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The diagnosis and therapy of pulmonary hypertension

The diagnosis and therapy of pulmonary hypertension has dramatically changed these last years both in the understanding of the physiopathology and in the treatment. Our currents works is dedicated to the creation of registries to have a better knowledge of the etiology and epidemiology of pediatric pulmonary hypertension. We are also working on the assessments of the new therapies in the pediatric patients as well as to develop specific formulation for this population. Several studies are also focused on pulmonary hypertension associated with congenital heart disease both in animals and humans. These studies are planned in association with different centers in UCSF California (Prof Fineman), Great ormond street London ( prof Schulze Neick) and Paris ( Prof Humbert)

Childhood obesity poses a major public health problem and there is increasing evidence that foundation of cardiovascular diseases and metabolic syndrome lays early in life. In a recent study, we demonstrated that obese pre-pubertal children have altered endothelial and smooth muscle function of the brachial artery, low cardiorespiratory fitness, reduced physical activity, low HDL-cholesterol, as well as augmented arterial stiffness of the carotid artery, systemic blood pressure, abdominal fat and fasting insulin. In a randomized controlled trial (RCT), we showed that a 3-month exercise training program at moderate intensity significantly reduced systemic blood pressure, whole body and abdominal fatness, and prevented intima-media thickning of the carotid artery. The cardiorespiratory fitness, physical activity and quality of life increased after exercise training. The intervention did not show any effects on endothelial and smooth muscle functions, that may be due to insufficient duration or intensity of training, as well as counteracting factors such as unhealthy diet or sedentary lifestyle in the family. We plan now to perform a RCT to evaluate the effects of a moderate 6-month exercise training program, compared to a combined family-based behavioral treatment plus exercise training on cardiovascular, metabolic and psychological co-morbidities. Results of this intervention will provide essential information to support the development of the therapy of childhood obesity in Switzerland.

Group's publications

Homografts and xenografts for right ventricular outflow tract reconstruction: long-term results.
ANNALS OF THORACIC SURGERY
2010 vol. 90(4) pp. 1287-1293
CHRISTENSON JT, SIERRA J, COLINA MANZANO NE, JOLOU J, BEGHETTI M, KALANGOS A

No-patch technique for complete atrioventricular canal repair.
ANNALS OF THORACIC SURGERY
2010 vol. 90(1) pp. 317-319
MYERS PO, CIKIRIKCIOGLU M, AGGOUN Y, MURITH N, KALANGOS A

Characteristics and prospective 2-year follow-up of children with pulmonary arterial hypertension in France.
ARCHIVES OF CARDIOVASCULAR DISEASES
2010 vol. 103(2) pp. 66-74
FRAISSE A AND AL.

Assessment of endpoints in the pediatric population: congenital heart disease and idiopathic pulmonary arterial hypertension.
CURRENT OPINION IN PULMONARY MEDICINE
2010 vol. 16 pp. 35-41
HAWORTH SG, BEGHETTI M

ESC Guidelines for the management of grown-up congenital heart disease (new version 2010).
EUROPEAN HEART JOURNAL
2010 vol. 31(23) pp. 2915-2957
BAUMGARTNER H. AND AL.

Tetralogy of Fallot with absent pulmonary valve, supracardiac total anomalous pulmonary venous connection, and infradiaphragmatic systemic to pulmonary collateral artery.
EUROPEAN HEART JOURNAL
2010 vol. 31(24) pp. 3005-3005
MYERS PO, KALANGOS A, DIDIER D, TISSOT C

Stairs instead of elevators at workplace: cardioprotective effects of a pragmatic intervention.
EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION
2010 vol. 17(5) pp. 569-575
MEYER P, KAYSER B, KOSSOVSKY MP, SIGAUD P, CARBALLO D, KELLER P, MARTIN X, FARPOUR-LAMBERT N, PICHARD C, MACH F

Reduced physical activity level and cardiorespiratory fitness in children with chronic diseases.
EUROPEAN JOURNAL OF PEDIATRICS
2010 vol. 169(10) pp. 1187-1193
MAGGIO A, HOFER M, MARTIN X, MARCHAND L, BEGHETTI M, FARPOUR-LAMBERT N

Precapillary pulmonary hypertension leads to reversible bronchial hyperreactivity in rats.
EXPERIMENTAL LUNG RESEARCH
2010 vol. 36(3) pp. 129-139
VON UNGERN-STERNBERG BS, HABRE W, REGLI A, PACHE JC, FONTAO F, JANOSI T, BEGHETTI M, PETAK F

Fontan and the pulmonary circulation: a potential role for new pulmonary hypertension therapies.
HEART
2010 vol. 96(12) pp. 911-916
BEGHETTI M

Central venous hypoxemia is a determinant of human atrial ATP-sensitive potassium channel expression: evidence for a novel hypoxia-inducible factor 1alpha-Forkhead box class O signaling pathway.
HYPERTENSION
2010 vol. 55(5) pp. 1186-1192
RAEIS V, PHILIP-COUDERC P, ROATTI A, HABRE W, SIERRA J, KALANGOS A, BEGHETTI M, BAERTSCHI AJ

Surfactant use based on the oxygenation response to lung recruitment during HFOV in VLBW infants.
INTENSIVE CARE MEDICINE
2010 vol. 36(7) pp. 1164-1170
TISSIERES P, MYERS PO, BEGHETTI M, BERNER M, RIMENSBERGER PC

Atrial septal defects versus ventricular septal defects in BREATHE-5, a placebo-controlled study of pulmonary arterial hypertension related to Eisenmenger's syndrome: a subgroup analysis.
INTERNATIONAL JOURNAL OF CARDIOLOGY
2010 vol. 144(3) pp. 373-378
BERGER RM, BEGHETTI M, GALIE N, GATZOULIS MA, GRANTON J, LAUER A, CHIOSSI E, LANDZBERG M

Decreased bone turnover in children and adolescents with well controlled type 1 diabetes.
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM : JPEM
2010 vol. 23(7) pp. 697-707
MAGGIO A, FERRARI S, KRAENZLIN M, MARCHAND L, SCHWITZGEBEL V, BEGHETTI M, RIZZOLI R, FARPOUR-LAMBERT N

Assessment of muscular performance in teenagers after a lower extremity fracture.
JOURNAL OF PEDIATRIC ORTHOPEDICS
2010 vol. 30(8) pp. 807-812
CERONI D, MARTIN X, FARPOUR-LAMBERT N, DELHUMEAU C, KAELIN A

Medical therapy for pediatric pulmonary arterial hypertension.
JOURNAL OF PEDIATRICS
2010 vol. 157(4) pp. 528-532
TISSOT C, IVY DD, BEGHETTI M

Preclinical noninvasive markers of atherosclerosis in children and adolescents with type 1 diabetes are influenced by physical activity.
JOURNAL OF PEDIATRICS
2010 vol. 157(4) pp. 533-539
TRIGONA B, AGGOUN Y, MAGGIO A, MARTIN X, MARCHAND L, BEGHETTI M, FARPOUR-LAMBERT N

Aortic valve repair by cusp extension for rheumatic aortic insufficiency in children: Long-term results and impact of extension material.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
2010 vol. 140(4) pp. 836-844
MYERS PO, TISSOT C, CHRISTENSON JT, CIKIRIKCIOGLU M, AGGOUN Y, KALANGOS A

Leaflet suspension to the contralateral annulus to address restriction or tethering-induced mitral and tricuspid regurgitation in children: results of a case-control study.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
2010 vol. 140(5) pp. 1110-1116
MYERS PO, CHRISTENSON JT, CIKIRIKCIOGLU M, TISSOT C, AGGOUN Y, KALANGOS A

Pulmonary hypertension in congenital shunts.
REVISTA ESPANOLA DE CARDIOLOGIA
2010 vol. 63(10) pp. 1179-1193
BEGHETTI M, TISSOT C

Vagal bradycardia at term.
ACTA PAEDIATRICA (OSLO, NORWAY : 1992)
2009 vol. 98(5) pp. 901-903
DELCO C, BEGHETTI M, PFISTER R

Pharmacokinetic and clinical profile of a novel formulation of bosentan in children with pulmonary arterial hypertension: the FUTURE-1 study
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
2009 vol. 68(6) pp. 948-955
BEGHETTI M AND AL.

Early postoperative care of patients with pulmonary hypertension associated with congenital cardiac disease
CARDIOLOGY IN THE YOUNG
2009 vol. 19 pp. 315-319
ADATIA I, BEGHETTI M

Immediate postoperative care.
CARDIOLOGY IN THE YOUNG
2009 vol. 19 pp. 23-27
ADATIA I, BEGHETTI M

Bosentan in pediatric patients with pulmonary arterial hypertension.
CURRENT VASCULAR PHARMACOLOGY
2009 vol. 7(2) pp. 225-233
BEGHETTI M

Guidelines for the diagnosis and treatment of pulmonary hypertension: The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the Europ ean Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT).
EUROPEAN HEART JOURNAL
2009 vol. 30(20) pp. 2493-2537
GALIE N AND AL.

Guidelines for the diagnosis and treatment of pulmonary hypertension.
EUROPEAN RESPIRATORY JOURNAL
2009 vol. 34(6) pp. 1219-1263
GALIE N AND AL.

Rescue circumflex artery stenting for major right ventricular dysfunction after Ross-Konno operation.
HEART SURGERY FORUM
2009 vol. 12(4) pp. 208-210
MYERS PO, AGGOUN Y, CIKIRIKCIOGLU M, KALANGOS A

VGAM induced high-flow congestive heart failure responsive to PGE1 infusion.
INTERNATIONAL JOURNAL OF CARDIOLOGY
2009 vol. 132(2) pp. 60-62
KARAM O, DA CRUZ E, RIMENSBERGER PC

Transpulmonary stenting of both pulmonary arteries with a surgical access through redo sternotomy.
JOURNAL OF CARDIAC SURGERY
2009 vol. 24(4) pp. 451-453
AGGOUN Y, SIERRA J, KALANGOS A

Pneumonia and pericarditis in a child with HRV-C infection: A case report
JOURNAL OF CLINICAL VIROLOGY
2009 vol. 45(2) pp. 157-160
TAPPAREL C, L'HUILLIER AG, ROUGEMONT AL, BEGHETTI M, BARAZZONE-ARGIROFFO C, KAISER L

Eisenmenger syndrome a clinical perspective in a new therapeutic era of pulmonary arterial hypertension.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
2009 vol. 53(9) pp. 733-740
BEGHETTI M, GALIE N

Physical Activity Reduces Systemic Blood Pressure and Improves Early Markers of Atherosclerosis in Pre-Pubertal Obese Children
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
2009 vol. 54 pp. 2396-2406
FARPOUR-LAMBERT N, AGGOUN Y, MARCHAND L, MARTIN X, AGGOUN Y, MARCHAND LM, MARTIN XE, HERRMANN FR, BEGHETTI M, HERRMANN FR, BEGHETTI M

Updated clinical classification of pulmonary hypertension.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
2009 vol. 54 pp. 43-54
SIMMONEAU G AND AL.

Pulmonary arterial hypertension and congenital heart disease: targeted therapies and operability.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
2009 vol. 138(3) pp. 785-786
BEGHETTI M, TISSOT C

Vascular ultrasound studies for the non-invasive assessment of vascular flow and patency in experimental surgery in the pig.
LABORATORY ANIMALS
2009 vol. 43(4) pp. 333-337
OSORIO-DA CRUZ SM, AGGOUN Y, CIKIRIKCIOGLU M, KHABIRI E, DJEBAILI K, KALANGOS A, WALPOTH BH

Pulmonary arterial hypertension in congenital heart diseases.
SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE
2009 vol. 30(4) pp. 421-428
BEGHETTI M, TISSOT C

Biodegradable mitral annuloplasty for congenital ischemic mitral regurgitation.
THE THORACIC AND CARDIOVASCULAR SURGEON
2009 vol. 57(6) pp. 363-364
MYERS PO, BEGHETTI M, KALANGOS A

Mitral valve repair for rheumatic valve disease in children: midterm results and impact of the use of a biodegradable mitral ring.
ANNALS OF THORACIC SURGERY
2008 vol. 86(1) pp. 161-168
KALANGOS A, CHRISTENSON JT, BEGHETTI M, CIKIRIKCIOGLU M, KAMENTSIDIS D, AGGOUN Y

Treatment of idiopathic pulmonary arterial hypertension in pediatrics
ARCHIVES DE PEDIATRIE
2008 vol. 15(5) pp. 702-704
BEGHETTI M

Sex-specific developmental changes in muscle size and bone geometry at the femoral shaft.
BONE
2008 vol. ;42(5) pp. 982-989
HOGLER W, BLIMKIE CJ, COWELL CT, INGLIS, RAUCH F, KEMPF AF, WIEBE P, DUNCAN S, FARPOUR-LAMBERT N, WOODHEAD HJ

Classifying pulmonary hypertension in the setting of the congenitally malformed heart--cleaning up a dog's dinner.
CARDIOLOGY IN THE YOUNG
2008 vol. 18(1) pp. 22-25
SCHULZE-NEICK I, BEGHETTI M

Impaired endothelial and smooth muscle functions and arterial stiffness appear before puberty in obese children and are associated with elevated ambulatory blood pressure.
EUROPEAN HEART JOURNAL
2008 vol. 29(6) pp. 792-799
AGGOUN Y, FARPOUR-LAMBERT N, MARCHAND L, GOLAY E, MAGGIO A, BEGHETTI M

Differential roles of endothelin-1 ETA and ETB receptors and vasoactive intestinal polypeptide in regulation of the airways and the pulmonary vasculature in isolated rat lung.�
EXPERIMENTAL PHYSIOLOGY
2008 vol. 93(11) pp. 1210-1219
JANOSI T, PETAK F, FONTAO F, MOREL DR, BEGHETTI M, HABRE W

A DNA resequencing array for pathogenic mutation detection in hypertrophic cardiomyopathy.
HUMAN MUTATION
2008 vol. 29(6) pp. 879-885
FOKSTUEN S AND AL

Value of brain natriuretic peptide in the perioperative follow-up of children with valvular disease.
INTENSIVE CARE MEDICINE
2008 vol. 34(6) pp. 1109-1113
TISSIERES P, DA CRUZ E, HABRE W, AGGOUN Y, MENSI N, KALANGOS A, BEGHETTI M

Longer-term bosentan therapy improves functional capacity in Eisenmenger syndrome: results of the BREATHE-5 open-label extension study.
INTERNATIONAL JOURNAL OF CARDIOLOGY
2008 vol. 127(1) pp. 27-32
GATZOULIS MA AND AL.

Mechanical support availability in pediatric cardiac surgery: program size should not matter.
INTERNATIONAL JOURNAL OF CARDIOLOGY
2008 vol. 129(2) pp. 282-284
DA CRUZ EM, BEGHETTI M, KALANGOS A, BERNER M, SIERRA J, AGGOUN Y, TISSOT C, PELLEGRINI M, SAUDAN S, HABRE W, RIMENSBERGER PC

Associations among obesity, blood pressure, and left ventricular mass.
JOURNAL OF PEDIATRICS
2008 vol. 152(4) pp. 489-493
MAGGIO A, AGGOUN Y, MARCHAND L, MARTIN X, HERRMANN F, BEGHETTI M, FARPOUR-LAMBERT N

Short- and long-term effects of inhaled iloprost therapy in children with pulmonary arterial hypertension.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
2008 vol. ;51(2) pp. 161-169
IVY DD AND AL.

Acute angulation of the aortic arch predisposes a patient to ascending aortic dilatation and aortic regurgitation late after the arterial switch operation for transposition of the great arteries.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
2008 vol. 135(3) pp. 568-572
AGNOLETTI P, CELERMAJER DS, BOUDJEMLINE Y, MARINI D, BONNET D, AGGOUN Y

Weight-bearing bones are more sensitive to physical exercise in boys than in girls during pre- and early puberty: a cross-sectional study.
OSTEOPOROSIS INTERNATIONAL
2008 vol. 19(12) pp. 1749-1758
KRIEMLER S, ZAHNER L, PUDER JJ, BRAUN-FAHRL�NDER C, SCHINDLER C, FARPOUR-LAMBERT N, KR�NZLIN M, RIZZOLI R

Bronchoscopic diagnosis of asymptomatic unilateral pulmonary vein atresia in an infant.
PEDIATRIC CARDIOLOGY
2008 vol. 29(5) pp. 976-979
TISSOT C, CORBELLI R, AGGOUN Y, BEGHETTI M, DA CRUZ E

Effects of single-leg drop-landing exercise from different heights on skeletal adaptations in prepubertal girls: a randomized controlled study.
PEDIATRIC EXERCISE SCIENCE
2008 vol. 20(2) pp. 211-228
WIEBE PN, BLIMKIE CJ, FARPOUR-LAMBERT N, BRIODY J, MARSH D, KEMP A, COWELL C, HOWMAN-GILES R

Safety experience with bosentan in 146 children 2-11 years old with pulmonary arterial hypertension: results from the European Postmarketing Surveillance program.
PEDIATRIC RESEARCH : AN INTERNATIONAL JOURNAL OF CLINICAL, LABORATORY AND DEVELOPMENTAL INVESTIGATION
2008 vol. 64(2) pp. 200-204
BEGHETTI M, HOEPER MM, KIELY DG, CARLSEN J, SCHWIERIN B, SEGAL ES, HUMBERT M

Pulmonary arterial hypertension in children: new therapeutic approaches
ANNALES FRANCAISES D'ANESTHESIE ET DE REANIMATION
2007 vol. 26(6) pp. 570-575
BEGHETTI M

Right ventricular outflow tract reconstruction: What conduit to use? Homograft or Contegra?
ANNALS OF THORACIC SURGERY
2007 vol. 84 pp. 606-611
SIERRA J, CHRISTENSON JT, LAHLAIDI NH, BEGHETTI M, KALANGOS A

The Lecompte maneuver as an alternative to reduction pulmonary arterioplasty for relief of airway compression in absent pulmonary valve syndrome.
ANNALS OF THORACIC SURGERY
2007 vol. 83(2) pp. 727-728
TISSOT C, AGGOUN Y, BEGHETTI M, DA CRUZ E, SIERRA J, KALANGOS A

Re: Systematic placement of left-sided pacing leads as an appealing option for cardiac resynchronization as treatment of congestive cardiac failure in children dependent on chronic cardiac pacing
CARDIOLOGY IN THE YOUNG
2007 vol. 17 pp. 234-235
DA CRUZ E, AGGOUN Y, TISSOT C, BEGHETTI M

Rescue left main coronary artery stenting for acute myocardial ischemia after coronary angiography in a 7-year-old girl with homozygous familial hypercholesterolemia
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS : OFFICIAL JOURNAL OF THE SOCIETY FOR CARDIAC ANGIOGRAPHY & INTERVENTIONS
2007 vol. 69 pp. 243-247
TISSOT C, DA CRUZ E, AGGOUN Y

A giant congenital left ventricular diverticulum simulating an aneurysm
EUROPEAN HEART JOURNAL
2007 vol. 28 pp. 25-25
TISSOT C, PACHE JC, DA CRUZ E

A neonate with isolated combined aortic and pulmonary valvar stenosis.
INTERNATIONAL JOURNAL OF CARDIOLOGY
2007 vol. 116(1) pp. 13-14
DA CRUZ EDUARDO, BILLIEUX MH, BEGHETTI M

Left ventricular epicardial VVI pacing for a congenital complete heart block with severe myocardial dysfunction: shall epicardial pacing wires be positioned left?
INTERNATIONAL JOURNAL OF CARDIOLOGY
2007 vol. 116(1) pp. 7-9
TISSOT CECILE, AGGOUN YACINE, RIMENSBERGER PETER C., SIERRA JORGE, KALANGOS AFKSENDYIOS, BEGHETTI MAURICE, DA CRUZ EDUARDO

Successful use of a new Amplatzer Vascular plug for percutaneous closure of a large aortopulmonary collateral artery in a pulmonary atresia with ventricular septal defect prior to complete repair.
INTERNATIONAL JOURNAL OF CARDIOLOGY
2007 vol. 116(2) pp. 39-41
TISSOT C, DA CRUZ E, BEGHETTI M, AGGOUN Y

Enhanced intimal thickening of expanded polytetrafluoroethylene grafts coated with fibrin or fibrin-releasing vascular endothelial growth factor in the pig carotid artery interposition model
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
2007 vol. 133 pp. 1163-1170
WALPOTH BH, ZAMMARETTI P, CIKIRIKCIOGLU M, KHABIRI E, DJEBAILI MK, PACHE JC, TILLE JC, AGGOUN Y, MOREL D, KALANGOS A, HUBBELL JA, ZISCH AH

Cardiac rhythm and left ventricular function of infants at 1 MAC sevoflurane and halothane
PEDIATRIC ANESTHESIA
2007 vol. 17(6) pp. 540-546
SAUDAN S, BEGHETTI M, SPAHR-SCHOPFER I, MAMIE C, HABRE W

Tissue plasminogen activator for a left atrial thrombus after Senning repair.
PEDIATRIC CRITICAL CARE MEDICINE : A JOURNAL OF THE SOCIETY OF CRITICAL CARE MEDICINE AND THE WORLD FEDERATION OF PEDIATRIC INTENSIVE AND CRITICAL CARE SOCIETIES
2007 vol. 8(3) pp. 279-281
TISSOT C, RIMENSBERGER PC, AGGOUN Y, KALANGOS A, OZSAHIN H, BEGHETTI M, DA CRUZ E

Postoperative gram-negative anaerobic bacterial endocarditis
PEDIATRIC INFECTIOUS DISEASE JOURNAL
2007 vol. 26 pp. 369-369
MYERS C, AGGOUN Y, GERVAIX A, NINET B, SCHRENZEL J, KUHNERT P

Obesity, metabolic syndrome, and cardiovascular disease.
PEDIATRIC RESEARCH : AN INTERNATIONAL JOURNAL OF CLINICAL, LABORATORY AND DEVELOPMENTAL INVESTIGATION
2007 vol. 61(6) pp. 653-659
AGGOUN Y

The Swiss registry for pulmonary arterial hypertension: the paediatric experience
SWISS MEDICAL WEEKLY
2007 vol. 137 pp. 510-513
FASNACHT MS, TOLSA JF, BEGHETTI M

Bosentan therapy in patients with Eisenmenger syndrome: a multicenter, double-blind, randomized, placebo-controlled study
CIRCULATION
2006 vol. 114(1) pp. 48-54
GALIE NAZZARENO, BEGHETTI MAURICE, GATZOULIS MICHAEL A., GRANTON JOHN, BERGER ROLF M.F., LAUER ANDREA, CHIOSSI ELEONORA, LANDZBERG MICHAEL

Bosentan for the treatment of pulmonary arterial hypertension associated with congenital heart defects
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
2006 vol. 36 Suppl 3 pp. 25-31
SITBON O., BEGHETTI M., PETIT J., ISERIN L., HUMBERT M., GRESSIN V., SIMONNEAU G.

Current treatment options in children with pulmonary arterial hypertension and experiences with oral bosentan
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
2006 vol. 36 Suppl 3 pp. 16-24
BEGHETTI MAURICE

Fatal coronary artery anomaly presenting as bronchiolitis
EUROPEAN JOURNAL OF PEDIATRICS
2006 vol. 165(7) pp. 505-
DA CRUZ EDUARDO, AGGOUN YACINE, TISSOT-DAGUETTE CECILE, BEGHETTI MAURICE

Coarctation of the aorta: pre and postoperative evaluation with MRI and MR angiography; correlation with echocardiography and surgery
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
2006 vol. 22 pp. 457-475
DIDIER D, SAINT-MARTIN C, LAPIERRE C, TRINDADE PT, LAHALAIDI N, VALLEE JP, KALANGOS A, FRIEDLI B, BEGHETTI M

Operative correction of cor triatriatum sinister with systemic venous return anomaly (inferior vena cava-left atrium)
JOURNAL OF CARDIAC SURGERY
2006 vol. 21 pp. 578-579
CIKIRIKCIOGLU M, TATAR T, ANTAL AD, CRUZ EDA, DIDIER D, KALANGOS A

Comparison of classifications for heart failure in children undergoing valvular surgery
JOURNAL OF PEDIATRICS
2006 vol. 149 pp. 210-215
TISSIERES P, AGGOUN Y, DA CRUZ E, SIERRA J, MENSI N, KALANGOS A, BEGHETTI M

Long-term outcome after surgical intervention and interventional procedures for the management of Takayasu's arteritis in children
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
2006 vol. 132 pp. 656-664
KALANGOS A, CHRISTENSON JT, CIKIRIKCIOGLU M, VALA D, BUERGE A, SIMONET F, DIDIER D, BEGHETTI M, JAEGGI E

Nitric oxide precursors and congenital cardiac surgery: a randomized controlled trial of oral citrulline. Definition of pulmonary hypertension in Fontan circulation?
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
2006 vol. 32(6) pp. 1501-1502
BEGHETTI MAURICE, AGGOUN YACINE, DA CRUZ EDUARDO

Intravenous adenosine for refractory pulmonary hypertension in a low-weight premature newborn: a potential new drug for rescue therapy
PEDIATRIC CRITICAL CARE MEDICINE : A JOURNAL OF THE SOCIETY OF CRITICAL CARE MEDICINE AND THE WORLD FEDERATION OF PEDIATRIC INTENSIVE AND CRITICAL CARE SOCIETIES
2006 vol. 7(4) pp. 380-382
MOTTI ALESSANDRO, TISSOT CECILE, RIMENSBERGER PETER C., PRINA-ROUSSO ALINE, AGGOUN YACINE, BERNER MICHEL, BEGHETTI MAURICE, DA CRUZ EDUARDO

The role of endothelin-I in hyperoxia-induced lung injury in mice
RESPIRATORY RESEARCH
2006 vol. 7(1) pp. 45-0
HABRE W, PETAK F, RUCHONNET-METRAILLER I, DONATI Y, TOLSA JF, LELE E, ALBU G, BEGHETTI M, BARAZZONE-ARGIROFFO C

Hypertension artérielle pulmonaire des cardiopathies congénitales
REVUE DES MALADIES RESPIRATOIRES
2006 vol. 23(4 Suppl) pp. 49-59
BEGHETTI MAURICE

Evolution après dérivation cavo-pulmonaire partielle : l'expérience genevoise de 1985 à 2000
ARCHIVES DES MALADIES DU COEUR ET DES VAISSEAUX
2003 vol. 96 pp. 92-99
STAUFFER ETTLIN M, FAIDUTTI B, FRIEDLI B

Effects of inhaled nitric oxide and intravenous magnesium sulphate, alone and in combination, in a porcine model of hypoxic pulmonary hypertension
MEDICAL SCIENCE MONITOR : INTERNATIONAL MEDICAL JOURNAL OF EXPERIMENTAL AND CLINICAL RESEARCH
2003 vol. 9 pp. 193-198
BEGHETTI MAURICE, SPAHR-SCHOPFER ISABELLE, MENSI NOURY, MOREL DENIS, RIMENSBERGER PETER

How to diminish reoperation rates after initial repair of Tetralogy of Fallot
ANNALS OF THORACIC SURGERY
2002 vol. 73 pp. 96-101
FAIDUTTI B, CHRISTENSON JT, BEGHETTI M, FRIEDLI B, KALANGOS A

Aerosolized iloprost induces a mild but sustained inhibition of platelet aggregation
EUROPEAN RESPIRATORY JOURNAL
2002 vol. 19 pp. 518-524
BEGHETTI M, REBER G, DE MOERLOOSE P, VADAS L, CHIAPPE A, SPAHR-SCHOPFER I, RIMENSBERGER PC

Images in cardiology. Thoraco-omphalagus twins : heart to heart
HEART
2002 vol. 87 pp. 278-
BEGHETTI M, ABDEL-MASSIH T, BONHOEFFER P

Research's domains




DATABASE-RESEARCH	GROUP OF CLINICAL PATIENT RESEARCH

Maurice BEGHETTI	Head of group CV	Research subject	Members of the group