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Staphylococcus aureus

S.aureus are major pathogens in human infections. Methicillin-resistant Staphylococcus aureus (MRSA) are major pathogens of hospital-acquired and more recently community-acquired infections. Antibiotic therapy of patients infected with hospital-acquired MRSA strains, which are frequently resistant to most other antibiotics, generally requires parenteral administration of glycopeptide antibiotics, namely vancomycin or teicoplanin. Intensive use of vancomycin or teicoplanin potentially leads to the selection of MRSA isolates displaying low-level intermediate (GISA) or high (VRSA) levels of resistance to glycopeptides. Clinical GISA isolates represent a special risk because the molecular mechanisms underlying resistance are endogenous and poorly understood, and phenotypic detection of such isolates is particularly difficult.

Working Hypothesis: Emergence of glycopeptide resistance is currently viewed as the progressive selection of subpopulations of GISA precursors by long-term glycopeptide therapy, eventually leading to homogeneous GISA populations. GISA are generally characterized by cell wall thickening that seem to result from multiple genomic changes altering in an unknown manner transcription of several cell-wall regulation pathways.

Specific Aims: The primary goal (goal A) of this proposal is to identify by transcription profiling and genetic methods specific genes and metabolic pathways playing a key role in emergence of glycopeptide resistance in S.aureus.
A secondary goal, built on new knowledge obtained from mechanistic studies of gene expression (goal A), is to develop a simplified, reliable assay for targeted screening of putative GISA isolates that can be exploited in a clinical microbiological laboratory both for clinical and epidemiological studies (goal B).

Group's publications

Foreign body infections due to Staphylococcus epidermidis.
ANNALS OF MEDICINE
2009 vol. 41(2) pp. 109-119
UCKAY I, PITTET D, VAUDAUX P, SAX H, LEW D, WALDVOGEL FA

Comparison of tigecycline and vancomycin for treatment of experimental foreign-body infection due to methicillin-resistant Staphylococcus aureus.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
2009 vol. 53(7) pp. 3150-3152
VAUDAUX P, FLEURY B, GJINOVCI A, HUGGLER E, BENTO M, LEW D

Identification by genomic and genetic analysis of two new genes playing a key role in intermediate glycopeptide resistance in Staphylococcus aureus.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
2009 vol. 53(3) pp. 903-911
RENZONI A, KELLEY WL, BARRAS C, MONOD A, HUGGLER E, FRANCOIS P, SCHRENZEL J, STUDER R, VAUDAUX P, LEW D

Transcriptomic and metabolic responses of Staphylococcus aureus exposed to supra-physiological temperatures.
BMC MICROBIOLOGY [COMPUTER FILE]
2009 vol. 22 pp. 76-76
FLEURY B, KELLEY W, LEW D, GOTZ F, PROCTOR RA, VAUDAUX P

Increased uptake and improved intracellular survival of a teicoplanin-resistant mutant of methicillin-resistant Staphylococcus aureus in non-professional phagocytes.
CHEMOTHERAPY
2009 vol. 55(3) pp. 183-188
RENZONI A, HUGGLER E, KELLEY WL, LEW D, VAUDAUX P

Clinical consensus conference: survey on Gram-positive bloodstream infections with a focus on Staphylococcus aureus.
CLINICAL INFECTIOUS DISEASES
2009 vol. 48 pp. 260-270
NABER CK AND AL.

Comparative activity of oritavancin against meticillin-resistant Staphylococcus aureus (MRSA) bloodstream isolates from Geneva University Hospital.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
2009 vol. 34(6) pp. 540-543
VAUDAUX P, HUGGLER E, ARHIN FF, MOECK G, RENZONI A, LEW D

Use of serum antistreptolysin O titers in the microbial diagnosis of orthopedic infections.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
2009 vol. 13(4) pp. 421-424
UCKAY I, FERRY T, STERN R, AMBROSIONI J, GAMULIN A, ANDREY D, DJORDJEVIC M, BERNARD L, HOFFMEYER P, LEW D

Activity and impact on antibiotic use and costs of a dedicated infectious diseases consultant on a septic orthopaedic unit.
THE JOURNAL OF INFECTION
2009 vol. 58(3) pp. 205-212
UCKAY I, VERNAZ-HEGI N, HARBARTH S, STERN R, LEGOUT L, VAUTHEY L, FERRY T, LUBBEKE A, ASSAL M, LEW D, HOFFMEYER P, BERNARD L

Low incidence of haematogenous seeding to total hip and knee prostheses in patients with remote infections
THE JOURNAL OF INFECTION
2009 vol. 59(5) pp. 337-345
UCKAY I, LUBBEKE A, EMONET STEPHANE, TOVMIRZAEVA L, STERN R, FERRY T, ASSAL M, LEW D, HOFFMEYER P, BERNARD L, LEW D, HOFFMEYER P

Antibiotic prophylaxis before invasive dental procedures in patients with arthroplasties of the hip and knee.
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME
2008 vol. 90(7) pp. 833-838
UCKAY ILKER, PITTET D, BERNARD L, LEW D, PERRIER A, PETER R

A global view of Staphylococcus aureus whole genome expression upon internalization in human epithelial cells
BMC GENOMICS
2007 vol. 8(1) pp. 171-185
GARZONI C, FRANCOIS P, HUYGHE A, COUZINET S, TAPPAREL C, CHARBONNIER Y, RENZONI A, LUCCHINI S, LEW D.P, VAUDAUX P, KELLEY W.L, SCHRENZEL J

Inactivation of a subpopulation of human neutrophils by exposure to ultrahigh-molecular-weight polyethylene wear debris
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
2007 vol. 49 pp. 425-432
BERNARD L, VAUDAUX P, HUGGLER E, STERN R, FREHEL C, FRANCOIS P, LEW D, HOFFMEYER P

A randomized prospective study of cefepime plus metronidazole with imipenem-cilastatin in the treatment of intra-abdominal infections
INFECTION
2007 vol. 35(3) pp. 161-166

Transcriptomic and functional analysis of an autolysis-deficient, teicoplanin-resistant derivative of methicillin-resistant Staphylococcus aureus
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
2006 vol. 50 pp. 3048-3061
RENZONI A, BARRAS C, FRANCOIS P, CHARBONNIER Y, HUGGLER E, GARZONI C, KELLEY WL, MAJCHERCZYK P, SCHRENZEL J, LEW DP, VAUDAUX P

Exploring glycopeptide-resistance in Staphylococcus aureus: A combined proteomics and transcriptomics approach for the identification of resistance-related markers
BMC GENOMICS
2006 vol. 7 pp. 296-296
SCHERL A AND AL.

Evaluation of high-dose daptomycin for therapy of experimental Staphylococcus aureus foreign body infection
BMC INFECTIOUS DISEASES
2006 vol. 6:74 pp. 0-0
SCHAAD HJ, BENTO M, LEW DP, VAUDAUX P

Evaluation of high-dose daptomycin for therapy of experimental Staphylococcus aureus foreign body infection.
BMC INFECTIOUS DISEASES
2006 vol. 6 pp. 74-
SCHAAD H, BENTO M, LEW D, VAUDAUX P

Analysis of factors that contribute to treatment failure in patients with community-acquired pneumonia
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
2006 vol. 25 pp. 159-166
GENNE D, SOMMER R, KAISER L, SAAIDIA A, PASCHE A, UNGER P, LEW D

Tolerance of staphylococci to bactericidal antibiotics
INJURY
2006 vol. 37 Suppl 2 pp. 15-19
VAUDAUX PIERRE, LEW DANIEL

Rapid Staphylococcus aureus agr type determination by a novel multiplex real-time quantitative PCR assay
JOURNAL OF CLINICAL MICROBIOLOGY
2006 vol. 44 pp. 1892-1895
FRANCOIS P, KOESSLER T, HUYGHE A, HARBARTH S, BENTO M, LEW D, ETIENNE J, PITTET D, SCHRENZEL J

Recurrent osteomyelitis caused by infection with different bacterial strains without obvious source of reinfection
JOURNAL OF CLINICAL MICROBIOLOGY
2006 vol. 44(3) pp. 1194-1196
UÇKAY ILKER, ASSAL MATHIEU, LEGOUT LAURENCE, ROHNER PETER, STERN RICHARD, LEW DANIEL, HOFFMEYER PIERRE, BERNARD LOUIS

Use of oligoarrays for characterization of community-onset methicillin-resistant Staphylococcus aureus
JOURNAL OF CLINICAL MICROBIOLOGY
2006 vol. 44 pp. 1040-1048
KOESSLER T, FRANCOIS P, CHARBONNIER Y, HUYGHE A, BENTO M, DHARAN S, RENZI G, LEW D, HARBARTH S, PITTET D, SCHRENZEL J

Rapid bacterial identification using evanescent-waveguide oligonucleotide microarray classification
JOURNAL OF MICROBIOLOGICAL METHODS
2006 vol. 65 pp. 390-403
FRANCOIS P, CHARBONNIER Y, JACQUET J, UTINGER D, BENTO M, LEW D, KRESBACH GM, EHRAT M, SCHLEGEL W, SCHRENZEL J

Diagnosis and treatment of diabetic foot infections
PLASTIC AND RECONSTRUCTIVE SURGERY
2006 vol. 117 pp. 212-238
LIPSKY BA, BERENDT AR, DEERY HG, EMBIL JM, JOSEPH WS, KARCHMER AW, LEFROCK JL, LEW DP, MADER JT, NORDEN C, TAN JS

Intracellular residency is frequently associated with recurrent Staphylococcus aureus rhinosinusitis
RHINOLOGY
2006 vol. 44 pp. 249-254
PLOUIN-GAUDON I, CLEMENT S, HUGGLER E, CHAPONNIER C, FRANCOIS P, LEW D, SCHRENZEL J, VAUDAUX P, LACROIX JS

Successful treatment of Candida parapsilosis (fluconazole-resistant) osteomyelitis with caspofungin in a HIV patient
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES
2006 vol. 38 pp. 728-730
LEGOUT L, ASSAL M, ROHNER P, LEW D, BERNARD L, HOFFMEYER P

Evaluation of a high-density oligonucleotide array for characterization of grlA, grlB, gyrA and gyrB mutations in fluoroquinolone resistant Staphylococcus aureus isolates
JOURNAL OF MICROBIOLOGICAL METHODS
2005 vol. 60 pp. 275-279
COUZINET SABINE ET AL.

Symptoms and clinical and radiological signs predicting the presence of pathogenic bacteria in acute rhinosinusitis
ACTA OTO-LARYNGOLOGICA
2002 vol. 122 pp. 192-196
LACROIX JS, RICCHETTI A, LEW D, DELHUMEAU C, MORABIA A, STALDER H, TERRIER F, KAISER L

Comparison of levofloxacin, alatrofloxacin, and vancomycin for prophylaxis and treatment of experimental foreign-body-associated infection by methicillin-resistant Staphylococcus aureus.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
2002 vol. 46 pp. 1503-1509
VAUDAUX P, FRANCOIS P, BISOGNANO C, SCHRENZEL J, LEW DP

Synaptotagmin II could confer Ca2+ sensitivity to phagocytosis in human neutrophils
BIOCHIMICA ET BIOPHYSICA ACTA : INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS.
2002 vol. 1590 pp. 159-166
LINDMARK M, KARLSSON A, SERRANDER L, FRANCOIS P, LEW D, RASMUSSON B, STENDAHL O, NUESSE O

Increased expression of clumping factor and fibronectin-binding proteins by hemB mutants of Staphylococcus aureus expressing small colony variant phenotypes.
INFECTION AND IMMUNITY
2002 vol. 70 pp. 5428-5437
VAUDAUX P, FRANCOIS P, BISOGNANO C, KELLEY WL, LEW DP, SCHRENZEL J, PROCTOR R.A., MCNAMARA P.J., PETERS G, VON EIFF C

Granule-specific ATP requirements for Ca2+-induced exocytosis in human neutrophils. Evidence for substantial ATP-independent release
JOURNAL OF CELL SCIENCE
2002 vol. 115 pp. 2975-2983
THEANDER S, LEW DP, NUESSE O

Research's domains




DATABASE-RESEARCH	GROUP OF CLINICAL PATIENT RESEARCH

Daniel LEW et Adriana RENZONI	Head of group CV	Research subject	Members of the group


	Links about the group Pro. D. LEW / A. Renzoni HUG/Spécialités de Médecine Serv. Maladies infectieuses Rue Gabrielle-Perret-Gentil 4 1211 Genève 14 Suisse Daniel.Lew@hcuge.ch Tel.: 022.372.98.00 / 95652 Fax: 022.372.98.30 Comments Pages updated the 17.11.2015		Reseach's subject \| Group's publications \| Research's domains Staphylococcus aureus S.aureus are major pathogens in human infections. Methicillin-resistant Staphylococcus aureus (MRSA) are major pathogens of hospital-acquired and more recently community-acquired infections. Antibiotic therapy of patients infected with hospital-acquired MRSA strains, which are frequently resistant to most other antibiotics, generally requires parenteral administration of glycopeptide antibiotics, namely vancomycin or teicoplanin. Intensive use of vancomycin or teicoplanin potentially leads to the selection of MRSA isolates displaying low-level intermediate (GISA) or high (VRSA) levels of resistance to glycopeptides. Clinical GISA isolates represent a special risk because the molecular mechanisms underlying resistance are endogenous and poorly understood, and phenotypic detection of such isolates is particularly difficult. Working Hypothesis: Emergence of glycopeptide resistance is currently viewed as the progressive selection of subpopulations of GISA precursors by long-term glycopeptide therapy, eventually leading to homogeneous GISA populations. GISA are generally characterized by cell wall thickening that seem to result from multiple genomic changes altering in an unknown manner transcription of several cell-wall regulation pathways. Specific Aims: The primary goal (goal A) of this proposal is to identify by transcription profiling and genetic methods specific genes and metabolic pathways playing a key role in emergence of glycopeptide resistance in S.aureus. A secondary goal, built on new knowledge obtained from mechanistic studies of gene expression (goal A), is to develop a simplified, reliable assay for targeted screening of putative GISA isolates that can be exploited in a clinical microbiological laboratory both for clinical and epidemiological studies (goal B). Group's publications Foreign body infections due to Staphylococcus epidermidis. ANNALS OF MEDICINE 2009 vol. 41(2) pp. 109-119 UCKAY I, PITTET D, VAUDAUX P, SAX H, LEW D, WALDVOGEL FA Comparison of tigecycline and vancomycin for treatment of experimental foreign-body infection due to methicillin-resistant Staphylococcus aureus. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2009 vol. 53(7) pp. 3150-3152 VAUDAUX P, FLEURY B, GJINOVCI A, HUGGLER E, BENTO M, LEW D Identification by genomic and genetic analysis of two new genes playing a key role in intermediate glycopeptide resistance in Staphylococcus aureus. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2009 vol. 53(3) pp. 903-911 RENZONI A, KELLEY WL, BARRAS C, MONOD A, HUGGLER E, FRANCOIS P, SCHRENZEL J, STUDER R, VAUDAUX P, LEW D Transcriptomic and metabolic responses of Staphylococcus aureus exposed to supra-physiological temperatures. BMC MICROBIOLOGY [COMPUTER FILE] 2009 vol. 22 pp. 76-76 FLEURY B, KELLEY W, LEW D, GOTZ F, PROCTOR RA, VAUDAUX P Increased uptake and improved intracellular survival of a teicoplanin-resistant mutant of methicillin-resistant Staphylococcus aureus in non-professional phagocytes. CHEMOTHERAPY 2009 vol. 55(3) pp. 183-188 RENZONI A, HUGGLER E, KELLEY WL, LEW D, VAUDAUX P Clinical consensus conference: survey on Gram-positive bloodstream infections with a focus on Staphylococcus aureus. CLINICAL INFECTIOUS DISEASES 2009 vol. 48 pp. 260-270 NABER CK AND AL. Comparative activity of oritavancin against meticillin-resistant Staphylococcus aureus (MRSA) bloodstream isolates from Geneva University Hospital. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 2009 vol. 34(6) pp. 540-543 VAUDAUX P, HUGGLER E, ARHIN FF, MOECK G, RENZONI A, LEW D Use of serum antistreptolysin O titers in the microbial diagnosis of orthopedic infections. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES 2009 vol. 13(4) pp. 421-424 UCKAY I, FERRY T, STERN R, AMBROSIONI J, GAMULIN A, ANDREY D, DJORDJEVIC M, BERNARD L, HOFFMEYER P, LEW D Activity and impact on antibiotic use and costs of a dedicated infectious diseases consultant on a septic orthopaedic unit. THE JOURNAL OF INFECTION 2009 vol. 58(3) pp. 205-212 UCKAY I, VERNAZ-HEGI N, HARBARTH S, STERN R, LEGOUT L, VAUTHEY L, FERRY T, LUBBEKE A, ASSAL M, LEW D, HOFFMEYER P, BERNARD L Low incidence of haematogenous seeding to total hip and knee prostheses in patients with remote infections THE JOURNAL OF INFECTION 2009 vol. 59(5) pp. 337-345 UCKAY I, LUBBEKE A, EMONET STEPHANE, TOVMIRZAEVA L, STERN R, FERRY T, ASSAL M, LEW D, HOFFMEYER P, BERNARD L, LEW D, HOFFMEYER P Antibiotic prophylaxis before invasive dental procedures in patients with arthroplasties of the hip and knee. JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME 2008 vol. 90(7) pp. 833-838 UCKAY ILKER, PITTET D, BERNARD L, LEW D, PERRIER A, PETER R A global view of Staphylococcus aureus whole genome expression upon internalization in human epithelial cells BMC GENOMICS 2007 vol. 8(1) pp. 171-185 GARZONI C, FRANCOIS P, HUYGHE A, COUZINET S, TAPPAREL C, CHARBONNIER Y, RENZONI A, LUCCHINI S, LEW D.P, VAUDAUX P, KELLEY W.L, SCHRENZEL J Inactivation of a subpopulation of human neutrophils by exposure to ultrahigh-molecular-weight polyethylene wear debris FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY 2007 vol. 49 pp. 425-432 BERNARD L, VAUDAUX P, HUGGLER E, STERN R, FREHEL C, FRANCOIS P, LEW D, HOFFMEYER P A randomized prospective study of cefepime plus metronidazole with imipenem-cilastatin in the treatment of intra-abdominal infections INFECTION 2007 vol. 35(3) pp. 161-166 Transcriptomic and functional analysis of an autolysis-deficient, teicoplanin-resistant derivative of methicillin-resistant Staphylococcus aureus ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2006 vol. 50 pp. 3048-3061 RENZONI A, BARRAS C, FRANCOIS P, CHARBONNIER Y, HUGGLER E, GARZONI C, KELLEY WL, MAJCHERCZYK P, SCHRENZEL J, LEW DP, VAUDAUX P Exploring glycopeptide-resistance in Staphylococcus aureus: A combined proteomics and transcriptomics approach for the identification of resistance-related markers BMC GENOMICS 2006 vol. 7 pp. 296-296 SCHERL A AND AL. Evaluation of high-dose daptomycin for therapy of experimental Staphylococcus aureus foreign body infection BMC INFECTIOUS DISEASES 2006 vol. 6:74 pp. 0-0 SCHAAD HJ, BENTO M, LEW DP, VAUDAUX P Evaluation of high-dose daptomycin for therapy of experimental Staphylococcus aureus foreign body infection. BMC INFECTIOUS DISEASES 2006 vol. 6 pp. 74- SCHAAD H, BENTO M, LEW D, VAUDAUX P Analysis of factors that contribute to treatment failure in patients with community-acquired pneumonia EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 2006 vol. 25 pp. 159-166 GENNE D, SOMMER R, KAISER L, SAAIDIA A, PASCHE A, UNGER P, LEW D Tolerance of staphylococci to bactericidal antibiotics INJURY 2006 vol. 37 Suppl 2 pp. 15-19 VAUDAUX PIERRE, LEW DANIEL Rapid Staphylococcus aureus agr type determination by a novel multiplex real-time quantitative PCR assay JOURNAL OF CLINICAL MICROBIOLOGY 2006 vol. 44 pp. 1892-1895 FRANCOIS P, KOESSLER T, HUYGHE A, HARBARTH S, BENTO M, LEW D, ETIENNE J, PITTET D, SCHRENZEL J Recurrent osteomyelitis caused by infection with different bacterial strains without obvious source of reinfection JOURNAL OF CLINICAL MICROBIOLOGY 2006 vol. 44(3) pp. 1194-1196 UÇKAY ILKER, ASSAL MATHIEU, LEGOUT LAURENCE, ROHNER PETER, STERN RICHARD, LEW DANIEL, HOFFMEYER PIERRE, BERNARD LOUIS Use of oligoarrays for characterization of community-onset methicillin-resistant Staphylococcus aureus JOURNAL OF CLINICAL MICROBIOLOGY 2006 vol. 44 pp. 1040-1048 KOESSLER T, FRANCOIS P, CHARBONNIER Y, HUYGHE A, BENTO M, DHARAN S, RENZI G, LEW D, HARBARTH S, PITTET D, SCHRENZEL J Rapid bacterial identification using evanescent-waveguide oligonucleotide microarray classification JOURNAL OF MICROBIOLOGICAL METHODS 2006 vol. 65 pp. 390-403 FRANCOIS P, CHARBONNIER Y, JACQUET J, UTINGER D, BENTO M, LEW D, KRESBACH GM, EHRAT M, SCHLEGEL W, SCHRENZEL J Diagnosis and treatment of diabetic foot infections PLASTIC AND RECONSTRUCTIVE SURGERY 2006 vol. 117 pp. 212-238 LIPSKY BA, BERENDT AR, DEERY HG, EMBIL JM, JOSEPH WS, KARCHMER AW, LEFROCK JL, LEW DP, MADER JT, NORDEN C, TAN JS Intracellular residency is frequently associated with recurrent Staphylococcus aureus rhinosinusitis RHINOLOGY 2006 vol. 44 pp. 249-254 PLOUIN-GAUDON I, CLEMENT S, HUGGLER E, CHAPONNIER C, FRANCOIS P, LEW D, SCHRENZEL J, VAUDAUX P, LACROIX JS Successful treatment of Candida parapsilosis (fluconazole-resistant) osteomyelitis with caspofungin in a HIV patient SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES 2006 vol. 38 pp. 728-730 LEGOUT L, ASSAL M, ROHNER P, LEW D, BERNARD L, HOFFMEYER P Evaluation of a high-density oligonucleotide array for characterization of grlA, grlB, gyrA and gyrB mutations in fluoroquinolone resistant Staphylococcus aureus isolates JOURNAL OF MICROBIOLOGICAL METHODS 2005 vol. 60 pp. 275-279 COUZINET SABINE ET AL. Symptoms and clinical and radiological signs predicting the presence of pathogenic bacteria in acute rhinosinusitis ACTA OTO-LARYNGOLOGICA 2002 vol. 122 pp. 192-196 LACROIX JS, RICCHETTI A, LEW D, DELHUMEAU C, MORABIA A, STALDER H, TERRIER F, KAISER L Comparison of levofloxacin, alatrofloxacin, and vancomycin for prophylaxis and treatment of experimental foreign-body-associated infection by methicillin-resistant Staphylococcus aureus. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2002 vol. 46 pp. 1503-1509 VAUDAUX P, FRANCOIS P, BISOGNANO C, SCHRENZEL J, LEW DP Synaptotagmin II could confer Ca2+ sensitivity to phagocytosis in human neutrophils BIOCHIMICA ET BIOPHYSICA ACTA : INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2002 vol. 1590 pp. 159-166 LINDMARK M, KARLSSON A, SERRANDER L, FRANCOIS P, LEW D, RASMUSSON B, STENDAHL O, NUESSE O Increased expression of clumping factor and fibronectin-binding proteins by hemB mutants of Staphylococcus aureus expressing small colony variant phenotypes. INFECTION AND IMMUNITY 2002 vol. 70 pp. 5428-5437 VAUDAUX P, FRANCOIS P, BISOGNANO C, KELLEY WL, LEW DP, SCHRENZEL J, PROCTOR R.A., MCNAMARA P.J., PETERS G, VON EIFF C Granule-specific ATP requirements for Ca2+-induced exocytosis in human neutrophils. Evidence for substantial ATP-independent release JOURNAL OF CELL SCIENCE 2002 vol. 115 pp. 2975-2983 THEANDER S, LEW DP, NUESSE O Research's domains