DATABASE-RESEARCH | GROUP OF CLINICAL PATIENT RESEARCH | ||||||
Jean-Philippe GUYOT | Head of group CV | Research subject | Members of the group |
Links about the group
Prof. J.-F. GUYOT HUG/ Dpt NEUCLID Serv. ORL Rue Gabrielle-Perret-Gentil 4 1211 Genève 14 Suisse Angelica.Perez-Fornos@hcuge.ch Tel.: 022 372 82 42 Fax: 022 372 82 40 Comments Pages updated the 17.11.2015 |
Reseach's subject
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Group's publications
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Research's domains
Sensory neuroprostheses for the restitution of hearing and balance
We work on the development of functional rehabilitation tools for patients with sensory deficits of the inner ear :
1. We develop a vestibular implant, a neuroprosthesis designed to restore vestibular function in patients with a complete bilateral deficit. We have demonstrated the feasibility of the concept in humans, developed surgical techniques for implanting electrodes in contact with the vestibular apparatus, and developed specific electrical stimulation paradigms. Currently, our work focuses on two areas: (a) we evaluate the actual functional rehabilitation that could be provided to patients by the implant; (b) we investigate the specific contribution of the different sensory modalities involved in balance, since our unique experimental setup allows the de-coupling of the different sources of information (e.g., vestibular and somesthetic/visual information). 2. The cochlear implant is a very effective tool for the rehabilitation of profound bilateral hearing loss. However, it still does not provide sufficient information in some situations, such as speech perception in noise and sound localization in space. We investigate strategies to improve these aspects. Our goal is to restore an artificial hearing that is as close to normal hearing as possible and to develop a completely implantable neuroprosthesis. We closely collaborate with the groups of Prof. Herman Kingma (Clinical Vestibular Laboratory, Maastricht University Medical Center, Maastricht, The Netherlands), Prof. Fred Mast (Cognitive Psychology, University of Bern, Bern, Switzerland), Prof. Daniel Merfeld (Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Boston, United States of America), and Prof. Silvestro Micera (Translational Neural Engineering Laboratory, Center for Neuroprosthetics and Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne). Group's publications Quality of life of patients with bilateral vestibulopathy. ANNALS OF OTOLOGY, RHINOLOGY, AND LARYNGOLOGY 2012 vol. 121(7) pp. 471-477 GUINAND N, BOSELIE F, GUYOT JP, KINGMA H Visual acuity while walking and oscillopsia severity in healthy subjects and patients with unilateral and bilateral vestibular function loss. ARCHIVES OF OTOLARYNGOLOGY--HEAD & NECK SURGERY 2012 vol. 138(3) pp. 301-306 GUINAND N, PIJNENBURG M, JANSSEN M, KINGMA H Tinnitus before and 6 months after cochlear implantation. AUDIOLOGY & NEURO-OTOLOGY 2012 vol. 17(3) pp. 161-168 KOMPIS M, PELIZZONE M, DILLIER N, ALLUM J, DEMIN N, SENN P Temporal properties of visual perception on electrical stimulation of the retina. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 2012 vol. 53(6) pp. 2720-2731 PEREZ FORNOS A, SOMMERHALDER J, DA CRUZ L, SAHEL JA, MOHAND-SAID S, HAFEZI F, PELIZZONE M Ethical, anatomical and physiological issues in developing vestibular implants for human use. JOURNAL OF VESTIBULAR RESEARCH : EQUILIBRIUM & ORIENTATION 2012 vol. 22(1) pp. 3-9 GUYOT JP, GAY A, KOS MI, PELIZZONE M [Causal relationship: and if "yes", and if "not"... on basis of which criterias?]. REVUE MÉDICALE SUISSE 2012 vol. 8(356) pp. 1881-1883 HEYMANS F, NICOUCAR K, GUYOT JP [Does the Physician's lack of scientific rigor cost him?]. REVUE MÉDICALE SUISSE 2012 vol. 8(356) pp. 1851-1852 GUYOT JP [Odd stories of patients suffering from Menière's disease]. REVUE MÉDICALE SUISSE 2012 vol. 8(356) pp. 1872-1875 GUYOT JP Adaptation to steady-state electrical stimulation of the vestibular system in humans. ANNALS OF OTOLOGY, RHINOLOGY, AND LARYNGOLOGY 2011 vol. 120(3) pp. 143-149 GUYOT JP, SIGRIST A, PELIZZONE M, KOS MI Eye movements in response to electrical stimulation of the lateral and superior ampullary nerves. ANNALS OF OTOLOGY, RHINOLOGY, AND LARYNGOLOGY 2011 vol. 120(2) pp. 81-87 GUYOT JP, SIGRIST A, PELIZZONE M, FEIGL G, KOS MI Mental transformation abilities in patients with unilateral and bilateral vestibular loss. EXPERIMENTAL BRAIN RESEARCH 2011 vol. 209(2) pp. 205-214 GRABHERR L, CUFFEL C, GUYOT JP, MAST FW Simulations to study spatial extent of stimulation and effect of electrode-tissue gap in subretinal implants. MEDICAL ENGINEERING AND PHYSICS 2011 vol. 33(6) pp. 755-763 KASI H, BERTSCH A, GUYOMARD JL, KOLOMIETS B, PICAUD S, PELIZZONE M, RENAUD P Measurement of dynamic visual acuity in patients with vestibular areflexia. ACTA OTO-LARYNGOLOGICA 2010 vol. 130(7) pp. 820-823 LAMBERT S, SIGRIST A, DELASPRE O, PELIZZONE M, GUYOT JP Where does essential reporting stop and where does 'l'art pour l'art' begin while imaging the middle ear? ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY HEAD AND NECK SURGERY 2010 vol. 72(3) pp. 131-132 GUYOT JP [Have we made progress in the development of a vestibular implant?]. REVUE MÉDICALE SUISSE 2010 vol. 6(265) pp. 1878-1880 GUYOT JP, SIGRIST AD, PELIZZONE M, KOS MI [Otoneurology, a full specialty?]. REVUE MÉDICALE SUISSE 2010 vol. 6(265) pp. 1851-1852 GUYOT JP, MAIRE R Atypical presentations of malignant otitis externa. THE JOURNAL OF LARYNGOLOGY AND OTOLOGY 2010 vol. 124(11) pp. 1205-1208 VOUREXAKIS Z, KOS MI, GUYOT JP Immuno-detection of Staphylococcus aureus Biofilm on a Cochlear Implant INFECTION 2009 vol. 37(5) pp. 450-454 KOS MI, STENZ L, GUYOT JP, FRANCOIS P, SCHRENZEL J What can be expected from a late cochlear implantation? INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY 2009 vol. 73(2) pp. 189-193 KOS MI, DERIAZ M, GUYOT JP, PELIZZONE M Selective taste disorder after temporal bone fracture JOURNAL OF CLINICAL NEUROSCIENCE 2009 vol. 16(4) pp. 605-605 LANDIS BN, GUINAND N Management of congenital fourth branchial arch anomalies: a review and analysis of published cases. JOURNAL OF PEDIATRIC SURGERY 2009 vol. 44(7) pp. 1432-1439 NICOUCAR K, GIGER R, POPE HG, JAECKLIN T, DULGUEROV P Retronasal Olfactory Function in Parkinson's Disease LARYNGOSCOPE 2009 vol. 119(11) pp. 2280-2283 LANDIS BN, VAN HC, GUINAND N, HORVATH J, HAEHNER A, SAVVA E, HUGENTOBLER M, LACROIX JS, BURKHARD PR Superior vestibular neurectomy: a novel transmeatal approach for a denervation of the superior and lateral semicircular canals. OTOLOGY & NEUROTOLOGY 2009 vol. 30(5) pp. 586-591 FEIGL G, FASEL J, ANDERHUBER F, ULZ H, RIENMÜLLER R, GUYOT JP, KOS MI [Cervical vertigo: myth or reality?]. REVUE MÉDICALE SUISSE 2009 vol. 5(219) pp. 1922-1924 GUINAND N, GUYOT JP [Development of a vestibular implant for the rehabilitation of bilateral deafness]. REVUE MÉDICALE SUISSE 2009 vol. 5(219) pp. 1918-1921 GUYOT JP, SIGRIST A, KOS MI [Ignace-Philippe Semmelweiss and Prosper Menière]. REVUE MÉDICALE SUISSE 2009 vol. 5(219) pp. 1915-1916 GUYOT JP [Neonatal hearing screening program and school education for deaf children in Switzerland]. REVUE MÉDICALE SUISSE 2009 vol. 5(219) pp. 1930-1932 CAO-NGUYEN MH, GUYOT JP [Rehabilitation of deaf children with a cochlear implant]. REVUE MÉDICALE SUISSE 2009 vol. 5(219) pp. 1933-1935 DERIAZ M Olfactory disorders: the patients' view. RHINOLOGY 2009 vol. 47(4) pp. 454-459 LANDIS BN, STOW NW, LACROIX JS, HUGENTOBLER M, HUMMEL T Benign paroxysmal positional vertigo: a series of eight singular neurectomies. ACTA OTO-LARYNGOLOGICA 2008 vol. 128(1) pp. 5-8 POURNARAS I, KOS MI, GUYOT JP Evaluation of subjectivity in the interpretation of videonystagmography. ACTA OTO-LARYNGOLOGICA 2008 vol. 128(8) pp. 892-895 DES COURTIS A, CASTRILLON R, HAENGGELI CA, DELASPRE O, LIARD P, GUYOT JP Development of surgical skill with singular neurectomy using human cadaveric temporal bones. ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER 2008 vol. 190(4) pp. 316-323 FEIGL GEORG, KOS MARIA IZABEL, ANDERHUBER F, GUYOT JP, FASEL J Phantosmias and Parkinson disease. ARCHIVES OF NEUROLOGY 2008 vol. 65(9) pp. 1237-1239 LANDIS BN, BURKHARD PR APRIL secreted by neutrophils binds to heparan sulfate proteoglycans to create plasma cell niches in human mucosa. JOURNAL OF CLINICAL INVESTIGATION 2008 vol. 118(8) pp. 2887-2895 HUARD B AND AL In reference to Tactile dysgeusia: a new clinical observation of middle ear and skull base surgery. LARYNGOSCOPE 2008 vol. 118(11) pp. 2097-2098 LANDIS BN, EL MAKHLOUFI K, GUYOT JP, KOS MI, MAGISTRIS MR Rhinorrhea and olfaction in Parkinson disease. NEUROLOGY 2008 vol. 71(13) pp. 1041-1042 LANDIS BN, BURKHARD PR Improved smell pleasantness after odor-taste associative learning in humans. NEUROSCIENCE LETTERS 2008 vol. 434(1) pp. 108-112 BARKAT S, PONCELET J, LANDIS BN, ROUBY C, BENSAFI M Intratympanic application of an antiviral agent for the treatment of Ménière's disease. ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES 2008 vol. 70(1) pp. 21-26 GUYOT JP, MAIRE R, DELASPRE O Re: Chorda tympani injury: operative findings and postoperative symptoms. OTOLARYNGOLOGY AND HEAD AND NECK SURGERY 2008 vol. 138(5) pp. 694-695 LANDIS BN, HUMMEL T Implication of dipeptidylpeptidase IV activity in human bronchial inflammation and in bronchoconstriction evaluated in anesthetized rabbits. RESPIRATION : INTERNATIONAL REVIEW OF THORACIC DISEASES 2008 vol. 75(1) pp. 89-97 LANDIS BN, GROUZMANN E, MONOD M, BUSSO N, PETAK F, SPILIOPOULOS A, ROBERT JH, SZALAY-QUINODOZ I, MOREL DR, LACROIX JS Nasal lavage with sodium hypochlorite solution in Staphylococcus aureus persistent rhinosinusitis. RHINOLOGY 2008 vol. 46(1) pp. 15-22 RAZA T, ELSHERIF HS, ZULIANELLO L, PLOUIN-GAUDON I, LANDIS BN, LACROIX JS Neurogenic inflammation of the upper airway mucosa. RHINOLOGY 2008 vol. 46(3) pp. 163-165 LACROIX JS, LANDIS BASILE Late and sudden recovery of sudden deafness or vestibular neuronitis ANNALES D'OTO-LARYNGOLOGIE ET DE CHIRURGIE CERVICO FACIALE : BULLETIN DE LA SOCIETE D'OTO-LARYNGOLOGIE DES HOPITAUX DE PARIS 2007 vol. 124(4) pp. 205-209 GUYOT JP, TOUPET M Spontaneous temporomandibular joint herniation into the external auditory canal ANNALES D'OTO-LARYNGOLOGIE ET DE CHIRURGIE CERVICO FACIALE : BULLETIN DE LA SOCIETE D'OTO-LARYNGOLOGIE DES HOPITAUX DE PARIS 2007 vol. 124(6) pp. 305-308 PSILLAS G, GUYOT JP Eye movements in response to electric stimulation of the human posterior ampullary nerve ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY 2007 vol. 116 pp. 369-374 WALL C, WALL, C, KOS, MI, GUYOT, JP, KOS MI, GUYOT JP Partial withdrawal of deeply inserted cochlear electrodes: observations of two patients EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY 2007 vol. 264 pp. 1369-1372 KOS MI, BOEX C, GUYOT JP, PELIZZONE M Benefits and costs of universal hearing screening programme INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY 2007 vol. 71 pp. 1591-1595 CAO-NGUYEN, MH, KOS, MI, GUYOT, JP Professional occupation after cochlear implantation. THE JOURNAL OF LARYNGOLOGY AND OTOLOGY 2007 vol. 121(3) pp. 215-218 KOS MI, DEGIVE C, BOEX C, GUYOT JP Radical scavengers in presbyacusis ACTA OTO-LARYNGOLOGICA 2006 vol. 126(11) pp. 1232-1232 GUYOT JP Patients' lives following stapedectomy complications ADVANCES IN OTO-RHINO-LARYNGOLOGY 2006 vol. 65 pp. 348-352 GUYOT JEAN-PHILIPPE, SAKBANI KENAN Transcanal approach to the singular nerve OTOLOGY & NEUROTOLOGY 2006 vol. 27 pp. 542-546 KOS MI, FEIGL G, ANDERHUBER F, WALL C, FASEL JHD, GUYOT JP Activité professionnelle des utilisateurs d'implant cochléaire REVUE MÉDICALE SUISSE 2006 vol. 2(81) pp. 2226-2228 KOS M-I., DEGIVE C., BOEX C., MAIRE R., GUYOT J.-P. Appareillage acoustique ou implantation cochléaire : les cas limites REVUE MÉDICALE SUISSE 2006 vol. 2(81) pp. 2230-2232 HAENGGELI CA, KOS MI, PELIZZONE, GUYOT JP Les avatars de patients sourds appareillés : le point de vue du praticien REVUE MÉDICALE SUISSE 2006 vol. 2(81) pp. 2236-2239 LIARD P, BANG P, GUYOT JP Une défaite déguisée en victoire...et qui visera bientôt le praticiens REVUE MÉDICALE SUISSE 2006 vol. 2(81) pp. 2211-2212 GUYOT JP, MONNIER P Obliteration of the tympanomastoid cavity: long term results of the Rambo operation THE JOURNAL OF LARYNGOLOGY AND OTOLOGY 2006 vol. 120(12) pp. 1014-1018 KOS MI, CHAVAILLAZ O, GUYOT J P Munchausen syndrome mimicking Meniere's disease ANNALES D'OTO-LARYNGOLOGIE ET DE CHIRURGIE CERVICO FACIALE : BULLETIN DE LA SOCIETE D'OTO-LARYNGOLOGIE DES HOPITAUX DE PARIS 2002 vol. 119 pp. 159-163 KOS MI, GUYOT JP Research's domains HEARING BALANCE FUNCTIONAL REHABILITATON NEUROPROTHESES NEURO-OTOLOGY |