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Clinical research group of the Clinic of Adult Psychiatry

Several ongoing research projects take place within the context of a clinical research group of the Clinic of Adult Psychiatry (GRETTHA -Groupe de Recherche sur les Thérapeutiques des Troubles de l'Humeur et de l'Anxiété). This group is co-directed by Drs G. Bondolfi and J.-M. Aubry and benefits from the contributions of a network of young doctors and clinical psychologists in the clinic. The group continually networks in order to establish relations with research groups in the basic sciences (pharmacokinetics, neurobiology, genetics).At the heart of GRETTHA's research, the implication of the party concerned deals more particularly with the evaluation and treatment of depression and mixed disorders through an integrative viewpoint of psychopathology and biological psychiatry (neurosciences, psychopharmacology, transcranial magnetic stimulation).

Group's publications

Frequency of dysphoria and mixed states.
PSYCHOPATHOLOGY
2008 vol. 41(3) pp. 187-193
BERTSCHY G, GERVASONI N, FAVRE S, LIBEREK C, RAGAMA PARDOS EMNA, AUBRY JM, GEX-FABRY M, DAYER A

CYP2D6 and ABCB1 genetic variability: influence on paroxetine plasma level and therapeutic response.
THERAPEUTIC DRUG MONITORING
2008 vol. 30(4) pp. 474-482
GEX-FABRY M, EAP CB, ONEDA B, GERVASONI N, AUBRY JM, BONDOLFI G, BERTSCHY G

The lactate provocation test to investigate the relationships between panic attacks and psychosis: a report of two cases.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
2008 vol. 9(2) pp. 154-158
EPELLY S, BERTSCHY G

Phenomenology of mixed states: a principal component analysis study
BIPOLAR DISORDERS
2007 vol. 9 pp. 907-912
BERTSCHY, G, GERVASONI, N, FAVRE, S, LIBEREK, C, RAGAMA-PARDOS, E, AUBRY, JM, GEX-FABRY, M, DAYER, A

The DEX/CRH neuroendocrine test and the prediction of depressive relapse in remitted depressed outpatients
JOURNAL OF PSYCHIATRIC RESEARCH
2007 vol. 41 pp. 290-294
AUBRY JM, GERVASONI N, OSIEK C, PERRET G, ROSSIER MF, BERTSCHY G, BONDOLFI G

Time course of response to paroxetine: Influence of plasma level
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
2007 vol. 31 pp. 892-900
GEX-FABRY M, GERVASONI N, EAP CB, AUBRY JM, BONDOLFI G, BERTSCHY G

No human tryptophan hydroxylase-2 gene R441H mutation in a large cohort of psychiatric patients and control subjects
BIOLOGICAL PSYCHIATRY
2006 vol. 60 pp. 202-203
DELORME R, DURAND CM, BETANCUR C, WAGNER M, RUHRMANN S, GRABE HJ, NYGREN G, GILLBERG C, LEBOYER M, BOURGERON T, COURTET P, JOLLANT F, BURESI C, AUBRY JM, BAUD P, BONDOLFI G, BERTSCHY G

Safety and efficacy of repetitive transcranial magnetic stimulation in the treatment of depression: a critical appraisal of the last 10 years
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
2006 vol. 36(3) pp. 157-183
RACHID F, BERTSCHY G

Olanzapine plasma level in relation to antimanic effect in the acute therapy of manic states
NORDIC JOURNAL OF PSYCHIATRY
2006 vol. 60 pp. 181-182
BECH P, GEX-FABRY M, AUBRY JM, FAVRE S, BERTSCHY G

Body dysmorphic disorder, psychosis and insight: A report of four cases
PSYCHOPATHOLOGY
2006 vol. 39 pp. 130-135
LUCCHELLI JP, BONDOLFI G, BERTSCHY G

Psychiatrie
REVUE MEDICALE DE LA SUISSE ROMANDE
2006 vol. 2 pp. 61-66
BERTSCHY G, BARBE R, GERVASONI N, BRYOIS C

A stepwise drug treatment algorithm to obtain complete remission in depression: a Geneva study
SWISS MEDICAL WEEKLY
2006 vol. 136 pp. 78-85
BONDOLFI G, AUBRY JM, GOLAZ J, GEX-FABRY M, GERVASONI N, BERTSCHY G

Induction of a mixed depressive episode during rTMS treatment in a patient with refractory major depression
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
2006 vol. 7 pp. 261-264
RACHID F, GOLAZ J, BONDOLFI G, BERTSCHY G

Acquisitions thérapeutiques 2004 : psychiatrie
MEDECINE ET HYGIENE : JOURNAL SUISSE D'INFORMATIONS MEDICALES
2005 vol. 1/2 pp. 159-167
BRYOIS C., NANZER NATHALIE, ELIEZ STEPHAN, ETTER M., AUBRY JEAN-MICHEL, BERTSCHY GILLES

Psychiatry
REVUE MEDICALE DE LA SUISSE ROMANDE
2005 vol. pp. 159-167
BRYOIS, C., NANZER NATHALIE, ELIEZ STEPHAN, ETTER, M., AUBRY JEAN-MICHEL, BERTSCHY GILLES

Early onset of response to venlafaxine:association with higher plasma level
EUROPEAN PSYCHIATRY : THE JOURNAL OF THE ASSOCIATION OF EUROPEAN PSYCHIATRISTS
2004 vol. 19 pp. 120-121
GEX-FABRY PUN MARIANNE, BALANT-GORGIA A.E., BALANT LUC, RUDAZ SERGE, VEUTHEY JEAN-LUC, BERTSCHY GILLES

Normalization of serum BDNF in remitted patients after a major depressive episode
EUROPEAN PSYCHIATRY : THE JOURNAL OF THE ASSOCIATION OF EUROPEAN PSYCHIATRISTS
2004 vol. 19 pp. 207-208
GERVASONI NICOLA, AUBRY JEAN-MICHEL, BONDOLFI GUIDO-X, OSIEK CHRISTIAN, KAREGE FELICIEN, SCHWALD M., BERTSCHY GILLES

Normalization of serum BDNF in remitted patients after a major depressive episode
JOURNAL OF AFFECTIVE DISORDERS
2004 vol. 78 pp. 112-112
GERVASONI NICOLA, AUBRY JEAN-MICHEL, BONDOLFI GUIDO-X, OSIEK CHRISTIAN, KAREGE FELICIEN, BERTSCHY GILLES

Cortisol responses to combined dexamethasone/CRH test in ambulatory patients with a major depressive episode
JOURNAL OF PSYCHIATRIC RESEARCH
2004 vol. 38 pp. 553-557
GERVASONI NICOLA, BERTSCHY GILLES, OSIEK CHRISTIAN, PERRET GUILLAUME, DENIS RACHEL, GOLAZ JEAN, ROSSIER MICHEL, BONDOLFI GUIDO-X, AUBRY JEAN-MICHEL

Acquisitions thérapeutiques 2003. Psychiatrie
MEDECINE ET HYGIENE : JOURNAL SUISSE D'INFORMATIONS MEDICALES
2004 vol. 62 pp. 133-138
MERLO MARCO, BRYOIS C, BERTSCHY GILLES

Lithium augmentation in venlafaxine non-responders : an open study
EUROPEAN PSYCHIATRY : THE JOURNAL OF THE ASSOCIATION OF EUROPEAN PSYCHIATRISTS
2003 vol. 18 pp. 314-317
BERTSCHY G, RAGAMA-PARDOS E, AĪT-AMEUR A., MUSCIONICO M, FAVRE S, ROTH L

Efficacy and safety of olanzapine plus valproate in the treatment of acute mania: an open study
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
2003 vol. 7 pp. 131-134
AUBRY JM, RAGAMA-PARDOS E, FAVRE S, M MENZINGER, MUSCIONICO M, SANCHEZ S, GEX-FABRY M, FERRERO F, BERTSCHY G

Lithium dose prediction based on 24 hours single dose levels : a prospective evaluation
PHARMACOLOGICAL RESEARCH
2003 vol. 48 pp. 649-653
GERVASONI N, OSIEK C, ROTH L, BONDOLFI G, BERTSCHY G

The effect of fluoxetine on the pharmacokinetics and safety of risperidone in psychiatric patients
PHARMACOPSYCHIATRY
2002 vol. 35 pp. 50-56
BONDOLFI G, EAP CB, BERTSCHY G, ZULLINO D, VERMEULEN A, BAUMANN P

A theoretical reappraisal of mixed states: dysphoria as a third dimension
BIPOLAR DISORDERS
2000 vol. 2 pp. 316-324
DAYER A, AUBRY JM, ROTH L, DUCRET S, BERTSCHY G

Mania and hypomania induced by olanzapine or risperidone : a critical review of reported cases
THE JOURNAL OF CLINICAL PSYCHIATRY
2000 vol. 61 pp. 649-655
AUBRY JEAN-MICHEL, SIMON AE, BERTSCHY GILLES

Research's domains




DATABASE-RESEARCH	GROUP OF CLINICAL PATIENT RESEARCH

GRETTHA (GROUPE DE G BERTSCHY)	Head of group CV	Research subject	Members of the group


	Links about the group Dr. G. BERTSCHY HUG/ Dpt Psychiatrie Belle-Idée/ Le Salève Ch. du Petit-Bel-Air 2 1225 Chêne-Bourg Suisse gilles.bertschy@hcuge.ch Tel.: 022/305.47.01 Fax: 022/305.47.97 Comments Pages updated the 17.11.2015		Reseach's subject \| Group's publications \| Research's domains Clinical research group of the Clinic of Adult Psychiatry Several ongoing research projects take place within the context of a clinical research group of the Clinic of Adult Psychiatry (GRETTHA -Groupe de Recherche sur les Thérapeutiques des Troubles de l'Humeur et de l'Anxiété). This group is co-directed by Drs G. Bondolfi and J.-M. Aubry and benefits from the contributions of a network of young doctors and clinical psychologists in the clinic. The group continually networks in order to establish relations with research groups in the basic sciences (pharmacokinetics, neurobiology, genetics).At the heart of GRETTHA's research, the implication of the party concerned deals more particularly with the evaluation and treatment of depression and mixed disorders through an integrative viewpoint of psychopathology and biological psychiatry (neurosciences, psychopharmacology, transcranial magnetic stimulation). Group's publications Frequency of dysphoria and mixed states. PSYCHOPATHOLOGY 2008 vol. 41(3) pp. 187-193 BERTSCHY G, GERVASONI N, FAVRE S, LIBEREK C, RAGAMA PARDOS EMNA, AUBRY JM, GEX-FABRY M, DAYER A CYP2D6 and ABCB1 genetic variability: influence on paroxetine plasma level and therapeutic response. THERAPEUTIC DRUG MONITORING 2008 vol. 30(4) pp. 474-482 GEX-FABRY M, EAP CB, ONEDA B, GERVASONI N, AUBRY JM, BONDOLFI G, BERTSCHY G The lactate provocation test to investigate the relationships between panic attacks and psychosis: a report of two cases. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY 2008 vol. 9(2) pp. 154-158 EPELLY S, BERTSCHY G Phenomenology of mixed states: a principal component analysis study BIPOLAR DISORDERS 2007 vol. 9 pp. 907-912 BERTSCHY, G, GERVASONI, N, FAVRE, S, LIBEREK, C, RAGAMA-PARDOS, E, AUBRY, JM, GEX-FABRY, M, DAYER, A The DEX/CRH neuroendocrine test and the prediction of depressive relapse in remitted depressed outpatients JOURNAL OF PSYCHIATRIC RESEARCH 2007 vol. 41 pp. 290-294 AUBRY JM, GERVASONI N, OSIEK C, PERRET G, ROSSIER MF, BERTSCHY G, BONDOLFI G Time course of response to paroxetine: Influence of plasma level PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 2007 vol. 31 pp. 892-900 GEX-FABRY M, GERVASONI N, EAP CB, AUBRY JM, BONDOLFI G, BERTSCHY G No human tryptophan hydroxylase-2 gene R441H mutation in a large cohort of psychiatric patients and control subjects BIOLOGICAL PSYCHIATRY 2006 vol. 60 pp. 202-203 DELORME R, DURAND CM, BETANCUR C, WAGNER M, RUHRMANN S, GRABE HJ, NYGREN G, GILLBERG C, LEBOYER M, BOURGERON T, COURTET P, JOLLANT F, BURESI C, AUBRY JM, BAUD P, BONDOLFI G, BERTSCHY G Safety and efficacy of repetitive transcranial magnetic stimulation in the treatment of depression: a critical appraisal of the last 10 years NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY 2006 vol. 36(3) pp. 157-183 RACHID F, BERTSCHY G Olanzapine plasma level in relation to antimanic effect in the acute therapy of manic states NORDIC JOURNAL OF PSYCHIATRY 2006 vol. 60 pp. 181-182 BECH P, GEX-FABRY M, AUBRY JM, FAVRE S, BERTSCHY G Body dysmorphic disorder, psychosis and insight: A report of four cases PSYCHOPATHOLOGY 2006 vol. 39 pp. 130-135 LUCCHELLI JP, BONDOLFI G, BERTSCHY G Psychiatrie REVUE MEDICALE DE LA SUISSE ROMANDE 2006 vol. 2 pp. 61-66 BERTSCHY G, BARBE R, GERVASONI N, BRYOIS C A stepwise drug treatment algorithm to obtain complete remission in depression: a Geneva study SWISS MEDICAL WEEKLY 2006 vol. 136 pp. 78-85 BONDOLFI G, AUBRY JM, GOLAZ J, GEX-FABRY M, GERVASONI N, BERTSCHY G Induction of a mixed depressive episode during rTMS treatment in a patient with refractory major depression WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY 2006 vol. 7 pp. 261-264 RACHID F, GOLAZ J, BONDOLFI G, BERTSCHY G Acquisitions thérapeutiques 2004 : psychiatrie MEDECINE ET HYGIENE : JOURNAL SUISSE D'INFORMATIONS MEDICALES 2005 vol. 1/2 pp. 159-167 BRYOIS C., NANZER NATHALIE, ELIEZ STEPHAN, ETTER M., AUBRY JEAN-MICHEL, BERTSCHY GILLES Psychiatry REVUE MEDICALE DE LA SUISSE ROMANDE 2005 vol. pp. 159-167 BRYOIS, C., NANZER NATHALIE, ELIEZ STEPHAN, ETTER, M., AUBRY JEAN-MICHEL, BERTSCHY GILLES Early onset of response to venlafaxine:association with higher plasma level EUROPEAN PSYCHIATRY : THE JOURNAL OF THE ASSOCIATION OF EUROPEAN PSYCHIATRISTS 2004 vol. 19 pp. 120-121 GEX-FABRY PUN MARIANNE, BALANT-GORGIA A.E., BALANT LUC, RUDAZ SERGE, VEUTHEY JEAN-LUC, BERTSCHY GILLES Normalization of serum BDNF in remitted patients after a major depressive episode EUROPEAN PSYCHIATRY : THE JOURNAL OF THE ASSOCIATION OF EUROPEAN PSYCHIATRISTS 2004 vol. 19 pp. 207-208 GERVASONI NICOLA, AUBRY JEAN-MICHEL, BONDOLFI GUIDO-X, OSIEK CHRISTIAN, KAREGE FELICIEN, SCHWALD M., BERTSCHY GILLES Normalization of serum BDNF in remitted patients after a major depressive episode JOURNAL OF AFFECTIVE DISORDERS 2004 vol. 78 pp. 112-112 GERVASONI NICOLA, AUBRY JEAN-MICHEL, BONDOLFI GUIDO-X, OSIEK CHRISTIAN, KAREGE FELICIEN, BERTSCHY GILLES Cortisol responses to combined dexamethasone/CRH test in ambulatory patients with a major depressive episode JOURNAL OF PSYCHIATRIC RESEARCH 2004 vol. 38 pp. 553-557 GERVASONI NICOLA, BERTSCHY GILLES, OSIEK CHRISTIAN, PERRET GUILLAUME, DENIS RACHEL, GOLAZ JEAN, ROSSIER MICHEL, BONDOLFI GUIDO-X, AUBRY JEAN-MICHEL Acquisitions thérapeutiques 2003. Psychiatrie MEDECINE ET HYGIENE : JOURNAL SUISSE D'INFORMATIONS MEDICALES 2004 vol. 62 pp. 133-138 MERLO MARCO, BRYOIS C, BERTSCHY GILLES Lithium augmentation in venlafaxine non-responders : an open study EUROPEAN PSYCHIATRY : THE JOURNAL OF THE ASSOCIATION OF EUROPEAN PSYCHIATRISTS 2003 vol. 18 pp. 314-317 BERTSCHY G, RAGAMA-PARDOS E, AĪT-AMEUR A., MUSCIONICO M, FAVRE S, ROTH L Efficacy and safety of olanzapine plus valproate in the treatment of acute mania: an open study INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE 2003 vol. 7 pp. 131-134 AUBRY JM, RAGAMA-PARDOS E, FAVRE S, M MENZINGER, MUSCIONICO M, SANCHEZ S, GEX-FABRY M, FERRERO F, BERTSCHY G Lithium dose prediction based on 24 hours single dose levels : a prospective evaluation PHARMACOLOGICAL RESEARCH 2003 vol. 48 pp. 649-653 GERVASONI N, OSIEK C, ROTH L, BONDOLFI G, BERTSCHY G The effect of fluoxetine on the pharmacokinetics and safety of risperidone in psychiatric patients PHARMACOPSYCHIATRY 2002 vol. 35 pp. 50-56 BONDOLFI G, EAP CB, BERTSCHY G, ZULLINO D, VERMEULEN A, BAUMANN P A theoretical reappraisal of mixed states: dysphoria as a third dimension BIPOLAR DISORDERS 2000 vol. 2 pp. 316-324 DAYER A, AUBRY JM, ROTH L, DUCRET S, BERTSCHY G Mania and hypomania induced by olanzapine or risperidone : a critical review of reported cases THE JOURNAL OF CLINICAL PSYCHIATRY 2000 vol. 61 pp. 649-655 AUBRY JEAN-MICHEL, SIMON AE, BERTSCHY GILLES Research's domains