Jean-Philippe GUYOT  Head of group CV  Members of the group

  Links about the group

Prof. J.-F. GUYOT
HUG/ Dpt NEUCLID
Serv. ORL
Rue Gabrielle-Perret-Gentil 4
1211 Genève 14
Suisse

Angelica.Perez-Fornos@hcuge.ch

Tel.: 022 372 82 42
Fax: 022 372 82 40




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Pages updated the 17.11.2015
Reseach's subject | Group's publications | Research's domains

Sensory neuroprostheses for the restitution of hearing and balance

We work on the development of functional rehabilitation tools for patients with sensory deficits of the inner ear :

1. We develop a vestibular implant, a neuroprosthesis designed to restore vestibular function in patients with a complete bilateral deficit. We have demonstrated the feasibility of the concept in humans, developed surgical techniques for implanting electrodes in contact with the vestibular apparatus, and developed specific electrical stimulation paradigms. Currently, our work focuses on two areas: (a) we evaluate the actual functional rehabilitation that could be provided to patients by the implant; (b) we investigate the specific contribution of the different sensory modalities involved in balance, since our unique experimental setup allows the de-coupling of the different sources of information (e.g., vestibular and somesthetic/visual information).

2. The cochlear implant is a very effective tool for the rehabilitation of profound bilateral hearing loss. However, it still does not provide sufficient information in some situations, such as speech perception in noise and sound localization in space. We investigate strategies to improve these aspects. Our goal is to restore an artificial hearing that is as close to normal hearing as possible and to develop a completely implantable neuroprosthesis.

We closely collaborate with the groups of Prof. Herman Kingma (Clinical Vestibular Laboratory, Maastricht University Medical Center, Maastricht, The Netherlands), Prof. Fred Mast (Cognitive Psychology, University of Bern, Bern, Switzerland), Prof. Daniel Merfeld (Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Boston, United States of America), and Prof. Silvestro Micera (Translational Neural Engineering Laboratory, Center for Neuroprosthetics and Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne).




Group's publications

Quality of life of patients with bilateral vestibulopathy.
ANNALS OF OTOLOGY, RHINOLOGY, AND LARYNGOLOGY
2012 vol. 121(7) pp. 471-477
GUINAND N, BOSELIE F, GUYOT JP, KINGMA H

Visual acuity while walking and oscillopsia severity in healthy subjects and patients with unilateral and bilateral vestibular function loss.
ARCHIVES OF OTOLARYNGOLOGY--HEAD & NECK SURGERY
2012 vol. 138(3) pp. 301-306
GUINAND N, PIJNENBURG M, JANSSEN M, KINGMA H

Tinnitus before and 6 months after cochlear implantation.
AUDIOLOGY & NEURO-OTOLOGY
2012 vol. 17(3) pp. 161-168
KOMPIS M, PELIZZONE M, DILLIER N, ALLUM J, DEMIN N, SENN P

Temporal properties of visual perception on electrical stimulation of the retina.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
2012 vol. 53(6) pp. 2720-2731
PEREZ FORNOS A, SOMMERHALDER J, DA CRUZ L, SAHEL JA, MOHAND-SAID S, HAFEZI F, PELIZZONE M

Ethical, anatomical and physiological issues in developing vestibular implants for human use.
JOURNAL OF VESTIBULAR RESEARCH : EQUILIBRIUM & ORIENTATION
2012 vol. 22(1) pp. 3-9
GUYOT JP, GAY A, KOS MI, PELIZZONE M

[Causal relationship: and if "yes", and if "not"... on basis of which criterias?].
REVUE MÉDICALE SUISSE
2012 vol. 8(356) pp. 1881-1883
HEYMANS F, NICOUCAR K, GUYOT JP

[Does the Physician's lack of scientific rigor cost him?].
REVUE MÉDICALE SUISSE
2012 vol. 8(356) pp. 1851-1852
GUYOT JP

[Odd stories of patients suffering from Menière's disease].
REVUE MÉDICALE SUISSE
2012 vol. 8(356) pp. 1872-1875
GUYOT JP

Adaptation to steady-state electrical stimulation of the vestibular system in humans.
ANNALS OF OTOLOGY, RHINOLOGY, AND LARYNGOLOGY
2011 vol. 120(3) pp. 143-149
GUYOT JP, SIGRIST A, PELIZZONE M, KOS MI

Eye movements in response to electrical stimulation of the lateral and superior ampullary nerves.
ANNALS OF OTOLOGY, RHINOLOGY, AND LARYNGOLOGY
2011 vol. 120(2) pp. 81-87
GUYOT JP, SIGRIST A, PELIZZONE M, FEIGL G, KOS MI

Mental transformation abilities in patients with unilateral and bilateral vestibular loss.
EXPERIMENTAL BRAIN RESEARCH
2011 vol. 209(2) pp. 205-214
GRABHERR L, CUFFEL C, GUYOT JP, MAST FW

Simulations to study spatial extent of stimulation and effect of electrode-tissue gap in subretinal implants.
MEDICAL ENGINEERING AND PHYSICS
2011 vol. 33(6) pp. 755-763
KASI H, BERTSCH A, GUYOMARD JL, KOLOMIETS B, PICAUD S, PELIZZONE M, RENAUD P

Measurement of dynamic visual acuity in patients with vestibular areflexia.
ACTA OTO-LARYNGOLOGICA
2010 vol. 130(7) pp. 820-823
LAMBERT S, SIGRIST A, DELASPRE O, PELIZZONE M, GUYOT JP

Where does essential reporting stop and where does 'l'art pour l'art' begin while imaging the middle ear?
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY HEAD AND NECK SURGERY
2010 vol. 72(3) pp. 131-132
GUYOT JP

[Have we made progress in the development of a vestibular implant?].
REVUE MÉDICALE SUISSE
2010 vol. 6(265) pp. 1878-1880
GUYOT JP, SIGRIST AD, PELIZZONE M, KOS MI

[Otoneurology, a full specialty?].
REVUE MÉDICALE SUISSE
2010 vol. 6(265) pp. 1851-1852
GUYOT JP, MAIRE R

Atypical presentations of malignant otitis externa.
THE JOURNAL OF LARYNGOLOGY AND OTOLOGY
2010 vol. 124(11) pp. 1205-1208
VOUREXAKIS Z, KOS MI, GUYOT JP

Immuno-detection of Staphylococcus aureus Biofilm on a Cochlear Implant
INFECTION
2009 vol. 37(5) pp. 450-454
KOS MI, STENZ L, GUYOT JP, FRANCOIS P, SCHRENZEL J

What can be expected from a late cochlear implantation?
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
2009 vol. 73(2) pp. 189-193
KOS MI, DERIAZ M, GUYOT JP, PELIZZONE M

Selective taste disorder after temporal bone fracture
JOURNAL OF CLINICAL NEUROSCIENCE
2009 vol. 16(4) pp. 605-605
LANDIS BN, GUINAND N

Management of congenital fourth branchial arch anomalies: a review and analysis of published cases.
JOURNAL OF PEDIATRIC SURGERY
2009 vol. 44(7) pp. 1432-1439
NICOUCAR K, GIGER R, POPE HG, JAECKLIN T, DULGUEROV P

Retronasal Olfactory Function in Parkinson's Disease
LARYNGOSCOPE
2009 vol. 119(11) pp. 2280-2283
LANDIS BN, VAN HC, GUINAND N, HORVATH J, HAEHNER A, SAVVA E, HUGENTOBLER M, LACROIX JS, BURKHARD PR

Superior vestibular neurectomy: a novel transmeatal approach for a denervation of the superior and lateral semicircular canals.
OTOLOGY & NEUROTOLOGY
2009 vol. 30(5) pp. 586-591
FEIGL G, FASEL J, ANDERHUBER F, ULZ H, RIENMÜLLER R, GUYOT JP, KOS MI

[Cervical vertigo: myth or reality?].
REVUE MÉDICALE SUISSE
2009 vol. 5(219) pp. 1922-1924
GUINAND N, GUYOT JP

[Development of a vestibular implant for the rehabilitation of bilateral deafness].
REVUE MÉDICALE SUISSE
2009 vol. 5(219) pp. 1918-1921
GUYOT JP, SIGRIST A, KOS MI

[Ignace-Philippe Semmelweiss and Prosper Menière].
REVUE MÉDICALE SUISSE
2009 vol. 5(219) pp. 1915-1916
GUYOT JP

[Neonatal hearing screening program and school education for deaf children in Switzerland].
REVUE MÉDICALE SUISSE
2009 vol. 5(219) pp. 1930-1932
CAO-NGUYEN MH, GUYOT JP

[Rehabilitation of deaf children with a cochlear implant].
REVUE MÉDICALE SUISSE
2009 vol. 5(219) pp. 1933-1935
DERIAZ M

Olfactory disorders: the patients' view.
RHINOLOGY
2009 vol. 47(4) pp. 454-459
LANDIS BN, STOW NW, LACROIX JS, HUGENTOBLER M, HUMMEL T

Benign paroxysmal positional vertigo: a series of eight singular neurectomies.
ACTA OTO-LARYNGOLOGICA
2008 vol. 128(1) pp. 5-8
POURNARAS I, KOS MI, GUYOT JP

Evaluation of subjectivity in the interpretation of videonystagmography.
ACTA OTO-LARYNGOLOGICA
2008 vol. 128(8) pp. 892-895
DES COURTIS A, CASTRILLON R, HAENGGELI CA, DELASPRE O, LIARD P, GUYOT JP

Development of surgical skill with singular neurectomy using human cadaveric temporal bones.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
2008 vol. 190(4) pp. 316-323
FEIGL GEORG, KOS MARIA IZABEL, ANDERHUBER F, GUYOT JP, FASEL J

Phantosmias and Parkinson disease.
ARCHIVES OF NEUROLOGY
2008 vol. 65(9) pp. 1237-1239
LANDIS BN, BURKHARD PR

APRIL secreted by neutrophils binds to heparan sulfate proteoglycans to create plasma cell niches in human mucosa.
JOURNAL OF CLINICAL INVESTIGATION
2008 vol. 118(8) pp. 2887-2895
HUARD B AND AL

In reference to Tactile dysgeusia: a new clinical observation of middle ear and skull base surgery.
LARYNGOSCOPE
2008 vol. 118(11) pp. 2097-2098
LANDIS BN, EL MAKHLOUFI K, GUYOT JP, KOS MI, MAGISTRIS MR

Rhinorrhea and olfaction in Parkinson disease.
NEUROLOGY
2008 vol. 71(13) pp. 1041-1042
LANDIS BN, BURKHARD PR

Improved smell pleasantness after odor-taste associative learning in humans.
NEUROSCIENCE LETTERS
2008 vol. 434(1) pp. 108-112
BARKAT S, PONCELET J, LANDIS BN, ROUBY C, BENSAFI M

Intratympanic application of an antiviral agent for the treatment of Ménière's disease.
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES
2008 vol. 70(1) pp. 21-26
GUYOT JP, MAIRE R, DELASPRE O

Re: Chorda tympani injury: operative findings and postoperative symptoms.
OTOLARYNGOLOGY AND HEAD AND NECK SURGERY
2008 vol. 138(5) pp. 694-695
LANDIS BN, HUMMEL T

Implication of dipeptidylpeptidase IV activity in human bronchial inflammation and in bronchoconstriction evaluated in anesthetized rabbits.
RESPIRATION : INTERNATIONAL REVIEW OF THORACIC DISEASES
2008 vol. 75(1) pp. 89-97
LANDIS BN, GROUZMANN E, MONOD M, BUSSO N, PETAK F, SPILIOPOULOS A, ROBERT JH, SZALAY-QUINODOZ I, MOREL DR, LACROIX JS

Nasal lavage with sodium hypochlorite solution in Staphylococcus aureus persistent rhinosinusitis.
RHINOLOGY
2008 vol. 46(1) pp. 15-22
RAZA T, ELSHERIF HS, ZULIANELLO L, PLOUIN-GAUDON I, LANDIS BN, LACROIX JS

Neurogenic inflammation of the upper airway mucosa.
RHINOLOGY
2008 vol. 46(3) pp. 163-165
LACROIX JS, LANDIS BASILE

Late and sudden recovery of sudden deafness or vestibular neuronitis
ANNALES D'OTO-LARYNGOLOGIE ET DE CHIRURGIE CERVICO FACIALE : BULLETIN DE LA SOCIETE D'OTO-LARYNGOLOGIE DES HOPITAUX DE PARIS
2007 vol. 124(4) pp. 205-209
GUYOT JP, TOUPET M

Spontaneous temporomandibular joint herniation into the external auditory canal
ANNALES D'OTO-LARYNGOLOGIE ET DE CHIRURGIE CERVICO FACIALE : BULLETIN DE LA SOCIETE D'OTO-LARYNGOLOGIE DES HOPITAUX DE PARIS
2007 vol. 124(6) pp. 305-308
PSILLAS G, GUYOT JP

Eye movements in response to electric stimulation of the human posterior ampullary nerve
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
2007 vol. 116 pp. 369-374
WALL C, WALL, C, KOS, MI, GUYOT, JP, KOS MI, GUYOT JP

Partial withdrawal of deeply inserted cochlear electrodes: observations of two patients
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
2007 vol. 264 pp. 1369-1372
KOS MI, BOEX C, GUYOT JP, PELIZZONE M

Benefits and costs of universal hearing screening programme
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
2007 vol. 71 pp. 1591-1595
CAO-NGUYEN, MH, KOS, MI, GUYOT, JP

Professional occupation after cochlear implantation.
THE JOURNAL OF LARYNGOLOGY AND OTOLOGY
2007 vol. 121(3) pp. 215-218
KOS MI, DEGIVE C, BOEX C, GUYOT JP

Radical scavengers in presbyacusis
ACTA OTO-LARYNGOLOGICA
2006 vol. 126(11) pp. 1232-1232
GUYOT JP

Patients' lives following stapedectomy complications
ADVANCES IN OTO-RHINO-LARYNGOLOGY
2006 vol. 65 pp. 348-352
GUYOT JEAN-PHILIPPE, SAKBANI KENAN

Transcanal approach to the singular nerve
OTOLOGY & NEUROTOLOGY
2006 vol. 27 pp. 542-546
KOS MI, FEIGL G, ANDERHUBER F, WALL C, FASEL JHD, GUYOT JP

Activité professionnelle des utilisateurs d'implant cochléaire
REVUE MÉDICALE SUISSE
2006 vol. 2(81) pp. 2226-2228
KOS M-I., DEGIVE C., BOEX C., MAIRE R., GUYOT J.-P.

Appareillage acoustique ou implantation cochléaire : les cas limites
REVUE MÉDICALE SUISSE
2006 vol. 2(81) pp. 2230-2232
HAENGGELI CA, KOS MI, PELIZZONE, GUYOT JP

Les avatars de patients sourds appareillés : le point de vue du praticien
REVUE MÉDICALE SUISSE
2006 vol. 2(81) pp. 2236-2239
LIARD P, BANG P, GUYOT JP

Une défaite déguisée en victoire...et qui visera bientôt le praticiens
REVUE MÉDICALE SUISSE
2006 vol. 2(81) pp. 2211-2212
GUYOT JP, MONNIER P

Obliteration of the tympanomastoid cavity: long term results of the Rambo operation
THE JOURNAL OF LARYNGOLOGY AND OTOLOGY
2006 vol. 120(12) pp. 1014-1018
KOS MI, CHAVAILLAZ O, GUYOT J P

Munchausen syndrome mimicking Meniere's disease
ANNALES D'OTO-LARYNGOLOGIE ET DE CHIRURGIE CERVICO FACIALE : BULLETIN DE LA SOCIETE D'OTO-LARYNGOLOGIE DES HOPITAUX DE PARIS
2002 vol. 119 pp. 159-163
KOS MI, GUYOT JP


Research's domains

HEARING
BALANCE
FUNCTIONAL REHABILITATON
NEUROPROTHESES
NEURO-OTOLOGY