Paolo MEDA  CV du Chef de Groupe  Composition du Groupe

  Coordonnées du groupe

Prof. P. MEDA
CMU/ Dpt PHYM
1 rue Michel-Servet
1211 Genève 04
Suisse

Paolo.Meda@unige.ch

Tél.: 022 379 52 07 / 05
Fax: 022 379 52 60


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Pages générées le 07.05.2013
Sujet de recherche | Publications du groupe | Domaines de recherche

Couplage cellulaire et connexines

Gauche:Jonction Gap Droite:Couplage Inter-Cellulaire

Les connexines sont des protéines intégrales de membrane qui sont exprimées par pratiquement tous les types cellulaires et dans toutes les espèces animales. Leur structure primaire et leur topographie ont été très conservées au cours de l'évolution. Chez les mammifères, ces protéines forment une famille multi-génique, comprenant une vingtaine d'iisoformes. Les connexines sont concentrées dans des régions membranaires qui établissent des contacts entre cellules adjacentes. A ces endroits, appelés jonctions " gap ", les connexines forment des canaux inter-cellulaires, au travers desquels les cellules échangent des ions et des métabolites cytoplasmiques. Ce phénomène est appelé couplage cellulaire. Les fonctions physiologiques du couplage cellulaire sont encore peu comprises. Cependant, l'observation que des modifications de diverses connexines dans des animaux transgéniques résulte en de multiples et sévères phénotypes, indique que le couplage assure des rôles importants dans la régulation du fonctionnement cellulaire. Plus récemment, la découverte que des mutations de connexines sont liées à diverses maladies humaines héréditaires, a indiqué que les connexines jouent également un rôle pathogénique crucial dans certains organes, via un mécanisme encore non élucidé. En utilisant des approches de biologie cellulaire et moléculaire, notre équipe étudie ce mécanisme de signalisation et les fonctions de plusieurs connexines dans divers tissus épithéliaux et nerveux, in vitro et in vivo.




Publications du groupe

The Lou/C rat: a model of spontaneous food restriction associated with improved insulin sensitivity and decreased lipid storage in adipose tissue.
AMERICAN JOURNAL OF PHYSIOLOGY. ENDOCRINOLOGY AND METABOLISM
2009 vol. 296(5) pp. 1120-1132
VEYRAT-DUREBEX C, MONTET X, VINCIGUERRA M, GJINOVCI A, MEDA P, FOTI M, ROHNER-JEANRENAUD F

Junctional Adhesion Molecule-C Mediates Leukocyte Infiltration in Response to Ischemia Reperfusion Injury
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
2009 vol. 29(10) pp. 1509-1515
SCHEIERMANN C AND AL.

Regulation of PKD by the MAPK p38 delta in Insulin Secretion and Glucose Homeostasis
CELL
2009 vol. 136(2) pp. 235-248
SUMARA G AND AL.

Connexins Diabetes and the Metabolic Syndrome
CURRENT PROTEIN & PEPTIDE SCIENCE
2009 vol. 10(1) pp. 18-29
HAMELIN R, ALLAGNAT F, HAEFLIGER JA, MEDA P

In vivo imaging of murine endocrine islets of Langerhans with extended-focus optical coherence microscopy
DIABETOLOGIA
2009 vol. 52(8) pp. 1599-1607
VILLIGER M, GOULLEY J, FRIEDRICH M, GRAPIN-BOTTON A, MEDA P, LASSER T, LEITGEB RA

Cx36 makes channels coupling human pancreatic beta-cells and correlates with insulin expression
HUMAN MOLECULAR GENETICS
2009 vol. 18(3) pp. 428-439
SERRE-BEINIER V AND AL.

Mitochondrial Glutamate Carrier GC1 as a Newly Identified Player in the Control of Glucose-stimulated Insulin Secretion
JOURNAL OF BIOLOGICAL CHEMISTRY
2009 vol. 284(37) pp. 25004-25014
CASIMIR M, LASORSA FM, RUBI B, CAILLE D, PALMIERI F, MEDA P, MAECHLER P

Increased Expression of Renal Cyclooxygenase-2 and Neuronal Nitric Oxide Synthase in Hypertensive Cx40-Deficient Mice
JOURNAL OF VASCULAR RESEARCH
2009 vol. 46(3) pp. 188-198
KRATTINGER N, ALONSO F, CAPPONI A, MAZZOLAI L, NICOD P, MEDA P, HAEFLIGER JA

"Connexins pannexins innexins: novel roles of ""hemi-channels"""
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
2009 vol. 457(6) pp. 1207-1226
SCEMES E, SPRAY DC, MEDA P

Derivation of functional insulin-producing cell lines from primary mouse embryo culture.
STEM CELL RESEARCH
2009 vol. 2(1) pp. 29-40
LI G. AND AL.

Generating mESC-derived insulin-producing cell lines through an intermediate lineage-restricted progenitor line.
STEM CELL RESEARCH
2009 vol. 2(1) pp. 41-55
LI G. AND AL.

Lack of "hemichannel" activity in insulin-producing cells.
CELL COMMUNICATION AND ADHESION
2008 vol. 15(1) pp. 143-154
SCEMES E, BAVAMIAN S, CHAROLLAIS A, SPRAY DC, MEDA P

Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism.
DIABETES
2008 vol. 57(5) pp. 1176-1185
CEDERROTH CR AND AL.

Functional significance of repressor element 1 silencing transcription factor (REST) target genes in pancreatic beta cells.
DIABETOLOGIA
2008 vol. 51(8) pp. 1429-1439
MARTIN D, ALLAGNAT F, CHAFFARD GAELLE, CAILLE D, FUKUDA M, REGAZZI R, ABDERRAHMANI A, WAEBER G, MEDA P, MAECHLER P, HAEFLIGER JA

A new conditional mouse mutant reveals specific expression and functions of connexin36 in neurons and pancreatic beta-cells.
EXPERIMENTAL CELL RESEARCH
2008 vol. 314(5) pp. 997-1012
WELLERSHAUS K, DEGEN J, DEUCHARS J, THEIS M, CHAROLLAIS A, CAILLE D, GAUTHIER BENOIT, JANSSEN-BIENHOLD U, SONNTAG S, HERRERA PEDRO, MEDA P, WILLECKE K

Munc 18-1 and granuphilin collaborate during insulin granule exocytosis.
TRAFFIC
2008 vol. 9(5) pp. 813-832
TOMAS A, MEDA P, REGAZZI R, PESSIN JE, HALBAN PA

EphA-ephrin-A-mediated beta cell communication regulates insulin secretion from pancreatic islets
CELL
2007 vol. 129 pp. 359-370
KONSTANTINOVA, I, NIKOLOVA, G, OHARA-IMAIZUMI, M, MEDA, P, KUCERA, T, ZARBALIS, K, WURST, W, NAGAMATSU, S, LAMMERT, E

Cx36-mediated coupling reduces beta-cell heterogeneity, confines the stimulating glucose concentration range, and affects insulin release kinetics
DIABETES
2007 vol. 56 pp. 1078-1086
SPEIER, S, GJINOVCI, A, CHAROLLAIS, A, MEDA, P, RUPNIK, M

Novel function of the ciliogenic transcription factor RFX3 in development of the endocrine pancreas
DIABETES
2007 vol. 56 pp. 950-959
AIT-LOUNIS, A, BAAS, D, BARRAS, E, BENADIBA, C, CHAROLLAIS, A, NLEND, RN, LIEGEOIS, D, MEDA, P, DURAND, B, REITH, W

Islet-cell-to-cell communication as basis for normal insulin secretion.
DIABETES, OBESITY AND METABOLISM
2007 vol. 9 pp. 118-132
BAVAMIAN S, KLEE P, BRITAN A, POPULAIRE C, CAILLE D, CANCELA J, CHAROLLAIS A, MEDA P

Beta cells preferentially exchange cationic molecules via connexin 36 gap junction channels
DIABETOLOGIA
2007 vol. 50 pp. 2332-2341
CHARPANTIER, E, CANCELA, J, MEDA, P

Exocytosis of ATP from astrocyte progenitors modulates spontaneous Ca2+ oscillations and cell migration
GLIA
2007 vol. 55 pp. 652-662
STRIEDINGER, K, MEDA, P, SCEMES, E

Improved visualization of vessels and hepatic tumors by micro-computed tomography (CT) using iodinated liposomes
INVESTIGATIVE RADIOLOGY
2007 vol. 42 pp. 652-658
MONTET X, PASTOR CM, VALLEE JP, BECKER CD, GEISSBUHLER A, MOREL DR, MEDA P

Inhibition of insulin secretion by betagranin, an N-terminal chromogranin A fragment.
JOURNAL OF BIOLOGICAL CHEMISTRY
2007 vol. 282(17) pp. 12717-12724
SCHMID GM, MEDA P, CAILLE D, WARGENT E, O'DOWD J, HOCHSTRASSER DF, CAWTHORNE MA, SANCHEZ JC

Cutting edge: Lack of evidence for connexin-43 expression in human epidermal Langerhans cells.
JOURNAL OF IMMUNOLOGY
2007 vol. 179(7) pp. 4318-4321
ZIMMERLI SC, MASSON F, CANCELA J, MEDA P, HAUSER C

Connexin40 regulates renin production and blood pressure.
KIDNEY INTERNATIONAL
2007 vol. 72(7) pp. 814-822
KRATTINGER N, CAPPONI AM, MAZZOLAI L, AUBERT JF, CAILLE D, NICOD P, WAEBER G, MEDA P, HAEFLIGER JA

Connexin30 deficiency causes instrastrial fluid-blood barrier disruption within the cochlear stria vascularis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AME
2007 vol. 104(15) pp. 6229-6234
COHEN-SALMON M, REGNAULT B, CAYET N, CAILLE D, DEMUTH K, HARDELIN JP, JANEL N, MEDA P, PETIT C

Expression and function of junctional adhesion molecule-C in myelinated peripheral nerves
SCIENCE
2007 vol. 318 pp. 1472-1475
SCHEIERMANN, C, MEDA, P, AURRAND-LIONS, M, MADANI, R, YIANGOU, Y, COFFEY, P, SALT, TE, DUCREST-GAY, D, CAILLE, D, HOWELL, O, REYNOLDS, R, LOBRINUS, A, ADAMS, RH, YU, ASL, ANAND, P, IMHOF, BA, NOURSHARGH, S

Expression and function of junctional adhesion molecule-C in myelinated peripheral nerves.
SCIENCE
2007 vol. 318(5855) pp. 1472-1475
SCHEIERMANN C ET AL

Connexin36 and pancreatic beta-cell functions.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
2006 vol. 112(2) pp. 74-81
NLEND RN, MICHON LAETITIA, BAVAMIAN S, BOUCARD N, CAILLE D, CANCELA J, CHAROLLAIS A, CHARPANTIER E, KLEE P, PEYROU M, POPULAIRE C, ZULIANELLO L, MEDA P

The class I HLA repertoire of pancreatic islets comprises the nonclassical class Ib antigen HLA-G
DIABETES
2006 vol. 55(5) pp. 1214-1222
CIRULLI VINCENZO, ZALATAN JESSIE, MCMASTER MICHAEL, PRINSEN ROBYN, SALOMON DANIEL R., RICORDI CAMILLO, TORBETT BRUCE E., MEDA PAOLO, CRISA LAURA

Interleukin-1 receptor antagonist is upregulated during diet-induced obesity and regulates insulin sensitivity in rodents
DIABETOLOGIA
2006 vol. 49 pp. 387-393
SOMM E, CETTOUR-ROSE P, ASENSIO C, CHAROLLAIS A, KLEIN M, THEANDER-CARRILLO C, JUGE-AUBRY CE, DAYER JM, NICKLIN MJH, MEDA P, ROHNER-JEANRENAUD F, MEIER CA

Live imaging of neural structure and function by fibred fluorescence microscopy
EMBO REPORTS
2006 vol. 7(11) pp. 1154-1161
VINCENT PIERRE ET AL.

Airway epithelial (nasal) cell monolayers used to study Pseudomonas aeruginosa invasion are hyperpolarized and not representative of the human airway epithelium - Author's reply
INFECTION AND IMMUNITY
2006 vol. 74 pp. 7043-7044
ZULIANELLO L

Rhamnolipids are virulence factors that promote early infiltration of primary human airway epithelia by Pseudomonas aeruginosa
INFECTION AND IMMUNITY
2006 vol. 74 pp. 3134-3147
ZULIANELLO L, CANARD C, KOHLER T, CAILLE D, LACROIX JS, MEDA P

Connexin43-dependent mechanism modulates renin secretion and hypertension
JOURNAL OF CLINICAL INVESTIGATION
2006 vol. 116(2) pp. 405-413
HAEFLIGER J.-A. ET AL.

Connexins, renin and hypertension
M S-MEDECINE SCIENCES
2006 vol. 22 pp. 826-827
HAEFLIGER JA, MEDA P

Trichostatin a enhances gap junctional intercellular communication in primary cultures of adult rat hepatocytes
TOXICOLOGICAL SCIENCES
2006 vol. 91(2) pp. 484-492
VINKEN MATHIEU, HENKENS TOM, VANHAECKE TAMARA, PAPELEU PEGGY, GEERTS ALBERT, VAN ROSSEN ELKE, CHIPMAN JAMES KEVIN, MEDA PAOLO, ROGIERS VERA

Production of chemokines by perivascular adipose tissue. A role in the pathogenesis of atherosclerosis?
ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY
2005 vol. 25 pp. 2594-2599
HENRICHOT ELVIRE, JUGE CRISTIANA, PERNIN CHOLLET AGNES, PACHE JEAN-CLAUDE, VELEBIT V, DAYER JEAN-MICHEL, MEDA PAOLO, CHIZZOLINI CARLO, MEIER CHRISTOPH

Ectopic expression of syncollin in INS-1 beta-cells sorts it into granules and impairs regulated secretion.
BIOCHEMISTRY : A BIWEEKLY PUBLICATION OF THE AMERICAN CHEMICAL SOCIETY
2005 vol. 44 pp. 4365-4374
LI J, LUO R, HOOI SC, RUGA FAHY PILAR, ZHANG J, MEDA PAOLO, LI G

Involvement of gap junctional communication in secretion.
BIOCHIMICA ET BIOPHYSICA ACTA : INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS.
2005 vol. 1719 pp. 82-101
MICHON LAETITIA ET AL

Shear stress and cyclic circumferential stretch, but not pressure, alter connexin43 expression in endothelial cells
CELL COMMUNICATION AND ADHESION
2005 vol. 12(5-6) pp. 261-270
KWAK CHANSON BRENDA, SILACCI PAOLO, MANDICOURT GUILLAUME, HAYOZ D, MEDA PAOLO

Loss of connexin36 channels alters beta-cell coupling, islet synchronization of glucose-induced Ca2+ and insulin oscillations, and basal insulin release.
DIABETES
2005 vol. 54 pp. 1798-1807
RAVIER MA, GULDENAGEL M, CHAROLLAIS ANNE, GJINOVCI ASLAN, CAILLE CHOFFAT DOROTHEE, SOHL G, WOLLHEIM CLAES, WILLECKE K, HENQUIN JC, MEDA PAOLO

Expression and secretion of alpha1-proteinase inhibitor are regulated by proinflammatory cytokines in human pancreatic islet cells.
DIABETOLOGIA
2005 vol. 48 pp. 1523-1533
BOSCO DOMENICO, MEDA PAOLO, MOREL PHILIPPE, MATTHEY-DORET DAVID, CAILLE CHOFFAT DOROTHEE, TOSO CHRISTIAN, BUHLER LEO, BERNEY THIERRY

Interleukin-1 receptor antagonist is upregulated during diet-induced obesity and regulates insulin sensitivity in rodents
DIABETOLOGIA
2005 vol. 49 pp. 387-393
SOMM EMMANUEL, CETTOUR ROSE PHILIPPE, ASENSIO CEDERIC, CHAROLLAIS ANNE, KLEIN MARCELLA, THEANDER-CARRRILLO CLAUDIA, JUGE-AUBRY CRISTIANA, DAYER JEAN-MICHEL, NICKLIN MJH, MEDA PAOLO, ROHNER-JEANRENAUD FRANCOISE, MEIER CHRISTOPH A

Sequential activation of p75 and TrkB is involved in dendritic development of subventricular zone-derived neuronal progenitors in vitro
EUROPEAN JOURNAL OF NEUROSCIENCE
2005 vol. 21 pp. 69-80
GASCON EDUARDO, VUTSKITS LASZLO, ZHANG H, BARRAL-MORAN MJ, KISS PJ, MAS CHRISTOPHE, KISS JOZSEF

Quality control of fibrinogen secretion in the molecular pathogenesis of congenital afibrinogenemia
HUMAN MOLECULAR GENETICS
2005 vol. 14 pp. 3271-3280
VU DUNG, DI SANZA CORINNE, CAILLE CHOFFAT DOROTHEE, DE MOERLOOSE PHILIPPE, SCHEIB HOLGER, MEDA PAOLO, NEERMAN-ARBEZ MARGUERITE

Different mechanisms preclude mutant CLDN14 proteins from forming tight junctions in vitro.
HUMAN MUTATION
2005 vol. 25 pp. 543-549
CHAROLLAIS ANNE, CAILLE CHOFFAT DOROTHEE, BOREL CHRISTELLE, LYLE ROBERT, MEDA PAOLO, ANTONARAKIS STYLIANOS

Dual interaction of JAM-C with JAM-B and alpha(M)beta2 integrin: function in junctional complexes and leukocyte adhesion.
MOLECULAR BIOLOGY OF THE CELL
2005 vol. 16 pp. 4992-5003
LAMAGNA CHRYSTELLE ET AL.

Diagnostic optique des lésions dysplasiques du col utérin
BULLETIN DU CANCER : JOURNAL DE LA SOCIETE FRANCAISE DU CANCER
2004 vol. 91 pp. 45-53
CHARVET I, MEDA P, GENET M, PELTE MF, VLASTOS AT

Contribution of connexins to the function of the vascular wall
CARDIOVASCULAR RESEARCH
2004 vol. 62 pp. 345-356
JACQUES-ANTOINE HAEFLIGER, PASCAL NICOD, MEDA PAOLO

Pax2 mutant mice display increased number and size of islets of Langerhans but no change in insulin and glucagon content.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
2004 vol. 150 pp. 389-395
ZAIKO MAIA, ANNE ESTREICHER, RITZ BEATE, HERRERA PEDRO, JACK FAVOR, MEDA PAOLO, PHILIPPE JACQUES

Diagnosis and grading of gastritis by non-invasive optical analysis
EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
2004 vol. 16 pp. 1189-1198
CHARVET IGOR, ORY G, THUELER P, BRUNDLER MARIE-ANNE, SAINT-GHISLAIN M, AZARPEY N, HADENGUE ANTOINE, DEPEURSINGE C, VERMEULEN BEN, MEDA PAOLO

Differentiating the effects of Cx36 and E-cadherin for proper insulin secretion of MIN6 cells.
EXPERIMENTAL CELL RESEARCH
2004 vol. 294 pp. 379-391
CALABRESE ALESSANDRA, CATON DAVID, MEDA PAOLO

Replacement by a lacZ reporter gene assigns mouse connexin36, 45 and 43 to distinct cell types in pancreatic islets.
EXPERIMENTAL CELL RESEARCH
2004 vol. 294 pp. 18-29
MARTIN THEIS, MAS CHRISTOPHE, BRITTA DÖRING, JOACHIM DEGEN, CHRISTOPHER BRINK, DOROTHEE CAILLE, CHAROLLAIS ANNE, OLAF KRÜGER, ACHIM PLUM, NEPOTE VIRGINE, HERRERA PEDRO, MEDA PAOLO, KLAUS WILLECKE

Connexin30 mutations responsible for hidrotic ectodermal dysplasia cause abnormal hemichannel activity
HUMAN MOLECULAR GENETICS
2004 vol. 13 pp. 1703-1714
GUILHERME MUNHOZ ESSENFELDER, ROBERTO BRUZZONE, JEROME LAMARTINE, CHAROLLAIS ANNE, CLAUDINE BLANCHET-BARDON, MICHAEL T. BARBE, MEDA PAOLO, GILLES WAKSMAN

Disruption of the cingulin gene does not prevent tight junction formation but alters gene expression.
JOURNAL OF CELL SCIENCE.
2004 vol. 117 pp. 5245-5256
LAURENT GUILLEMOT, EVA HAMMAR, CHRISTIAN KAISTER, JORGE RITZ, CAILLE CHOFFAT DOROTHEE, LIONEL JOND, CHRISTOPH BAUER, MEDA PAOLO, SANDRA CITI

Association of the connexin36 gene with juvenile myoclonic epilepsy
JOURNAL OF MEDICAL GENETICS
2004 vol. 41 pp. 93-
MAS C, TASKE N, DEUTSCH S, GUIPPONI M, THOMAS P, CAVANIS A, FRIIS M, KJELDSEN MJ, PIZZOLATO GP, VILLEMURE JG, BURESI C, REES M, MALAFOSSE A, GARDINER M, ANTONARAKIS SE, MEDA P

On-line analysis of gap junctions reveals more efficient electrical than dye coupling between islet cells.
AMERICAN JOURNAL OF PHYSIOLOGY. ENDOCRINOLOGY AND METABOLISM
2003 vol. 284 pp. 980-987
QUESADA I, FUENTES E, ANDREU E, MEDA P, NADAL A, SORIA B

Cx36 involvement in insulin secretion: characteristics and mechanism.
CELL COMMUNICATION AND ADHESION
2003 vol. 10 pp. 431-435
MEDA P

Connexin 36 controls synchronization of Ca2+ oscillations and insulin secretion in MIN6 cells.
DIABETES
2003 vol. 52 pp. 417-424
CALABRESE A, ZHANG M, SERRE-BEINIER V, CATON D, MAS C, SATIN L.S., MEDA P

Molecular interaction of connexin 30.3 and connexin 31 suggests a dominant-negative mechanism associated with erythrokeratodermia variabilis.
HUMAN MOLECULAR GENETICS
2003 vol. 12 pp. 3287-3294
PLANTARD L, HUBER M, MACARI F, MEDA P, HOHL D

Connexin-36 contributes to control function of insulin-producing cells.
JOURNAL OF BIOLOGICAL CHEMISTRY
2003 vol. 278 pp. 37690-37697
LE GURUN S, MARTIN D, FORMENTON A, MAECHLER P, CAILLE D, WAEBER G, MEDA P, HAEFLIGER J.-A.

Intracellular localization of keratinocyte Fas ligand explains lack of cytolytic activity under physiological conditions.
JOURNAL OF BIOLOGICAL CHEMISTRY
2003 vol. 278 pp. 16183-16188
VIARD-LEVEUGLE I, BULLANI R, MEDA P, MICHEAU O, SAURAT JH, LIMAT A, TSCHOPP J, FRENCH LE

In vivo endoscopic tissue diagnostics based on spectroscopic absorption, scattering, and phase function properties.
JOURNAL OF BIOMEDICAL OPTICS
2003 vol. 8 pp. 495-503
THUELER P, CHARVET I, BEVILACQUA F, ST GHISLAIN M, ORY G, MARQUET P, MEDA P, VERMEULEN B, DEPEURSINGE

Lentivirus-mediated transduction of connexin cDNAs shows level- and isoform-specific alterations in insulin secretion of primary pancreatic beta-cells.
JOURNAL OF CELL SCIENCE
2003 vol. 116(Pt 11) pp. 2285-2294
CATON D, CALABRESE A, MAS C, SERRE-BEINIER V, CHAROLLAIS A, CAILLE D, ZUFFEREY R, TRONO D, MEDA P

Reduced expression of P2Y1 receptors in connexin43-null mice alters calcium signaling and migration of neural progenitor cells.
JOURNAL OF NEUROSCIENCE
2003 vol. 23 pp. 11444-11452
SCEMES E, DUVAL N, MEDA P

Connexins and secretion
BIOLOGY OF THE CELL
2002 vol. 94(7-8) pp. 477-492
SERRE-BEINIER V, MAS C, CALABRESE A, CATON D, BAUQUIS J, CAILLE D, CHAROLLAIS A, CIRULLI V, MEDA P

Tissue-type plasminogen activator (t-PA) is stored in Weibel-Palade bodies in human endothelial cells both in vitro and in vivo
BLOOD
2002 vol. 99 pp. 3637-3645
HUBER D, CRAMER EM, KAUFMANN JE, MEDA P, MASSE JM, KRUITHOF EK, VISCHER UM

Beta-cell crosstalk: A further dimension in the stimulus-secretion coupling of glucose-induced insulin release.
DIABETES & METABOLISM
2002 vol. 28(6Pt2) pp. 0-0
CATON D, CALABRESE A, MAS C, SERRE-BEINIER V, WONKAM A, MEDA P

Connexins 43 and 26 are differentially increased after rat bladder outlet obstruction.
EXPERIMENTAL CELL RESEARCH
2002 vol. 274(2) pp. 216-225
HAEFLIGER JA, TISSIERES P, TAWADROS T, FORMENTON A, BENY JL, NICOD P, FREY P, MEDA P

Expression and regulation of gap junctions in rat cholangiocytes.
HEPATOLOGY
2002 vol. 36(3) pp. 631-640
BODE HP, WANG L, CASSIO D, LEITE MF, ST-PIERRE MV, HIRATA K, OKAZAKI K, SEARS ML, MEDA P, NATHANSON MH, DUFOUR JF

Intracellular Localization of Keratinocyte Fas Ligand Explains Lack of Cytolytic Activity under Physiological Conditions
JOURNAL OF BIOLOGICAL CHEMISTRY
2002 vol. 278 pp. 16183-16188
VIARD-LEVEUGLE I, BULLANI RR, MEDA P, MICHEAU O, LIMAT A, SAURAT JH, TSCHOPP J, FRENCH LE

Cell coupling and Cx43 expression in embryonic mouse neural progenitor cells.
JOURNAL OF CELL SCIENCE
2002 vol. 115(PT16) pp. 3241-3251
DUVAL N, GOMES D, CALAORA V, CALABRESE A, MEDA P, BRUZZONE R

A new optical method for the non-invasive detection of minimal tissue alterations.
PHYSICS IN MEDICINE AND BIOLOGY
2002 vol. 47(12) pp. 2095-2108
CHARVET I, THUELER P, VERMEULEN B, SAINT-GHISLAIN M, BITON C, JACQUET J, BEVILACQUA F, DEPEURSINGE C, MEDA P

Urokinase-type plasminogen activator and its receptor synergize to promote pathogenic proteolysis.
EMBO JOURNAL
2000 vol. 19 pp. 4817-4826
ZHOU HM, NICHOLS A, MEDA P, VASSALLI JD


Domaines de recherche

BIOLOGIE CELLULAIRE
BIOCHIMIE ET BIOLOGIE MOLECULAIRE