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Steatohepatitis

Steatohepatitis may be due to alcohol comsumption (called Alcoholic SteatoHepatitis - ASH), the metabolic syndrome involving insulin resistance (called Non-Alcoholic SteatoHepatits ż NASH), drugs, or a combination of these factors. These diseases have similar features at microscopic examination of the liver, and probably share similar risk factors and mechanisms. All may result in cirrhosis and liver cancer. Because of the pandemic of obesity and diabetes, the world-wide incidence of steatohepatitis, mainly non-alcoholic, is on the rise.

In Geneva, we tackle the following aspects of steatohepatitis:
1. Human hepatocyte culture models are rendered steatotic. Mouse models of steatohepatitis are produced using high fat/high glucose diets. Both in vitro and in vivo, among other factors, we focus on the role of TNF-alpha, bile acid regulation, and cytokines.
2. Pathophysiology-oriented studies in man are centered on the role of cytokines, gene expression profiles, as well as prognostic factors in alcoholic steatohepatitis.
3. Therapeutic studies using anti-TNF agents, insulin-sensitizing strategies, and, in alcoholic steatohepatitis, stem cells mobilization to induce liver regeneration.
4. Studies in liver transplant recipients, focusing on factors associated with graft steatohepatitis.

Group's publications

Tezosentan normalizes hepatomesenteric perfusion in a porcine model of cardiac tamponade.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
2009 vol. 53(2) pp. 203-209
ANEMAN A, TREGGIARI MM, BURGENER D, LAESSER M, STRASSER S, HADENGUE A

Etiology, management, and outcome of the Budd-Chiari syndrome.
ANNALS OF INTERNAL MEDICINE
2009 vol. 151(3) pp. 167-175
DARWISH MURAD S AND AL.

Anticoagulants in portal vein thrombosis: don't be so shy!
BLOOD
2009 vol. 113(20) pp. 5031-5032
SPAHR L, BOEHLEN F, DE MOERLOOSE P, HADENGUE A

Phlegmonous colitis: another source of sepsis in cirrhotic patients?
BMC GASTROENTEROLOGY
2009 vol. 9 pp. 94-
HOLZER T, GERVAZ P, SPAHR L, MCKEE T, BUCHER P, MOREL P

Dangerous halo after neoadjuvant chemotherapy and two-step hepatectomy for colorectal liver metastases.
BRITISH JOURNAL OF SURGERY
2009 vol. 96(1) pp. 95-103
MENTHA G, TERRAZ S, MOREL P, ANDRES A, GIOSTRA E, ROTH A, RUBBIA-BRANDT L, MAJNO P

Risk of complications after abdominal paracentesis in cirrhotic patients: a prospective study.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
2009 vol. 7(8) pp. 906-909
DE GOTTARDI A, THEVENOT T, SPAHR L, MORARD I, BRESSON-HADNI S, TORRES F, GIOSTRA E, HADENGUE A

Intragastric balloon for weight loss: results in 100 individuals followed for at least 2.5 years.
ENDOSCOPY
2009 vol. 41(7) pp. 575-580
DASTIS NS, FRANCOIS E, DEVIERE J, HITTELET A, ILAH MEHDI A, BAREA M, DUMONCEAU JM

Partially covered self-expandable metallic stents for benign biliary strictures due to chronic pancreatitis.
ENDOSCOPY
2009 vol. 41(6) pp. 547-551
BEHM B, BROCK A, CLARKE BW, ELLEN K, NORTHUP PG, DUMONCEAU JM, KAHALEH M

Symptomatic esophageal stricture and buried metaplasia after radiofrequency ablation of Barrett's esophagus.
ENDOSCOPY
2009 vol. 41 pp. 214-215
JANSSENS F, ROUGEMONT AL, DEVIERE J, FOCKENS P, DUMONCEAU JM

Proteomic analysis of human bile and potential applications for cancer diagnosis.
EXPERT REVIEW OF PROTEOMICS
2009 vol. 6(3) pp. 285-301
FARINA A, DUMONCEAU JM, LESCUYER P

High-grade common bile duct stricture caused by diffuse adenomyomatosis.
GASTROINTESTINAL ENDOSCOPY
2009 vol. 69(6) pp. 1167-1168
GENEVAY M, FROSSARD JL, HUBER O, RUBBIA-BRANDT L, DUMONCEAU JM

Fatal course of recurrent primary biliary cirrhosis after liver transplantation.
JOURNAL OF CLINICAL GASTROENTEROLOGY
2009 vol. 43(2) pp. 196-197
DUMORTIER J, RUBBIA-BRANDT L, MORARD I, HADENGUE A, MENTHA G, GIOSTRA E

Acute hepatitis due to brivudin: a case report.
JOURNAL OF HEPATOLOGY
2009 vol. 51(5) pp. 967-969
MOTTU A, RUBBIA-BRANDT L, BIHL F, HADENGUE A, SPAHR L

Genotype 3 is associated with accelerated fibrosis progression in chronic hepatitis C.
JOURNAL OF HEPATOLOGY
2009 vol. 51(4) pp. 655-666
BOCHUD PY AND AL.

Paroxysmal nocturnal hemoglobinuria in Budd-Chiari syndrome: findings from a cohort study.
JOURNAL OF HEPATOLOGY
2009 vol. 51(4) pp. 696-706
HOEKSTRA J AND AL.

Proteomic Analysis of Human Bile from Malignant Biliary Stenosis Induced by Pancreatic Cancer
JOURNAL OF PROTEOME RESEARCH
2009 vol. 8(1) pp. 159-169
FARINA A, DUMONCEAU JM, FROSSARD JL, HADENGUE A, HOCHSTRASSER DF, LESCUYER P

Little evidence that hepatitis C virus leads to a higher risk of mortality in the absence of cirrhosis and excess alcohol intake: the Swiss Hepatitis C Cohort Study.
JOURNAL OF VIRAL HEPATITIS
2009 vol. 16(9) pp. 644-649
PRASAD L AND AL.

Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis.
THE LANCET ONCOLOGY
2009 vol. 10(1) pp. 35-43
MAZZAFERRO V AND AL.

Pegylated interferon-alpha2a/ribavirin treatment of recurrent hepatitis C after liver transplantation.
TRANSPLANT INFECTIOUS DISEASE : AN OFFICIAL JOURNAL OF THE TRANSPLANTATION SOCIETY
2009 vol. 11(1) pp. 33-39
DINGES S AND AL.

Humoral and cellular rejection after combined liver-kidney transplantation in low immunologic risk recipients
TRANSPLANT INTERNATIONAL
2009 vol. 22(2) pp. 242-246
HADAYA K, FERRARI-LACRAZ SYLVIE, GIOSTRA E, MAJNO P, MOLL S, RUBBIA-BRANDT L, MARANGON NICOLA, VENETZ JP, BOLLE JF, MENTHA G, VILLARD J

False serologic evidence for acute primary toxoplasmosis during liver transplantation for fulminant hepatitis B: a case report.
TRANSPLANTATION PROCEEDINGS
2009 vol. 41(10) pp. 4425-4427
UCKAY I, WUNDERLI W, GIOSTRA E, MAJNO P, MENTHA G, VAN DELDEN C

Grasp or brush for biliary sampling at endoscopic retrograde cholangiography? A blinded randomized controlled trial.
AMERICAN JOURNAL OF GASTROENTEROLOGY
2008 vol. 103(2) pp. 333-340
DUMONCEAU JM, MACIAS GOMEZ C, CASCO C, GENEVAY-INFANTE MURIEL, MARCOLONGO M, BONGIOVANNI MASSIMO, MOREL P, MAJNO P, HADENGUE A

Combined written and oral information prior to gastrointestinal endoscopy compared with oral information alone: a randomized trial.
BMC GASTROENTEROLOGY
2008 vol. 8 pp. 22-22
FELLEY CHRISTIAN, PERNEGER TV, GOULET I, ROUILLARD C, AZAR-PEY N, DORTA G, HADENGUE A, FROSSARD JL

Fat diet and alcohol-induced steatohepatitis after LPS challenge in mice: role of bioactive TNF and Th1 type cytokines.
CYTOKINE
2008 vol. 44(1) pp. 118-125
OLLEROS ML, MARTIN ML, VESIN D, FOTIO AL, SANTIAGO-RABER ML, RUBBIA L, SPAHR L, HADENGUE A, GARCIA I

'Liver first' approach in the treatment of colorectal cancer with synchronous liver metastases.
DIGESTIVE SURGERY
2008 vol. 25(6) pp. 430-435
MENTHA G, ROTH AD, TERRAZ S, GIOSTRA E, GERVAZ P, ANDRES A, MOREL P, RUBBIA-BRANDT L, MAJNO PE

Is TIPS really superior to endoscopic therapy in the prevention of rebleeding from gastric varices?
ENDOSCOPY
2008 vol. 40(5) pp. 448-
SPAHR L, MAFFEI M, HADENGUE A

Is TIPS really superior to endoscopic therapy in the prevention of rebleeding from gastric varices?
ENDOSCOPY
2008 vol. 40(5) pp. 405-408
SPAHR L, MAFFEI M, HADENGUE A

Retinoids, bile acids and PPARs in Barrett's oesophagus.
GUT
2008 vol. 57(1) pp. 137-137
DE GOTTARDI A, HADENGUE A, DUMONCEAU JM

Granulocyte-colony stimulating factor induces proliferation of hepatic progenitors in alcoholic steatohepatitis: a randomized trial.
HEPATOLOGY
2008 vol. 48(1) pp. 221-229
SPAHR L, LAMBERT JF, RUBBIA-BRANDT L, CHALANDON Y, FROSSARD JL, GIOSTRA E, HADENGUE A

Baclofen improves abstinence in alcoholic cirrhosis: Still better to come?
JOURNAL OF HEPATOLOGY
2008 vol. 49(6) pp. 1083-1085
GACHE P, HADENGUE A

Proteomic profiling in an animal model of acute pancreatitis.
PROTEOMICS
2008 vol. 8(17) pp. 3621-3631
FETAUD V, FROSSARD JL, FARINA A, PASTOR CM, BUHLER L, DUMONCEAU JM, HADENGUE A, HOCHSTRASSER DENIS, LESCUYER P

Concomitant autoimmune and genetic pancreatitis leads to severe inflammatory conditions.
WORLD JOURNAL OF GASTROENTEROLOGY
2008 vol. 14(16) pp. 2596-2598
FROSSARD JL, DUMONCEAU JM, PASTOR CATHERINE, SPAHR L, HADENGUE A

A new method of biliary sampling for cytopathological examination during endoscopic retrograde cholangiography
AMERICAN JOURNAL OF GASTROENTEROLOGY
2007 vol. 102 pp. 550-557
DUMONCEAU, JM, CASCO, C, LANDONI, N, FROSSARD, JL, HADENGUE, A, PACHE, JC, GENEVAY, M, MOREL, P, KUMAR, N, BONGIOVANNI, M

A 3-month course of long-acting repeatable octreotide (Sandostatin LAR) improves portal hypertension in patients with cirrhosis: A randomized controlled study
AMERICAN JOURNAL OF GASTROENTEROLOGY
2007 vol. 102 pp. 1397-1405
SPAHR, L, GIOSTRA, E, FROSSARD, JL, MORARD, I, MENTHA, G, HADENGUE, A

Histamine H1 blocker hydroxyzine improves sleep in patients with cirrhosis and minimal hepatic encephalopathy: A randomized controlled pilot trial
AMERICAN JOURNAL OF GASTROENTEROLOGY
2007 vol. 102 pp. 744-753
SPAHR L, COEYTAUX A, GIOSTRA E, HADENGUE A, ANNONI JM

Emergency liver transplantation in amodiaquine-induced fulminant hepatitis
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
2007 vol. 77 pp. 14-15
MARKHAM LN, GIOSTRA E, HADENGUE A, ROSSIER M, REBSAMEN M, DESMEULES J

A simple score for predicting alcohol relapse after liver transplantation - Results from 387 patients over 15 years
ARCHIVES OF INTERNAL MEDICINE
2007 vol. 167 pp. 1183-1188
DE GOTTARDI, A, SPAHR, L, GELEZ, P, MORARD, I, MENTHA, G, GUILLAUD, O, MAJNO, P, MOREL, P, HADENGUE, A, PALIARD, P, SCOAZEC, JY, BOILLOT, O, GIOSTRA, E, DUMORTIER, J

Microarray analyses and molecular profiling of steatosis induction in immortalized human hepatocytes
LABORATORY INVESTIGATION
2007 vol. 87 pp. 792-806
DE GOTTARDI, A, VINCIGUERRA, M, SGROI, A, MOUKIL, M, RAVIER-DALL'ANTONIA, F, PAZIENZA, V, PUGNALE, P, FOTI, M, HADENGUE, A

Allopurinol, oxidative stress and intestinal permeability in patients with cirrhosis: an open-label pilot study
LIVER INTERNATIONAL
2007 vol. 27 pp. 54-60
SPAHR L, BRESSON-HADNI S, AMANN P, KERN I, GOLAZ O, FROSSARD JL, HADENGUE A

Conversion to sirolimus-based immunosuppression in maintenance liver transplantation patients
LIVER TRANSPLANTATION
2007 vol. 13 pp. 658-664
MORARD I, DUMORTIER J, SPAHR L, HADENGUE A, MAJNO P, MOREL P, MENTHA G, GIOSTRA E

Function of both sinusoidal and canalicular transporters controls the concentration of organic anions within hepatocytes
MOLECULAR PHARMACOLOGY
2007 vol. 71 pp. 1089-1097
PLANCHAMP C, HADENGUE A, STIEGER B, BOURQUIN J, VONLAUFEN A, FROSSARD JL, QUADRI R, BECKER CD, PASTOR CM

Coincidental CFTR mutation and Sjogren syndrome revealing a pancreatic disease
PANCREAS
2007 vol. 35 pp. 94-95
FROSSARD, JL, DUMONCEAU, JM, SPAHR, L, GIOSTRA, E, HADENGUE, A

Notre ami...le café
REVUE MÉDICALE SUISSE
2007 vol. 3(123) pp. 1931-
HADENGUE A, NEGRO F

Peroxisome proliferator-activated receptor-alpha and -gamma mRNA levels are reduced in chronic hepatitis C with steatosis and genotype 3 infection
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
2006 vol. 23(1) pp. 107-1114
DE GOTTARDI A, PAZIENZIA V, PUGNALE P, BRUTTINI F, RUBBIA-BRANDT L, JUGE-AUBRY CE, MEIER CA, HADENGUE A, NEGRO F

Fibrinogen gamma 375 Arg -> Trp mutation (fibrinogen Aguadilla) causes hereditary hypofibrinogenemia, hepatic endoplasmic reticulum storage disease and cirrhosis
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
2006 vol. 30 pp. 906-911
RUBBIA-BRANDT L, NEERMAN-ARBEZ M, ROUGEMONT AL, MALE PJ, SPAHR L

Hepatopulmonary syndrome increases the postoperative mortality rate following liver transplantation: a prospective study in 90 patients
AMERICAN JOURNAL OF TRANSPLANTATION
2006 vol. 6(6) pp. 1430-1437
SCHIFFER E. ET AL.

Systematic appraisal of the role of metallic endobiliary stents in the treatment of benign bile duct stricture
ANNALS OF SURGERY
2006 vol. 244 pp. 164-165
DUMONCEAU JM

Acute partial Budd-Chiari syndrome and portal vein thrombosis in cytomegalovirus primary infection: a case report
BMC GASTROENTEROLOGY
2006 vol. 6 pp. 0-0
SPAHR L, CERNY A, MORARD I, RUBBIA-BRANDT L, SCHRENZEL J

Long-term renal function after liver transplantation is related to calcineurin inhibitors blood levels
CLINICAL TRANSPLANTATION
2006 vol. 20 pp. 96-101
MORARD I, MENTHA G, SPAHR L, MAJNO P, HADENGUE A, HUBER O, MOREL P, GIOSTRA E

Sensitivity to endothelin-1 is decreased in isolated livers of endothelial constitutive nitric oxide synthase knockout mice
COMPARATIVE HEPATOLOGY
2006 vol. 5 pp. 9-
DE GOTTARDI A, BIECKER E, KOSHY A, BOHLER D, SHAW S, SAGESSER H, REICHEN J

Acute delayed gastric emptying after ablation of atrial fibrillation: Treatment with botulinum toxin injection
ENDOSCOPY
2006 vol. 38 pp. 543-543
DUMONCEAU JM, GIOSTRA E, BECH C, SPAHR L, SCHROFT A, SHAH D

ERCP and biliary topics
ENDOSCOPY
2006 vol. 38 pp. 11-15
DUMONCEAU JM

In vivo microscopic examination of the esophagus for the detection of cancer before liver transplantation in patients with alcoholic cirrhosis
ENDOSCOPY
2006 vol. 38 pp. 282-284
DUMONCEAU JM, GIOSTRA E, GENTA R, MENTHA G, RUBBIA-BRANDT L, HADENGUE A

Perendoscopic variceal pressure measurement - A reliable estimation of portal pressure in patients with cirrhosis?
GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE
2006 vol. 30 pp. 1012-1018
SPAHR L, GIOSTRA E, MORARD I, MENTHA G, HADENGUE A

Clinical challenges and images in GI - A gastric glomus tumor
GASTROENTEROLOGY
2006 vol. 131 pp. 1380-1982
MAFFEI M, ANDEREGGEN E, GENEVAY M, HUBER O, DUMONCEAU JM

Relationship between steatosis, inflammation, and fibrosis in chronic hepatitis C: a meta-analysis of individual patient data
GASTROENTEROLOGY
2006 vol. 130(6) pp. 1636-1642
GIOACCHINO LEANDRO ET AL.

Cardiovascular collapse due to massive pulmonary thromboembolism during orthotopic liver transplantation
JOURNAL OF CLINICAL ANESTHESIA
2006 vol. 18(5) pp. 367-371
ELLENBERGER CHRISTOPH, MENTHA GILLES, GIOSTRA EMILIANO, LICKER MARC

XPS and XAS studies of copper(II) sorbed onto a synthetic pyrite surface
JOURNAL OF COLLOID AND INTERFACE SCIENCE
2006 vol. 303(1) pp. 25-31
NAVEAU A, MONTEIL-RIVERA F, GUILLON E, DUMONCEAU J

Multidetector multiphase contrast-enhanced liver CT: Prospective study comparing two contrast material injection rates on vascular and liver parenchyma enhancement in patients with varied cirrhotic st atus
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY
2006 vol. 30 pp. 368-371
ALIMENTI A, SPAHR L, LOUBEYRE P

Liver transplantation for Budd-Chiari syndrome: A European study on 248 patients from 51 centres
JOURNAL OF HEPATOLOGY
2006 vol. 44(3) pp. 520-528
MENTHA GILLES ET AL.

The role of junctional adhesion molecule C (JAM-C) in acute pancreatitis
JOURNAL OF PATHOLOGY
2006 vol. 209 pp. 540-548
VONLAUFEN A, AURRAND-LIONS M, PASTOR CM, LAMAGNA C, HADENGUE A, IMHOF BA, FROSSARD JL

Expression of the bile acid receptor FXR in Barrett's esophagus and enhancement of apoptosis by guggulsterone in vitro
MOLECULAR CANCER
2006 vol. 5 pp. 0-0
DE GOTTARDI A, DUMONCEAU JM, BRUTTIN F, VONLAUFEN A, MORARD I, SPAHR L, RUBBIA-BRANDT L, FROSSARD JL, DINJENS WN, RABINOVITCH PS, HADENGUE A

Preoperative work-up in asymptomatic patients undergoing Roux-en-Y gastric bypass: is endoscopy mandatory?
OBESITY SURGERY
2006 vol. 16(10) pp. 1304-13011
AZAGURY D, DUMONCEAU JM, MOREL P, CHASSOT G, HUBER O

Cholestasis in adults. 1. Diagnostic procedure approach
REVUE MEDICALE DE LA SUISSE ROMANDE
2006 vol. 2(77) pp. 1960-1962
MAFFEI M, HADENGUE A

Cholestasis in adults. 2. Clinical signs and symptomatic treatment
REVUE MEDICALE DE LA SUISSE ROMANDE
2006 vol. 2(77) pp. 1965-1966
MAFFEI M, HADENGUE A

Clinical management of a patient with alcoholic cirrhosis
REVUE MEDICALE DE LA SUISSE ROMANDE
2006 vol. 2(77) pp. 1974-1978
NGUYEN-TANG T, HADENGUE A, SPAHR L

Functional bowel disorders: impact and limitations of evidence-based medicine
REVUE MEDICALE DE LA SUISSE ROMANDE
2006 vol. 2(77) pp. 1987-1991
DE SAUSSURE P, BERTOLINI D

Le point sur le traitement antiviral de l'hépatite B chronique
REVUE MEDICALE DE LA SUISSE ROMANDE
2006 vol. 2(77) pp. 1981-1985
NEGRO FRANCESCO, HADENGUE ANTOINE

Les enfants de Zanzibar, l'hepcidine et le fer
REVUE MEDICALE DE LA SUISSE ROMANDE
2006 vol. 2(77) pp. 1947-1948
HADENGUE ANTOINE, NEGRO FRANCESCO

Persistent diarrhea in the returned traveler
REVUE MEDICALE DE LA SUISSE ROMANDE
2006 vol. 2(65) pp. 1235-1236
DE SAUSSURE P, HADENGUE A

Management of liver cirrhosis: how far is not too far?
REVUE MÉDICALE SUISSE
2006 vol. 2(86) pp. 2561-2571
ABETEL G, DANTHE C, HUNGERBOHLER P, LAVANCHY JD, NICOLLIER A, RUSS D, HADENGUE A, VANNOTTI M

HIV and solid organ transplantation: The Swiss experience
SWISS MEDICAL WEEKLY
2006 vol. 136 pp. 194-196
MULLER NJ, HIRSCHEL B, FURRER H, KAISER L, CAVASSINI M, FELLAY J, CHAVE JP, WUTHRICH RP, WEBER M, MULLHAUPT B, CANDINAS D, REICHEN F, GIOSTRA E, MENTHA G, HALKIC N, HIRSCH HH, WEBER R

Oesophageal and fundic variceal bleeding
THERAPEUTISCHE UMSCHAU : MONATSSCHRIFT FUER PRAKTISCHE MEDIZIN = REVUE THERAPEUTIQUE : REVUE MENSUELLE DE MEDECINE PRATIQUE
2006 vol. 63(5) pp. 295-299
DE GOTTARDI A, DUFOUR JF

Portal vein thrombosis following a primary cytomegalovirus infection in an immunocompetent adult
THROMBOSIS AND HAEMOSTASIS
2006 vol. 95 pp. 199-201
GUEDDI S, RIGHINI M, MEZGER N, MORARD I, KAISER L, GIOSTRA E, BOUNAMEAUX H, ANGELILLO-SCHERRER A

Endothelial nitric oxide synthase regulation is altered in pancreas from cirrhotic rats
WORLD JOURNAL OF GASTROENTEROLOGY
2006 vol. 12 pp. 228-233
FROSSARD JL, PASTOR CM, QUADRI R, HADENGUE A, MOREI P

Neutrophil depletion--but not prevention of Kupffer cell activation--decreases the severity of cerulein-induced acute pancreatitis
WORLD JOURNAL OF GASTROENTEROLOGY
2006 vol. 12(8) pp. 1219-1224
PASTOR CATHERINE, VONLAUFEN ALAIN, GREGORI F, HADENGUE ANTOINE, MOREL PHILIPPE, FROSSARD JEAN-LOUIS

Treatment of hepatocellular carcinoma at the dawn of the third millenium: liver transplantation and its alternatives.
ACTA GASTRO-ENTEROLOGICA BELGICA
2004 vol. 67 pp. 206-222
MAJNO P, MENTHA G, GIOSTRA E, TERRAZ S, RUBBIA-BRANDT L, BERNEY T, BUHLER L, TOSO C, HUBER O, SPAHR L, MORARD I, HADENGUE A, BECKER C, TERRIER F, MOREL P

Natural history of long-term injury in mouse experimental pancreatitis
CRITICAL CARE MEDICINE
2002 vol. 30 pp. 1541-1546
FROSSARD JL, HADENGUE A, SPAHR L, MOREL P, PASTOR CM

Erythromycin intravenous bolus infusion in acute upper gastrointestinal bleeding: a randomized, controlled, double-blind trial
GASTROENTEROLOGY
2002 vol. 123 pp. 17-23
FROSSARD JL, SPAHR L, QUENEAU PE, GIOSTRA E, BURCKHARDT B, ORY G, De Saussure P, ARMENIAN B, DE PEYER R, HADENGUE A

Terlipressin in patients with cirrhosis and type 1 hepatorenal syndrome: a restrospective multicenter study
GASTROENTEROLOGY
2002 vol. 122 pp. 923-930
MOREAU R, DURAND F, POYNARD T, DUHAMEL C, CERVONI JP, ICHAI P, ABERGEL A, HALIMI C, PAUWELS M, BERNARD B, BUTEL J, CADRANEL JF, GIOSTRA E, HADENGUE A, LEBREC D, LEVY S, PARIENTE A, PERARNAU JM, PLATEK A, ROCHE J, SAMUEL D, SCRIBE-OUTTAS M, VALLA D, BRONOWICKI JP, FLEUROT C, GURNOT D, NOUEL O, RENARD P, RIVOAL M, BLANC P, COUMAROS D, DUCLOUX S

Combination of steroids with infliximab or placebo in severe alcoholic hepatitis: a randomized controlled pilot study
JOURNAL OF HEPATOLOGY
2002 vol. 37 pp. 448-455
SPAHR L, RUBBIA-BRANDT L, FROSSARD JL, GIOSTRA E, ANNE-LAURE ROUGEMONT, PUGIN J, MARIA FISCHER, HANSPETER EGGER, HADENGUE A

Acute effects of nitric oxide synthase inhibition on systemic hepatic and renal hemodynamics in patients with cirrhosis and ascites
JOURNAL OF INVESTIGATIVE MEDICINE
2002 vol. 50 pp. 116-124
SPAHR L, MARTIN PY, GIOSTRA E, NIEDERBERGER M, LANG U, CAPPONI AM, HADENGUE A

Suivi médical au long cours après transplantation hépatique
MEDECINE ET HYGIENE : JOURNAL SUISSE D'INFORMATIONS MEDICALES
2002 vol. 60 pp. 254-259
GIOSTRA E, MOSIMANN F, HADENGUE A., MENTHA G

Liver transplantation for alcoholic liver disease: a medical and ethical debate
SWISS MEDICAL WEEKLY
2002 vol. 132 pp. 298-298
BUEHLER LH, GELEZ P, GIOSTRA E, HADENGUE A, MOREL P, MENTHA G

Persistence of mild parkinsonism 4 months after liver transplantation in patients with preoperative minimal hepatic encephalopathy: a study on neuroradiological and blood manganese changes
TRANSPLANT INTERNATIONAL
2002 vol. 15 pp. 188-195
LAZEYRAS F, SPAHR L, DU PASQUIER R, DELAVELLE J, BURKHARD P, HADENGUE A, HOCHSTRASSER DF, MENTHA G, GIOSTRA E, TERRIER F, VINGERHOETS F

Immunological and virological effects of ribarivin in hepatitis C after liver transplantation
TRANSPLANTATION
2002 vol. 73 pp. 373-378
QUADRI R, GIOSTRA E, ROSKAMS T, PAWLOTSKY JM, MENTHA G, RUBBIA-BRANDT L, PERRIN L, HADENGUE A, NEGRO F

Research's domains




DATABASE-RESEARCH	GROUP OF CLINICAL PATIENT RESEARCH

Antoine HADENGUE	Head of group CV	Research subject	Members of the group