Alain GERVAIX  Head of group CV  Members of the group

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Dr. A. GERVAIX
HUG/ Dpt Pédiatrie
Clin. Pédiatrie
Rue Willy-Donzé 6
1211 Genève 14
Suisse

Alain.Gervaix@hcuge.ch

Tel.: 022/372.45.41
Fax: 0227372.47.24




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Pages updated the 17.11.2015
Reseach's subject | Group's publications | Research's domains

Etiology of community-acquired pneumonie and Inflam. markers in febrile children

1)Etiology of community-acquired pneumonie (CAP) in children. The etiology of CAP in still a challenge in children because of the absence of adequate pulmonary samples. However, viruses replicate in nasal mucosa before spreading to the lung tissues, and bacterial DNA (ex. S. pneumoniae) can be found in the blood of children with CAP despite negative blood cultures. Our studies focus on the development and the use of PCR in nasopharyngeal samples and blood to determine the etiology of community-acquired pneumonie in children.

2) Inflammatory markers in febrile children. Distinguishing viral from bacterial infection in very young children is still a challenge because of the absence of specific clinical signs. This leads to overhospitalisation and overuse of antibiotics. Our clinical studies want to determine the usefulness of inflammatory markers, such as procalcitonin, IL-6, IL-8, C-reactive protein as markers of severe bacterial infections in young children.




Group's publications

[Multicenter validation of the clinical dehydration scale for children].
ARCHIVES DE PEDIATRIE : ORGANE OFFICIEL DE LA SOCIETE FRANCAISE DE PEDIATRIE
2010 vol. 17(12) pp. 1645-1651
GRAVEL J, MANZANO S, GUIMONT C, LACROIX LE, GERVAIX A, BAILEY B

Distinguishing between bacterial and aseptic meningitis in children: European comparison of two clinical decision rules.
ARCHIVES OF DISEASE IN CHILDHOOD
2010 vol. 95(12) pp. 963-967
DUBOS F AND AL.

Long-term safety and effectiveness of lopinavir/ritonavir in antiretroviral-experienced HIV-1-infected children.
ARCHIVES OF DISEASE IN CHILDHOOD
2010 vol. 95(6) pp. 478-481
RUDIN C AND AL.

Validation of a laboratory risk index score for the identification of severe bacterial infection in children with fever without source.
ARCHIVES OF DISEASE IN CHILDHOOD
2010 vol. 95(12) pp. 968-973
GALETTO-LACOUR A, ZAMORA SA, ANDREOLA B, BRESSAN S, LACROIX LE, DA DALT L, GERVAIX A

Molecular epidemiology of the nasal colonization by methicillin-susceptible Staphylococcus aureus in Swiss children.
CLINICAL MICROBIOLOGY AND INFECTION
2010 vol. pp. 1414-1420
MEGEVAND C AND AL.

Disease burden of rotavirus gastroenteritis in children up to 5 years of age in two Swiss cantons: paediatrician- and hospital-based surveillance.
EUROPEAN JOURNAL OF PEDIATRICS
2010 vol. 169(3) pp. 319-325
LACROIX LE, GALETTO-LACOUR A, ALTWEGG M, EGLI K, SCHMIDT M, GERVAIX A

Identifying severe bacterial infection in children with fever without source.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
2010 vol. 8(11) pp. 1231-1237
GALETTO-LACOUR A, GERVAIX A

Delayed recognition of Guillain-Barré syndrome in a child: a misleading respiratory distress.
JOURNAL OF EMERGENCY MEDICINE
2010 vol. 38(5) pp. 59-61
LACROIX LE, GALETTO-LACOUR A, HAENGGELI CA, GERVAIX A

Videos in clinical medicine. Catheterization of the urethra in male children.
NEW ENGLAND JOURNAL OF MEDICINE
2010 vol. 363(14) pp. 19-19
LACROIX LE, VUNDA A, BAJWA N, GALETTO-LACOUR A, GERVAIX A

Pseudomonas aeruginosa outbreak in a pediatric intensive care unit linked to a humanitarian organization residential center.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
2010 vol. 29(3) pp. 233-237
LONGTIN Y, TROILLET N, TOUVENEAU S, BOILLAT N, RIMENSBERGER PC, DHARAN S, GERVAIX A, PITTET D, HARBARTH S

Comparison of procalcitonin measurement by a semi-quantitative method and an ultra-sensitive quantitative method in a pediatric emergency department.
CLINICAL BIOCHEMISTRY
2009 vol. 42(15) pp. 1557-1560
MANZANO S, BAILEY B, GIRODIAS JB, COUSINEAU J, DELVIN E, GERVAIX A

Community-associated methicillin-resistant Staphylococcus aureus: risk factors for infection, and long-term follow-up.
CLINICAL MICROBIOLOGY AND INFECTION
2009 vol. 15(6) pp. 552-559
LONGTIN Y, SUDRE P, FRANCOIS P, SCHRENZEL J, ARAMBURU C, PASTOR R, GERVAIX A, RENZI G, PITTET D, HARBARTH S

Congenital transmission of Chagas disease in Latin American immigrants in Switzerland.
EMERGING INFECTIOUS DISEASES (PRINT)
2009 vol. 15(4) pp. 601-603
JACKSON Y, MYERS C, DIANA A, MARTI HP, WOLFF H, CHAPPUIS F, LOUTAN L, GERVAIX A

Development of a real-time PCR for the specific detection of Waddlia chondrophila in clinical samples.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
2009 vol. 28(12) pp. 1483-1486
GOY G, CROXATTO A, POSFAY-BARBE K, GERVAIX A, GREUB G

Etiology of community-acquired pneumonia in hospitalized children based on WHO clinical guidelines
EUROPEAN JOURNAL OF PEDIATRICS
2009 vol. 168(12) pp. 1429-1436
CEVEY-MACHEREL M, GALETTO-LACOUR A, GERVAIX A, SIEGRIST CA, BILLE J, BESCHER-NINET B, KAISER L, KRAHENBUHL JD, GEHRI M

Determinants of Vaccine Immunity in the Cohort of Human Immunodeficiency Virus-infected Children Living in Switzerland
PEDIATRIC INFECTIOUS DISEASE JOURNAL
2009 vol. 28(11) pp. 996-1001
MYERS C AND AL.

Serum procalcitonin level and other biological markers to distinguish between bacterial and aseptic meningitis in children: a European multicenter case cohort study.
ARCHIVES OF PEDIATRICS AND ADOLESCENT MEDICINE
2008 vol. 162(12) pp. 1157-1163
DUBOS F AND AL.

A multicenter, cross-sectional study on the prevalence and risk factors for nasal colonization with Staphylococcus aureus in patients admitted to children's hospitals in Switzerland.
CLINICAL INFECTIOUS DISEASES
2008 vol. 47(7) pp. 923-926
DATTA F AND AL.

Use of the rapid antigenic test to determine the duration of isolation in infants hospitalized for respiratory syncytial virus infections.
CLINICAL PEDIATRICS
2008 vol. 47(5) pp. 493-495
MYERS C, WAGNER N, KAISER L, POSFAY-BARBE KLARA, GERVAIX A

Methicillin-resistant Staphylococcus aureus, Geneva, Switzerland, 1993-2005.
EMERGING INFECTIOUS DISEASES (PRINT)
2008 vol. 14(2) pp. 304-307
FRANCOIS P, HARBARTH S, HUYGHE ANTOINE, RENZI G, BENTO M, GERVAIX A, PITTET D, SCHRENZEL J

Randomised trial of oral versus sequential intravenous/oral cephalosporins in children with pyelonephritis.
EUROPEAN JOURNAL OF PEDIATRICS
2008 vol. 167(9) pp. 1037-1047
NEUHAUS TJ AND AL.

VZV retinal vasculitis without systemic infection: diagnosis and monitoring with quantitative polymerase chain reaction.
INTERNATIONAL OPHTHALMOLOGY
2008 vol. pp. 0-
WIMMERSBERGER Y, GERVAIX A, BAGLIVO E

New diagnostic real-time PCR for specific detection of Parachlamydia acanthamoebae DNA in clinical samples.
JOURNAL OF CLINICAL MICROBIOLOGY
2008 vol. 46(4) pp. 1491-1493
CASSON N, POSFAY-BARBE KLARA, GERVAIX A, GREUB G

Delayed recognition of Guillain-Barré syndrome in a child: A misleading respiratory distress.
JOURNAL OF EMERGENCY MEDICINE
2008 vol. pp. 0-
LACROIX LE, GALETTO A, HAENGGELI CA, GERVAIX A

A score identifying serious bacterial infections in children with fever without source.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
2008 vol. 27(7) pp. 654-656
GALETTO-LACOUR A, ZAMORA SA, GERVAIX A

Long-term safety and effectiveness of ritonavir, nelfinavir, and lopinavir/ritonavir in antiretroviral-experienced HIV-infected children.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
2008 vol. 27(5) pp. 431-437
RUDIN C AND AL.

Paediatricians' perception of antibiotic use in children in two large Swiss cities
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
2007 vol. 30 pp. 281-283
GERVAIX A, EGGER M, LACROIX L, HARBARTH S

Streptococcus pneumoniae bacteraernia in children
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
2007 vol. 30 pp. 24-28
MYERS C, GERVAIX A

Procalcitonin to reduce the number of unnecessary cystographies in children with a urinary tract infection: A European Validation Study
JOURNAL OF PEDIATRICS
2007 vol. 150 pp. 89-95
LEROY S, ROMANELLO C, GALETTO-LACOUR A, SMOLKIN V, KORCZOWSKI B, RODRIGO C, TUERLINCKX D, GAJSOS F, MOULIN F, CONTARDO M, GERVAIX A, HALEVY R, DUHL B, PRAT C, VANDER BORGHT T, FOIX-L'HELIAS L, DUBOS F, GENDREL D, BREART G, CHALUMEAU M

Postoperative gram-negative anaerobic bacterial endocarditis
PEDIATRIC INFECTIOUS DISEASE JOURNAL
2007 vol. 26 pp. 369-369
MYERS C, AGGOUN Y, GERVAIX A, NINET B, SCHRENZEL J, KUHNERT P

Prevalence of nasal colonization with methicillin-resistant Staphylococcus aureus (MRSA) in children a multicenter cross-sectional study
PEDIATRIC INFECTIOUS DISEASE JOURNAL
2007 vol. 26(6) pp. 544-546
HEININGER U, DATTA F, GERVAIX A, SCHAAD UB, BERGER C, AEBI C, HITZLER M, KIND C, GNEHM HE, FREI R, PIGS/MRSA STUDY GROUP

Community-acquired methicillin-resistant Staphylococcus aureus in Switzerland: first surveillance report
EURO SURVEILLANCE
2006 vol. 11(1) pp. 42-43
ARAMBURU C, HARBARTH S, LIASSINE N, GIRARD M, GERVAIX A, SCHRENZEL J, RENZI G, SUDRE P

Trends in antibiotic resistance of respiratory tract pathogens in children in Geneva, Switzerland
EUROPEAN JOURNAL OF PEDIATRICS
2006 vol. 165 pp. 3-8
JAECKLIN T, ROHNER P, JACOMO V, SCHMIDHEINY K, GERVAIX A

Control of a cluster of community-associated, methicillin-resistant Staphylocloccus aureus in neonatology
JOURNAL OF HOSPITAL INFECTION
2006 vol. 63 pp. 93-100
SAX H, POSFAY-BARBE K, HARBARTH S, FRANCOIS P, TOUVENEAU S, PESSOA-SILVA CL, SCHRENZEL J, DHARAN S, GERVAIX A, PITTET D

Multiple pulmonary abscesses caused by Legionella pneumophila infection in an infant with croup
PEDIATRIC INFECTIOUS DISEASE JOURNAL
2006 vol. 25(8) pp. 753-754
MYERS C, CORBELLI R, SCHRENZEL J, GERVAIX A

Borréliose de Lyme 1ère partie : épidémiologie et diagnostic
REVUE MEDICALE DE LA SUISSE ROMANDE
2006 vol. 2(60) pp. 919-924
EVISON J., AEBI C., FRANCIOLI P., PETER O., BASSETTI S., GERVAIX A, ZIMMERLI S., WEBER R.

Borréliose de Lyme 2e partie : clinique et traitement
REVUE MEDICALE DE LA SUISSE ROMANDE
2006 vol. 2(60) pp. 925-928
EVISON J., AEBI C., PETER O., BASSETTI S., GERVAIX A, ZIMMERLI S., WEBER R.

Borréliose de Lyme 3e partie : prévention, grossesse, états d'immunodéficience, syndrome post-borréliose de Lyme
REVUE MEDICALE DE LA SUISSE ROMANDE
2006 vol. 2(60) pp. 935-940
EVISON J., AEBI C., FRANCIOLI P., PETER O., BASSETTI X., GERVAIX A, ZIMMERLI S., WEBER R.

Cutaneous asperillosis in a child with an acute lymphoblastic leukemia.
PEDIATRIC BLOOD & CANCER
2005 vol. 45 pp. 1005-1006
ANSARI M, OZSAHIN AYSE, GERVAIX ALAIN, WACKER PIERRE, TAYLOR SOPHIA

Response to treatment and disease progression linked to CD4+ T cell surface CC chemokine receptor 5 density in human immunodeficiency virus type 1 vertical infection
JOURNAL OF INFECTIOUS DISEASES
2002 vol. 185 pp. 1055-1061
GERVAIX A, NICOLAS J, PORTALES P, POSFAY-BARBE K, WYLER CA, SEGONDY M, AVINENS O, SIEGRIST CA, CLOT J, ELIAOU JF, ASTRUC J, CORBEAU P


Research's domains