DATABASE-RESEARCH | GROUP OF CLINICAL PATIENT RESEARCH | ||||||
Petra Susan HÜPPI | Head of group CV | Research subject | Members of the group |
Links about the group
Prof. P. HÜPPI HUG/ Dpt Enfants Adolescents Hôp. Enfants/ Serv. Dev.Crois. Rue Willy-Donzé 6 1211 Genève 14 Suisse petra.huppi@hcuge.ch Tel.: 022/372.43.52 Fax: 022/382.43.15 Comments Pages updated the 17.11.2015 |
Reseach's subject
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Group's publications
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Research's domains
Study of normal and abnormal brain development
Study of normal and abnormal brain development in high risk neonates with neuro-imaging
Our research includes clinical and fundamental neurosciences projects with the aim to use and develop neuro-imaging techniques for the study of normal and altered brain development in high-risk neonate and in animal models of brain injury. Clinical: New magnetic resonance imaging (MRI) techniques such as 3D-quantitative volumetry and diffusion in the newborn infant are used to delineate the temporal and anatomic development of the brain in the preterm and the term newborn. In collaboration with the Centre d¿Imagerie Biomédicale (CIBM) and the Radiology Department (Dr. Lazeyras, Geneva) we use advanced MRI techniques and neuro-developmental assessment to look at the effects of intra-uterine growth restriction on structural and functional development of the brain. Our MONIBRAIN project aims at defining markers the brain developmental vulnerability to injury. The combination of MRI, of bedside continuous electrophysiological brain activity recordings and of measures of serum markers (Proteomic Centre, Dr. Sanchez, Geneva) should allow to better delineate brain damage and consequences on longterm neurodevelopmental outcome of asphyxiated newborns and preterm infants. This study will be extended in 13 neonatal units in Europe (www.NEOBRAIN.eu). In collaboration with the School of Psychology (Pr. Barisnikov, University of Geneva)) and the Child Development Unit of the Pediatric Department (Mme Forcada, CHUV-Lausanne) we will be studying the development of the executive functions in extremely preterm infants. Fundamental: In order to understand the alteration of brain development seen in high-risk infants, we have developed translational research of brain development compromise such as intra-uterine growth restriction or foetal exposition to adverse conditions and acute hypoxic-ischemic brain injury in the newborn rat pup. These experimental paradigms allow us to study mechanisms of damage and repair in the developing brain. The use of high-field and advanced MRI techniques in collaboration with the CIBM (Pr. Gruetter, EPFL, Lausanne) will allow us to correlate MRI alterations with histopathological changes. These studies will enhance the understanding of developmental brain injury and should lead to the development of therapeutic strategies and their assessment. Obesity and Foetal Programming Clinical Obesity in children and adolescents is increasing as well as its complications such as type 2 diabetes. It represents an important health problem and challenge. Adipose tissue is considered as an endocrine tissue that secretes adipokines and cytokines that induce an inflammatory state in part responsible of the adverse outcome. Our study aims to analyse the inflammatory and blood clotting status of obese children and adolescents in collaboration with the Plateforme de Recherche Clinique of the Department of Children and Adolescent (Pr. Siegrist) Fundamental We are participating in the research program on adverse conditions during gestation and are looking at the effect of growth restriction on the pancreas and adipose tissue development. We are specifically looking changes of expression of metabolic and pancreatic genes during postnatal development using molecular analysis. Within the concept of Foetal origins of Adult Disease we are also looking at epigenetic changes in these adverse conditions. Group's publications [Erythropoietin and neuroprotection]. ARCHIVES DE PEDIATRIE : ORGANE OFFICIEL DE LA SOCIETE FRANCAISE DE PEDIATRIE 2010 vol. 17 pp. 78-84 CHATAGNER A, HUPPI P, HA-VINH LEUCHTER R, SIZONENKO S Functional deficit and recovery of developing sensorimotor networks following neonatal hypoxic-ischemic injury in the rat. CEREBRAL CORTEX 2010 vol. 20(9) pp. 2080-2091 QUAIRIAUX C, SIZONENKO S, MEGEVAND P, MICHEL CM, KISS JZ Neuroimaging of cortical development and brain connectivity in human newborns and animal models. JOURNAL OF ANATOMY 2010 vol. 217(4) pp. 418-428 LODYGENSKY G, VASUNG L, SIZONENKO S, HUPPI P Attentional networks efficiency in preterm children. JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY : JINS 2010 vol. 16(1) pp. 130-137 PIZZO R, URBEN S, VAN DER LINDEN M, BORRADORI TOLSA C, FRESCHI M, FORCADA-GUEX M, HUPPI P, BARISNIKOV K Diffusion-weighted spectroscopy: a novel approach to determine macromolecule resonances in short-echo time 1H-MRS. MAGNETIC RESONANCE IN MEDICINE : OFFICIAL JOURNAL OF THE SOCIETY OF MAGNETIC RESONANCE IN MEDICINE / SOCIETY OF MAGNETIC RESONANCE IN MEDICINE 2010 vol. 64(4) pp. 939-946 KUNZ N, CUDALBU C, MLYNARIK V, HUPPI P, SIZONENKO S, GRUETTER R Structural asymmetries of perisylvian regions in the preterm newborn. NEUROIMAGE 2010 vol. 52(1) pp. 32-42 DUBOIS J, BENDERS M, LAZEYRAS F, BORRADORI TOLSA CRISTINA, HAVINH LEUCHTER RUSSIA, MANGIN JF, HUPPI P Perinatal Exposure to Bisphenol A Alters Early Adipogenesis in the Rat ENVIRONMENTAL HEALTH PERSPECTIVES 2009 vol. 117(10) pp. 1549-1555 SOMM E, SCHWITZGEBEL V, TOULOTTE A, CEDERROTH CR, COMBESCURE C, NEF S, AUBERT ML, HUPPI PETRA Prospective population-based study of RSV-related intermediate care and intensive care unit admissions in Switzerland over a 4-year period (2001-2005). INFECTION 2009 vol. 37(2) pp. 109-116 BERGER TM AND AL. Imaging biomarkers of outcome in the developing preterm brain. LANCET NEUROLOGY 2009 vol. 8(11) pp. 1042-1055 MENT LR, HIRTZ D, HUPPI PETRA Prenatal nicotine exposure and the programming of metabolic and cardiovascular disorders. MOLECULAR AND CELLULAR ENDOCRINOLOGY 2009 vol. 304(1-2) pp. 69-77 SOMM E, SCHWITZGEBEL V, VAUTHAY D, AUBERT ML, HUPPI PETRA Brain development of the preterm neonate after neonatal hydrocortisone treatment for chronic lung disease. PEDIATRIC RESEARCH : AN INTERNATIONAL JOURNAL OF CLINICAL, LABORATORY AND DEVELOPMENTAL INVESTIGATION 2009 vol. 66(5) pp. 555-559 BENDERS MJ, GROENENDAAL F, VAN BEL F, HA VINH R, DUBOIS J, LAZEYRAS F, WARFIELD SK, HUPPI PETRA, DE VRIES LS Title: Brain development of the preterm neonate after neonatal hydrocortisone treatment for chronic lung disease. PEDIATRIC RESEARCH : AN INTERNATIONAL JOURNAL OF CLINICAL, LABORATORY AND DEVELOPMENTAL INVESTIGATION 2009 vol. pp. 0- BENDERS MJ, GROENENDAAL F, VAN BEL F, HA VINH R, DUBOIS J, LAZEYRAS F, WARFIELD SK, HUPPI P, DE VRIES LS Neonate hippocampal volumes: prematurity, perinatal predictors, and 2-year outcome. ANNALS OF NEUROLOGY 2008 vol. ;63(5) pp. 642-651 THOMPSON DK, WOOD SJ, DOYLE LW, WARFIELD SK, LODYGENSKY GREGORY, ANDERSON PJ, EGAN GF, INDER TE Primary cortical folding in the human newborn: an early marker of later functional development. BRAIN 2008 vol. 131(Pt 8) pp. 2028-2041 DUBOIS J, BENDERS M, BORRADORI TOLSA CRISTINA, CACHIA A, LAZEYRAS FRANCOIS, HA-VINH LEUCHTER R, SIZONENKO S, WARFIELD SK, MANGIN JF, HUPPI PETRA Nicotine promotes mammary tumor migration via a signaling cascade involving protein kinase C and CDC42. CANCER RESEARCH 2008 vol. 68(20) pp. 8473-8481 GUO J, IBARAGI S, ZHU T, LUO L, HU GF, HUPPI PETRA, CHEN CY Mapping the early cortical folding process in the preterm newborn brain. CEREBRAL CORTEX 2008 vol. 18(6) pp. 1444-1454 DUBOIS J, BENDERS M, CACHIA A, LAZEYRAS FRANCOIS, HA-VINH LEUCHTER R, SIZONENKO STEPHANE, BORRADORI TOLSA CRISTINA, MANGIN JF, HUPPI PETRA Prenatal nicotine exposure alters early pancreatic islet and adipose tissue development with consequences on the control of body weight and glucose metabolism later in life. ENDOCRINOLOGY 2008 vol. 149(12) pp. 6289-6299 SOMM E, SCHWITZGEBEL V, VAUTHAY D, CAMM EJ, CHEN CY, GIACOBINO JP, SIZONENKO STEPHANE, AUBERT ML, HUPPI PETRA Glial responses to neonatal hypoxic-ischemic injury in the rat cerebral cortex. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE 2008 vol. 26(1) pp. 37-45 SIZONENKO S, CAMM E, DAYER A, KISS J Intrauterine growth restriction affects the preterm infant's hippocampus. PEDIATRIC RESEARCH : AN INTERNATIONAL JOURNAL OF CLINICAL, LABORATORY AND DEVELOPMENTAL INVESTIGATION 2008 vol. 63(4) pp. 438-443 LODYGENSKY GREGORY, SEGHIER ML, WARFIELD S, TOLSA C, SIZONENKO S, LAZEYRAS FRANCOIS, HUPPI PETRA Neuroimaging of brain development--discovering the origins of neuropsychiatric disorders? PEDIATRIC RESEARCH : AN INTERNATIONAL JOURNAL OF CLINICAL, LABORATORY AND DEVELOPMENTAL INVESTIGATION 2008 vol. 64(4) pp. 325- HUPPI PETRA Nutrition for the brain: commentary on the article by Isaacs et al. on page 308. PEDIATRIC RESEARCH : AN INTERNATIONAL JOURNAL OF CLINICAL, LABORATORY AND DEVELOPMENTAL INVESTIGATION 2008 vol. 63(3) pp. 229-231 HUPPI PETRA Neural tube defects in Switzerland from 2001 to 2007: are periconceptual folic acid recommendations being followed? SWISS MEDICAL WEEKLY 2008 vol. 138(41-42) pp. 608-613 PORETTI A AND AL. Developmental changes and injury induced disruption of the radial organization of the cortex in the immature rat brain revealed by in vivo diffusion tensor MRI CEREBRAL CORTEX 2007 vol. 17 pp. 2609-2617 SIZONENKO SPV, CAMM EJ, GARBOW JR, MAIER SE, INDER TE, WILLIAMS CE, NEIL JJ, HUPPI PS Effect of the reperfusion after cerebral ischemia in neonatal rats using MRI monitoring EXPERIMENTAL NEUROLOGY 2007 vol. 208 pp. 297-304 FAU S, PO C, GILLET B, SIZONENKO S, MARIANI J, MERIC P, CHARRIAUT-MARLANGUE C Displacement of brain regions in preterm infants with non-synostotic dolichocephaly investigated by MRI. NEUROIMAGE 2007 vol. 36(4) pp. 1074-1085 MEWES AU, ZÖLLEI L, HUPPI PETRA, ALS H, MCANULTY GB, INDER TE, WELLS WM, WARFIELD SK Are prenatal ultrasounds safe for the developing brain? PEDIATRIC RESEARCH : AN INTERNATIONAL JOURNAL OF CLINICAL, LABORATORY AND DEVELOPMENTAL INVESTIGATION 2007 vol. 61(3) pp. 265-266 GRESSENS P, HUEPPI PETRA Growth factors and plasticity. SEMINARS IN FETAL & NEONATAL MEDICINE 2007 vol. 12(4) pp. 241-249 SIZONENKO S, BEDNAREK N, GRESSENS Early assessment of brain maturation by MR imaging segmentation in neonates and premature infants AMERICAN JOURNAL OF NEURORADIOLOGY 2006 vol. 27 pp. 972-977 ZACHARIA A, ZIMINE S, LOVBLAD KO, WARFIELD S, THOENY H, OZDOBA C, BOSSI E, KREIS R, BOESCH C, SCHROTH G, HUPPI PS Lung disease and brain development BIOLOGY OF THE NEONATE 2006 vol. 89(4) pp. 284-297 HUEPPI PETRA, SIZONENKO STEPHANE, AMATO MAURIZIO Impact of intrauterine growth restriction and glucocorticoids on brain development: Insights using advanced magnetic resonance imaging MOLECULAR AND CELLULAR ENDOCRINOLOGY 2006 vol. 254 pp. 163-171 SIZONENKO SV, BAUTHAY DM, BORRADORI-TOLSA C, LODYGENSKY G, LAZEYRAS F, HUPPI PS Regional brain development in serial magnetic resonance imaging of low-risk preterm infants PEDIATRICS 2006 vol. 118(1) pp. 23-33 MEWES AUJ ET AL. Diffusion tensor imaging of brain development SEMINARS IN FETAL & NEONATAL MEDICINE 2006 vol. 11 pp. 489-497 HUPPI PS, DUBOIS J Functional MRI of the newborn SEMINARS IN FETAL & NEONATAL MEDICINE 2006 vol. 11 pp. 479-488 SEGHIER ML, LAZEYRAS F, HUPPI PS National ethical directives and practical aspects of forgoing life-sustaining treatment in newborn infants in a Swiss intensive care unit SWISS MEDICAL WEEKLY 2006 vol. 136 pp. 597-602 BERNER ME, RIMENSBERGER PC, HUPPI PS, PFISTER RE Advances in postnatal neuroimaging : relevance to pathogenesis and treatment of brain injury CLINICS IN PERINATOLOGY 2002 vol. 29 pp. 827-856 HUPPI PS Diffusion tensor imaging of normal and injured developing human brain : a technical review NMR IN BIOMEDICINE 2002 vol. 15 pp. 543-552 NEIL J, MILLER J, MUKHERJEE P, HUPPI PS Research's domains |