BASE DE DONNÉES-RECHERCHE | GROUPE DE RECHERCHE FONDAMENTALE | ||||||
Daniel HOESSLI | CV du Chef de Groupe | Sujet de Recherche | Composition du Groupe |
Coordonnées du groupe
Prof. D. HOESSLI CMU / Dpt PATIM Rue Michel-Servet 1 1211 Genève04 Suisse Daniel.Hoessli@unige.ch Tél.: 022 379 58 93 Fax: 022 379 57 46 Site web du groupe / département Commentaires Pages générées le 17.11.2015 |
Sujet de recherche
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Publications du groupe
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Domaines de recherche
Organisation de la membrane plasmique des cellules hématopoiétiques
Notre laboratoire s'intéresse à l'organisation de la membrane plasmique des cellules hématopoiétiques, et plus particulièrement à la fonction des microdomaines enrichis en sphingolipids, ou rafts.
Cette entité nouvelle a été reconnue dans la membrane plasmique de cellules polarisées et non-polarisée, et résulte d'interactions entre sphingolipides. Les interactions menant à la formation de rafts
implique les chaînes acylées des ceramides entrant dans la composition des gangliosides, de la sphingomyéline et des protéines GPI-liées. Ces lipides forment des agrégats supramoléculaires ou "rafts"
dans le feuillet externe de la membrane plasmique and permettent l'interaction fonctionelle des diverses protéines impliquées dand la signalisation transmembranaire et d'adhésion.
Publications du groupe Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts. BLOOD 2008 vol. 111(4) pp. 2310-2320 TAUZIN S, DING H, KHATIB K, AHMAD I, BURDEVET D, VAN ECHTEN G, LINDQUIST, SCHRAVEN B, NASIR U, BORISCH B, HOESSLI DC Immediate-early gene regulation by interplay between different post-translational modifications on human histone H3. JOURNAL OF CELLULAR BIOCHEMISTRY 2008 vol. 103(3) pp. 835-851 KALEEM A, HOESSLI DC, AHMAD I, WALKER-NASIR E, NASIM A, SHAKOORI AR, NASIR-UD-DIN In silico modulation of apoptotic Bcl-2 proteins by mistletoe lectin-1: functional consequences of protein modifications. JOURNAL OF CELLULAR BIOCHEMISTRY 2008 vol. 103(2) pp. 479-491 KHWAJA T, WAJAHAT T, AHMAD I, HOESSLI DC, WALKER-NASIR E, KALEEM A, QAZI WM, SHAKOORI AR, DIN NU MAPRes: an efficient method to analyze protein sequence around post-translational modification sites. JOURNAL OF CELLULAR BIOCHEMISTRY 2008 vol. 104(4) pp. 1220-1231 AHMAD I, HOESSLI DC, QAZI WM, KHURSHID A, MEHMOOD A, WALKER-NASIR E, AHMAD M, SHAKOORI AR, NASIR U Epidermal growth factor receptors: function modulation by phosphorylation and glycosylation interplay. MOLECULAR BIOLOGY REPORTS 2008 vol. 36(4) pp. 631-639 KALEEM A, AHMAD I, HOESSLI DC, WALKER-NASIR E, SALEEM M, SHAKOORI AR, NASIR U In silico modulation of HMGN-1 binding to histones and gene expression by interplay of phosphorylation and O-GlcNAc modification. PROTEIN AND PEPTIDE LETTERS 2008 vol. 15(2) pp. 193-199 AHMAD I, KHAN TS, HOESSLI DC, WALKER-NASIR E, KALEEM A, SHAKOORI AR, NASIR U MAPRes: Mining association patterns among preferred amino acid residues in the vicinity of amino acids targeted for post-translational modifications. PROTEOMICS 2008 vol. 8(10) pp. 1954-1958 AHMAD I, QAZI WM, KHURSHID A, AHMAD M, HOESSLI DC, KHAWAJA I, CHOUDHARY MI, SHAKOORI AR, NASIR U Functional and structural roles of GPI moieties in mammalian plasma membranes CURRENT ORGANIC CHEMISTRY 2007 vol. 11 pp. 619-626 HOESSLI, DC, TAUZIN, S, NASIR-UD-DIN, BORISCH, B Glycosylphosphatidylinositol (GPI) anchored proteins of Plasmodium falciparum: Antigenic determinants and role of sugar moieties in the GPI anchor CURRENT ORGANIC CHEMISTRY 2007 vol. 11 pp. 609-618 NASIR-UD-DIN, AHMAD, I, HOESSLI, DC, WALKER-NASIR, E, CHOUDHARY, MI Glycosyltransferase and glypiation inhibitors CURRENT ORGANIC CHEMISTRY 2007 vol. 11 pp. 591-607 WALKER-NASIR, E, AHMAD, I, SALEEM, M, HOESSLI, DC In silico determination of intracellular glycosylation and phosphorylation sites in human selectins: Implications for biological function JOURNAL OF CELLULAR BIOCHEMISTRY 2007 vol. 100 pp. 1558-1572 AHMAD, I, HOESSLI, DC, GUPTA, R, WALKER-NASIR, E, RAFIK, SM, CHOUDHARY, MI, SHAKOORI, AR, NASIR-UD-DIN Phosphorylation and glycosylation interplay: protein modifications at hydroxy amino acids and prediction of signaling functions of the human beta3 integrin family JOURNAL OF CELLULAR BIOCHEMISTRY 2006 vol. 99(3) pp. 706-718 AHMAD ISHTIAQ, HOESSLI DANIEL C., WALKER-NASIR EVELYNE, CHOUDHARY M. IQBAL, RAFIC SALEEM M., SHAKOORI ABDUL RAUF, NASIR-UD-DIN Oct-2 DNA binding transcription factor: functional consequences of phosphorylation and glycosylation NUCLEIC ACIDS RESEARCH 2006 vol. 34(1) pp. 175-184 AHMAD I, HOESSLI D, WALKER-NASIR E, RAFIK SM, SHAKOORI AR, NASIR-UD-DIN Mycobacterial lipoarabinomannans modulate cytokine production in human T helper cells by interfering with raft/microdomain signalling CELLULAR AND MOLECULAR LIFE SCIENCES 2005 vol. 62 pp. 179-187 SHABAANA AK, KULANGARA KARINA, SEMAC ISABELLE, PAREL Y, ILANGUMARAN SUBBURAJ, DHARMALINGAM K, CHIZZOLINI CARLO, HOESSLI DANIEL Combinatorial metabolism in Plasmodium falciparum-infected erythrocyte and interplay of glycosylation & phosphorylation CURRENT ORGANIC CHEMISTRY 2004 vol. 8 pp. 453-461 NASIR-UD-DIN, AHMAD I, IQBAL ASMA, HOESSLI DANIEL Glycosphingolipid clusters as organizers of plasma membrane rafts and caveolae CURRENT ORGANIC CHEMISTRY 2004 vol. 8 pp. 439-452 HOESSLI DANIEL, SEMAC ISABELLE, IQBAL ASMA, NASIR-UD-DIN, BORISCH BETTINA Role of sialic acid and sulfate groups in cervical mucus physiological functions: study of Macaca radiata glycoproteins BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 2003 vol. 1623 pp. 53-61 NASIR-UD-DIN, HOESSLI DC, RUNGGER-BRANDLE E, HUSSAIN SA, WALKER NASIR E Anti-CD20 therapeutic antibody rituximab modifies the functional organization of Rafts/microdomains of B lymphoma cells CANCER RESEARCH 2003 vol. 63 pp. 534-540 SEMAC I, PALOMBA C, KULANGARA K, KLAGES N, VAN ECHTEN-DECKERT G, BORISCH B, HOESSLI DC Plasmodium falciparum merozoite surface protein 1. Glycosylation and localization to low-density, detergent-resistant membranes in the parasitized erythrocyte EUROPEAN JOURNAL OF BIOCHEMISTRY 2003 vol. 270 pp. 366-375 HOESSLI DC, POINCELET M, GUPTA R, ILANGUMARAN S, NASIR-UD-DIN ALK-positive anaplastic large-cell lymphoma: strong T and B anti-tumour responses may cause hypocellular aspects of lymph nodes mimicking inflammatory lesions EUROPEAN JOURNAL OF HAEMATOLOGY 2003 vol. 71 pp. 243-249 BORISCH B, YERLY S, CERATO CH, SCHWALLER J, WACKER P, OZSAHIN H, BROUSSE N, HOESSLI DC HIV-1 entry into T-cells is not dependent on CD4 and CCR5 localization to sphingolipid-enriched, detergent-resistant, Raft membrane domains JOURNAL OF BIOLOGICAL CHEMISTRY 2003 vol. 278 pp. 3153-3161 PERCHERANCIER Y, LAGANE B, PLANCHENAULT T, STAROPOLI I, ALTMEYER R, ARENZANA-SEISDEDOS F, VIRELIZIER JL, HOESSLI DC, BACHELERIE F Differentially regulated expression and function of CD22 in activated B-1 and B-2 lymphocytes JOURNAL OF IMMUNOLOGY 2002 vol. 168 pp. 6078-6083 LAJAUNIAS F, NITSCHKE L, MOLL T, MARTINEZ-SORIA E, SEMAC I, CHICHEPORTICHE Y, PARKHOUSE R M E, IZUI S Anti-CD20 treatments and the lymphocyte membrane: pathology for therapy VERHANDLUNGEN DER DEUTSCHEN GESELLSCHAFT FUR PATHOLOGIE 2001 vol. 85 pp. 161-166 BORISCH B, SEMAC I, SOLTERMANN A, APALOMBA C, HOESSLI DC Domaines de recherche |