DATABASE-RESEARCH | GROUP OF CLINICAL PATIENT RESEARCH | ||||||
Alain GERVAIX | Head of group CV | Research subject | Members of the group |
Links about the group
Dr. A. GERVAIX HUG/ Dpt Pédiatrie Clin. Pédiatrie Rue Willy-Donzé 6 1211 Genève 14 Suisse Alain.Gervaix@hcuge.ch Tel.: 022/372.45.41 Fax: 0227372.47.24 Comments Pages updated the 17.11.2015 |
Reseach's subject
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Group's publications
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Research's domains
Etiology of community-acquired pneumonie and Inflam. markers in febrile children
1)Etiology of community-acquired pneumonie (CAP) in children. The etiology of CAP in still a challenge in children because of the absence of adequate pulmonary samples. However, viruses replicate in
nasal mucosa before spreading to the lung tissues, and bacterial DNA (ex. S. pneumoniae) can be found in the blood of children with CAP despite negative blood cultures. Our studies focus on the
development and the use of PCR in nasopharyngeal samples and blood to determine the etiology of community-acquired pneumonie in children.
2) Inflammatory markers in febrile children. Distinguishing viral from bacterial infection in very young children is still a challenge because of the absence of specific clinical signs. This leads to overhospitalisation and overuse of antibiotics. Our clinical studies want to determine the usefulness of inflammatory markers, such as procalcitonin, IL-6, IL-8, C-reactive protein as markers of severe bacterial infections in young children. Group's publications [Multicenter validation of the clinical dehydration scale for children]. ARCHIVES DE PEDIATRIE : ORGANE OFFICIEL DE LA SOCIETE FRANCAISE DE PEDIATRIE 2010 vol. 17(12) pp. 1645-1651 GRAVEL J, MANZANO S, GUIMONT C, LACROIX LE, GERVAIX A, BAILEY B Distinguishing between bacterial and aseptic meningitis in children: European comparison of two clinical decision rules. ARCHIVES OF DISEASE IN CHILDHOOD 2010 vol. 95(12) pp. 963-967 DUBOS F AND AL. Long-term safety and effectiveness of lopinavir/ritonavir in antiretroviral-experienced HIV-1-infected children. ARCHIVES OF DISEASE IN CHILDHOOD 2010 vol. 95(6) pp. 478-481 RUDIN C AND AL. Validation of a laboratory risk index score for the identification of severe bacterial infection in children with fever without source. ARCHIVES OF DISEASE IN CHILDHOOD 2010 vol. 95(12) pp. 968-973 GALETTO-LACOUR A, ZAMORA SA, ANDREOLA B, BRESSAN S, LACROIX LE, DA DALT L, GERVAIX A Molecular epidemiology of the nasal colonization by methicillin-susceptible Staphylococcus aureus in Swiss children. CLINICAL MICROBIOLOGY AND INFECTION 2010 vol. pp. 1414-1420 MEGEVAND C AND AL. Disease burden of rotavirus gastroenteritis in children up to 5 years of age in two Swiss cantons: paediatrician- and hospital-based surveillance. EUROPEAN JOURNAL OF PEDIATRICS 2010 vol. 169(3) pp. 319-325 LACROIX LE, GALETTO-LACOUR A, ALTWEGG M, EGLI K, SCHMIDT M, GERVAIX A Identifying severe bacterial infection in children with fever without source. EXPERT REVIEW OF ANTI-INFECTIVE THERAPY 2010 vol. 8(11) pp. 1231-1237 GALETTO-LACOUR A, GERVAIX A Delayed recognition of Guillain-Barré syndrome in a child: a misleading respiratory distress. JOURNAL OF EMERGENCY MEDICINE 2010 vol. 38(5) pp. 59-61 LACROIX LE, GALETTO-LACOUR A, HAENGGELI CA, GERVAIX A Videos in clinical medicine. Catheterization of the urethra in male children. NEW ENGLAND JOURNAL OF MEDICINE 2010 vol. 363(14) pp. 19-19 LACROIX LE, VUNDA A, BAJWA N, GALETTO-LACOUR A, GERVAIX A Pseudomonas aeruginosa outbreak in a pediatric intensive care unit linked to a humanitarian organization residential center. PEDIATRIC INFECTIOUS DISEASE JOURNAL 2010 vol. 29(3) pp. 233-237 LONGTIN Y, TROILLET N, TOUVENEAU S, BOILLAT N, RIMENSBERGER PC, DHARAN S, GERVAIX A, PITTET D, HARBARTH S Comparison of procalcitonin measurement by a semi-quantitative method and an ultra-sensitive quantitative method in a pediatric emergency department. CLINICAL BIOCHEMISTRY 2009 vol. 42(15) pp. 1557-1560 MANZANO S, BAILEY B, GIRODIAS JB, COUSINEAU J, DELVIN E, GERVAIX A Community-associated methicillin-resistant Staphylococcus aureus: risk factors for infection, and long-term follow-up. CLINICAL MICROBIOLOGY AND INFECTION 2009 vol. 15(6) pp. 552-559 LONGTIN Y, SUDRE P, FRANCOIS P, SCHRENZEL J, ARAMBURU C, PASTOR R, GERVAIX A, RENZI G, PITTET D, HARBARTH S Congenital transmission of Chagas disease in Latin American immigrants in Switzerland. EMERGING INFECTIOUS DISEASES (PRINT) 2009 vol. 15(4) pp. 601-603 JACKSON Y, MYERS C, DIANA A, MARTI HP, WOLFF H, CHAPPUIS F, LOUTAN L, GERVAIX A Development of a real-time PCR for the specific detection of Waddlia chondrophila in clinical samples. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 2009 vol. 28(12) pp. 1483-1486 GOY G, CROXATTO A, POSFAY-BARBE K, GERVAIX A, GREUB G Etiology of community-acquired pneumonia in hospitalized children based on WHO clinical guidelines EUROPEAN JOURNAL OF PEDIATRICS 2009 vol. 168(12) pp. 1429-1436 CEVEY-MACHEREL M, GALETTO-LACOUR A, GERVAIX A, SIEGRIST CA, BILLE J, BESCHER-NINET B, KAISER L, KRAHENBUHL JD, GEHRI M Determinants of Vaccine Immunity in the Cohort of Human Immunodeficiency Virus-infected Children Living in Switzerland PEDIATRIC INFECTIOUS DISEASE JOURNAL 2009 vol. 28(11) pp. 996-1001 MYERS C AND AL. Serum procalcitonin level and other biological markers to distinguish between bacterial and aseptic meningitis in children: a European multicenter case cohort study. ARCHIVES OF PEDIATRICS AND ADOLESCENT MEDICINE 2008 vol. 162(12) pp. 1157-1163 DUBOS F AND AL. A multicenter, cross-sectional study on the prevalence and risk factors for nasal colonization with Staphylococcus aureus in patients admitted to children's hospitals in Switzerland. CLINICAL INFECTIOUS DISEASES 2008 vol. 47(7) pp. 923-926 DATTA F AND AL. Use of the rapid antigenic test to determine the duration of isolation in infants hospitalized for respiratory syncytial virus infections. CLINICAL PEDIATRICS 2008 vol. 47(5) pp. 493-495 MYERS C, WAGNER N, KAISER L, POSFAY-BARBE KLARA, GERVAIX A Methicillin-resistant Staphylococcus aureus, Geneva, Switzerland, 1993-2005. EMERGING INFECTIOUS DISEASES (PRINT) 2008 vol. 14(2) pp. 304-307 FRANCOIS P, HARBARTH S, HUYGHE ANTOINE, RENZI G, BENTO M, GERVAIX A, PITTET D, SCHRENZEL J Randomised trial of oral versus sequential intravenous/oral cephalosporins in children with pyelonephritis. EUROPEAN JOURNAL OF PEDIATRICS 2008 vol. 167(9) pp. 1037-1047 NEUHAUS TJ AND AL. VZV retinal vasculitis without systemic infection: diagnosis and monitoring with quantitative polymerase chain reaction. INTERNATIONAL OPHTHALMOLOGY 2008 vol. pp. 0- WIMMERSBERGER Y, GERVAIX A, BAGLIVO E New diagnostic real-time PCR for specific detection of Parachlamydia acanthamoebae DNA in clinical samples. JOURNAL OF CLINICAL MICROBIOLOGY 2008 vol. 46(4) pp. 1491-1493 CASSON N, POSFAY-BARBE KLARA, GERVAIX A, GREUB G Delayed recognition of Guillain-Barré syndrome in a child: A misleading respiratory distress. JOURNAL OF EMERGENCY MEDICINE 2008 vol. pp. 0- LACROIX LE, GALETTO A, HAENGGELI CA, GERVAIX A A score identifying serious bacterial infections in children with fever without source. PEDIATRIC INFECTIOUS DISEASE JOURNAL 2008 vol. 27(7) pp. 654-656 GALETTO-LACOUR A, ZAMORA SA, GERVAIX A Long-term safety and effectiveness of ritonavir, nelfinavir, and lopinavir/ritonavir in antiretroviral-experienced HIV-infected children. PEDIATRIC INFECTIOUS DISEASE JOURNAL 2008 vol. 27(5) pp. 431-437 RUDIN C AND AL. Paediatricians' perception of antibiotic use in children in two large Swiss cities INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 2007 vol. 30 pp. 281-283 GERVAIX A, EGGER M, LACROIX L, HARBARTH S Streptococcus pneumoniae bacteraernia in children INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 2007 vol. 30 pp. 24-28 MYERS C, GERVAIX A Procalcitonin to reduce the number of unnecessary cystographies in children with a urinary tract infection: A European Validation Study JOURNAL OF PEDIATRICS 2007 vol. 150 pp. 89-95 LEROY S, ROMANELLO C, GALETTO-LACOUR A, SMOLKIN V, KORCZOWSKI B, RODRIGO C, TUERLINCKX D, GAJSOS F, MOULIN F, CONTARDO M, GERVAIX A, HALEVY R, DUHL B, PRAT C, VANDER BORGHT T, FOIX-L'HELIAS L, DUBOS F, GENDREL D, BREART G, CHALUMEAU M Postoperative gram-negative anaerobic bacterial endocarditis PEDIATRIC INFECTIOUS DISEASE JOURNAL 2007 vol. 26 pp. 369-369 MYERS C, AGGOUN Y, GERVAIX A, NINET B, SCHRENZEL J, KUHNERT P Prevalence of nasal colonization with methicillin-resistant Staphylococcus aureus (MRSA) in children a multicenter cross-sectional study PEDIATRIC INFECTIOUS DISEASE JOURNAL 2007 vol. 26(6) pp. 544-546 HEININGER U, DATTA F, GERVAIX A, SCHAAD UB, BERGER C, AEBI C, HITZLER M, KIND C, GNEHM HE, FREI R, PIGS/MRSA STUDY GROUP Community-acquired methicillin-resistant Staphylococcus aureus in Switzerland: first surveillance report EURO SURVEILLANCE 2006 vol. 11(1) pp. 42-43 ARAMBURU C, HARBARTH S, LIASSINE N, GIRARD M, GERVAIX A, SCHRENZEL J, RENZI G, SUDRE P Trends in antibiotic resistance of respiratory tract pathogens in children in Geneva, Switzerland EUROPEAN JOURNAL OF PEDIATRICS 2006 vol. 165 pp. 3-8 JAECKLIN T, ROHNER P, JACOMO V, SCHMIDHEINY K, GERVAIX A Control of a cluster of community-associated, methicillin-resistant Staphylocloccus aureus in neonatology JOURNAL OF HOSPITAL INFECTION 2006 vol. 63 pp. 93-100 SAX H, POSFAY-BARBE K, HARBARTH S, FRANCOIS P, TOUVENEAU S, PESSOA-SILVA CL, SCHRENZEL J, DHARAN S, GERVAIX A, PITTET D Multiple pulmonary abscesses caused by Legionella pneumophila infection in an infant with croup PEDIATRIC INFECTIOUS DISEASE JOURNAL 2006 vol. 25(8) pp. 753-754 MYERS C, CORBELLI R, SCHRENZEL J, GERVAIX A Borréliose de Lyme 1ère partie : épidémiologie et diagnostic REVUE MEDICALE DE LA SUISSE ROMANDE 2006 vol. 2(60) pp. 919-924 EVISON J., AEBI C., FRANCIOLI P., PETER O., BASSETTI S., GERVAIX A, ZIMMERLI S., WEBER R. Borréliose de Lyme 2e partie : clinique et traitement REVUE MEDICALE DE LA SUISSE ROMANDE 2006 vol. 2(60) pp. 925-928 EVISON J., AEBI C., PETER O., BASSETTI S., GERVAIX A, ZIMMERLI S., WEBER R. Borréliose de Lyme 3e partie : prévention, grossesse, états d'immunodéficience, syndrome post-borréliose de Lyme REVUE MEDICALE DE LA SUISSE ROMANDE 2006 vol. 2(60) pp. 935-940 EVISON J., AEBI C., FRANCIOLI P., PETER O., BASSETTI X., GERVAIX A, ZIMMERLI S., WEBER R. Cutaneous asperillosis in a child with an acute lymphoblastic leukemia. PEDIATRIC BLOOD & CANCER 2005 vol. 45 pp. 1005-1006 ANSARI M, OZSAHIN AYSE, GERVAIX ALAIN, WACKER PIERRE, TAYLOR SOPHIA Response to treatment and disease progression linked to CD4+ T cell surface CC chemokine receptor 5 density in human immunodeficiency virus type 1 vertical infection JOURNAL OF INFECTIOUS DISEASES 2002 vol. 185 pp. 1055-1061 GERVAIX A, NICOLAS J, PORTALES P, POSFAY-BARBE K, WYLER CA, SEGONDY M, AVINENS O, SIEGRIST CA, CLOT J, ELIAOU JF, ASTRUC J, CORBEAU P Research's domains |