHARINA, PARNAUD G, RIBAUX PASCALE, BOSCO DOMENICO, ROUILLER DG, HALBAN PHILIPPE A.

Effects of I(Ks) channel inhibitors in insulin-secreting INS-1 cells.
PFLUGERS ARCHIV FUR DIE GESAMTE PHYSIOLOGIE DES MENSCHEN UND DER TIERE
2005 vol. 451 pp. 428-436
ULLRICH S, SU J, RANTA F, WITTEKINDT OH, RIS FREDERIC, ROSLER M, GERLACH U, WARTH R, LANG F

Extracellular matrix protects pancreatic beta-cells against apoptosis: role of short- and long-term signaling pathways
DIABETES
2004 vol. 53 pp. 2034-2041
HAMMAR E, PARNAUD G, BOSCO D, PERRIRAZN, MAEDLER K, DONATH M, ROUILLER DG, HALBAN PA

Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide
DIABETES
2004 vol. 53(1) pp. 141-148
MARZBAN L, TRIGO-GONZALES G, ZHU X, RHODES CJ, HALBAN PHILIPPE A., STEINER DF, VERCHERE CB

Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications
DIABETOLOGIA
2004 vol. 47(3) pp. 581-589
DONATH MY, HALBAN PHILIPPE A.

Pioglitazone and sodium salicylate protect human (beta)-cells against apoptosis and impaired function induced by glucose interleukin-1(beta)
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
2004 vol. 89 pp. 5059-5066
ZEENDER E, MAEDLER K, BOSCO D, BERNEY T, DONATH MY, HALBAN PA

Cellular sources of new pancreatic beta cells and therapeutic implications for regenerative medicine.
NATURE CELL BIOLOGY
2004 vol. 6 pp. 1021-1025
HALBAN PHILIPPE A.

Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1 beta in human islets
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2004 vol. 101 pp. 8138-8143
MAEDLER K, SERGEEV P, EHSES JA, MATHE Z, BOSCO D, BERNEY T, DAYER JM, REINECKE M, HALBAN PA, DONATH M

Towards a perfect beta cell replacement
SEMINARS IN CELL AND DEVELOPMENTAL BIOLOGY
2004 vol. 15(3) pp. 325-326
HALBAN PHILIPPE A.

Sorting ourselves out: seeking consensus on trafficking in the beta-cell
TRAFFIC
2004 vol. 5(1) pp. 53-61
ARVAN P, HALBAN PHILIPPE A.

Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse.
DIABETES
2003 vol. 52 pp. 409-416
T. IZUMI, H. YOKOTA-HASHIMOTO, S. ZHAO, J. WANG, HALBAN PA, T. TAKEUCHI

Ectopic expression of the beta-cell specific transcription factor Pdx1 inhibits glucagon gene transcription.
DIABETOLOGIA
2003 vol. 46(6) pp. 810-821
RITZ-LASER B, GAUTHIER BR, ESTREICHER VON ROZBIERSKI A, MAMIN A, BRUN T, RIS F, SALMON P, HALBAN PA, TRONO D, PHILIPPE J

Thank you Vienna-over to you, BristolA message of thanks to the outgoing Editor-in-Chief of Diabetologia, Professor Werner Waldhausl.
DIABETOLOGIA
2003 vol. 47 pp. 595-596
HALBAN P

Differential gene expression in well-regulated and dysregulated pancreatic beta-cell (MIN6) sublines.
ENDOCRINOLOGY
2003 vol. 144 pp. 1368-1379
LILLA V, G. WEBB, RICKENBACH K, MATURANA ANDRES, D.F. STEINER, HALBAN PA, IRMINGER JC

Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis.
JOURNAL OF BIOLOGICAL CHEMISTRY
2003 vol. 278 pp. 471-478
Y. LI, T. HANSOTIA, B. YUSTA, RIS F, HALBAN PA, D.J. DRUCKER

Mutant proinsulin that cannot be converted is secreted efficiently from primary rat beta-cells via the regulated pathway.
MOLECULAR BIOLOGY OF THE CELL
2003 vol. 14 pp. 1195-1203
HALBAN PA, IRMINGER JC

Glucose-stimulated insulin secretion is coupled to the interaction of actin with the t-SNARE (target membrane soluble N-ethylmaleimide-sensitive factor attachment protein receptor protein) complex.
MOLECULAR ENDOCRINOLOGY
2003 vol. 17 pp. 732-742
D. THURMOND, GONELLE-GISPERT C, M. FURUKAWA, HALBAN PA, J.E. PESSIN

Phosphorylation of SNAP-25 on serine-187 is induced by secretagogues in insulin-secreting cells, but is not correlated with insulin secretion.
BIOCHEMICAL JOURNAL
2002 vol. 15 pp. 223-232
GONELLE-GISPERT C, COSTA M, TAKAHASHI M, SADOUL K, HALBAN P

Molecular detection of circulating beta-cells after islet transplantation
DIABETES
2002 vol. 51 pp. 557-561
RITZ-LASER B, OBERHOLZER J, TOSO C, BRULHART MC, ZAKRZEWSKA K, RIS F, BUCHER P, MOREL P, PHILIPPE J

Impact of integrin-matrix matching and inhibition of apoptosis on the survival of purified human beta-cells in vitro.
DIABETOLOGIA
2002 vol. 45 pp. 841-850
RIS F, HAMMAR E, BOSCO D, PILLOUD C, MAEDLER K, DONATH MY, OBERHOLZER J, ZEENDER E, MOREL P, ROUILLER D, HALBAN PA

Truncated (des-[27-31]) C-peptide is not a major secretory product of human islets.
DIABETOLOGIA
2002 vol. 45 pp. 1523-1527
PAOLETTA M, KAHN SE, HALBAN PA

Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets.
JOURNAL OF CLINICAL INVESTIGATION
2002 vol. 110 pp. 851-860
MAEDLER K, SERGEEV P, RIS F, OBERHOLZER J, JOLLER-JEMELKA HI, SPINAS GA, KAISER N, HALBAN PA, DONATH MY

Isolation and characterization of VGF peptides in rat brain. Role of PC1/3 and PC2 in the maturation of VGF precursor.
JOURNAL OF NEUROCHEMISTRY
2002 vol. 81 pp. 565-574
TRANI E, GIORGI A, CANU N, AMADORO G, RINALDI AM, HALBAN PA, FERRI GL, POSSENTI R, SCHININA ME, LEVI A

FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2002 vol. 99(12) pp. 8236-8241
MAEDLER K, FONTANA A, RIS F, SERGEEV P, TOSO C, OBERHOLZER J, LEHMANN R, BACHMANN F, SPINAS GA, TASINATO A, HALBAN PA, DONATH MY

FLIP switches fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2002 vol. 99 pp. 8236-8241
MAEDLER K, FONTANA A, RIS F, SERGEEV P, TOSO C, OBERHOLZER J, LEHMANN R, BACHMANN F, TASINATO A, SPINAS GA, HALBAN PA, DONATH MY

Potential impact of in situ liver splitting on the number of available grafts
TRANSPLANTATION
2002 vol. 74 pp. 222-226
TOSO C, RIS F, MENTHA G, OBERHOLZER J, MOREL P, MAJNO P

Factors affecting human islets of Langerhans isolation yields
TRANSPLANTATION PROCEEDINGS
2002 vol. 34 pp. 826-827
TOSO C, OBERHOLZER J, RIS F, TRIPONEZ F, BUCHER P, DEMIRAG A, ANDEREGGEN E, BUEHLER LH, CRETIN N, FOURNIER B, MAJNO P, HONG Y, LOU J, MOREL P

Human islet allotransplantation with Basiliximab in type 1 diabetic patients with end-stage renal failure
TRANSPLANTATION PROCEEDINGS
2002 vol. 34 pp. 823-825
OBERHOLZER J, TOSO C, TRIPONEZ F, RIS F, BUCHER P, DEMIRAG A, LOU J, MAJNO P, BUEHLER LH, PHILIPPE J, MOREL P

Domaines de recherche




BASE DE DONNÉES-RECHERCHE	GROUPE DE RECHERCHE CLINIQUE ORIENTEE BIOLOGIE

Philippe A. HALBAN	CV du Chef de Groupe	Sujet de Recherche	Composition du Groupe


	Coordonnées du groupe Prof. Ph. HALBAN CMU / Dpt GEDEV Rue Michel-Servet 1 1211 Genève 4 Suisse philippe.halban@unige.ch Tél.: 022 379 55 36 Fax: 022 379 55 28 Commentaires Pages générées le 10.02.2012		Sujet de recherche \| Publications du groupe \| Domaines de recherche Fonction de l'îlot de Langerhans Ce groupe étudie la fonction de l'îlot de Langerhans afin de mieux comprendre la défaillance fonctionnelle des îlots chez les patients diabétiques. Nous nous intéressons également à la thérapie cellulaire du diabète Nous avons deux principaux projets: 1. La synthèse et la sécrétion de l'insuline: La Proinsuline est acheminée vers l'aire de Golgi (TGN) où elle est triée afin d' être emballée dans les granules sécrétoires. Par la suite, la proinsuline est transformée à l'intérieur des granules en insuline et C-peptide. Nous nous intéressons au mécanisme du tri dans le TGN ainsi qu'à celui de la rétention sélective de l'insuline dans les granules. Nous étudions également les différentes étapes de l'exocytose et notamment le rôle des protéines SNARE et du cytosquelette. Ces études in vitro nous aident à mieux comprendre les anomalies fonctionnnelles des cellules bêta dans les divers états pathologiques. Ils sont associés à l'dentification par "microarray" de gènes essentiels au bon fonctionnement de cette cellule. 2. La sauvegarde de la masse des cellules bêta et le développement d'une thérapie cellulaire du diabète En collaboration avec le département de Chirurgie et des groupes à Lausanne et à Zürich, nous aimerions élaborer une stratégie pour une thérapie cellulaire du diabète en remplaçant les cellules bêta défaillantes ou absentes par des cellules de remplacement. Notre groupe cherche à améliorer la survie des cellules bêta humaines en culture. Ces cellules sont particulièrement sujettes à la mort par apoptose. Nous tentons de comprendre les voies de signalisation de cette apoptose et de la prévenir, soit à l'aide d'inhibiteurs solubles, soit par l'expression de gènes appropriés. De telles interventions pourront également servir à préserver la masse de cellules bêta chez l'homme dans des conditions d'apoptose élevée. Publications du groupe Role of the Rho-ROCK (Rho-Associated Kinase) Signaling Pathway in the Regulation of Pancreatic beta-Cell Function ENDOCRINOLOGY 2009 vol. 150 pp. 2072-2079 HAMMAR BOUVERET EVA, TOMAS A, BOSCO D, HALBAN PA Silencing Mitogen-activated Protein 4 Kinase 4 (MAP4K4) Protects Beta Cells from Tumor Necrosis Factor-alpha-induced Decrease of IRS-2 and Inhibition of Glucose-stimulated Insulin Secretion JOURNAL OF BIOLOGICAL CHEMISTRY 2009 vol. 284(41) pp. 27892-27898 BOUZAKRI K, RIBAUX P, HALBAN PA Signaling Pathways Implicated in the Stimulation of beta-Cell Proliferation by Extracellular Matrix MOLECULAR ENDOCRINOLOGY 2009 vol. 23(8) pp. 1264-1271 PARNAUD G, HAMMAR BOUVERET EVA, RIBAUX P, DONATH M, BERNEY T, HALBAN PA The right stuff: beta-cell channels, cycles, and sensors. AMERICAN JOURNAL OF PHYSIOLOGY. ENDOCRINOLOGY AND METABOLISM 2008 vol. 295(6) pp. 1277-1278 HALBAN PA Increasing GLP-1-induced beta-cell proliferation by silencing the negative regulators of signaling cAMP response element modulator-alpha and DUSP14. DIABETES 2008 vol. 57(3) pp. 584-593 KLINGER S, POUSSIN C, DEBRIL MB, DOLCI W, HALBAN PA, THORENS B Rab GTPase-activating protein AS160 is a major downstream effector of protein kinase B/Akt signaling in pancreatic beta-cells. DIABETES 2008 vol. 57(5) pp. 1195-1204 BOUZAKRI K, RIBAUX P, TOMAS A, PARNAUD G, RICKENBACH K, HALBAN PA Cell therapy for type 2 diabetes: is it desirable and can we get it? DIABETES, OBESITY AND METABOLISM 2008 vol. 10 pp. 205-211 HALBAN PA Order! Order! Order in the House! DIAMAP: a road map for European diabetes research. DIABETOLOGIA 2008 vol. 51(10) pp. 1765-1767 HALBAN PA, SMITH U Proliferation of sorted human and rat beta cells. DIABETOLOGIA 2008 vol. 51(1) pp. 91-100 PARNAUD G, BOSCO D, BERNEY T, PATTOU F, KERR-CONTE J, DONATH MY, BRUUN C, MANDRUP-POULSEN T, BILLESTRUP N, HALBAN PA Dual effect of cell-cell contact disruption on cytosolic calcium and insulin secretion. ENDOCRINOLOGY 2008 vol. 149(5) pp. 2494-2505 JAQUES F, JOUSSET H, TOMAS A, PROST AL, WOLLHEIM CB, IRMINGER JC, DEMAUREX N, HALBAN P Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 2008 vol. 93(10) pp. 4065-4074 BÖNI-SCHNETZLER M, THORNE J, PARNAUD G, MARSELLI L, EHSES JA, KERR-CONTE J, PATTOU F, HALBAN PA, WEIR GC, DONATH MY Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture. LE DIABETE 2008 vol. 57(11) pp. 3045-3055 MARZBAN L, TOMAS A, BECKER TC, ROSENBERG L, OBERHOLZER J, FRASER PE, HALBAN PA, VERCHERE CB Interleukin-6 regulates pancreatic alpha-cell mass expansion. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2008 vol. 105(35) pp. 13163-13168 ELLINGSGAARD H AND AL. Munc 18-1 and granuphilin collaborate during insulin granule exocytosis. TRAFFIC 2008 vol. 9(5) pp. 813-832 TOMAS A, MEDA P, REGAZZI R, PESSIN JE, HALBAN PA Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice DIABETES 2007 vol. 56(5) pp. 1268-1276 HERBACH NADJA ET AL. Pro-survival role of gelsolin in mouse beta-cells DIABETES 2007 vol. 56 pp. 80-87 YERMEN, B, TOMAS, A, HALBAN, PA The innovative medicines initiative (IMI): a shot in the arm for European diabetes research? DIABETOLOGIA 2007 vol. 50 pp. 1791-1794 HALBAN, PA Induction of CXCL1 by extracellular matrix and autocrine enhancement by interleukin-1 in rat pancreatic beta-cells ENDOCRINOLOGY 2007 vol. 148 pp. 5582-5590 RIBAUX, P, EHSES, JA, LIN-MARQ, N, CARROZZINO, F, BONI-SCHNETZLER, M, HAMMAR, E, IRMINGER, JC, DONATH, MY, HALBAN, PA Dynamin is functionally coupled to insulin granule exocytosis JOURNAL OF BIOLOGICAL CHEMISTRY 2007 vol. 282 pp. 33530-33536 MIN, L, LEUNG, YM, TOMAS, A, WATSON, RT, GAISANO, HY, HALBAN, PA, PESSIN, JE, HOU, JC Differential expression of E-cadherin at the surface of rat beta-cells as a marker of functional heterogeneity JOURNAL OF ENDOCRINOLOGY 2007 vol. 194 pp. 21-29 BOSCO, D, ROUILLER, DG, HALBAN, PA The Fas pathway is involved in pancreatic beta cell secretory function PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2007 vol. 104 pp. 2861-2866 SCHUMANN DM, MAEDLER K, FRANKLIN I, KONRAD D, STORLING J, BONI-SCHNETZLER M, GJINOVCI A, KURRER MO, GAUTHIER BR, BOSCO D, ANDRES A, BERNEY T, GRETER M, BECHER B, CHERVONSKY AV, HALBAN PA, MANDRUP-POULSEN T, WOLLHEIM CB, DONATH MY Blockade of beta 1 integrin-laminin-5 interaction affects spreading and insulin secretion of rat beta-cells attached on extracellular matrix DIABETES 2006 vol. 55 pp. 1413-1420 PARNAUD G, HAMMAR E, ROUILLER DG, ARMANET M, HALBAN PA, BOSCO D Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death DIABETES 2006 vol. 55(8) pp. 2192-2201 MARZBAN LUCY, RHODES CHRISTOPHER J, STEINER DONALD F, HAATAJA LEENA, HALBAN PHILIPPE A, VERCHERE C. BRUCE Islet Inflammation and Fibrosis in a Spontaneous Model of Type 2 Diabetes, the GK Rat DIABETES 2006 vol. 55(6) pp. 1625-1633 HOMO-DELARCHE FRANCOISE ET AL. Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor JOURNAL OF BIOLOGICAL CHEMISTRY 2006 vol. 281(16) pp. 11050-11057 UGLEHOLDT RANDI ET AL. Regulation of pancreatic beta-cell insulin secretion by actin cytoskeleton remodelling: role of gelsolin and cooperation with the MAPK signalling pathway JOURNAL OF CELL SCIENCE 2006 vol. 119(Pt 10) pp. 2156-2167 TOMAS ALEJANDRA, YERMEN BARBARA, LE MIN, PESSIN JEFFREY E, HALBAN PHILIPPE A Diabetes research investment in the European union NATURE MEDICINE 2006 vol. 12 pp. 70-72 HALBAN PA, FERRANNINI E, NERUP J Inhibition of calpain blocks pancreatic beta-cell spreading and insulin secretion AMERICAN JOURNAL OF PHYSIOLOGY. ENDOCRINOLOGY AND METABOLISM 2005 vol. 289 pp. 313-321 PARNAUD GERALDINE, HAMMAR BOUVERET EVA, ROUILLER DOMINIQUE, BOSCO DOMENICO Restitution of defective glucose-stimulated insulin secretion in diabetic GK rat by acetylcholine uncovers paradoxical stimulatory effect of beta-cell muscarinic receptor activation on cAMP production . DIABETES 2005 vol. 54 pp. 3229-3237 DOLZ M, BAILBE D, GIROIX MH, CALDERARI S, GANGNERAU MN, SERRADAS P, RICKENBACH KATHARINA, IRMINGER JEAN-CLAUDE Suppression of Pdx-1 perturbs proinsulin processing, insulin secretion and GLP-1 signalling in INS-1 cells. DIABETOLOGIA 2005 vol. 48 pp. 720-731 WANG HAIYAN, IEZZI-BAKHTIARI MARIELLA, THEANDER STEN, ANTINOZZI PETER, GAUTHIER BENOIT, HALBAN PHILIPPE A., WOLLHEIM CLAES 10th EASD/JDRF Oxford Workshop. What is a beta-cell and can we improve it? DIABETOLOGIA 2005 vol. 48 pp. 93-101 SCHUIT F, HALBAN PHILIPPE A., RHODES C Activation of NF-kappaB by extracellular matric is involved in spreading and glucose-stimulated insulin secretion of pancreatic beta cells JOURNAL OF BIOLOGICAL CHEMISTRY 2005 vol. 280 pp. 30630-30637 HAMMAR EB, IRMINGER JEAN-CLAUDE, RICKENBACH KATHARINA, PARNAUD G, RIBAUX PASCALE, BOSCO DOMENICO, ROUILLER DG, HALBAN PHILIPPE A. Effects of I(Ks) channel inhibitors in insulin-secreting INS-1 cells. PFLUGERS ARCHIV FUR DIE GESAMTE PHYSIOLOGIE DES MENSCHEN UND DER TIERE 2005 vol. 451 pp. 428-436 ULLRICH S, SU J, RANTA F, WITTEKINDT OH, RIS FREDERIC, ROSLER M, GERLACH U, WARTH R, LANG F Extracellular matrix protects pancreatic beta-cells against apoptosis: role of short- and long-term signaling pathways DIABETES 2004 vol. 53 pp. 2034-2041 HAMMAR E, PARNAUD G, BOSCO D, PERRIRAZN, MAEDLER K, DONATH M, ROUILLER DG, HALBAN PA Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide DIABETES 2004 vol. 53(1) pp. 141-148 MARZBAN L, TRIGO-GONZALES G, ZHU X, RHODES CJ, HALBAN PHILIPPE A., STEINER DF, VERCHERE CB Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications DIABETOLOGIA 2004 vol. 47(3) pp. 581-589 DONATH MY, HALBAN PHILIPPE A. Pioglitazone and sodium salicylate protect human (beta)-cells against apoptosis and impaired function induced by glucose interleukin-1(beta) JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 2004 vol. 89 pp. 5059-5066 ZEENDER E, MAEDLER K, BOSCO D, BERNEY T, DONATH MY, HALBAN PA Cellular sources of new pancreatic beta cells and therapeutic implications for regenerative medicine. NATURE CELL BIOLOGY 2004 vol. 6 pp. 1021-1025 HALBAN PHILIPPE A. Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1 beta in human islets PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2004 vol. 101 pp. 8138-8143 MAEDLER K, SERGEEV P, EHSES JA, MATHE Z, BOSCO D, BERNEY T, DAYER JM, REINECKE M, HALBAN PA, DONATH M Towards a perfect beta cell replacement SEMINARS IN CELL AND DEVELOPMENTAL BIOLOGY 2004 vol. 15(3) pp. 325-326 HALBAN PHILIPPE A. Sorting ourselves out: seeking consensus on trafficking in the beta-cell TRAFFIC 2004 vol. 5(1) pp. 53-61 ARVAN P, HALBAN PHILIPPE A. Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse. DIABETES 2003 vol. 52 pp. 409-416 T. IZUMI, H. YOKOTA-HASHIMOTO, S. ZHAO, J. WANG, HALBAN PA, T. TAKEUCHI Ectopic expression of the beta-cell specific transcription factor Pdx1 inhibits glucagon gene transcription. DIABETOLOGIA 2003 vol. 46(6) pp. 810-821 RITZ-LASER B, GAUTHIER BR, ESTREICHER VON ROZBIERSKI A, MAMIN A, BRUN T, RIS F, SALMON P, HALBAN PA, TRONO D, PHILIPPE J Thank you Vienna-over to you, BristolA message of thanks to the outgoing Editor-in-Chief of Diabetologia, Professor Werner Waldhausl. DIABETOLOGIA 2003 vol. 47 pp. 595-596 HALBAN P Differential gene expression in well-regulated and dysregulated pancreatic beta-cell (MIN6) sublines. ENDOCRINOLOGY 2003 vol. 144 pp. 1368-1379 LILLA V, G. WEBB, RICKENBACH K, MATURANA ANDRES, D.F. STEINER, HALBAN PA, IRMINGER JC Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. JOURNAL OF BIOLOGICAL CHEMISTRY 2003 vol. 278 pp. 471-478 Y. LI, T. HANSOTIA, B. YUSTA, RIS F, HALBAN PA, D.J. DRUCKER Mutant proinsulin that cannot be converted is secreted efficiently from primary rat beta-cells via the regulated pathway. MOLECULAR BIOLOGY OF THE CELL 2003 vol. 14 pp. 1195-1203 HALBAN PA, IRMINGER JC Glucose-stimulated insulin secretion is coupled to the interaction of actin with the t-SNARE (target membrane soluble N-ethylmaleimide-sensitive factor attachment protein receptor protein) complex. MOLECULAR ENDOCRINOLOGY 2003 vol. 17 pp. 732-742 D. THURMOND, GONELLE-GISPERT C, M. FURUKAWA, HALBAN PA, J.E. PESSIN Phosphorylation of SNAP-25 on serine-187 is induced by secretagogues in insulin-secreting cells, but is not correlated with insulin secretion. BIOCHEMICAL JOURNAL 2002 vol. 15 pp. 223-232 GONELLE-GISPERT C, COSTA M, TAKAHASHI M, SADOUL K, HALBAN P Molecular detection of circulating beta-cells after islet transplantation DIABETES 2002 vol. 51 pp. 557-561 RITZ-LASER B, OBERHOLZER J, TOSO C, BRULHART MC, ZAKRZEWSKA K, RIS F, BUCHER P, MOREL P, PHILIPPE J Impact of integrin-matrix matching and inhibition of apoptosis on the survival of purified human beta-cells in vitro. DIABETOLOGIA 2002 vol. 45 pp. 841-850 RIS F, HAMMAR E, BOSCO D, PILLOUD C, MAEDLER K, DONATH MY, OBERHOLZER J, ZEENDER E, MOREL P, ROUILLER D, HALBAN PA Truncated (des-[27-31]) C-peptide is not a major secretory product of human islets. DIABETOLOGIA 2002 vol. 45 pp. 1523-1527 PAOLETTA M, KAHN SE, HALBAN PA Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. JOURNAL OF CLINICAL INVESTIGATION 2002 vol. 110 pp. 851-860 MAEDLER K, SERGEEV P, RIS F, OBERHOLZER J, JOLLER-JEMELKA HI, SPINAS GA, KAISER N, HALBAN PA, DONATH MY Isolation and characterization of VGF peptides in rat brain. Role of PC1/3 and PC2 in the maturation of VGF precursor. JOURNAL OF NEUROCHEMISTRY 2002 vol. 81 pp. 565-574 TRANI E, GIORGI A, CANU N, AMADORO G, RINALDI AM, HALBAN PA, FERRI GL, POSSENTI R, SCHININA ME, LEVI A FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2002 vol. 99(12) pp. 8236-8241 MAEDLER K, FONTANA A, RIS F, SERGEEV P, TOSO C, OBERHOLZER J, LEHMANN R, BACHMANN F, SPINAS GA, TASINATO A, HALBAN PA, DONATH MY FLIP switches fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2002 vol. 99 pp. 8236-8241 MAEDLER K, FONTANA A, RIS F, SERGEEV P, TOSO C, OBERHOLZER J, LEHMANN R, BACHMANN F, TASINATO A, SPINAS GA, HALBAN PA, DONATH MY Potential impact of in situ liver splitting on the number of available grafts TRANSPLANTATION 2002 vol. 74 pp. 222-226 TOSO C, RIS F, MENTHA G, OBERHOLZER J, MOREL P, MAJNO P Factors affecting human islets of Langerhans isolation yields TRANSPLANTATION PROCEEDINGS 2002 vol. 34 pp. 826-827 TOSO C, OBERHOLZER J, RIS F, TRIPONEZ F, BUCHER P, DEMIRAG A, ANDEREGGEN E, BUEHLER LH, CRETIN N, FOURNIER B, MAJNO P, HONG Y, LOU J, MOREL P Human islet allotransplantation with Basiliximab in type 1 diabetic patients with end-stage renal failure TRANSPLANTATION PROCEEDINGS 2002 vol. 34 pp. 823-825 OBERHOLZER J, TOSO C, TRIPONEZ F, RIS F, BUCHER P, DEMIRAG A, LOU J, MAJNO P, BUEHLER LH, PHILIPPE J, MOREL P Domaines de recherche